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PubMed:18180294 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 68-74 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T3 410-416 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138

sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease.
T2 84-328 Sentence denotes The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
T3 329-484 Sentence denotes Severe unconjugated hyperbilirubinemia in humans that suffer from Crigler-Najjar type I disease results from lesions in the UGT1A1 gene and is often fatal.
T4 485-639 Sentence denotes To examine the physiological importance of the Ugt1 locus in mice, this locus was rendered non-functional by interrupting exon 4 to create Ugt1(-/-) mice.
T5 640-869 Sentence denotes Because UGT1A1 in humans is responsible for 100% of the conjugated bilirubin, it followed that newborn Ugt1(-/-) mice developed serum levels of unconjugated bilirubin that were 40-60 times higher than Ugt1(+/-) or wild-type mice.
T6 870-1088 Sentence denotes The result of extreme unconjugated bilirubin in Ugt1(-/-) mice, comparable to the induced levels noted in patients with Crigler-Najjar type 1 disease, is fatal in neonatal Ugt1(-/-) mice within 2 weeks following birth.
T7 1089-1160 Sentence denotes The extreme jaundice is present as a phenotype in skin color after 8 h.
T8 1161-1305 Sentence denotes Neonatal Ugt1(-/-) mice exhibit no detectable UGT1A-specific RNA, which corresponds to a complete absence of UGT1A proteins in liver microsomes.
T9 1306-1466 Sentence denotes Conserved glucuronidation activity attributed to the Ugt1 locus can be defined in Ugt1(-/-) mice, because UGT2-dependent glucuronidation activity is unaffected.
T10 1467-1629 Sentence denotes Remarkably, the loss of UGT1A functionality in liver results in significant alterations in cellular metabolism as investigated through changes in gene expression.
T11 1630-1855 Sentence denotes Thus, the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1139-1143 http://purl.obolibrary.org/obo/MAT_0000284 denotes skin
T2 1288-1293 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T3 1514-1519 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

DisGeNET

Id Subject Object Predicate Lexical cue
T0 453-459 gene:54658 denotes UGT1A1
T1 336-367 disease:C0268306 denotes unconjugated hyperbilirubinemia
T2 918-922 gene:56886 denotes Ugt1
T3 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T4 918-922 gene:54657 denotes Ugt1
T5 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T6 918-922 gene:7361 denotes Ugt1
T7 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T8 918-922 gene:54600 denotes Ugt1
T9 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T10 918-922 gene:54659 denotes Ugt1
T11 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T12 918-922 gene:54658 denotes Ugt1
T13 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T14 918-922 gene:54575 denotes Ugt1
T15 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T16 918-922 gene:54576 denotes Ugt1
T17 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T18 918-922 gene:54577 denotes Ugt1
T19 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T20 918-922 gene:7355 denotes Ugt1
T21 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T22 918-922 gene:54578 denotes Ugt1
T23 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T24 918-922 gene:54579 denotes Ugt1
T25 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T26 1042-1046 gene:56886 denotes Ugt1
T27 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T28 1042-1046 gene:54657 denotes Ugt1
T29 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T30 1042-1046 gene:7361 denotes Ugt1
T31 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T32 1042-1046 gene:54600 denotes Ugt1
T33 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T34 1042-1046 gene:54659 denotes Ugt1
T35 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T36 1042-1046 gene:54658 denotes Ugt1
T37 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T38 1042-1046 gene:54579 denotes Ugt1
T39 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T40 1042-1046 gene:54576 denotes Ugt1
T41 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T42 1042-1046 gene:54577 denotes Ugt1
T43 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T44 1042-1046 gene:7355 denotes Ugt1
T45 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T46 1042-1046 gene:54578 denotes Ugt1
T47 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T48 1042-1046 gene:54575 denotes Ugt1
T49 990-1011 disease:C0010324 denotes Crigler-Najjar type 1
T50 1648-1653 gene:7361 denotes UGT1A
T51 1692-1710 disease:C0524620 denotes metabolic syndrome
T52 1648-1653 gene:54658 denotes UGT1A
T53 1692-1710 disease:C0524620 denotes metabolic syndrome
T54 1666-1670 gene:56886 denotes Ugt1
T55 1692-1710 disease:C0524620 denotes metabolic syndrome
T56 1666-1670 gene:54657 denotes Ugt1
T57 1692-1710 disease:C0524620 denotes metabolic syndrome
T58 1666-1670 gene:7361 denotes Ugt1
T59 1692-1710 disease:C0524620 denotes metabolic syndrome
T60 1666-1670 gene:54600 denotes Ugt1
T61 1692-1710 disease:C0524620 denotes metabolic syndrome
T62 1666-1670 gene:54659 denotes Ugt1
T63 1692-1710 disease:C0524620 denotes metabolic syndrome
T64 1666-1670 gene:54658 denotes Ugt1
T65 1692-1710 disease:C0524620 denotes metabolic syndrome
T66 1666-1670 gene:54575 denotes Ugt1
T67 1692-1710 disease:C0524620 denotes metabolic syndrome
T68 1666-1670 gene:54576 denotes Ugt1
T69 1692-1710 disease:C0524620 denotes metabolic syndrome
T70 1666-1670 gene:54577 denotes Ugt1
T71 1692-1710 disease:C0524620 denotes metabolic syndrome
T72 1666-1670 gene:7355 denotes Ugt1
T73 1692-1710 disease:C0524620 denotes metabolic syndrome
T74 1666-1670 gene:54578 denotes Ugt1
T75 1692-1710 disease:C0524620 denotes metabolic syndrome
T76 1666-1670 gene:54579 denotes Ugt1
T77 1692-1710 disease:C0524620 denotes metabolic syndrome
R1 T0 T1 associated_with UGT1A1,unconjugated hyperbilirubinemia
R2 T2 T3 associated_with Ugt1,Crigler-Najjar type 1
R3 T4 T5 associated_with Ugt1,Crigler-Najjar type 1
R4 T6 T7 associated_with Ugt1,Crigler-Najjar type 1
R5 T8 T9 associated_with Ugt1,Crigler-Najjar type 1
R6 T10 T11 associated_with Ugt1,Crigler-Najjar type 1
R7 T12 T13 associated_with Ugt1,Crigler-Najjar type 1
R8 T14 T15 associated_with Ugt1,Crigler-Najjar type 1
R9 T16 T17 associated_with Ugt1,Crigler-Najjar type 1
R10 T18 T19 associated_with Ugt1,Crigler-Najjar type 1
R11 T20 T21 associated_with Ugt1,Crigler-Najjar type 1
R12 T22 T23 associated_with Ugt1,Crigler-Najjar type 1
R13 T24 T25 associated_with Ugt1,Crigler-Najjar type 1
R14 T26 T27 associated_with Ugt1,Crigler-Najjar type 1
R15 T28 T29 associated_with Ugt1,Crigler-Najjar type 1
R16 T30 T31 associated_with Ugt1,Crigler-Najjar type 1
R17 T32 T33 associated_with Ugt1,Crigler-Najjar type 1
R18 T34 T35 associated_with Ugt1,Crigler-Najjar type 1
R19 T36 T37 associated_with Ugt1,Crigler-Najjar type 1
R20 T38 T39 associated_with Ugt1,Crigler-Najjar type 1
R21 T40 T41 associated_with Ugt1,Crigler-Najjar type 1
R22 T42 T43 associated_with Ugt1,Crigler-Najjar type 1
R23 T44 T45 associated_with Ugt1,Crigler-Najjar type 1
R24 T46 T47 associated_with Ugt1,Crigler-Najjar type 1
R25 T48 T49 associated_with Ugt1,Crigler-Najjar type 1
R26 T50 T51 associated_with UGT1A,metabolic syndrome
R27 T52 T53 associated_with UGT1A,metabolic syndrome
R28 T54 T55 associated_with Ugt1,metabolic syndrome
R29 T56 T57 associated_with Ugt1,metabolic syndrome
R30 T58 T59 associated_with Ugt1,metabolic syndrome
R31 T60 T61 associated_with Ugt1,metabolic syndrome
R32 T62 T63 associated_with Ugt1,metabolic syndrome
R33 T64 T65 associated_with Ugt1,metabolic syndrome
R34 T66 T67 associated_with Ugt1,metabolic syndrome
R35 T68 T69 associated_with Ugt1,metabolic syndrome
R36 T70 T71 associated_with Ugt1,metabolic syndrome
R37 T72 T73 associated_with Ugt1,metabolic syndrome
R38 T74 T75 associated_with Ugt1,metabolic syndrome
R39 T76 T77 associated_with Ugt1,metabolic syndrome

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 349-367 Disease denotes hyperbilirubinemia http://purl.obolibrary.org/obo/MONDO_0002408|http://purl.obolibrary.org/obo/MONDO_0024288
T3 1692-1710 Disease denotes metabolic syndrome http://purl.obolibrary.org/obo/MONDO_0004955

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 336-367 Phenotype denotes unconjugated hyperbilirubinemia HP:0008282
T2 1101-1109 Phenotype denotes jaundice HP:0000952

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 32-36 OrganismTaxon denotes mice 10088
T2 47-52 OrganismTaxon denotes human 9606
T3 546-550 OrganismTaxon denotes mice 10088
T4 634-638 OrganismTaxon denotes mice 10088
T5 753-757 OrganismTaxon denotes mice 10088
T6 864-868 OrganismTaxon denotes mice 10088
T7 928-932 OrganismTaxon denotes mice 10088
T8 1052-1056 OrganismTaxon denotes mice 10088
T9 1180-1184 OrganismTaxon denotes mice 10088
T10 1398-1402 OrganismTaxon denotes mice 10088
T11 1676-1680 OrganismTaxon denotes mice 10088

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1139-1143 Body_part denotes skin http://purl.obolibrary.org/obo/MAT_0000284
T2 1288-1293 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 1514-1519 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 250-254 Body_part denotes bile http://purl.obolibrary.org/obo/UBERON_0001970
T2 1139-1143 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014|http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0002097|http://purl.obolibrary.org/obo/UBERON_0002199
T6 1288-1293 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T7 1514-1519 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107