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PubMed:18180298 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration.
T2 80-250 Sentence denotes Cyclin D1 is an important cell cycle regulator, but in cancer its overexpression also increases cellular migration mediated by p27 KIP1 stabilization and RhoA inhibition.
T3 251-429 Sentence denotes Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1 gene within a splice donor region was associated with an altered risk of developing cancer.
T4 430-632 Sentence denotes Altered RNA splicing caused by this polymorphism gives rise to a variant cyclin D1 isoform termed cyclin D1b, which has the same N terminus as the canonical cyclin D1a isoform but a distinct C terminus.
T5 633-768 Sentence denotes In this study we show that these different isoforms have unique properties with regard to the cellular migration function of cyclin D1.
T6 769-1009 Sentence denotes Although they displayed little difference in transcriptional co-repression assays on idealized reporter genes, microarray cDNA expression analysis revealed differential regulation of genes, including those that influence cellular migration.
T7 1010-1245 Sentence denotes Additionally, whereas cyclin D1a stabilized p27 KIP1 and inhibited RhoA-induced ROCK kinase activity, promoting cellular migration, cyclin D1b failed to stabilize p27 KIP1 or inhibit ROCK kinase activity and had no effect on migration.
T8 1246-1368 Sentence denotes Our findings argue that alternate splicing is an important determinant of the function of cyclin D1 in cellular migration.
T1 0-79 Sentence denotes Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration.
T2 80-250 Sentence denotes Cyclin D1 is an important cell cycle regulator, but in cancer its overexpression also increases cellular migration mediated by p27 KIP1 stabilization and RhoA inhibition.
T3 251-429 Sentence denotes Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1 gene within a splice donor region was associated with an altered risk of developing cancer.
T4 430-632 Sentence denotes Altered RNA splicing caused by this polymorphism gives rise to a variant cyclin D1 isoform termed cyclin D1b, which has the same N terminus as the canonical cyclin D1a isoform but a distinct C terminus.
T5 633-768 Sentence denotes In this study we show that these different isoforms have unique properties with regard to the cellular migration function of cyclin D1.
T6 769-1009 Sentence denotes Although they displayed little difference in transcriptional co-repression assays on idealized reporter genes, microarray cDNA expression analysis revealed differential regulation of genes, including those that influence cellular migration.
T7 1010-1245 Sentence denotes Additionally, whereas cyclin D1a stabilized p27 KIP1 and inhibited RhoA-induced ROCK kinase activity, promoting cellular migration, cyclin D1b failed to stabilize p27 KIP1 or inhibit ROCK kinase activity and had no effect on migration.
T8 1246-1368 Sentence denotes Our findings argue that alternate splicing is an important determinant of the function of cyclin D1 in cellular migration.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 135-141 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 422-428 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 135-141 Phenotype denotes cancer HP:0002664
T2 422-428 Phenotype denotes cancer HP:0002664

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 322-327 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 106-116 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098