PubMed:17988639 JSONTXT

{"project":"OryzaGP_2021_v2","denotations":[{"id":"T1","span":{"begin":422,"end":427},"obj":"http://identifiers.org/oryzabase.gene/6045"},{"id":"T2","span":{"begin":545,"end":547},"obj":"http://identifiers.org/oryzabase.gene/645"},{"id":"T24794","span":{"begin":422,"end":427},"obj":"http://identifiers.org/rapdb.locus/Os02g0249900"}],"text":"Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy.\nAs an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 microg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy."}

{"project":"OryzaGP_2022","denotations":[{"id":"T1","span":{"begin":134,"end":142},"obj":"http://identifiers.org/oryzabase.gene/2280"},{"id":"T2","span":{"begin":229,"end":237},"obj":"http://identifiers.org/oryzabase.gene/2280"},{"id":"T3","span":{"begin":245,"end":246},"obj":"http://identifiers.org/oryzabase.gene/11216"},{"id":"T4","span":{"begin":317,"end":318},"obj":"http://identifiers.org/oryzabase.gene/11216"},{"id":"T5","span":{"begin":319,"end":327},"obj":"http://identifiers.org/oryzabase.gene/2280"},{"id":"T6","span":{"begin":444,"end":445},"obj":"http://identifiers.org/oryzabase.gene/11216"},{"id":"T7","span":{"begin":600,"end":601},"obj":"http://identifiers.org/oryzabase.gene/11216"},{"id":"T8","span":{"begin":696,"end":697},"obj":"http://identifiers.org/oryzabase.gene/11216"},{"id":"T9","span":{"begin":840,"end":841},"obj":"http://identifiers.org/oryzabase.gene/11216"}],"text":"Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy.\nAs an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 microg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy."}

{"project":"OryzaGP_2021_FLAIR","denotations":[{"id":"M_2","span":{"begin":716,"end":719},"obj":"hunflair:NA:Gene"},{"id":"M_3","span":{"begin":239,"end":246},"obj":"hunflair:NA:Gene"},{"id":"M_4","span":{"begin":311,"end":318},"obj":"hunflair:NA:Gene"},{"id":"M_5","span":{"begin":438,"end":445},"obj":"hunflair:NA:Gene"},{"id":"M_6","span":{"begin":594,"end":601},"obj":"hunflair:NA:Gene"},{"id":"M_7","span":{"begin":690,"end":697},"obj":"hunflair:NA:Gene"},{"id":"M_8","span":{"begin":834,"end":841},"obj":"hunflair:NA:Gene"},{"id":"M_9","span":{"begin":422,"end":427},"obj":"hunflair:NA:Gene"},{"id":"M_10","span":{"begin":27,"end":31},"obj":"hunflair:NA:Species"},{"id":"M_11","span":{"begin":178,"end":182},"obj":"hunflair:NA:Species"},{"id":"M_12","span":{"begin":842,"end":846},"obj":"hunflair:NA:Species"},{"id":"M_13","span":{"begin":918,"end":929},"obj":"hunflair:NA:Disease"},{"id":"M_0","span":{"begin":66,"end":81},"obj":"hunflair:NA:Species"},{"id":"M_1","span":{"begin":207,"end":222},"obj":"hunflair:NA:Species"},{"id":"M_14","span":{"begin":658,"end":664},"obj":"hunflair:NA:Chemical"},{"id":"M_15","span":{"begin":573,"end":577},"obj":"hunflair:NA:Gene"},{"id":"M_16","span":{"begin":645,"end":652},"obj":"hunflair:NA:Chemical"},{"id":"M_17","span":{"begin":82,"end":89},"obj":"hunflair:NA:Disease"},{"id":"M_18","span":{"begin":922,"end":929},"obj":"hunflair:NA:Disease"}],"text":"Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy.\nAs an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 microg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy."}

{"project":"OryzaGP_2021","denotations":[{"id":"T1","span":{"begin":134,"end":142},"obj":"http://identifiers.org/oryzabase.gene/2280"},{"id":"T2","span":{"begin":229,"end":237},"obj":"http://identifiers.org/oryzabase.gene/2280"},{"id":"T3","span":{"begin":319,"end":327},"obj":"http://identifiers.org/oryzabase.gene/2280"},{"id":"T4","span":{"begin":422,"end":427},"obj":"http://identifiers.org/oryzabase.gene/6045"},{"id":"T5","span":{"begin":545,"end":547},"obj":"http://identifiers.org/oryzabase.gene/645"},{"id":"T32388","span":{"begin":422,"end":427},"obj":"http://identifiers.org/ricegap/LOC_Os02g15169"},{"id":"T79678","span":{"begin":422,"end":427},"obj":"http://identifiers.org/rapdb.locus/Os02g0249900"},{"id":"T73492","span":{"begin":422,"end":427},"obj":"http://identifiers.org/uniprot/P14323"},{"id":"M_0","span":{"begin":66,"end":81},"obj":"hunflair:NA:Species"},{"id":"M_1","span":{"begin":207,"end":222},"obj":"hunflair:NA:Species"},{"id":"M_2","span":{"begin":716,"end":719},"obj":"hunflair:NA:Gene"},{"id":"M_3","span":{"begin":239,"end":246},"obj":"hunflair:NA:Gene"},{"id":"M_4","span":{"begin":311,"end":318},"obj":"hunflair:NA:Gene"},{"id":"M_5","span":{"begin":438,"end":445},"obj":"hunflair:NA:Gene"},{"id":"M_6","span":{"begin":594,"end":601},"obj":"hunflair:NA:Gene"},{"id":"M_7","span":{"begin":690,"end":697},"obj":"hunflair:NA:Gene"},{"id":"M_8","span":{"begin":834,"end":841},"obj":"hunflair:NA:Gene"},{"id":"M_9","span":{"begin":422,"end":427},"obj":"hunflair:NA:Gene"},{"id":"M_10","span":{"begin":27,"end":31},"obj":"hunflair:NA:Species"},{"id":"M_11","span":{"begin":178,"end":182},"obj":"hunflair:NA:Species"},{"id":"M_12","span":{"begin":842,"end":846},"obj":"hunflair:NA:Species"},{"id":"M_13","span":{"begin":918,"end":929},"obj":"hunflair:NA:Disease"},{"id":"M_14","span":{"begin":658,"end":664},"obj":"hunflair:NA:Chemical"},{"id":"M_15","span":{"begin":573,"end":577},"obj":"hunflair:NA:Gene"},{"id":"M_16","span":{"begin":645,"end":652},"obj":"hunflair:NA:Chemical"},{"id":"M_17","span":{"begin":82,"end":89},"obj":"hunflair:NA:Disease"},{"id":"M_18","span":{"begin":922,"end":929},"obj":"hunflair:NA:Disease"}],"text":"Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy.\nAs an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 microg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":922,"end":929},"obj":"HP_0012393"}],"text":"Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy.\nAs an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 microg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy."}

{"project":"Oryza_sentences","blocks":[{"id":"T1","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T2","span":{"begin":91,"end":283},"obj":"Sentence"},{"id":"T3","span":{"begin":284,"end":437},"obj":"Sentence"},{"id":"T4","span":{"begin":438,"end":579},"obj":"Sentence"},{"id":"T5","span":{"begin":580,"end":676},"obj":"Sentence"},{"id":"T6","span":{"begin":677,"end":796},"obj":"Sentence"},{"id":"T7","span":{"begin":797,"end":930},"obj":"Sentence"}],"text":"Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy.\nAs an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 microg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy."}