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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
4550 18-34 GeneOrGeneProduct denotes apolipoprotein E NCBIGene:348
4551 46-66 SequenceVariant denotes arginine 150 proline p|SUB|R|150|P
4552 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy MESH:C567089
4553 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy MESH:C567089
4554 172-175 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
4555 212-220 DiseaseOrPhenotypicFeature denotes thrombus MESH:D013927
4556 249-279 DiseaseOrPhenotypicFeature denotes dilated glomerular capillaries MESH:D007674
4557 310-326 GeneOrGeneProduct denotes apolipoprotein E NCBIGene:348
4558 328-332 GeneOrGeneProduct denotes apoE NCBIGene:348
4559 389-393 GeneOrGeneProduct denotes apoE NCBIGene:348
4560 432-435 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
4561 441-444 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
4562 466-470 GeneOrGeneProduct denotes apoE NCBIGene:348
4563 497-505 OrganismTaxon denotes patients NCBITaxon:9606
4564 567-571 GeneOrGeneProduct denotes apoE NCBIGene:348
4565 577-580 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
4566 615-619 GeneOrGeneProduct denotes apoE NCBIGene:348
4567 644-647 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
4568 648-656 OrganismTaxon denotes patients NCBITaxon:9606
4569 730-734 GeneOrGeneProduct denotes apoE NCBIGene:348
4570 843-847 GeneOrGeneProduct denotes apoE NCBIGene:348
4571 877-880 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
4572 881-889 OrganismTaxon denotes patients NCBITaxon:9606
4573 965-1007 SequenceVariant denotes G to C point mutation in exon 4 (base 308) c|SUB|G|308|C
4574 1015-1019 GeneOrGeneProduct denotes apoE NCBIGene:348
4575 1032-1040 OrganismTaxon denotes patients NCBITaxon:9606
4576 1139-1191 SequenceVariant denotes proline residue for arginine residue at position 150 p|SUB|R|150|P
4577 1195-1199 GeneOrGeneProduct denotes apoE NCBIGene:348
4578 1207-1215 OrganismTaxon denotes patients NCBITaxon:9606
4579 1244-1248 GeneOrGeneProduct denotes apoE NCBIGene:348
4580 1309-1313 GeneOrGeneProduct denotes apoE NCBIGene:348
4581 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria MESH:D011507
4582 1414-1418 GeneOrGeneProduct denotes apoE NCBIGene:348
4583 1420-1440 SequenceVariant denotes arginine 150 proline p|SUB|R|150|P
4584 1453-1457 GeneOrGeneProduct denotes apoE NCBIGene:348
4585 1496-1499 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
4586 1515-1519 GeneOrGeneProduct denotes apoE NCBIGene:348
4587 1589-1593 GeneOrGeneProduct denotes apoE NCBIGene:348
4588 1633-1639 ChemicalEntity denotes lipids MESH:D008055

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy.
T2 127-143 Sentence denotes BACKGROUND/AIMS:
T3 144-334 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by thrombus-like substances in markedly dilated glomerular capillaries and elevated plasma levels of apolipoprotein E (apoE).
T4 335-506 Sentence denotes Previous studies have shown that genetic disorders of apoE may contribute to the pathogenesis of LPG, but LPG may not be caused by apoE gene mutations in Chinese patients.
T5 507-601 Sentence denotes This study investigated the association of a new variant of apoE with LPG in a Chinese family.
T6 602-610 Sentence denotes METHODS:
T7 611-671 Sentence denotes The apoE gene in a family with 4 LPG patients was sequenced.
T8 672-793 Sentence denotes The polymerase chain reaction product of coding region of apoE exon 4 was cloned into pMD 18-T vector and then sequenced.
T9 794-802 Sentence denotes RESULTS:
T10 803-923 Sentence denotes A novel point mutation in exon 4 of the apoE gene was identified in all 4 LPG patients and 1 asymptomatic family member.
T11 924-1076 Sentence denotes Sequence analysis confirmed a nucleotide G to C point mutation in exon 4 (base 308) of the apoE gene in all patients and the asymptomatic family member.
T12 1077-1200 Sentence denotes This missense mutation denotes amino acid substitution of the proline residue for arginine residue at position 150 of apoE.
T13 1201-1259 Sentence denotes Those patients were all heterozygotes with apoE Guangzhou.
T14 1260-1362 Sentence denotes One of 2 grandsons was a heterozygous carrier of apoE Guangzhou, although he did not have proteinuria.
T15 1363-1374 Sentence denotes CONCLUSION:
T16 1375-1500 Sentence denotes The results of this study suggest that apoE (arginine 150 proline) is a novel apoE variant that etiologically related to LPG.
T17 1501-1640 Sentence denotes This variant (apoE Guangzhou) may cause a marked molecular conformational change of the apoE and thus impair its binding ability to lipids.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 212-220 OrganismTaxon denotes thrombus NCBItxid:1006837

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy 0012725
T2 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy 0012725
T3 172-175 DiseaseOrPhenotypicFeature denotes LPG 0012725
T4 212-220 DiseaseOrPhenotypicFeature denotes thrombus 0000831
T5 368-385 DiseaseOrPhenotypicFeature denotes genetic disorders 0003847
T6 432-435 DiseaseOrPhenotypicFeature denotes LPG 0012725
T7 441-444 DiseaseOrPhenotypicFeature denotes LPG 0012725
T8 577-580 DiseaseOrPhenotypicFeature denotes LPG 0012725
T9 644-647 DiseaseOrPhenotypicFeature denotes LPG 0012725
T10 877-880 DiseaseOrPhenotypicFeature denotes LPG 0012725
T11 1334-1336 DiseaseOrPhenotypicFeature denotes he 0017319
T12 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T13 1496-1499 DiseaseOrPhenotypicFeature denotes LPG 0012725

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy 0012725
T2 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy 0012725
T3 182-186 DiseaseOrPhenotypicFeature denotes rare 0021136
T4 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria 0003634

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 762-766 SequenceVariant denotes 18-T

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 18-34 GeneOrGeneProduct denotes apolipoprotein E
T2 99-110 GeneOrGeneProduct denotes lipoprotein
T3 144-155 GeneOrGeneProduct denotes Lipoprotein
T4 182-186 GeneOrGeneProduct denotes rare
T5 221-225 GeneOrGeneProduct denotes like
T6 240-248 GeneOrGeneProduct denotes markedly
T7 310-326 GeneOrGeneProduct denotes apolipoprotein E
T8 328-332 GeneOrGeneProduct denotes apoE
T9 389-393 GeneOrGeneProduct denotes apoE
T10 466-470 GeneOrGeneProduct denotes apoE
T11 476-485 GeneOrGeneProduct denotes mutations
T12 567-571 GeneOrGeneProduct denotes apoE
T13 581-585 GeneOrGeneProduct denotes in a
T14 602-609 GeneOrGeneProduct denotes METHODS
T15 615-619 GeneOrGeneProduct denotes apoE
T16 620-629 GeneOrGeneProduct denotes gene in a
T17 676-686 GeneOrGeneProduct denotes polymerase
T18 687-692 GeneOrGeneProduct denotes chain
T19 702-709 GeneOrGeneProduct denotes product
T20 730-734 GeneOrGeneProduct denotes apoE
T21 746-752 GeneOrGeneProduct denotes cloned
T22 805-810 GeneOrGeneProduct denotes novel
T23 811-816 GeneOrGeneProduct denotes point
T24 817-825 GeneOrGeneProduct denotes mutation
T25 843-847 GeneOrGeneProduct denotes apoE
T26 871-874 GeneOrGeneProduct denotes all
T27 890-895 GeneOrGeneProduct denotes and 1
T28 972-977 GeneOrGeneProduct denotes point
T29 978-986 GeneOrGeneProduct denotes mutation
T30 998-1002 GeneOrGeneProduct denotes base
T31 1015-1019 GeneOrGeneProduct denotes apoE
T32 1028-1031 GeneOrGeneProduct denotes all
T33 1082-1090 GeneOrGeneProduct denotes missense
T34 1091-1099 GeneOrGeneProduct denotes mutation
T35 1108-1118 GeneOrGeneProduct denotes amino acid
T36 1195-1199 GeneOrGeneProduct denotes apoE
T37 1221-1224 GeneOrGeneProduct denotes all
T38 1244-1248 GeneOrGeneProduct denotes apoE
T39 1298-1305 GeneOrGeneProduct denotes carrier
T40 1309-1313 GeneOrGeneProduct denotes apoE
T41 1414-1418 GeneOrGeneProduct denotes apoE
T42 1447-1452 GeneOrGeneProduct denotes novel
T43 1453-1457 GeneOrGeneProduct denotes apoE
T44 1515-1519 GeneOrGeneProduct denotes apoE
T45 1543-1549 GeneOrGeneProduct denotes marked
T46 1589-1593 GeneOrGeneProduct denotes apoE
T47 1614-1621 GeneOrGeneProduct denotes binding

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 18-34 GeneOrGeneProduct denotes apolipoprotein E
T2 99-110 GeneOrGeneProduct denotes lipoprotein
T3 144-155 GeneOrGeneProduct denotes Lipoprotein
T4 182-186 GeneOrGeneProduct denotes rare
T5 221-225 GeneOrGeneProduct denotes like
T6 310-326 GeneOrGeneProduct denotes apolipoprotein E
T7 328-332 GeneOrGeneProduct denotes apoE
T8 389-393 GeneOrGeneProduct denotes apoE
T9 466-470 GeneOrGeneProduct denotes apoE
T10 567-571 GeneOrGeneProduct denotes apoE
T11 615-619 GeneOrGeneProduct denotes apoE
T12 676-686 GeneOrGeneProduct denotes polymerase
T13 687-692 GeneOrGeneProduct denotes chain
T14 702-709 GeneOrGeneProduct denotes product
T15 730-734 GeneOrGeneProduct denotes apoE
T16 805-810 GeneOrGeneProduct denotes novel
T17 843-847 GeneOrGeneProduct denotes apoE
T18 890-895 GeneOrGeneProduct denotes and 1
T19 1015-1019 GeneOrGeneProduct denotes apoE
T20 1108-1118 GeneOrGeneProduct denotes amino acid
T21 1195-1199 GeneOrGeneProduct denotes apoE
T22 1244-1248 GeneOrGeneProduct denotes apoE
T23 1298-1305 GeneOrGeneProduct denotes carrier
T24 1309-1313 GeneOrGeneProduct denotes apoE
T25 1414-1418 GeneOrGeneProduct denotes apoE
T26 1447-1452 GeneOrGeneProduct denotes novel
T27 1453-1457 GeneOrGeneProduct denotes apoE
T28 1515-1519 GeneOrGeneProduct denotes apoE
T29 1589-1593 GeneOrGeneProduct denotes apoE
T30 1614-1621 GeneOrGeneProduct denotes binding

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T2 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T3 172-175 DiseaseOrPhenotypicFeature denotes LPG C567089
T4 182-194 DiseaseOrPhenotypicFeature denotes rare disease D035583
T5 212-220 DiseaseOrPhenotypicFeature denotes thrombus D013927
T6 368-385 DiseaseOrPhenotypicFeature denotes genetic disorders D030342
T7 432-435 DiseaseOrPhenotypicFeature denotes LPG C567089
T8 441-444 DiseaseOrPhenotypicFeature denotes LPG C567089
T9 577-580 DiseaseOrPhenotypicFeature denotes LPG C567089
T10 644-647 DiseaseOrPhenotypicFeature denotes LPG C567089
T11 877-880 DiseaseOrPhenotypicFeature denotes LPG C567089
T12 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T13 1496-1499 DiseaseOrPhenotypicFeature denotes LPG C567089

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 18-34 GeneOrGeneProduct denotes apolipoprotein E
T2 99-110 GeneOrGeneProduct denotes lipoprotein
T3 144-155 GeneOrGeneProduct denotes Lipoprotein
T4 310-326 GeneOrGeneProduct denotes apolipoprotein E
T5 328-332 GeneOrGeneProduct denotes apoE
T6 389-393 GeneOrGeneProduct denotes apoE
T7 466-470 GeneOrGeneProduct denotes apoE
T8 567-571 GeneOrGeneProduct denotes apoE
T9 615-619 GeneOrGeneProduct denotes apoE
T10 730-734 GeneOrGeneProduct denotes apoE
T11 843-847 GeneOrGeneProduct denotes apoE
T12 1015-1019 GeneOrGeneProduct denotes apoE
T13 1195-1199 GeneOrGeneProduct denotes apoE
T14 1244-1248 GeneOrGeneProduct denotes apoE
T15 1309-1313 GeneOrGeneProduct denotes apoE
T16 1414-1418 GeneOrGeneProduct denotes apoE
T17 1453-1457 GeneOrGeneProduct denotes apoE
T18 1515-1519 GeneOrGeneProduct denotes apoE
T19 1589-1593 GeneOrGeneProduct denotes apoE

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy 0012725
T2 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy 0012725
T3 172-175 DiseaseOrPhenotypicFeature denotes LPG 0012725
T4 212-220 DiseaseOrPhenotypicFeature denotes thrombus 0000831
T5 368-385 DiseaseOrPhenotypicFeature denotes genetic disorders 0003847
T6 432-435 DiseaseOrPhenotypicFeature denotes LPG 0012725
T7 441-444 DiseaseOrPhenotypicFeature denotes LPG 0012725
T8 577-580 DiseaseOrPhenotypicFeature denotes LPG 0012725
T9 644-647 DiseaseOrPhenotypicFeature denotes LPG 0012725
T10 877-880 DiseaseOrPhenotypicFeature denotes LPG 0012725
T11 1334-1336 DiseaseOrPhenotypicFeature denotes he 0017319
T12 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria 0003634
T13 1496-1499 DiseaseOrPhenotypicFeature denotes LPG 0012725

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T2 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T3 172-175 DiseaseOrPhenotypicFeature denotes LPG C567089
T4 182-194 DiseaseOrPhenotypicFeature denotes rare disease D035583
T5 212-220 DiseaseOrPhenotypicFeature denotes thrombus D013927
T6 249-279 DiseaseOrPhenotypicFeature denotes dilated glomerular capillaries DISEASE
T7 368-385 DiseaseOrPhenotypicFeature denotes genetic disorders D030342
T8 432-435 DiseaseOrPhenotypicFeature denotes LPG C567089
T9 441-444 DiseaseOrPhenotypicFeature denotes LPG C567089
T10 577-580 DiseaseOrPhenotypicFeature denotes LPG C567089
T11 644-647 DiseaseOrPhenotypicFeature denotes LPG C567089
T12 877-880 DiseaseOrPhenotypicFeature denotes LPG C567089
T13 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T14 1496-1499 DiseaseOrPhenotypicFeature denotes LPG C567089

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T2 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T3 172-175 DiseaseOrPhenotypicFeature denotes LPG C567089
T4 212-220 DiseaseOrPhenotypicFeature denotes thrombus D013927
T5 432-435 DiseaseOrPhenotypicFeature denotes LPG C567089
T6 441-444 DiseaseOrPhenotypicFeature denotes LPG C567089
T7 577-580 DiseaseOrPhenotypicFeature denotes LPG C567089
T8 644-647 DiseaseOrPhenotypicFeature denotes LPG C567089
T9 877-880 DiseaseOrPhenotypicFeature denotes LPG C567089
T10 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T11 1496-1499 DiseaseOrPhenotypicFeature denotes LPG C567089

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 18-32 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T2 46-54 ChemicalEntity denotes arginine http://purl.obolibrary.org/obo/CHEBI_32696|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_16467
T5 59-66 ChemicalEntity denotes proline http://purl.obolibrary.org/obo/CHEBI_26271|http://purl.obolibrary.org/obo/CHEBI_17203
T7 172-175 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T8 310-324 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T9 432-435 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T10 441-444 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T11 577-580 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T12 644-647 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T13 877-880 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T14 1139-1154 ChemicalEntity denotes proline residue http://purl.obolibrary.org/obo/CHEBI_32874
T15 1159-1175 ChemicalEntity denotes arginine residue http://purl.obolibrary.org/obo/CHEBI_32700
T16 1420-1428 ChemicalEntity denotes arginine http://purl.obolibrary.org/obo/CHEBI_32696|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_16467
T19 1433-1440 ChemicalEntity denotes proline http://purl.obolibrary.org/obo/CHEBI_26271|http://purl.obolibrary.org/obo/CHEBI_17203
T21 1496-1499 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 212-220 OrganismTaxon denotes thrombus
T2 497-505 OrganismTaxon denotes patients
T3 648-656 OrganismTaxon denotes patients
T4 881-889 OrganismTaxon denotes patients
T5 1032-1040 OrganismTaxon denotes patients
T6 1207-1215 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T21 1496-1499 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T19 1433-1440 ChemicalEntity denotes proline http://purl.obolibrary.org/obo/CHEBI_17203|http://purl.obolibrary.org/obo/CHEBI_26271
T16 1420-1428 ChemicalEntity denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T15 1159-1175 ChemicalEntity denotes arginine residue http://purl.obolibrary.org/obo/CHEBI_32700
T14 1139-1154 ChemicalEntity denotes proline residue http://purl.obolibrary.org/obo/CHEBI_32874
T13 877-880 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T12 644-647 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T11 577-580 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T10 441-444 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T9 432-435 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T8 310-324 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T7 172-175 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T5 59-66 ChemicalEntity denotes proline http://purl.obolibrary.org/obo/CHEBI_17203|http://purl.obolibrary.org/obo/CHEBI_26271
T2 46-54 ChemicalEntity denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T1 18-32 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T14222 1589-1593 GeneOrGeneProduct denotes apoE
T18 1515-1519 GeneOrGeneProduct denotes apoE
T17 1453-1457 GeneOrGeneProduct denotes apoE
T40089 1414-1418 GeneOrGeneProduct denotes apoE
T52355 1309-1313 GeneOrGeneProduct denotes apoE
T35995 1244-1248 GeneOrGeneProduct denotes apoE
T49298 1195-1199 GeneOrGeneProduct denotes apoE
T5611 1015-1019 GeneOrGeneProduct denotes apoE
T23575 843-847 GeneOrGeneProduct denotes apoE
T19350 730-734 GeneOrGeneProduct denotes apoE
T73798 615-619 GeneOrGeneProduct denotes apoE
T23569 567-571 GeneOrGeneProduct denotes apoE
T18240 466-470 GeneOrGeneProduct denotes apoE
T6 389-393 GeneOrGeneProduct denotes apoE
T73885 328-332 GeneOrGeneProduct denotes apoE
T4 310-326 GeneOrGeneProduct denotes apolipoprotein E
T3 144-155 GeneOrGeneProduct denotes Lipoprotein
T35214 99-110 GeneOrGeneProduct denotes lipoprotein
T17448 18-34 GeneOrGeneProduct denotes apolipoprotein E
T76702 1496-1499 DiseaseOrPhenotypicFeature denotes LPG C567089
T93240 1350-1361 DiseaseOrPhenotypicFeature denotes proteinuria D011507
T30916 877-880 DiseaseOrPhenotypicFeature denotes LPG C567089
T48527 644-647 DiseaseOrPhenotypicFeature denotes LPG C567089
T13365 577-580 DiseaseOrPhenotypicFeature denotes LPG C567089
T27156 441-444 DiseaseOrPhenotypicFeature denotes LPG C567089
T37406 432-435 DiseaseOrPhenotypicFeature denotes LPG C567089
T41687 212-220 DiseaseOrPhenotypicFeature denotes thrombus D013927
T31707 172-175 DiseaseOrPhenotypicFeature denotes LPG C567089
T61934 144-170 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T37594 99-125 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T9467 1207-1215 OrganismTaxon denotes patients
T89404 1032-1040 OrganismTaxon denotes patients
T86290 881-889 OrganismTaxon denotes patients
T96854 648-656 OrganismTaxon denotes patients
T31995 497-505 OrganismTaxon denotes patients
T23900 212-220 OrganismTaxon denotes thrombus
T17546 762-766 SequenceVariant denotes 18-T

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-126 Sentence denotes Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy.
TextSentencer_T2 127-143 Sentence denotes BACKGROUND/AIMS:
TextSentencer_T3 144-334 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by thrombus-like substances in markedly dilated glomerular capillaries and elevated plasma levels of apolipoprotein E (apoE).
TextSentencer_T4 335-506 Sentence denotes Previous studies have shown that genetic disorders of apoE may contribute to the pathogenesis of LPG, but LPG may not be caused by apoE gene mutations in Chinese patients.
TextSentencer_T5 507-601 Sentence denotes This study investigated the association of a new variant of apoE with LPG in a Chinese family.
TextSentencer_T6 602-610 Sentence denotes METHODS:
TextSentencer_T7 611-671 Sentence denotes The apoE gene in a family with 4 LPG patients was sequenced.
TextSentencer_T8 672-793 Sentence denotes The polymerase chain reaction product of coding region of apoE exon 4 was cloned into pMD 18-T vector and then sequenced.
TextSentencer_T9 794-802 Sentence denotes RESULTS:
TextSentencer_T10 803-923 Sentence denotes A novel point mutation in exon 4 of the apoE gene was identified in all 4 LPG patients and 1 asymptomatic family member.
TextSentencer_T11 924-1076 Sentence denotes Sequence analysis confirmed a nucleotide G to C point mutation in exon 4 (base 308) of the apoE gene in all patients and the asymptomatic family member.
TextSentencer_T12 1077-1200 Sentence denotes This missense mutation denotes amino acid substitution of the proline residue for arginine residue at position 150 of apoE.
TextSentencer_T13 1201-1259 Sentence denotes Those patients were all heterozygotes with apoE Guangzhou.
TextSentencer_T14 1260-1362 Sentence denotes One of 2 grandsons was a heterozygous carrier of apoE Guangzhou, although he did not have proteinuria.
TextSentencer_T15 1363-1374 Sentence denotes CONCLUSION:
TextSentencer_T16 1375-1500 Sentence denotes The results of this study suggest that apoE (arginine 150 proline) is a novel apoE variant that etiologically related to LPG.
TextSentencer_T17 1501-1640 Sentence denotes This variant (apoE Guangzhou) may cause a marked molecular conformational change of the apoE and thus impair its binding ability to lipids.
T1 0-126 Sentence denotes Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy.
T2 127-143 Sentence denotes BACKGROUND/AIMS:
T3 144-334 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by thrombus-like substances in markedly dilated glomerular capillaries and elevated plasma levels of apolipoprotein E (apoE).
T4 335-506 Sentence denotes Previous studies have shown that genetic disorders of apoE may contribute to the pathogenesis of LPG, but LPG may not be caused by apoE gene mutations in Chinese patients.
T5 507-601 Sentence denotes This study investigated the association of a new variant of apoE with LPG in a Chinese family.
T6 602-610 Sentence denotes METHODS:
T7 611-671 Sentence denotes The apoE gene in a family with 4 LPG patients was sequenced.
T8 672-793 Sentence denotes The polymerase chain reaction product of coding region of apoE exon 4 was cloned into pMD 18-T vector and then sequenced.
T9 794-802 Sentence denotes RESULTS:
T10 803-923 Sentence denotes A novel point mutation in exon 4 of the apoE gene was identified in all 4 LPG patients and 1 asymptomatic family member.
T11 924-1076 Sentence denotes Sequence analysis confirmed a nucleotide G to C point mutation in exon 4 (base 308) of the apoE gene in all patients and the asymptomatic family member.
T12 1077-1200 Sentence denotes This missense mutation denotes amino acid substitution of the proline residue for arginine residue at position 150 of apoE.
T13 1201-1259 Sentence denotes Those patients were all heterozygotes with apoE Guangzhou.
T14 1260-1362 Sentence denotes One of 2 grandsons was a heterozygous carrier of apoE Guangzhou, although he did not have proteinuria.
T15 1363-1374 Sentence denotes CONCLUSION:
T16 1375-1500 Sentence denotes The results of this study suggest that apoE (arginine 150 proline) is a novel apoE variant that etiologically related to LPG.
T17 1501-1640 Sentence denotes This variant (apoE Guangzhou) may cause a marked molecular conformational change of the apoE and thus impair its binding ability to lipids.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 18-34 gene:348 denotes apolipoprotein E
T1 99-125 disease:C2673196 denotes lipoprotein glomerulopathy
T2 310-326 gene:348 denotes apolipoprotein E
T3 172-175 disease:C2673196 denotes LPG
T4 310-326 gene:348 denotes apolipoprotein E
T5 144-170 disease:C2673196 denotes Lipoprotein glomerulopathy
T6 310-326 gene:348 denotes apolipoprotein E
T7 182-194 disease:C0678236 denotes rare disease
R1 T0 T1 associated_with apolipoprotein E,lipoprotein glomerulopathy
R2 T2 T3 associated_with apolipoprotein E,LPG
R3 T4 T5 associated_with apolipoprotein E,Lipoprotein glomerulopathy
R4 T6 T7 associated_with apolipoprotein E,rare disease

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18046082-0#18#34#gene348 18-34 gene348 denotes apolipoprotein E
18046082-0#99#125#diseaseC2673196 99-125 diseaseC2673196 denotes lipoprotein glomerulopathy
18#34#gene34899#125#diseaseC2673196 18046082-0#18#34#gene348 18046082-0#99#125#diseaseC2673196 associated_with apolipoprotein E,lipoprotein glomerulopathy

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 257-279 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T2 268-279 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 156-170 HP:0100820 denotes glomerulopathy
TI1 111-125 HP:0100820 denotes glomerulopathy
AB2 1350-1361 HP:0000093 denotes proteinuria

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 144-170 ORDO:329481 denotes Lipoprotein glomerulopathy
AB2 172-175 ORDO:329481 denotes LPG
TI1 99-125 ORDO:329481 denotes lipoprotein glomerulopathy
AB3 432-435 ORDO:329481 denotes LPG
AB4 441-444 ORDO:329481 denotes LPG
AB5 577-580 ORDO:329481 denotes LPG
AB6 644-647 ORDO:329481 denotes LPG
AB7 877-880 ORDO:329481 denotes LPG
AB8 1496-1499 ORDO:329481 denotes LPG

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 257-279 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T2 268-279 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 46-66 ProteinMutation:p|SUB|R|150|P denotes arginine 150 proline
T2 1420-1440 ProteinMutation:p|SUB|R|150|P denotes arginine 150 proline