PubMed:17978129
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-96 | Sentence | denotes | Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women. |
| TextSentencer_T2 | 97-107 | Sentence | denotes | OBJECTIVE: |
| TextSentencer_T3 | 108-327 | Sentence | denotes | To perform gene expression profiling and real-time quantitative reverse-transcription polymerase chain reaction (PCR) analysis to identify biomarkers of preeclampsia in cellular messenger RNA (mRNA) from maternal blood. |
| TextSentencer_T4 | 328-336 | Sentence | denotes | METHODS: |
| TextSentencer_T5 | 337-468 | Sentence | denotes | We performed a microarray analysis with five maternal blood samples from women with preeclampsia and five matched control subjects. |
| TextSentencer_T6 | 469-650 | Sentence | denotes | Up-regulated gene expression was further analyzed through reverse-transcription PCR analysis with 28 consecutive blood samples from women affected with preeclampsia and 29 controls. |
| TextSentencer_T7 | 651-659 | Sentence | denotes | RESULTS: |
| TextSentencer_T8 | 660-775 | Sentence | denotes | Both pregnancy-specific beta1 glycoprotein and trophoblast glycoprotein were selected based on microarray analysis. |
| TextSentencer_T9 | 776-902 | Sentence | denotes | Reverse-transcription PCR analysis detected significantly increased mRNA concentrations among women in the preeclampsia group. |
| TextSentencer_T10 | 903-1129 | Sentence | denotes | When stratified according to mild or severe preeclampsia, 19.2-fold and 41.8-fold increases in pregnancy-specific beta1 glycoprotein and 8.3-fold and 10.6-fold increases in trophoblast glycoprotein were observed, respectively. |
| TextSentencer_T11 | 1130-1347 | Sentence | denotes | Among women with hemolysis, elevated liver enzymes, and low platelet count syndrome, 51.6-fold and 13.1-fold increases in pregnancy-specific beta1 glycoprotein and trophoblast glycoprotein were observed, respectively. |
| TextSentencer_T12 | 1348-1498 | Sentence | denotes | In the preeclampsia group, pregnancy-specific beta1 glycoprotein correlated with severity of proteinuria (P<.001) and systolic blood pressure (P=.01). |
| TextSentencer_T13 | 1499-1510 | Sentence | denotes | CONCLUSION: |
| TextSentencer_T14 | 1511-1802 | Sentence | denotes | The mRNA expression of pregnancy-specific beta1 glycoprotein and trophoblast glycoprotein is up-regulated in cells circulating within blood from women with preeclampsia, and pregnancy-specific beta1 glycoprotein expression is positively correlated with the clinical severity of preeclampsia. |
| TextSentencer_T15 | 1803-1825 | Sentence | denotes | LEVEL OF EVIDENCE: II. |
| T1 | 0-96 | Sentence | denotes | Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women. |
| T2 | 97-107 | Sentence | denotes | OBJECTIVE: |
| T3 | 108-327 | Sentence | denotes | To perform gene expression profiling and real-time quantitative reverse-transcription polymerase chain reaction (PCR) analysis to identify biomarkers of preeclampsia in cellular messenger RNA (mRNA) from maternal blood. |
| T4 | 328-336 | Sentence | denotes | METHODS: |
| T5 | 337-468 | Sentence | denotes | We performed a microarray analysis with five maternal blood samples from women with preeclampsia and five matched control subjects. |
| T6 | 469-650 | Sentence | denotes | Up-regulated gene expression was further analyzed through reverse-transcription PCR analysis with 28 consecutive blood samples from women affected with preeclampsia and 29 controls. |
| T7 | 651-659 | Sentence | denotes | RESULTS: |
| T8 | 660-775 | Sentence | denotes | Both pregnancy-specific beta1 glycoprotein and trophoblast glycoprotein were selected based on microarray analysis. |
| T9 | 776-902 | Sentence | denotes | Reverse-transcription PCR analysis detected significantly increased mRNA concentrations among women in the preeclampsia group. |
| T10 | 903-1129 | Sentence | denotes | When stratified according to mild or severe preeclampsia, 19.2-fold and 41.8-fold increases in pregnancy-specific beta1 glycoprotein and 8.3-fold and 10.6-fold increases in trophoblast glycoprotein were observed, respectively. |
| T11 | 1130-1347 | Sentence | denotes | Among women with hemolysis, elevated liver enzymes, and low platelet count syndrome, 51.6-fold and 13.1-fold increases in pregnancy-specific beta1 glycoprotein and trophoblast glycoprotein were observed, respectively. |
| T12 | 1348-1498 | Sentence | denotes | In the preeclampsia group, pregnancy-specific beta1 glycoprotein correlated with severity of proteinuria (P<.001) and systolic blood pressure (P=.01). |
| T13 | 1499-1510 | Sentence | denotes | CONCLUSION: |
| T14 | 1511-1802 | Sentence | denotes | The mRNA expression of pregnancy-specific beta1 glycoprotein and trophoblast glycoprotein is up-regulated in cells circulating within blood from women with preeclampsia, and pregnancy-specific beta1 glycoprotein expression is positively correlated with the clinical severity of preeclampsia. |
| T15 | 1803-1825 | Sentence | denotes | LEVEL OF EVIDENCE: II. |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 261-273 | HP_0100602 | denotes | preeclampsia |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 17978129-7#164#188#gene7162 | 1294-1318 | gene7162 | denotes | trophoblast glycoprotein |
| 17978129-7#17#74#diseaseC0162739 | 1147-1204 | diseaseC0162739 | denotes | hemolysis, elevated liver enzymes, and low platelet count |
| 164#188#gene716217#74#diseaseC0162739 | 17978129-7#164#188#gene7162 | 17978129-7#17#74#diseaseC0162739 | associated_with | trophoblast glycoprotein,"hemolysis, elevated liver enzymes, and low platelet count" |
Preeclampsia
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-Preeclampsia-B_T1 | 261-273 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T2 | 421-433 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T3 | 621-633 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T4 | 883-895 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T5 | 947-959 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T6 | 1355-1367 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T7 | 1667-1679 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T8 | 1789-1801 | ORPHA:275555 | denotes | preeclampsia |
Preeclampsia-compare
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-Preeclampsia-B_T1 | 77-89 | ORPHA:275555 | denotes | preeclamptic |
| PD-Preeclampsia-B_T2 | 261-273 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T3 | 421-433 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T4 | 621-633 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T5 | 883-895 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T6 | 947-959 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T7 | 1355-1367 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T8 | 1667-1679 | ORPHA:275555 | denotes | preeclampsia |
| PD-Preeclampsia-B_T9 | 1789-1801 | ORPHA:275555 | denotes | preeclampsia |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 0-8 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | Placenta |
| PD-UBERON-AE-B_T2 | 68-73 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T3 | 321-326 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T4 | 391-396 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T5 | 582-587 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T6 | 1475-1480 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T7 | 1645-1650 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T8 | 707-718 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T9 | 1076-1087 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T10 | 1294-1305 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T11 | 1576-1587 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T12 | 1167-1172 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
preeclampsia_genes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-PreeclampsiaGenes-B_T1 | 665-702 | HGNC:PSG8 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T2 | 998-1035 | HGNC:PSG8 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T3 | 1252-1289 | HGNC:PSG8 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T4 | 1375-1412 | HGNC:PSG8 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T5 | 1534-1571 | HGNC:PSG8 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T6 | 1685-1722 | HGNC:PSG8 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T7 | 665-702 | HGNC:PSG1 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T8 | 998-1035 | HGNC:PSG1 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T9 | 1252-1289 | HGNC:PSG1 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T10 | 1375-1412 | HGNC:PSG1 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T11 | 1534-1571 | HGNC:PSG1 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T12 | 1685-1722 | HGNC:PSG1 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T13 | 665-702 | HGNC:PSG3 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T14 | 998-1035 | HGNC:PSG3 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T15 | 1252-1289 | HGNC:PSG3 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T16 | 1375-1412 | HGNC:PSG3 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T17 | 1534-1571 | HGNC:PSG3 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T18 | 1685-1722 | HGNC:PSG3 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T19 | 665-702 | HGNC:PSG9 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T20 | 998-1035 | HGNC:PSG9 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T21 | 1252-1289 | HGNC:PSG9 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T22 | 1375-1412 | HGNC:PSG9 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T23 | 1534-1571 | HGNC:PSG9 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T24 | 1685-1722 | HGNC:PSG9 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T25 | 665-702 | HGNC:PSG2 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T26 | 998-1035 | HGNC:PSG2 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T27 | 1252-1289 | HGNC:PSG2 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T28 | 1375-1412 | HGNC:PSG2 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T29 | 1534-1571 | HGNC:PSG2 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T30 | 1685-1722 | HGNC:PSG2 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T31 | 665-702 | HGNC:PSG5 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T32 | 998-1035 | HGNC:PSG5 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T33 | 1252-1289 | HGNC:PSG5 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T34 | 1375-1412 | HGNC:PSG5 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T35 | 1534-1571 | HGNC:PSG5 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T36 | 1685-1722 | HGNC:PSG5 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T37 | 665-702 | HGNC:PSG4 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T38 | 998-1035 | HGNC:PSG4 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T39 | 1252-1289 | HGNC:PSG4 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T40 | 1375-1412 | HGNC:PSG4 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T41 | 1534-1571 | HGNC:PSG4 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T42 | 1685-1722 | HGNC:PSG4 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T43 | 665-702 | HGNC:PSG6 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T44 | 998-1035 | HGNC:PSG6 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T45 | 1252-1289 | HGNC:PSG6 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T46 | 1375-1412 | HGNC:PSG6 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T47 | 1534-1571 | HGNC:PSG6 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T48 | 1685-1722 | HGNC:PSG6 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T49 | 665-702 | HGNC:PSG11 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T50 | 998-1035 | HGNC:PSG11 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T51 | 1252-1289 | HGNC:PSG11 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T52 | 1375-1412 | HGNC:PSG11 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T53 | 1534-1571 | HGNC:PSG11 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T54 | 1685-1722 | HGNC:PSG11 | denotes | pregnancy-specific beta1 glycoprotein |
| PD-PreeclampsiaGenes-B_T55 | 690-702 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T56 | 719-731 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T57 | 1023-1035 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T58 | 1088-1100 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T59 | 1277-1289 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T60 | 1306-1318 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T61 | 1400-1412 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T62 | 1559-1571 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T63 | 1588-1600 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T64 | 1710-1722 | HGNC:GP2 | denotes | glycoprotein |
| PD-PreeclampsiaGenes-B_T65 | 707-731 | HGNC:TPBG | denotes | trophoblast glycoprotein |
| PD-PreeclampsiaGenes-B_T66 | 1076-1100 | HGNC:TPBG | denotes | trophoblast glycoprotein |
| PD-PreeclampsiaGenes-B_T67 | 1294-1318 | HGNC:TPBG | denotes | trophoblast glycoprotein |
| PD-PreeclampsiaGenes-B_T68 | 1576-1600 | HGNC:TPBG | denotes | trophoblast glycoprotein |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 0-8 | http://purl.obolibrary.org/obo/UBERON_0001987 | denotes | Placenta |
| PD-UBERON-AE-B_T2 | 68-73 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T3 | 321-326 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T4 | 391-396 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T5 | 582-587 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T6 | 1475-1480 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T7 | 1645-1650 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| PD-UBERON-AE-B_T8 | 1167-1172 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| PD-UBERON-AE-B_T9 | 707-718 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T10 | 1076-1087 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T11 | 1294-1305 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |
| PD-UBERON-AE-B_T12 | 1576-1587 | http://purl.obolibrary.org/obo/UBERON_0000088 | denotes | trophoblast |