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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 122-242 DRI_Background denotes The DNA mismatch repair (MMR) family functions in a variety of contexts to preserve genome integrity in most eukaryotes.
T2 243-351 DRI_Background denotes In particular, members of the MMR family are involved in the process of meiotic recombination in germ cells.
T3 352-509 DRI_Outcome denotes MMR gene mutations in mice result in meiotic disruption during prophase I, but the extent of this disruption often differs between male and female meiocytes.
T4 510-792 DRI_Approach denotes To address the role of MMR proteins specifically in female meiosis, we explored the progression of oocytes through prophase I and the meiotic divisions in mice harboring deletions in members of the MMR pathway (Mlh1, Mlh3, Exo1, and an ATPase-deficient variant of Mlh1, Mlh1(G67R)).
T5 793-1028 DRI_Outcome denotes The colocalization of MLH1 and MLH3, key proteins involved in stabilization of nascent crossovers, was dependent on intact heterodimer formation and was highly correlated with the ability of oocytes to progress through to metaphase II.
T6 1029-1165 DRI_Background denotes The exception was Exo1(-/-) oocytes, in which normal MLH1/MLH3 localization was observed followed by failure to proceed to metaphase II.
T7 1166-1368 DRI_Background denotes All mutant oocytes were able to resume meiosis after dictyate arrest, but they showed a dramatic decline in chiasmata (to less than 25% of normal), accompanied by varied progression through metaphase I.
T8 1369-1767 DRI_Outcome denotes Taken together, these results demonstrate that MMR function is required for the formation and stabilization of crossovers in mammalian oocytes and that, in the absence of a functional MMR system, the failure to maintain chiasmata results in a reduced ability to proceed normally through the first and second meiotic divisions, despite near-normal levels of meiotic resumption after dictyate arrest.

c_corpus

Id Subject Object Predicate Lexical cue
T1 47-53 UBERON:0003100 denotes female
T2 54-58 PR:000005054 denotes mice
T4 54-58 O89094 denotes mice
T3 54-58 D051379 denotes mice
T5 54-58 10095 denotes mice
T8 93-96 SO:0000352 denotes DNA
T7 93-96 CHEBI:16991 denotes DNA
T9 93-96 D004247 denotes DNA
T6 93-96 GO:0005574 denotes DNA
T10 97-112 GO:0006298 denotes mismatch repair
T11 113-120 CHEBI:34922 denotes pathway
T14 126-129 SO:0000352 denotes DNA
T13 126-129 CHEBI:16991 denotes DNA
T15 126-129 D004247 denotes DNA
T12 126-129 GO:0005574 denotes DNA
T16 130-145 GO:0006298 denotes mismatch repair
T17 147-150 GO:0006298 denotes MMR
T19 147-150 P22897 denotes MMR
T20 147-150 PR:000002972 denotes MMR
T21 147-150 Q61830 denotes MMR
T18 147-150 CVCL_E779 denotes MMR
T22 206-212 SO:0001026 denotes genome
T23 231-241 D056890 denotes eukaryotes
T26 273-276 P22897 denotes MMR
T27 273-276 PR:000002972 denotes MMR
T28 273-276 Q61830 denotes MMR
T25 273-276 CVCL_E779 denotes MMR
T24 273-276 GO:0006298 denotes MMR
T29 340-350 UBERON:3010292 denotes germ cells
T30 352-355 GO:0006298 denotes MMR
T32 352-355 P22897 denotes MMR
T33 352-355 PR:000002972 denotes MMR
T34 352-355 Q61830 denotes MMR
T31 352-355 CVCL_E779 denotes MMR
T35 356-360 SO:0000704 denotes gene
T37 374-378 D051379 denotes mice
T39 374-378 10095 denotes mice
T36 374-378 PR:000005054 denotes mice
T38 374-378 O89094 denotes mice
T40 415-423 GO:0051324 denotes prophase
T41 483-487 UBERON:0003101 denotes male
T42 483-487 CHEBI:30780 denotes male
T43 492-498 UBERON:0003100 denotes female
T44 533-536 GO:0006298 denotes MMR
T46 533-536 P22897 denotes MMR
T47 533-536 PR:000002972 denotes MMR
T48 533-536 Q61830 denotes MMR
T45 533-536 CVCL_E779 denotes MMR
T49 537-545 CHEBI:36080 denotes proteins
T50 562-568 UBERON:0003100 denotes female
T51 562-576 GO:0007143 denotes female meiosis
T53 625-633 GO:0051324 denotes prophase
T55 665-669 D051379 denotes mice
T57 665-669 10095 denotes mice
T54 665-669 PR:000005054 denotes mice
T56 665-669 O89094 denotes mice
T58 708-711 GO:0006298 denotes MMR
T60 708-711 P22897 denotes MMR
T61 708-711 PR:000002972 denotes MMR
T62 708-711 Q61830 denotes MMR
T59 708-711 CVCL_E779 denotes MMR
T63 712-719 CHEBI:34922 denotes pathway
T64 721-725 PR:Q9ZRV4 denotes Mlh1
T65 721-725 PR:P38920 denotes Mlh1
T66 721-725 PR:Q54KD8 denotes Mlh1
T68 721-725 PR:Q9JK91 denotes Mlh1
T69 721-725 PR:P97679 denotes Mlh1
T70 721-725 PR:Q9P7W6 denotes Mlh1
T71 721-725 PR:000010442 denotes Mlh1
T72 721-725 PR:P40692 denotes Mlh1
T67 721-725 CVCL_G669 denotes Mlh1
T73 727-731 PR:F4JN26 denotes Mlh3
T74 727-731 PR:Q12083 denotes Mlh3
T75 727-731 PR:000010443 denotes Mlh3
T76 727-731 PR:Q9UHC1 denotes Mlh3
T77 730-736 PR:Q8IV48 denotes 3, Exo
T78 730-736 PR:Q7TMF2 denotes 3, Exo
T79 730-736 PR:000007178 denotes 3, Exo
T85 733-737 PR:P39875 denotes Exo1
T86 733-737 PR:Q24558 denotes Exo1
T87 733-737 PR:Q54ED2 denotes Exo1
T88 733-737 PR:Q803U7 denotes Exo1
T89 733-737 PR:Q9UQ84 denotes Exo1
T90 733-737 PR:Q9QZ11 denotes Exo1
T91 733-737 PR:P53695 denotes Exo1
T92 733-737 PR:000007245 denotes Exo1
T93 733-737 PR:Q8L6Z7 denotes Exo1
T94 746-752 A3DIJ8 denotes ATPase
T96 746-752 Q9SIY3 denotes ATPase
T95 746-752 D000251 denotes ATPase
T97 763-770 SO:0001147 denotes variant
T98 774-778 PR:Q9ZRV4 denotes Mlh1
T99 774-778 PR:P38920 denotes Mlh1
T100 774-778 PR:Q54KD8 denotes Mlh1
T102 774-778 PR:Q9JK91 denotes Mlh1
T103 774-778 PR:P97679 denotes Mlh1
T104 774-778 PR:Q9P7W6 denotes Mlh1
T105 774-778 PR:000010442 denotes Mlh1
T106 774-778 PR:P40692 denotes Mlh1
T101 774-778 CVCL_G669 denotes Mlh1
T107 780-784 PR:Q9ZRV4 denotes Mlh1
T108 780-784 PR:P38920 denotes Mlh1
T109 780-784 PR:Q54KD8 denotes Mlh1
T111 780-784 PR:Q9JK91 denotes Mlh1
T112 780-784 PR:P97679 denotes Mlh1
T113 780-784 PR:Q9P7W6 denotes Mlh1
T114 780-784 PR:000010442 denotes Mlh1
T115 780-784 PR:P40692 denotes Mlh1
T110 780-784 CVCL_G669 denotes Mlh1
T116 815-819 PR:Q9ZRV4 denotes MLH1
T117 815-819 PR:P38920 denotes MLH1
T118 815-819 PR:Q54KD8 denotes MLH1
T120 815-819 PR:Q9JK91 denotes MLH1
T121 815-819 PR:P97679 denotes MLH1
T122 815-819 PR:Q9P7W6 denotes MLH1
T123 815-819 PR:000010442 denotes MLH1
T124 815-819 PR:P40692 denotes MLH1
T119 815-819 CVCL_G669 denotes MLH1
T125 824-828 PR:F4JN26 denotes MLH3
T126 824-828 PR:Q12083 denotes MLH3
T127 824-828 PR:000010443 denotes MLH3
T128 824-828 PR:Q9UHC1 denotes MLH3
T129 834-842 CHEBI:36080 denotes proteins
T130 928-937 GO:0009058 denotes formation
T131 1015-1024 GO:0051323 denotes metaphase
T137 1047-1051 PR:P39875 denotes Exo1
T138 1047-1051 PR:Q24558 denotes Exo1
T139 1047-1051 PR:Q54ED2 denotes Exo1
T140 1047-1051 PR:Q803U7 denotes Exo1
T141 1047-1051 PR:Q9UQ84 denotes Exo1
T142 1047-1051 PR:Q9QZ11 denotes Exo1
T143 1047-1051 PR:P53695 denotes Exo1
T144 1047-1051 PR:000007245 denotes Exo1
T145 1047-1051 PR:Q8L6Z7 denotes Exo1
T146 1082-1086 PR:Q9ZRV4 denotes MLH1
T147 1082-1086 PR:P38920 denotes MLH1
T148 1082-1086 PR:Q54KD8 denotes MLH1
T150 1082-1086 PR:Q9JK91 denotes MLH1
T151 1082-1086 PR:P97679 denotes MLH1
T152 1082-1086 PR:Q9P7W6 denotes MLH1
T153 1082-1086 PR:000010442 denotes MLH1
T154 1082-1086 PR:P40692 denotes MLH1
T149 1082-1086 CVCL_G669 denotes MLH1
T155 1087-1091 PR:F4JN26 denotes MLH3
T156 1087-1091 PR:Q12083 denotes MLH3
T157 1087-1091 PR:000010443 denotes MLH3
T158 1087-1091 PR:Q9UHC1 denotes MLH3
T159 1092-1104 GO:0051179 denotes localization
T160 1152-1161 GO:0051323 denotes metaphase
T161 1205-1212 GO:0051321 denotes meiosis
T162 1356-1365 GO:0051323 denotes metaphase
T165 1416-1419 P22897 denotes MMR
T166 1416-1419 PR:000002972 denotes MMR
T167 1416-1419 Q61830 denotes MMR
T164 1416-1419 CVCL_E779 denotes MMR
T163 1416-1419 GO:0006298 denotes MMR
T168 1449-1458 GO:0009058 denotes formation
T171 1553-1556 P22897 denotes MMR
T172 1553-1556 PR:000002972 denotes MMR
T173 1553-1556 Q61830 denotes MMR
T170 1553-1556 CVCL_E779 denotes MMR
T169 1553-1556 GO:0006298 denotes MMR

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-121 DRI_Background denotes Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.
T2 122-242 DRI_Background denotes The DNA mismatch repair (MMR) family functions in a variety of contexts to preserve genome integrity in most eukaryotes.
T3 243-351 DRI_Background denotes In particular, members of the MMR family are involved in the process of meiotic recombination in germ cells.
T4 352-509 DRI_Outcome denotes MMR gene mutations in mice result in meiotic disruption during prophase I, but the extent of this disruption often differs between male and female meiocytes.
T5 510-792 DRI_Approach denotes To address the role of MMR proteins specifically in female meiosis, we explored the progression of oocytes through prophase I and the meiotic divisions in mice harboring deletions in members of the MMR pathway (Mlh1, Mlh3, Exo1, and an ATPase-deficient variant of Mlh1, Mlh1(G67R)).
T6 793-1028 DRI_Outcome denotes The colocalization of MLH1 and MLH3, key proteins involved in stabilization of nascent crossovers, was dependent on intact heterodimer formation and was highly correlated with the ability of oocytes to progress through to metaphase II.
T7 1029-1165 DRI_Background denotes The exception was Exo1(-/-) oocytes, in which normal MLH1/MLH3 localization was observed followed by failure to proceed to metaphase II.
T8 1166-1368 DRI_Background denotes All mutant oocytes were able to resume meiosis after dictyate arrest, but they showed a dramatic decline in chiasmata (to less than 25% of normal), accompanied by varied progression through metaphase I.
T9 1369-1767 DRI_Outcome denotes Taken together, these results demonstrate that MMR function is required for the formation and stabilization of crossovers in mammalian oocytes and that, in the absence of a functional MMR system, the failure to maintain chiasmata results in a reduced ability to proceed normally through the first and second meiotic divisions, despite near-normal levels of meiotic resumption after dictyate arrest.