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PubMed:1814434 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-16 protein denotes Protein kinase C
T2 32-45 DNA denotes protooncogene
T3 100-126 cell_line denotes human U-937 leukemia cells
T4 128-154 cell_line denotes Human U-937 leukemia cells
T5 179-196 cell_type denotes monocytic lineage
T6 395-427 DNA denotes differentiation-associated genes
T7 450-480 cell_type denotes TPA-differentiated U-937 cells
T8 723-731 protein denotes cytokine
T9 813-828 cell_type denotes uninduced cells
T10 843-854 cell_line denotes U-937 cells
T11 901-917 protein denotes protein kinase C
T12 919-922 protein denotes PKC
T13 1024-1027 protein denotes PKC
T14 1156-1159 protein denotes PKC
T15 1192-1195 protein denotes PKC
T16 1245-1275 DNA denotes immediate early response genes
T17 1325-1330 DNA denotes c-fos
T18 1335-1356 DNA denotes c-jun gene expression
T19 1368-1395 RNA denotes c-fos and c-jun transcripts
T20 1432-1435 protein denotes PKC
T21 1603-1606 protein denotes PKC

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-127 Sentence denotes Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells.
S2 128-269 Sentence denotes Human U-937 leukemia cells differentiate along the monocytic lineage following 3-day exposures to 12-O-tetradecanoylphorbol-13-acetate (TPA).
S3 270-428 Sentence denotes This induction of differentiation is accompanied by adherence and loss of proliferation, as well as expression/repression of differentiation-associated genes.
S4 429-574 Sentence denotes Long term culture of TPA-differentiated U-937 cells in the absence of phorbol ester for 32-36 days resulted in a process of retrodifferentiation.
S5 575-663 Sentence denotes The retrodifferentiated cells detached from the substrate and reinitiated proliferation.
S6 664-829 Sentence denotes Other cellular parameters, such as glycosidase activities, cytokine release, and filament expression, returned to levels similar to that observed in uninduced cells.
S7 830-983 Sentence denotes Treatment of U-937 cells with TPA resulted in a rapid translocation of protein kinase C (PKC) from the cytosol to cell membrane fractions within 2-8 min.
S8 984-1064 Sentence denotes Increased levels of membrane-associated PKC activity persisted until 17-29 days.
S9 1065-1177 Sentence denotes However, longer periods of incubation were associated with a return to the distribution of PKC in control cells.
S10 1178-1357 Sentence denotes Activation of PKC has been implicated in the regulation of certain immediate early response genes, and in the present studies, TPA rapidly induced c-fos and c-jun gene expression.
S11 1358-1560 Sentence denotes Levels of c-fos and c-jun transcripts remained elevated during periods of PKC activation and also returned to levels observed in control cells by 30-36 days, when the cells entered retrodifferentiation.
S12 1561-1742 Sentence denotes Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.
S13 1742-1775 Sentence denotes (ABSTRACT TRUNCATED AT 250 WORDS)

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 0-16 NP denotes Protein kinase C
C1 0-27 NP denotes Protein kinase C activation
C3 100-126 NP denotes human U-937 leukemia cells
C4 128-154 NP denotes Human U-937 leukemia cells
C5 226-268 NP denotes 12-O-tetradecanoylphorbol-13-acetate (TPA)
C7 450-453 NP denotes TPA
C6 450-480 NP denotes TPA-differentiated U-937 cells
C8 778-784 NP denotes levels
C9 796-800 NP denotes that
C10 843-854 NP denotes U-937 cells
C11 860-863 NP denotes TPA
C12 901-923 NP denotes protein kinase C (PKC)
C13 1024-1027 NP denotes PKC
C14 1156-1159 NP denotes PKC
C15 1163-1176 NP denotes control cells
C17 1192-1195 NP denotes PKC
C16 1178-1195 NP denotes Activation of PKC
C18 1305-1308 NP denotes TPA
C19 1325-1356 NP denotes c-fos and c-jun gene expression
C21 1432-1435 NP denotes PKC
C20 1432-1446 NP denotes PKC activation
C22 1487-1500 NP denotes control cells
C23 1521-1530 NP denotes the cells
C24 1561-1574 NP denotes Staurosporine
C26 1603-1606 NP denotes PKC
C25 1576-1606 NP denotes a nonspecific inhibitor of PKC
C27 1626-1629 NP denotes TPA
C29 1698-1701 NP denotes TPA
C28 1698-1741 NP denotes TPA-induced c-fos and c-jun gene expression
R1 C4 C3 coref-ident Human U-937 leukemia cells,human U-937 leukemia cells
R2 C7 C5 coref-ident TPA,12-O-tetradecanoylphorbol-13-acetate (TPA)
R3 C6 C4 coref-other TPA-differentiated U-937 cells,Human U-937 leukemia cells
R4 C9 C8 coref-pron that,levels
R5 C10 C4 coref-ident U-937 cells,Human U-937 leukemia cells
R6 C11 C7 coref-ident TPA,TPA
R7 C12 C2 coref-ident protein kinase C (PKC),Protein kinase C
R8 C13 C12 coref-ident PKC,protein kinase C (PKC)
R9 C14 C13 coref-ident PKC,PKC
R10 C17 C14 coref-ident PKC,PKC
R11 C16 C1 coref-ident Activation of PKC,Protein kinase C activation
R12 C18 C11 coref-ident TPA,TPA
R13 C21 C17 coref-ident PKC,PKC
R14 C20 C16 coref-ident PKC activation,Activation of PKC
R15 C22 C15 coref-ident control cells,control cells
R16 C23 C22 coref-ident the cells,control cells
R17 C26 C21 coref-ident PKC,PKC
R18 C25 C24 coref-appos a nonspecific inhibitor of PKC,Staurosporine
R19 C27 C18 coref-ident TPA,TPA
R20 C29 C27 coref-ident TPA,TPA
R21 C28 C19 coref-ident TPA-induced c-fos and c-jun gene expression,c-fos and c-jun gene expression

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-16 protein_molecule denotes Protein kinase C
T2 32-45 DNA_family_or_group denotes protooncogene
T3 60-96 other_name denotes differentiation/retrodifferentiation
T4 100-126 cell_line denotes human U-937 leukemia cells
T5 128-154 cell_line denotes Human U-937 leukemia cells
T6 179-196 cell_type denotes monocytic lineage
T7 226-262 other_organic_compound denotes 12-O-tetradecanoylphorbol-13-acetate
T8 264-267 other_organic_compound denotes TPA
T9 344-357 other_name denotes proliferation
T10 370-391 other_name denotes expression/repression
T11 395-427 DNA_domain_or_region denotes differentiation-associated genes
T12 450-453 other_organic_compound denotes TPA
T13 499-512 other_organic_compound denotes phorbol ester
T14 553-573 other_name denotes retrodifferentiation
T15 649-662 other_name denotes proliferation
T16 699-721 other_name denotes glycosidase activities
T17 723-731 protein_family_or_group denotes cytokine
T18 745-764 other_name denotes filament expression
T19 813-828 cell_type denotes uninduced cells
T20 843-854 cell_line denotes U-937 cells
T21 860-863 other_organic_compound denotes TPA
T22 901-917 protein_molecule denotes protein kinase C
T23 919-922 protein_molecule denotes PKC
T24 1004-1023 other_name denotes membrane-associated
T25 1024-1027 protein_molecule denotes PKC
T26 1140-1152 other_name denotes distribution
T27 1156-1159 protein_molecule denotes PKC
T28 1192-1195 protein_molecule denotes PKC
T29 1245-1275 DNA_family_or_group denotes immediate early response genes
T30 1305-1308 other_organic_compound denotes TPA
T31 1325-1330 DNA_domain_or_region denotes c-fos
T32 1335-1356 DNA_domain_or_region denotes c-jun gene expression
T33 1432-1435 protein_molecule denotes PKC
T34 1539-1559 other_name denotes retrodifferentiation
T35 1561-1574 other_organic_compound denotes Staurosporine
T36 1603-1606 protein_molecule denotes PKC
T37 1626-1629 other_organic_compound denotes TPA