PubMed:17975693 JSONTXT

{"project":"LitCoin-entities","denotations":[{"id":"4530","span":{"begin":0,"end":10},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4531","span":{"begin":24,"end":37},"obj":"ChemicalEntity"},{"id":"4532","span":{"begin":42,"end":53},"obj":"ChemicalEntity"},{"id":"4533","span":{"begin":57,"end":61},"obj":"OrganismTaxon"},{"id":"4534","span":{"begin":90,"end":100},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4535","span":{"begin":112,"end":128},"obj":"ChemicalEntity"},{"id":"4536","span":{"begin":137,"end":150},"obj":"ChemicalEntity"},{"id":"4537","span":{"begin":155,"end":166},"obj":"ChemicalEntity"},{"id":"4538","span":{"begin":217,"end":221},"obj":"OrganismTaxon"},{"id":"4539","span":{"begin":595,"end":608},"obj":"ChemicalEntity"},{"id":"4540","span":{"begin":614,"end":625},"obj":"ChemicalEntity"},{"id":"4541","span":{"begin":634,"end":638},"obj":"OrganismTaxon"},{"id":"4542","span":{"begin":646,"end":663},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4543","span":{"begin":689,"end":693},"obj":"OrganismTaxon"},{"id":"4544","span":{"begin":734,"end":747},"obj":"ChemicalEntity"},{"id":"4545","span":{"begin":753,"end":764},"obj":"ChemicalEntity"},{"id":"4546","span":{"begin":773,"end":777},"obj":"OrganismTaxon"},{"id":"4547","span":{"begin":941,"end":951},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4548","span":{"begin":965,"end":978},"obj":"ChemicalEntity"},{"id":"4549","span":{"begin":983,"end":994},"obj":"ChemicalEntity"}],"attributes":[{"id":"A19","pred":"db_id","subj":"4548","obj":"MESH:D002939"},{"id":"A8","pred":"db_id","subj":"4537","obj":"MESH:D009643"},{"id":"A7","pred":"db_id","subj":"4536","obj":"MESH:D002939"},{"id":"A10","pred":"db_id","subj":"4539","obj":"MESH:D002939"},{"id":"A3","pred":"db_id","subj":"4532","obj":"MESH:D009643"},{"id":"A5","pred":"db_id","subj":"4534","obj":"MESH:D001008"},{"id":"A15","pred":"db_id","subj":"4544","obj":"MESH:D002939"},{"id":"A2","pred":"db_id","subj":"4531","obj":"MESH:D002939"},{"id":"A12","pred":"db_id","subj":"4541","obj":"NCBITaxon:10116"},{"id":"A17","pred":"db_id","subj":"4546","obj":"NCBITaxon:10116"},{"id":"A16","pred":"db_id","subj":"4545","obj":"MESH:D009643"},{"id":"A1","pred":"db_id","subj":"4530","obj":"MESH:D001008"},{"id":"A4","pred":"db_id","subj":"4533","obj":"NCBITaxon:10116"},{"id":"A9","pred":"db_id","subj":"4538","obj":"NCBITaxon:10116"},{"id":"A13","pred":"db_id","subj":"4542","obj":"MESH:D001008"},{"id":"A14","pred":"db_id","subj":"4543","obj":"NCBITaxon:10116"},{"id":"A18","pred":"db_id","subj":"4547","obj":"MESH:D001008"},{"id":"A6","pred":"db_id","subj":"4535","obj":"MESH:D024841"},{"id":"A11","pred":"db_id","subj":"4540","obj":"MESH:D009643"},{"id":"A20","pred":"db_id","subj":"4549","obj":"MESH:D009643"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":62},"obj":"Sentence"},{"id":"T2","span":{"begin":63,"end":76},"obj":"Sentence"},{"id":"T3","span":{"begin":77,"end":256},"obj":"Sentence"},{"id":"T4","span":{"begin":257,"end":265},"obj":"Sentence"},{"id":"T5","span":{"begin":266,"end":394},"obj":"Sentence"},{"id":"T6","span":{"begin":395,"end":559},"obj":"Sentence"},{"id":"T7","span":{"begin":560,"end":568},"obj":"Sentence"},{"id":"T8","span":{"begin":569,"end":724},"obj":"Sentence"},{"id":"T9","span":{"begin":725,"end":857},"obj":"Sentence"},{"id":"T10","span":{"begin":858,"end":869},"obj":"Sentence"},{"id":"T11","span":{"begin":870,"end":995},"obj":"Sentence"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":57,"end":61},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":217,"end":221},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":634,"end":638},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":689,"end":693},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":773,"end":777},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:10118"},{"id":"A2","pred":"db_id","subj":"T1","obj":"NCBItxid:10116"},{"id":"A3","pred":"db_id","subj":"T1","obj":"NCBItxid:10114"},{"id":"A4","pred":"db_id","subj":"T4","obj":"NCBItxid:10118"},{"id":"A5","pred":"db_id","subj":"T4","obj":"NCBItxid:10116"},{"id":"A6","pred":"db_id","subj":"T4","obj":"NCBItxid:10114"},{"id":"A7","pred":"db_id","subj":"T7","obj":"NCBItxid:10118"},{"id":"A8","pred":"db_id","subj":"T7","obj":"NCBItxid:10116"},{"id":"A9","pred":"db_id","subj":"T7","obj":"NCBItxid:10114"},{"id":"A10","pred":"db_id","subj":"T10","obj":"NCBItxid:10118"},{"id":"A11","pred":"db_id","subj":"T10","obj":"NCBItxid:10116"},{"id":"A12","pred":"db_id","subj":"T10","obj":"NCBItxid:10114"},{"id":"A13","pred":"db_id","subj":"T13","obj":"NCBItxid:10118"},{"id":"A14","pred":"db_id","subj":"T13","obj":"NCBItxid:10116"},{"id":"A15","pred":"db_id","subj":"T13","obj":"NCBItxid:10114"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":210,"end":216},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":257,"end":264},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":310,"end":312},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":399,"end":404},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":414,"end":418},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":462,"end":466},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":485,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":491,"end":497},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":697,"end":700},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":817,"end":822},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":895,"end":903},"obj":"GeneOrGeneProduct"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":210,"end":216},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":817,"end":822},"obj":"GeneOrGeneProduct"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":90,"end":100},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":646,"end":663},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":941,"end":951},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"ID:","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"ID:","subj":"T3","obj":"DISEASE"},{"id":"A4","pred":"ID:","subj":"T4","obj":"DISEASE"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":90,"end":100},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":646,"end":663},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":941,"end":951},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"#label","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"#label","subj":"T3","obj":"DISEASE"},{"id":"A4","pred":"#label","subj":"T4","obj":"DISEASE"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":24,"end":37},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":42,"end":53},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":112,"end":128},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":137,"end":150},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":155,"end":166},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":595,"end":608},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":614,"end":625},"obj":"ChemicalEntity"},{"id":"T15","span":{"begin":734,"end":747},"obj":"ChemicalEntity"},{"id":"T17","span":{"begin":753,"end":764},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":965,"end":978},"obj":"ChemicalEntity"},{"id":"T21","span":{"begin":983,"end":994},"obj":"ChemicalEntity"}],"attributes":[{"id":"A17","pred":"ID:","subj":"T17","obj":"D009643"},{"id":"A18","pred":"ID:","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_100246"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D024841"},{"id":"A6","pred":"ID:","subj":"T5","obj":"ChemicalEntity"},{"id":"A19","pred":"ID:","subj":"T19","obj":"D002939"},{"id":"A20","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_100241"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D002939"},{"id":"A16","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_100241"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D002939"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_100241"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D009643"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_100246"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D002939"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_100241"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D002939"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_100241"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D009643"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_100246"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D009643"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_100246"},{"id":"A21","pred":"ID:","subj":"T21","obj":"D009643"},{"id":"A22","pred":"ID:","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_100246"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":57,"end":61},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":217,"end":221},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":634,"end":638},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":689,"end":693},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":773,"end":777},"obj":"OrganismTaxon"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}

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{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":210,"end":216},"obj":"HP_0001022"}],"text":"Anxiogenic potential of ciprofloxacin and norfloxacin in rats.\nINTRODUCTION: The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.\nMETHODS: The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.\nRESULTS: The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.\nCONCLUSION: The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin."}