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PubMed:18180297 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 1138-1142 DiseaseOrPhenotypicFeature denotes face 0010953

sentences

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.
T2 100-246 Sentence denotes Ricin A chain (RTA) inhibits protein synthesis by removing a specific adenine from the highly conserved alpha-sarcin/ricin loop in the large rRNA.
T3 247-398 Sentence denotes Expression of RTA with its own signal sequence in yeast resulted in its translocation into the endoplasmic reticulum (ER) and subsequent glycosylation.
T4 399-521 Sentence denotes Because RTA must unfold within the ER, it may be vulnerable to host defenses, such as the unfolded protein response (UPR).
T5 522-697 Sentence denotes UPR was induced in cells expressing an active site mutant but not the wild type RTA, indicating that the active site of RTA played a role in perturbing the ER stress response.
T6 698-839 Sentence denotes The inactive RTA without the signal sequence did not induce UPR, indicating that translocation into the ER was critical for induction of UPR.
T7 840-1010 Sentence denotes The wild type RTA inhibited activation of UPR not only due to ER stress induced by the protein itself but also by global effectors such as tunicamycin and dithiothreitol.
T8 1011-1153 Sentence denotes Mature RTA without the signal sequence also inhibited UPR, providing evidence that inhibition of UPR occurred on the cytosolic face of the ER.
T9 1154-1338 Sentence denotes RTA could not inhibit UPR when the spliced form of HAC1 mRNA was provided in trans, indicating that it had a direct effect on UPR upstream of HAC1-dependent transcriptional activation.
T10 1339-1527 Sentence denotes Only the precursor form of HAC1 mRNA was detected in cells expressing RTA after exposure to ER stress, demonstrating that ricin inhibits activation of UPR by preventing HAC1 mRNA splicing.
T11 1528-1773 Sentence denotes The RTA mutants that depurinated ribosomes but did not kill cells were not able to inhibit activation of UPR by tunicamycin, providing evidence that the inability to activate UPR in response to ER stress contributes to the cytotoxicity of ricin.
T1 0-99 Sentence denotes Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.
T2 100-246 Sentence denotes Ricin A chain (RTA) inhibits protein synthesis by removing a specific adenine from the highly conserved alpha-sarcin/ricin loop in the large rRNA.
T3 247-398 Sentence denotes Expression of RTA with its own signal sequence in yeast resulted in its translocation into the endoplasmic reticulum (ER) and subsequent glycosylation.
T4 399-521 Sentence denotes Because RTA must unfold within the ER, it may be vulnerable to host defenses, such as the unfolded protein response (UPR).
T5 522-697 Sentence denotes UPR was induced in cells expressing an active site mutant but not the wild type RTA, indicating that the active site of RTA played a role in perturbing the ER stress response.
T6 698-839 Sentence denotes The inactive RTA without the signal sequence did not induce UPR, indicating that translocation into the ER was critical for induction of UPR.
T7 840-1010 Sentence denotes The wild type RTA inhibited activation of UPR not only due to ER stress induced by the protein itself but also by global effectors such as tunicamycin and dithiothreitol.
T8 1011-1153 Sentence denotes Mature RTA without the signal sequence also inhibited UPR, providing evidence that inhibition of UPR occurred on the cytosolic face of the ER.
T9 1154-1338 Sentence denotes RTA could not inhibit UPR when the spliced form of HAC1 mRNA was provided in trans, indicating that it had a direct effect on UPR upstream of HAC1-dependent transcriptional activation.
T10 1339-1527 Sentence denotes Only the precursor form of HAC1 mRNA was detected in cells expressing RTA after exposure to ER stress, demonstrating that ricin inhibits activation of UPR by preventing HAC1 mRNA splicing.
T11 1528-1773 Sentence denotes The RTA mutants that depurinated ribosomes but did not kill cells were not able to inhibit activation of UPR by tunicamycin, providing evidence that the inability to activate UPR in response to ER stress contributes to the cytotoxicity of ricin.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 354-363 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 1138-1142 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T3 1561-1570 Body_part denotes ribosomes http://purl.obolibrary.org/obo/GO_0005840