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PubMed:18065756 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 101-208 DRI_Background denotes Very little is known about SET- and MYND-containing protein 2 (SMYD2), a member of the SMYD protein family.
T2 209-362 DRI_Background denotes However, the interest in better understanding the roles of SMYD2 has grown because of recent reports indicating that SMYD2 methylates p53 and histone H3.
T3 363-481 DRI_Outcome denotes In this study, we present a combined proteomics and genomics study of SMYD2 designed to elucidate its molecular roles.
T4 482-713 DRI_Outcome denotes We report the cytosolic and nuclear interactome of SMYD2 using a combination of immunoprecipitation coupled with high throughput MS, chromatin immunoprecipitation coupled with high throughput MS, and co-immunoprecipitation methods.
T5 714-894 DRI_Approach denotes In particular, we report that SMYD2 interacted with HSP90alpha independently of the SET and MYND domains, with EBP41L3 through the MYND domain, and with p53 through the SET domain.
T6 895-1066 DRI_Outcome denotes We demonstrated that the interaction of SMYD2 with HSP90alpha enhances SMYD2 histone methyltransferase activity and specificity for histone H3 at lysine 4 (H3K4) in vitro.
T7 1067-1225 DRI_Background denotes Interestingly histone H3K36 methyltransferase activity was independent of its interaction with HSP90alpha similar to LSD1 dependence on the androgen receptor.
T8 1226-1301 DRI_Approach denotes We also showed that the SET domain is required for the methylation at H3K4.
T9 1302-1508 DRI_Outcome denotes We demonstrated using a modified chromatin immunoprecipitation protocol that the SMYD2 gain of function leads to an increase in H3K4 methylation in vivo, whereas no observable levels of H3K36 were detected.
T10 1509-1742 DRI_Outcome denotes We also report that the SMYD2 gain of function was correlated with the up-regulation of 37 and down-regulation of four genes, the majority of which are involved in the cell cycle, chromatin remodeling, and transcriptional regulation.
T11 1743-1820 DRI_Background denotes TACC2 is one of the genes up-regulated as a result of SMYD2 gain of function.
T12 1821-1938 DRI_Background denotes Up-regulation of TACC2 by SMYD2 occurred as a result of SMYD2 binding to the TACC2 promoter where it methylates H3K4.
T13 1939-1973 DRI_Outcome denotes Furthermore the combination of the
T14 1992-2128 DRI_Outcome denotes with the gene expression data suggests that some of the genes regulated by SMYD2 are closely associated with SMYD2-interacting proteins.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 61-66 Protein denotes SMYD2
T2 128-162 Protein denotes SET- and MYND-containing protein 2
T3 164-169 Protein denotes SMYD2
T4 268-273 Protein denotes SMYD2
T5 326-331 Protein denotes SMYD2
T6 343-346 Protein denotes p53
T7 351-361 Protein denotes histone H3
T8 433-438 Protein denotes SMYD2
T9 533-538 Protein denotes SMYD2
T10 744-749 Protein denotes SMYD2
T11 766-776 Protein denotes HSP90alpha
T12 825-832 Protein denotes EBP41L3
T13 867-870 Protein denotes p53
T14 935-940 Protein denotes SMYD2
T15 946-956 Protein denotes HSP90alpha
T16 966-971 Protein denotes SMYD2
T17 1027-1037 Protein denotes histone H3
T18 1051-1053 Protein denotes H3
T19 1081-1091 Protein denotes histone H3
T20 1162-1172 Protein denotes HSP90alpha
T21 1184-1188 Protein denotes LSD1
T22 1207-1224 Protein denotes androgen receptor
T23 1296-1298 Protein denotes H3
T24 1383-1388 Protein denotes SMYD2
T25 1430-1432 Protein denotes H3
T26 1488-1490 Protein denotes H3
T27 1533-1538 Protein denotes SMYD2
T28 1743-1748 Protein denotes TACC2
T29 1797-1802 Protein denotes SMYD2
T30 1838-1843 Protein denotes TACC2
T31 1847-1852 Protein denotes SMYD2
T32 1877-1882 Protein denotes SMYD2
T33 1898-1903 Protein denotes TACC2
T34 1933-1935 Protein denotes H3
T35 1974-1979 Protein denotes SMYD2
T36 2067-2072 Protein denotes SMYD2
T37 2101-2106 Protein denotes SMYD2

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1677-1687 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098