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sentences

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
T2 112-270 Sentence denotes The signal transducer and activator of transcription 3 (STAT3) is an IL-6-inducible transcription factor that mediates the hepatic acute phase response (APR).
T3 271-486 Sentence denotes Using gamma-fibrinogen (FBG) as a model of the APR, we investigated the requirement of an IL-6-inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) on gamma-FBG expression in HepG2 hepatocarcinoma cells.
T4 487-670 Sentence denotes IL-6 induces rapid nuclear translocation of Tyr-phosphorylated STAT3 that forms a nuclear complex with CDK9 in nondenaturing co-immunoprecipitation and confocal colocalization assays.
T5 671-836 Sentence denotes To further understand this interaction, we found that CDK9-STAT3 binding is mediated via both STAT NH2-terminal modulatory and COOH-terminal transactivation domains.
T6 837-1036 Sentence denotes Both IL-6-inducible gamma-FBG reporter gene and endogenous mRNA expression are significantly decreased after CDK9 inhibition using the potent CDK inhibitor, flavopiridol (FP), or specific CDK9 siRNA.
T7 1037-1287 Sentence denotes Moreover, chromatin immunoprecipitation (ChIP) experiments revealed an IL-6-inducible STAT3 and CDK9 binding to the proximal gamma-FBG promoter as well as increased loading of RNA Pol II and phospho-Ser2 CTD Pol II on the TATA box and coding regions.
T8 1288-1489 Sentence denotes Finally, FP specifically and efficiently inhibits association of phospho-Ser2 CTD RNA Pol II on the gamma-FBG promoter, indicating that CDK9 kinase activity mediates IL-6-inducible CTD phosphorylation.
T9 1490-1684 Sentence denotes Our data indicate that IL-6 induces a STAT3.CDK9 complex mediated by bivalent STAT3 domains and CDK9 kinase activity is necessary for licensing Pol II to enter a transcriptional elongation mode.
T10 1685-1811 Sentence denotes Therefore, disruption of IL-6 signaling by CDK9 inhibitors could be a potential therapeutic strategy for inflammatory disease.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1153-1161 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
T2 112-270 Sentence denotes The signal transducer and activator of transcription 3 (STAT3) is an IL-6-inducible transcription factor that mediates the hepatic acute phase response (APR).
T3 271-486 Sentence denotes Using gamma-fibrinogen (FBG) as a model of the APR, we investigated the requirement of an IL-6-inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) on gamma-FBG expression in HepG2 hepatocarcinoma cells.
T4 487-670 Sentence denotes IL-6 induces rapid nuclear translocation of Tyr-phosphorylated STAT3 that forms a nuclear complex with CDK9 in nondenaturing co-immunoprecipitation and confocal colocalization assays.
T5 671-836 Sentence denotes To further understand this interaction, we found that CDK9-STAT3 binding is mediated via both STAT NH2-terminal modulatory and COOH-terminal transactivation domains.
T6 837-1036 Sentence denotes Both IL-6-inducible gamma-FBG reporter gene and endogenous mRNA expression are significantly decreased after CDK9 inhibition using the potent CDK inhibitor, flavopiridol (FP), or specific CDK9 siRNA.
T7 1037-1287 Sentence denotes Moreover, chromatin immunoprecipitation (ChIP) experiments revealed an IL-6-inducible STAT3 and CDK9 binding to the proximal gamma-FBG promoter as well as increased loading of RNA Pol II and phospho-Ser2 CTD Pol II on the TATA box and coding regions.
T8 1288-1489 Sentence denotes Finally, FP specifically and efficiently inhibits association of phospho-Ser2 CTD RNA Pol II on the gamma-FBG promoter, indicating that CDK9 kinase activity mediates IL-6-inducible CTD phosphorylation.
T9 1490-1684 Sentence denotes Our data indicate that IL-6 induces a STAT3.CDK9 complex mediated by bivalent STAT3 domains and CDK9 kinase activity is necessary for licensing Pol II to enter a transcriptional elongation mode.
T10 1685-1811 Sentence denotes Therefore, disruption of IL-6 signaling by CDK9 inhibitors could be a potential therapeutic strategy for inflammatory disease.
T1 0-111 Sentence denotes The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
T2 112-270 Sentence denotes The signal transducer and activator of transcription 3 (STAT3) is an IL-6-inducible transcription factor that mediates the hepatic acute phase response (APR).
T3 271-486 Sentence denotes Using gamma-fibrinogen (FBG) as a model of the APR, we investigated the requirement of an IL-6-inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) on gamma-FBG expression in HepG2 hepatocarcinoma cells.
T4 487-670 Sentence denotes IL-6 induces rapid nuclear translocation of Tyr-phosphorylated STAT3 that forms a nuclear complex with CDK9 in nondenaturing co-immunoprecipitation and confocal colocalization assays.
T5 671-836 Sentence denotes To further understand this interaction, we found that CDK9-STAT3 binding is mediated via both STAT NH2-terminal modulatory and COOH-terminal transactivation domains.
T6 837-1036 Sentence denotes Both IL-6-inducible gamma-FBG reporter gene and endogenous mRNA expression are significantly decreased after CDK9 inhibition using the potent CDK inhibitor, flavopiridol (FP), or specific CDK9 siRNA.
T7 1037-1287 Sentence denotes Moreover, chromatin immunoprecipitation (ChIP) experiments revealed an IL-6-inducible STAT3 and CDK9 binding to the proximal gamma-FBG promoter as well as increased loading of RNA Pol II and phospho-Ser2 CTD Pol II on the TATA box and coding regions.
T8 1288-1489 Sentence denotes Finally, FP specifically and efficiently inhibits association of phospho-Ser2 CTD RNA Pol II on the gamma-FBG promoter, indicating that CDK9 kinase activity mediates IL-6-inducible CTD phosphorylation.
T9 1490-1684 Sentence denotes Our data indicate that IL-6 induces a STAT3.CDK9 complex mediated by bivalent STAT3 domains and CDK9 kinase activity is necessary for licensing Pol II to enter a transcriptional elongation mode.
T10 1685-1811 Sentence denotes Therefore, disruption of IL-6 signaling by CDK9 inhibitors could be a potential therapeutic strategy for inflammatory disease.

relna

Id Subject Object Predicate Lexical cue
T1 26-39 Protein denotes interleukin 6
T2 50-54 Protein denotes CDK9
T3 55-60 DNA denotes STAT3
T4 116-166 DNA denotes signal transducer and activator of transcription 3
T5 168-173 DNA denotes STAT3
T6 181-185 Protein denotes IL-6
T7 243-263 Protein denotes acute phase response
T8 265-268 Protein denotes APR
T9 318-321 Protein denotes APR
T10 387-392 DNA denotes STAT3
T11 398-423 Protein denotes cyclin-dependent kinase 9
T12 425-429 Protein denotes CDK9
T13 487-491 Protein denotes IL-6
T14 550-555 DNA denotes STAT3
T15 590-594 Protein denotes CDK9
T16 725-729 Protein denotes CDK9
T17 730-735 DNA denotes STAT3
T18 842-846 Protein denotes IL-6
T19 946-950 Protein denotes CDK9
T20 1025-1029 Protein denotes CDK9
T21 1108-1112 Protein denotes IL-6
T22 1123-1128 DNA denotes STAT3
T23 1133-1137 Protein denotes CDK9
T24 1424-1428 Protein denotes CDK9
T25 1454-1458 Protein denotes IL-6
T26 1513-1517 Protein denotes IL-6
T27 1528-1533 DNA denotes STAT3
T28 1534-1538 Protein denotes CDK9
T29 1586-1590 Protein denotes CDK9
T30 1710-1714 Protein denotes IL-6
T31 1728-1732 Protein denotes CDK9
R0 T11 T10 linked cyclin-dependent kinase 9,STAT3
R1 T15 T14 linked CDK9,STAT3
R2 T16 T17 linked CDK9,STAT3
R3 T23 T22 linked CDK9,STAT3

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17956865-2#90#94#gene3569 361-365 gene3569 denotes IL-6
17956865-2#116#121#gene6774 387-392 gene6774 denotes STAT3
17956865-2#127#152#gene1025 398-423 gene1025 denotes cyclin-dependent kinase 9
17956865-2#154#158#gene1025 425-429 gene1025 denotes CDK9
17956865-2#193#208#diseaseC2239176 464-479 diseaseC2239176 denotes hepatocarcinoma
17956865-9#43#47#gene1025 1728-1732 gene1025 denotes CDK9
17956865-9#105#125#diseaseC1290884 1790-1810 diseaseC1290884 denotes inflammatory disease
90#94#gene3569193#208#diseaseC2239176 17956865-2#90#94#gene3569 17956865-2#193#208#diseaseC2239176 associated_with IL-6,hepatocarcinoma
116#121#gene6774193#208#diseaseC2239176 17956865-2#116#121#gene6774 17956865-2#193#208#diseaseC2239176 associated_with STAT3,hepatocarcinoma
127#152#gene1025193#208#diseaseC2239176 17956865-2#127#152#gene1025 17956865-2#193#208#diseaseC2239176 associated_with cyclin-dependent kinase 9,hepatocarcinoma
154#158#gene1025193#208#diseaseC2239176 17956865-2#154#158#gene1025 17956865-2#193#208#diseaseC2239176 associated_with CDK9,hepatocarcinoma
43#47#gene1025105#125#diseaseC1290884 17956865-9#43#47#gene1025 17956865-9#105#125#diseaseC1290884 associated_with CDK9,inflammatory disease

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1153-1161 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 243-263 Phenotype denotes acute phase response HP:0033331
T2 265-268 Phenotype denotes APR HP:0033331
T3 318-321 Phenotype denotes APR HP:0033331

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1790-1810 Disease denotes inflammatory disease http://purl.obolibrary.org/obo/MONDO_0021166

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 72-77 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 569-584 Body_part denotes nuclear complex http://purl.obolibrary.org/obo/UBERON_0007245