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sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin.
T2 108-215 Sentence denotes Palladin is a recently described phosphoprotein that plays an important role in cell adhesion and motility.
T3 216-341 Sentence denotes Previous studies have shown that palladin overexpression results in profound changes in actin organization in cultured cells.
T4 342-531 Sentence denotes Palladin binds to the actin-associated proteins alpha-actinin, vasodilator-stimulated phosphoprotein, profilin, Eps8, and ezrin, suggesting that it may affect actin organization indirectly.
T5 532-680 Sentence denotes To determine its molecular function in generating actin arrays, we purified palladin and asked if it is also capable of binding to F-actin directly.
T6 681-803 Sentence denotes In co-sedimentation and differential sedimentation assays, palladin was found to both bind and cross-link actin filaments.
T7 804-881 Sentence denotes This bundling activity was confirmed by fluorescence and electron microscopy.
T8 882-993 Sentence denotes Palladin fragments were then purified and used to determine the sequences necessary to bind and bundle F-actin.
T9 994-1182 Sentence denotes The Ig3 domain of palladin bound to F-actin, and a palladin fragment containing Ig3, Ig4, and the region linking these domains was identified as a fragment that was able to bundle F-actin.
T10 1183-1357 Sentence denotes Because palladin has multiple Ig domains, and only one of them binds to F-actin, this suggests that different Ig domains may be specialized for distinct biological functions.
T11 1358-1557 Sentence denotes In addition, our results suggest a potential role for palladin in generating specialized, actin-based cell morphologies via both direct actin cross-linking activity and indirect scaffolding activity.
T1 0-107 Sentence denotes Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin.
T2 108-215 Sentence denotes Palladin is a recently described phosphoprotein that plays an important role in cell adhesion and motility.
T3 216-341 Sentence denotes Previous studies have shown that palladin overexpression results in profound changes in actin organization in cultured cells.
T4 342-531 Sentence denotes Palladin binds to the actin-associated proteins alpha-actinin, vasodilator-stimulated phosphoprotein, profilin, Eps8, and ezrin, suggesting that it may affect actin organization indirectly.
T5 532-680 Sentence denotes To determine its molecular function in generating actin arrays, we purified palladin and asked if it is also capable of binding to F-actin directly.
T6 681-803 Sentence denotes In co-sedimentation and differential sedimentation assays, palladin was found to both bind and cross-link actin filaments.
T7 804-881 Sentence denotes This bundling activity was confirmed by fluorescence and electron microscopy.
T8 882-993 Sentence denotes Palladin fragments were then purified and used to determine the sequences necessary to bind and bundle F-actin.
T9 994-1182 Sentence denotes The Ig3 domain of palladin bound to F-actin, and a palladin fragment containing Ig3, Ig4, and the region linking these domains was identified as a fragment that was able to bundle F-actin.
T10 1183-1357 Sentence denotes Because palladin has multiple Ig domains, and only one of them binds to F-actin, this suggests that different Ig domains may be specialized for distinct biological functions.
T11 1358-1557 Sentence denotes In addition, our results suggest a potential role for palladin in generating specialized, actin-based cell morphologies via both direct actin cross-linking activity and indirect scaffolding activity.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 787-802 Body_part denotes actin filaments http://purl.obolibrary.org/obo/GO_0005884

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 326-340 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010