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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 0-7 Glycan_Motif denotes Glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 31-39 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T4 141-160 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T5 162-170 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T7 339-346 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T8 409-417 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T10 483-490 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T11 536-543 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T12 639-647 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T14 700-707 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T15 750-757 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T16 847-854 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T17 936-943 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T18 960-967 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T19 1045-1052 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T20 1075-1083 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T22 1176-1184 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T24 1407-1414 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T25 1516-1523 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T26 1557-1564 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T27 1670-1678 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T29 1706-1713 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 31-39 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 162-170 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 409-417 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T4 639-647 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T5 1075-1083 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T6 1176-1184 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T7 1670-1678 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 0-7 https://glytoucan.org/Structures/Glycans/G15021LG denotes Glucose
T2 31-39 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T3 31-39 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T4 141-160 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T5 162-170 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T6 162-170 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T7 339-346 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T8 409-417 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T9 409-417 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T10 483-490 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T11 536-543 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T12 639-647 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T13 639-647 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T14 700-707 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T15 750-757 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T16 847-854 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T17 936-943 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T18 960-967 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T19 1045-1052 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T20 1075-1083 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T21 1075-1083 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T22 1176-1184 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T23 1176-1184 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T24 1407-1414 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T25 1516-1523 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T26 1557-1564 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T27 1670-1678 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T28 1670-1678 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T29 1706-1713 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase.
T2 132-268 Sentence denotes O-Linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification of proteins that functions as a nutrient sensing mechanism.
T3 269-362 Sentence denotes Here we report on regulation of O-GlcNAcylation over a broad range of glucose concentrations.
T4 363-503 Sentence denotes We have discovered a significant induction of O-GlcNAc modification of a limited number of proteins under conditions of glucose deprivation.
T5 504-726 Sentence denotes Beginning 12 h after treatment, glucose-deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8-fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mm; p = 0.008).
T6 727-975 Sentence denotes Some of the targets of glucose deprivation-induced O-GlcNAcylation are distinct from those modified in response to high glucose (20 mm) or glucosamine (10 mm) treatment, suggesting differential targeting with glucose deprivation and glucose excess.
T7 976-1165 Sentence denotes O-GlcNAcylation of glycogen synthase is significantly increased with glucose deprivation, and this O-GlcNAc increase contributes to a 60% decrease (p = 0.004) in glycogen synthase activity.
T8 1166-1287 Sentence denotes Increased O-GlcNAc modification is not mediated by increased UDP-GlcNAc, the rate-limiting substrate for O-GlcNAcylation.
T9 1288-1439 Sentence denotes Rather, the mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (OGT) increases 3.4-fold within 6 h of glucose deprivation (p = 0.006).
T10 1440-1538 Sentence denotes Within 12 h, OGT protein increases 1.7-fold (p = 0.01) compared with normal glucose-treated cells.
T11 1539-1642 Sentence denotes In addition, 12-h glucose deprivation leads to a 49% decrease in O-GlcNAcase protein levels (p = 0.03).
T12 1643-1869 Sentence denotes We conclude that increased O-GlcNAc modification stimulated by glucose deprivation results from increased OGT and decreased O-GlcNAcase levels and that these changes affect cell metabolism, thus inactivating glycogen synthase.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 90-130 Protein denotes O-linked N-acetylglucosaminyltransferase
T2 1327-1367 Protein denotes O-linked N-acetylglucosaminyltransferase
T3 1369-1372 Protein denotes OGT
T4 1453-1456 Protein denotes OGT
T5 1604-1615 Protein denotes O-GlcNAcase
T6 1767-1778 Protein denotes O-GlcNAcase

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 33-39 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 141-160 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T3 164-170 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T4 411-417 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T5 641-647 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T6 1077-1083 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T7 1178-1184 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T8 1231-1237 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T9 1672-1678 chem:24139 denotes GlcNAc

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 559-583 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 559-583 Phenotype denotes hepatocellular carcinoma HP:0001402

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 31-39 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 162-170 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 409-417 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T4 639-647 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T5 1075-1083 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T6 1176-1184 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T7 1670-1678 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 31-39 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 162-170 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 409-417 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T4 639-647 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T5 1075-1083 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T6 1176-1184 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T7 1670-1678 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 559-583 Phenotype denotes hepatocellular carcinoma HP:0001402

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 559-583 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 553-558 OrganismTaxon denotes human 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1309-1326 Body_part denotes nucleocytoplasmic http://purl.obolibrary.org/obo/GO_0005622

sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase.
T2 132-268 Sentence denotes O-Linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification of proteins that functions as a nutrient sensing mechanism.
T3 269-362 Sentence denotes Here we report on regulation of O-GlcNAcylation over a broad range of glucose concentrations.
T4 363-503 Sentence denotes We have discovered a significant induction of O-GlcNAc modification of a limited number of proteins under conditions of glucose deprivation.
T5 504-726 Sentence denotes Beginning 12 h after treatment, glucose-deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8-fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mm; p = 0.008).
T6 727-975 Sentence denotes Some of the targets of glucose deprivation-induced O-GlcNAcylation are distinct from those modified in response to high glucose (20 mm) or glucosamine (10 mm) treatment, suggesting differential targeting with glucose deprivation and glucose excess.
T7 976-1165 Sentence denotes O-GlcNAcylation of glycogen synthase is significantly increased with glucose deprivation, and this O-GlcNAc increase contributes to a 60% decrease (p = 0.004) in glycogen synthase activity.
T8 1166-1287 Sentence denotes Increased O-GlcNAc modification is not mediated by increased UDP-GlcNAc, the rate-limiting substrate for O-GlcNAcylation.
T9 1288-1439 Sentence denotes Rather, the mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (OGT) increases 3.4-fold within 6 h of glucose deprivation (p = 0.006).
T10 1440-1538 Sentence denotes Within 12 h, OGT protein increases 1.7-fold (p = 0.01) compared with normal glucose-treated cells.
T11 1539-1642 Sentence denotes In addition, 12-h glucose deprivation leads to a 49% decrease in O-GlcNAcase protein levels (p = 0.03).
T12 1643-1869 Sentence denotes We conclude that increased O-GlcNAc modification stimulated by glucose deprivation results from increased OGT and decreased O-GlcNAcase levels and that these changes affect cell metabolism, thus inactivating glycogen synthase.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase.
T2 132-268 Sentence denotes O-Linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification of proteins that functions as a nutrient sensing mechanism.
T3 269-362 Sentence denotes Here we report on regulation of O-GlcNAcylation over a broad range of glucose concentrations.
T4 363-503 Sentence denotes We have discovered a significant induction of O-GlcNAc modification of a limited number of proteins under conditions of glucose deprivation.
T5 504-726 Sentence denotes Beginning 12 h after treatment, glucose-deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8-fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mm; p = 0.008).
T6 727-975 Sentence denotes Some of the targets of glucose deprivation-induced O-GlcNAcylation are distinct from those modified in response to high glucose (20 mm) or glucosamine (10 mm) treatment, suggesting differential targeting with glucose deprivation and glucose excess.
T7 976-1165 Sentence denotes O-GlcNAcylation of glycogen synthase is significantly increased with glucose deprivation, and this O-GlcNAc increase contributes to a 60% decrease (p = 0.004) in glycogen synthase activity.
T8 1166-1287 Sentence denotes Increased O-GlcNAc modification is not mediated by increased UDP-GlcNAc, the rate-limiting substrate for O-GlcNAcylation.
T9 1288-1439 Sentence denotes Rather, the mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (OGT) increases 3.4-fold within 6 h of glucose deprivation (p = 0.006).
T10 1440-1538 Sentence denotes Within 12 h, OGT protein increases 1.7-fold (p = 0.01) compared with normal glucose-treated cells.
T11 1539-1642 Sentence denotes In addition, 12-h glucose deprivation leads to a 49% decrease in O-GlcNAcase protein levels (p = 0.03).
T12 1643-1869 Sentence denotes We conclude that increased O-GlcNAc modification stimulated by glucose deprivation results from increased OGT and decreased O-GlcNAcase levels and that these changes affect cell metabolism, thus inactivating glycogen synthase.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 31-39 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 162-170 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 409-417 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T4 639-647 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T5 1075-1083 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T6 1176-1184 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T7 1670-1678 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 31-39 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 162-170 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 409-417 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T4 639-647 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T5 1075-1083 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T6 1176-1184 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T7 1670-1678 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 553-558 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1309-1326 Body_part denotes nucleocytoplasmic http://purl.obolibrary.org/obo/GO_0005622