
PubMed:17959715
Annnotations
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
4453 | 12-16 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4454 | 29-35 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
4455 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | MESH:D006689 |
4456 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | MESH:D006689 |
4457 | 248-255 | DiseaseOrPhenotypicFeature | denotes | cancers | MESH:D009369 |
4458 | 257-269 | DiseaseOrPhenotypicFeature | denotes | Cytotoxicity | MESH:D064420 |
4459 | 363-367 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4460 | 427-436 | DiseaseOrPhenotypicFeature | denotes | cytotoxic | MESH:D064420 |
4461 | 614-618 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4462 | 634-643 | SequenceVariant | denotes | rs1800734 | DBSNP:rs1800734 |
4463 | 666-672 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
4464 | 718-726 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
4465 | 741-747 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
4466 | 806-814 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
4467 | 838-855 | DiseaseOrPhenotypicFeature | denotes | myeloid leukaemia | MESH:D007938 |
4468 | 861-869 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
4469 | 885-909 | DiseaseOrPhenotypicFeature | denotes | primary Hodgkin lymphoma | MESH:D006689 |
4470 | 960-964 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4471 | 1137-1143 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
4472 | 1152-1156 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4473 | 1338-1342 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4474 | 1369-1377 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
4475 | 1408-1431 | DiseaseOrPhenotypicFeature | denotes | acute myeloid leukaemia | MESH:D015470 |
4476 | 1435-1438 | DiseaseOrPhenotypicFeature | denotes | AML | MESH:D015470 |
4477 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | MESH:D001943 |
4478 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | MESH:D006689 |
4479 | 1553-1561 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
4480 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | AML | MESH:D015470 |
4481 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | MESH:D001943 |
4482 | 1637-1645 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
4483 | 1667-1671 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4484 | 1722-1725 | DiseaseOrPhenotypicFeature | denotes | AML | MESH:D015470 |
4485 | 1757-1760 | DiseaseOrPhenotypicFeature | denotes | AML | MESH:D015470 |
4486 | 1894-1897 | DiseaseOrPhenotypicFeature | denotes | AML | MESH:D015470 |
4487 | 1968-1976 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
4488 | 2138-2142 | GeneOrGeneProduct | denotes | MLH1 | NCBIGene:4292 |
4489 | 2188-2194 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
4490 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | MESH:D006689 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-88 | Sentence | denotes | Polymorphic MLH1 and risk of cancer after methylating chemotherapy for Hodgkin lymphoma. |
T2 | 89-114 | Sentence | denotes | BACKGROUND AND OBJECTIVE: |
T3 | 115-256 | Sentence | denotes | Methylating agents are effective chemotherapy agents for Hodgkin lymphoma, but are associated with the development of second primary cancers. |
T4 | 257-354 | Sentence | denotes | Cytotoxicity of methylating agents is mediated primarily by the DNA mismatch repair (MMR) system. |
T5 | 355-545 | Sentence | denotes | Loss of MLH1, a major component of DNA MMR, results in tolerance to the cytotoxic effects of methylating agents and persistence of mutagenised cells at high risk of malignant transformation. |
T6 | 546-704 | Sentence | denotes | We hypothesised that a common substitution in the basal promoter of MLH1 (position -93, rs1800734) modifies the risk of cancer after methylating chemotherapy. |
T7 | 705-713 | Sentence | denotes | METHODS: |
T8 | 714-1091 | Sentence | denotes | 133 patients who developed cancer following chemotherapy and/or radiotherapy (n = 133), 420 patients diagnosed with de novo myeloid leukaemia, 242 patients diagnosed with primary Hodgkin lymphoma, and 1177 healthy controls were genotyped for the MLH1 -93 polymorphism by allelic discrimination polymerase chain reaction (PCR) and restriction fragment length polymorphism assay. |
T9 | 1092-1303 | Sentence | denotes | Odds ratios and 95% confidence intervals for cancer risk by MLH1 -93 polymorphism status, and stratified by previous exposure to methylating chemotherapy, were calculated using unconditional logistic regression. |
T10 | 1304-1312 | Sentence | denotes | RESULTS: |
T11 | 1313-1662 | Sentence | denotes | Carrier frequency of the MLH1 -93 variant was higher in patients who developed therapy related acute myeloid leukaemia (t-AML) (75.0%, n = 12) or breast cancer (53.3%. n = 15) after methylating chemotherapy for Hodgkin lymphoma compared to patients without previous methylating exposure (t-AML, 30.4%, n = 69; breast cancer patients, 27.2%, n = 22). |
T12 | 1663-2021 | Sentence | denotes | The MLH1 -93 variant allele was also over-represented in t-AML cases when compared to de novo AML cases (36.9%, n = 420) and healthy controls (36.3%, n = 952), and was associated with a significantly increased risk of developing t-AML (odds ratio 5.31, 95% confidence interval 1.40 to 20.15), but only in patients previously treated with a methylating agent. |
T13 | 2022-2034 | Sentence | denotes | CONCLUSIONS: |
T14 | 2035-2247 | Sentence | denotes | These data support the hypothesis that the common polymorphism at position -93 in the core promoter of MLH1 defines a risk allele for the development of cancer after methylating chemotherapy for Hodgkin lymphoma. |
T15 | 2248-2316 | Sentence | denotes | However, replication of this finding in larger studies is suggested. |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 29-35 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
T2 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T3 | 79-87 | DiseaseOrPhenotypicFeature | denotes | lymphoma | 0005062 |
T4 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T5 | 180-188 | DiseaseOrPhenotypicFeature | denotes | lymphoma | 0005062 |
T6 | 248-255 | DiseaseOrPhenotypicFeature | denotes | cancers | 0004992 |
T7 | 666-672 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
T8 | 741-747 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
T9 | 893-909 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T10 | 901-909 | DiseaseOrPhenotypicFeature | denotes | lymphoma | 0005062 |
T11 | 1137-1143 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
T12 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | 0007254 |
T13 | 1466-1472 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
T14 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T15 | 1532-1540 | DiseaseOrPhenotypicFeature | denotes | lymphoma | 0005062 |
T16 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | 0007254 |
T17 | 1630-1636 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
T18 | 2188-2194 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
T19 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T20 | 2238-2246 | DiseaseOrPhenotypicFeature | denotes | lymphoma | 0005062 |
LitCoin-SeqVar
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 634-643 | SequenceVariant | denotes | rs1800734 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 12-16 | GeneOrGeneProduct | denotes | MLH1 |
T2 | 295-303 | GeneOrGeneProduct | denotes | mediated |
T3 | 321-340 | GeneOrGeneProduct | denotes | DNA mismatch repair |
T4 | 363-367 | GeneOrGeneProduct | denotes | MLH1 |
T5 | 371-376 | GeneOrGeneProduct | denotes | major |
T6 | 410-419 | GeneOrGeneProduct | denotes | tolerance |
T7 | 471-482 | GeneOrGeneProduct | denotes | persistence |
T8 | 498-503 | GeneOrGeneProduct | denotes | cells |
T9 | 507-511 | GeneOrGeneProduct | denotes | high |
T10 | 530-544 | GeneOrGeneProduct | denotes | transformation |
T11 | 614-618 | GeneOrGeneProduct | denotes | MLH1 |
T12 | 705-712 | GeneOrGeneProduct | denotes | METHODS |
T13 | 857-860 | GeneOrGeneProduct | denotes | 242 |
T14 | 960-964 | GeneOrGeneProduct | denotes | MLH1 |
T15 | 1008-1018 | GeneOrGeneProduct | denotes | polymerase |
T16 | 1019-1024 | GeneOrGeneProduct | denotes | chain |
T17 | 1152-1156 | GeneOrGeneProduct | denotes | MLH1 |
T18 | 1313-1320 | GeneOrGeneProduct | denotes | Carrier |
T19 | 1321-1330 | GeneOrGeneProduct | denotes | frequency |
T20 | 1338-1342 | GeneOrGeneProduct | denotes | MLH1 |
T21 | 1433-1438 | GeneOrGeneProduct | denotes | t-AML |
T22 | 1448-1454 | GeneOrGeneProduct | denotes | n = 12 |
T23 | 1601-1606 | GeneOrGeneProduct | denotes | t-AML |
T24 | 1654-1660 | GeneOrGeneProduct | denotes | n = 22 |
T25 | 1667-1671 | GeneOrGeneProduct | denotes | MLH1 |
T26 | 1720-1725 | GeneOrGeneProduct | denotes | t-AML |
T27 | 1726-1731 | GeneOrGeneProduct | denotes | cases |
T28 | 1761-1766 | GeneOrGeneProduct | denotes | cases |
T29 | 1817-1820 | GeneOrGeneProduct | denotes | 952 |
T30 | 1892-1897 | GeneOrGeneProduct | denotes | t-AML |
T31 | 2121-2125 | GeneOrGeneProduct | denotes | core |
T32 | 2138-2142 | GeneOrGeneProduct | denotes | MLH1 |
T33 | 2277-2284 | GeneOrGeneProduct | denotes | finding |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 12-16 | GeneOrGeneProduct | denotes | MLH1 |
T2 | 321-340 | GeneOrGeneProduct | denotes | DNA mismatch repair |
T3 | 363-367 | GeneOrGeneProduct | denotes | MLH1 |
T4 | 371-376 | GeneOrGeneProduct | denotes | major |
T5 | 507-511 | GeneOrGeneProduct | denotes | high |
T6 | 614-618 | GeneOrGeneProduct | denotes | MLH1 |
T7 | 960-964 | GeneOrGeneProduct | denotes | MLH1 |
T8 | 1008-1018 | GeneOrGeneProduct | denotes | polymerase |
T9 | 1019-1024 | GeneOrGeneProduct | denotes | chain |
T10 | 1152-1156 | GeneOrGeneProduct | denotes | MLH1 |
T11 | 1313-1320 | GeneOrGeneProduct | denotes | Carrier |
T12 | 1321-1330 | GeneOrGeneProduct | denotes | frequency |
T13 | 1338-1342 | GeneOrGeneProduct | denotes | MLH1 |
T14 | 1667-1671 | GeneOrGeneProduct | denotes | MLH1 |
T15 | 1817-1820 | GeneOrGeneProduct | denotes | 952 |
T16 | 2121-2125 | GeneOrGeneProduct | denotes | core |
T17 | 2138-2142 | GeneOrGeneProduct | denotes | MLH1 |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 29-35 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T2 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T3 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T4 | 233-255 | DiseaseOrPhenotypicFeature | denotes | second primary cancers | D016609 |
T5 | 257-269 | DiseaseOrPhenotypicFeature | denotes | Cytotoxicity | DISEASE |
T6 | 427-436 | DiseaseOrPhenotypicFeature | denotes | cytotoxic | DISEASE |
T7 | 520-529 | DiseaseOrPhenotypicFeature | denotes | malignant | D009369 |
T8 | 666-672 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T9 | 741-747 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T10 | 893-909 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T11 | 1137-1143 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T12 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T13 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T14 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T15 | 2188-2194 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T16 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 12-16 | GeneOrGeneProduct | denotes | MLH1 |
T2 | 321-340 | GeneOrGeneProduct | denotes | DNA mismatch repair |
T3 | 363-367 | GeneOrGeneProduct | denotes | MLH1 |
T4 | 614-618 | GeneOrGeneProduct | denotes | MLH1 |
T5 | 960-964 | GeneOrGeneProduct | denotes | MLH1 |
T6 | 1152-1156 | GeneOrGeneProduct | denotes | MLH1 |
T7 | 1338-1342 | GeneOrGeneProduct | denotes | MLH1 |
T8 | 1667-1671 | GeneOrGeneProduct | denotes | MLH1 |
T9 | 1817-1820 | GeneOrGeneProduct | denotes | 952 |
T10 | 2138-2142 | GeneOrGeneProduct | denotes | MLH1 |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T2 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T3 | 893-909 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T4 | 1435-1438 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T5 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | 0007254|0004989 |
T7 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T8 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T9 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | 0007254|0004989 |
T11 | 1722-1725 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T12 | 1757-1760 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T13 | 1894-1897 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T14 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 29-35 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T2 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T3 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T4 | 233-255 | DiseaseOrPhenotypicFeature | denotes | second primary cancers | D016609 |
T5 | 257-269 | DiseaseOrPhenotypicFeature | denotes | Cytotoxicity | DISEASE |
T6 | 427-436 | DiseaseOrPhenotypicFeature | denotes | cytotoxic | DISEASE |
T7 | 666-672 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T8 | 741-747 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T9 | 838-855 | DiseaseOrPhenotypicFeature | denotes | myeloid leukaemia | DISEASE |
T10 | 893-909 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T11 | 1137-1143 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T12 | 1408-1431 | DiseaseOrPhenotypicFeature | denotes | acute myeloid leukaemia | DISEASE |
T13 | 1435-1438 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T14 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T15 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T16 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T17 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T18 | 1722-1725 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T19 | 1757-1760 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T20 | 1894-1897 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T21 | 2188-2194 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T22 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 29-35 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T2 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T3 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T4 | 233-255 | DiseaseOrPhenotypicFeature | denotes | second primary cancers | D016609 |
T5 | 257-269 | DiseaseOrPhenotypicFeature | denotes | Cytotoxicity | DISEASE |
T6 | 427-436 | DiseaseOrPhenotypicFeature | denotes | cytotoxic | DISEASE |
T7 | 666-672 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T8 | 741-747 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T9 | 838-855 | DiseaseOrPhenotypicFeature | denotes | myeloid leukaemia | DISEASE |
T10 | 893-909 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T11 | 1137-1143 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T12 | 1408-1431 | DiseaseOrPhenotypicFeature | denotes | acute myeloid leukaemia | DISEASE |
T13 | 1435-1438 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T14 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T15 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T16 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T17 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T18 | 1722-1725 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T19 | 1757-1760 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T20 | 1894-1897 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T21 | 2188-2194 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T22 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 718-726 | OrganismTaxon | denotes | patients |
T2 | 806-814 | OrganismTaxon | denotes | patients |
T3 | 861-869 | OrganismTaxon | denotes | patients |
T4 | 1369-1377 | OrganismTaxon | denotes | patients |
T5 | 1553-1561 | OrganismTaxon | denotes | patients |
T6 | 1637-1645 | OrganismTaxon | denotes | patients |
T7 | 1968-1976 | OrganismTaxon | denotes | patients |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T10 | 2138-2142 | GeneOrGeneProduct | denotes | MLH1 | |
T9 | 1817-1820 | GeneOrGeneProduct | denotes | 952 | |
T8 | 1667-1671 | GeneOrGeneProduct | denotes | MLH1 | |
T7 | 1338-1342 | GeneOrGeneProduct | denotes | MLH1 | |
T6 | 1152-1156 | GeneOrGeneProduct | denotes | MLH1 | |
T5 | 960-964 | GeneOrGeneProduct | denotes | MLH1 | |
T4 | 614-618 | GeneOrGeneProduct | denotes | MLH1 | |
T3 | 363-367 | GeneOrGeneProduct | denotes | MLH1 | |
T2 | 321-340 | GeneOrGeneProduct | denotes | DNA mismatch repair | |
T1 | 12-16 | GeneOrGeneProduct | denotes | MLH1 | |
T22 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T21 | 2188-2194 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T20 | 1894-1897 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T19 | 1757-1760 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T18 | 1722-1725 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T17 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T16 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T15 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T14 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | D001943 |
T13 | 1435-1438 | DiseaseOrPhenotypicFeature | denotes | AML | DISEASE |
T12 | 1408-1431 | DiseaseOrPhenotypicFeature | denotes | acute myeloid leukaemia | DISEASE |
T11 | 1137-1143 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T10224 | 893-909 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T87984 | 838-855 | DiseaseOrPhenotypicFeature | denotes | myeloid leukaemia | DISEASE |
T11181 | 741-747 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T6765 | 666-672 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T65917 | 427-436 | DiseaseOrPhenotypicFeature | denotes | cytotoxic | DISEASE |
T95922 | 257-269 | DiseaseOrPhenotypicFeature | denotes | Cytotoxicity | DISEASE |
T11067 | 233-255 | DiseaseOrPhenotypicFeature | denotes | second primary cancers | D016609 |
T2888 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T71713 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | D006689 |
T9623 | 29-35 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
T80947 | 1968-1976 | OrganismTaxon | denotes | patients | |
T26614 | 1637-1645 | OrganismTaxon | denotes | patients | |
T41113 | 1553-1561 | OrganismTaxon | denotes | patients | |
T50663 | 1369-1377 | OrganismTaxon | denotes | patients | |
T75296 | 861-869 | OrganismTaxon | denotes | patients | |
T41344 | 806-814 | OrganismTaxon | denotes | patients | |
T55653 | 718-726 | OrganismTaxon | denotes | patients | |
T28006 | 634-643 | SequenceVariant | denotes | rs1800734 |
PMID_GLOBAL
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 71-87 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T2 | 172-188 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T3 | 893-909 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T4 | 1435-1438 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T5 | 1459-1472 | DiseaseOrPhenotypicFeature | denotes | breast cancer | 0004989|0007254 |
T7 | 1524-1540 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
T8 | 1603-1606 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T9 | 1623-1636 | DiseaseOrPhenotypicFeature | denotes | breast cancer | 0004989|0007254 |
T11 | 1722-1725 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T12 | 1757-1760 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T13 | 1894-1897 | DiseaseOrPhenotypicFeature | denotes | AML | 0018874 |
T14 | 2230-2246 | DiseaseOrPhenotypicFeature | denotes | Hodgkin lymphoma | 0004952 |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 12-16 | gene:4292 | denotes | MLH1 |
T1 | 71-87 | disease:C0019829 | denotes | Hodgkin lymphoma |
T2 | 12-16 | gene:4292 | denotes | MLH1 |
T3 | 29-35 | disease:C0006826 | denotes | cancer |
T4 | 12-16 | gene:4292 | denotes | MLH1 |
T5 | 29-35 | disease:C1306459 | denotes | cancer |
T6 | 614-618 | gene:4292 | denotes | MLH1 |
T7 | 666-672 | disease:C1306459 | denotes | cancer |
T8 | 614-618 | gene:4292 | denotes | MLH1 |
T9 | 666-672 | disease:C0006826 | denotes | cancer |
T10 | 1152-1156 | gene:4292 | denotes | MLH1 |
T11 | 1137-1143 | disease:C1306459 | denotes | cancer |
T12 | 1152-1156 | gene:4292 | denotes | MLH1 |
T13 | 1137-1143 | disease:C0006826 | denotes | cancer |
T14 | 1338-1342 | gene:4292 | denotes | MLH1 |
T15 | 1459-1472 | disease:C0678222 | denotes | breast cancer |
T16 | 1338-1342 | gene:4292 | denotes | MLH1 |
T17 | 1459-1472 | disease:C0006142 | denotes | breast cancer |
R1 | T0 | T1 | associated_with | MLH1,Hodgkin lymphoma |
R2 | T2 | T3 | associated_with | MLH1,cancer |
R3 | T4 | T5 | associated_with | MLH1,cancer |
R4 | T6 | T7 | associated_with | MLH1,cancer |
R5 | T8 | T9 | associated_with | MLH1,cancer |
R6 | T10 | T11 | associated_with | MLH1,cancer |
R7 | T12 | T13 | associated_with | MLH1,cancer |
R8 | T14 | T15 | associated_with | MLH1,breast cancer |
R9 | T16 | T17 | associated_with | MLH1,breast cancer |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 172-188 | HP_0012189 | denotes | Hodgkin lymphoma |
T2 | 180-188 | HP_0002665 | denotes | lymphoma |
T3 | 248-255 | HP_0002664 | denotes | cancers |
T4 | 666-672 | HP_0002664 | denotes | cancer |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
17959715-0#12#16#gene4292 | 1152-1156 | gene4292 | denotes | MLH1 |
17959715-0#71#87#diseaseC0019829 | 2230-2246 | diseaseC0019829 | denotes | Hodgkin lymphoma |
17959715-7#25#29#gene4292 | 1338-1342 | gene4292 | denotes | MLH1 |
17959715-7#146#159#diseaseC0006142 | 1459-1472 | diseaseC0006142 | denotes | breast cancer |
17959715-7#146#159#diseaseC0678222 | 1459-1472 | diseaseC0678222 | denotes | breast cancer |
12#16#gene429271#87#diseaseC0019829 | 17959715-0#12#16#gene4292 | 17959715-0#71#87#diseaseC0019829 | associated_with | MLH1,Hodgkin lymphoma |
25#29#gene4292146#159#diseaseC0006142 | 17959715-7#25#29#gene4292 | 17959715-7#146#159#diseaseC0006142 | associated_with | MLH1,breast cancer |
25#29#gene4292146#159#diseaseC0678222 | 17959715-7#25#29#gene4292 | 17959715-7#146#159#diseaseC0678222 | associated_with | MLH1,breast cancer |
tmVarCorpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 634-643 | SNP:rs1800734 | denotes | rs1800734 |