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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis.
T2 117-248 Sentence denotes The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear.
T3 249-391 Sentence denotes It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest in the pharmacological management of preterm labor.
T4 392-532 Sentence denotes Although there is evidence implicating ADRB receptors in the control of inflammation, there are minimal data relating specifically to ADRB3.
T5 533-755 Sentence denotes To explore the cellular consequences of chorioamnionitis and detect apoptosis, we first performed immunostaining and Western blot experiments on human myometrial samples obtained from women with confirmed chorioamnionitis.
T6 756-936 Sentence denotes We then developed an in vitro model of chorioamnionitis by incubating the myometrial samples obtained from uncomplicated pregnancies with Escherichia coli lipopolysaccharide (LPS).
T7 937-1163 Sentence denotes We observed that chorioamnionitis was associated with a significant increase in cleaved CASP3 protein expression, as well as chromatin condensation, which were reproduced experimentally by LPS stimulation (10 microg/ml, 48 h).
T8 1164-1337 Sentence denotes Lipopolysaccharide stimulation of normal human myometrium also induced CASP3 transcripts, increased the proapoptotic marker BAX, and decreased the antiapoptotic marker BCL2.
T9 1338-1466 Sentence denotes Lipopolysaccharide-induced apoptosis was antagonized by neutralization of secreted tumor necrosis factor by a specific antibody.
T10 1467-1585 Sentence denotes Furthermore, LPS stimulation increased medium culture levels of proinflammatory cytokines interleukin 6 (IL6) and IL8.
T11 1586-1744 Sentence denotes Lipopolysaccharide-induced apoptosis and cytokine production were prevented by the new and potent ADRB3 agonist SAR150640 in a concentration-dependent manner.
T12 1745-1847 Sentence denotes SAR150640 by itself did not exhibit any effect on apoptosis or cytokine production in control tissues.
T13 1848-1942 Sentence denotes This study shows that chorioamnionitis is associated with apoptosis of human myometrial cells.
T14 1943-2074 Sentence denotes It emphasizes the potential therapeutic interest of ADRB3 agonists in the field of preterm labor and other inflammatory conditions.
T1 0-116 Sentence denotes ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis.
T2 117-248 Sentence denotes The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear.
T3 249-391 Sentence denotes It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest in the pharmacological management of preterm labor.
T4 392-532 Sentence denotes Although there is evidence implicating ADRB receptors in the control of inflammation, there are minimal data relating specifically to ADRB3.
T5 533-755 Sentence denotes To explore the cellular consequences of chorioamnionitis and detect apoptosis, we first performed immunostaining and Western blot experiments on human myometrial samples obtained from women with confirmed chorioamnionitis.
T6 756-936 Sentence denotes We then developed an in vitro model of chorioamnionitis by incubating the myometrial samples obtained from uncomplicated pregnancies with Escherichia coli lipopolysaccharide (LPS).
T7 937-1163 Sentence denotes We observed that chorioamnionitis was associated with a significant increase in cleaved CASP3 protein expression, as well as chromatin condensation, which were reproduced experimentally by LPS stimulation (10 microg/ml, 48 h).
T8 1164-1337 Sentence denotes Lipopolysaccharide stimulation of normal human myometrium also induced CASP3 transcripts, increased the proapoptotic marker BAX, and decreased the antiapoptotic marker BCL2.
T9 1338-1466 Sentence denotes Lipopolysaccharide-induced apoptosis was antagonized by neutralization of secreted tumor necrosis factor by a specific antibody.
T10 1467-1585 Sentence denotes Furthermore, LPS stimulation increased medium culture levels of proinflammatory cytokines interleukin 6 (IL6) and IL8.
T11 1586-1744 Sentence denotes Lipopolysaccharide-induced apoptosis and cytokine production were prevented by the new and potent ADRB3 agonist SAR150640 in a concentration-dependent manner.
T12 1745-1847 Sentence denotes SAR150640 by itself did not exhibit any effect on apoptosis or cytokine production in control tissues.
T13 1848-1942 Sentence denotes This study shows that chorioamnionitis is associated with apoptosis of human myometrial cells.
T14 1943-2074 Sentence denotes It emphasizes the potential therapeutic interest of ADRB3 agonists in the field of preterm labor and other inflammatory conditions.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1421-1426 HP_0002664 denotes tumor
T1 1421-1426 HP_0002664 denotes tumor