> top > docs > PubMed:17926108 > annotations

PubMed:17926108 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Concentration of soluble interleukin-6 receptors in tears of allergic conjunctival disease patients.
T2 101-109 Sentence denotes PURPOSE:
T3 110-294 Sentence denotes To evaluate the significance of soluble interleukin-6 receptor (sIL-6R) in tears as a clinical indicator of disease exacerbation in patients with allergic conjunctivitis disease (ACD).
T4 295-303 Sentence denotes METHODS:
T5 304-587 Sentence denotes The study groups comprised 13 patients (13 eyes) with vernal keratoconjunctivitis (VKC group), 13 patients (13 eyes) with atopic keratoconjunctivitis (AKC group), 11 patients (11 eyes) with giant papillary conjunctivitis (GPC group), and 10 healthy volunteers (10 eyes) as a control.
T6 588-660 Sentence denotes Tear samples were collected by the Schirmer I method using filter paper.
T7 661-786 Sentence denotes Tear samples were eluted and the concentration of sIL-6R in tear samples was determined by enzyme-linked immunosorbent assay.
T8 787-1123 Sentence denotes Impression cytology using a nitrocellulose membrane was applied to the upper tarsal conjunctiva, and the mRNA of the signal-transducing molecule glycoprotein 130 (gp130) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was extracted from the membrane and analyzed by semiquantitative reverse transcription-polymerase chain reaction.
T9 1124-1324 Sentence denotes In the VKC group, the clinical score was graded on the basis of allergic inflammation of the ocular surface, and the correlation between the concentration of sIL-6R and the clinical score was studied.
T10 1325-1333 Sentence denotes RESULTS:
T11 1334-1505 Sentence denotes The concentration of sIL-6R in tears in the VKC, AKC, GPC, and control groups was 5.1 +/- 4.7, 1.2 +/- 1.7, 2.6 +/- 2.8, and 0.5 +/- 4.3 (mean +/- SD) ng/ml, respectively.
T12 1506-1663 Sentence denotes The concentrations of sIL-6R in tears in the VKC and GPC groups were significantly higher than those in the control group (P < 0.001 and 0.05, respectively).
T13 1664-1784 Sentence denotes The AKC group showed no significant change in the concentration of sIL-6R in tears in comparison with the control group.
T14 1785-1901 Sentence denotes The gp130/GAPDH mRNA ratio was significantly higher in the patients with ACD than in control individuals (P < 0.05).
T15 1902-2077 Sentence denotes The concentration of sIL-6R in tears and the clinical score of allergic inflammation of the ocular surface were significantly correlated in the VKC group (r = 0.53, P < 0.01).
T16 2078-2090 Sentence denotes CONCLUSIONS:
T17 2091-2287 Sentence denotes We concluded that IL-6/sIL-6R complex trans-signaling via gp130 is an exacerbating factor of ACD, and that the concentration of sIL-6R in tears is a useful clinical biomarker in patients with ACD.
T1 0-100 Sentence denotes Concentration of soluble interleukin-6 receptors in tears of allergic conjunctival disease patients.
T2 101-109 Sentence denotes PURPOSE:
T3 110-294 Sentence denotes To evaluate the significance of soluble interleukin-6 receptor (sIL-6R) in tears as a clinical indicator of disease exacerbation in patients with allergic conjunctivitis disease (ACD).
T4 295-303 Sentence denotes METHODS:
T5 304-587 Sentence denotes The study groups comprised 13 patients (13 eyes) with vernal keratoconjunctivitis (VKC group), 13 patients (13 eyes) with atopic keratoconjunctivitis (AKC group), 11 patients (11 eyes) with giant papillary conjunctivitis (GPC group), and 10 healthy volunteers (10 eyes) as a control.
T6 588-660 Sentence denotes Tear samples were collected by the Schirmer I method using filter paper.
T7 661-786 Sentence denotes Tear samples were eluted and the concentration of sIL-6R in tear samples was determined by enzyme-linked immunosorbent assay.
T8 787-1123 Sentence denotes Impression cytology using a nitrocellulose membrane was applied to the upper tarsal conjunctiva, and the mRNA of the signal-transducing molecule glycoprotein 130 (gp130) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was extracted from the membrane and analyzed by semiquantitative reverse transcription-polymerase chain reaction.
T9 1124-1324 Sentence denotes In the VKC group, the clinical score was graded on the basis of allergic inflammation of the ocular surface, and the correlation between the concentration of sIL-6R and the clinical score was studied.
T10 1325-1333 Sentence denotes RESULTS:
T11 1334-1505 Sentence denotes The concentration of sIL-6R in tears in the VKC, AKC, GPC, and control groups was 5.1 +/- 4.7, 1.2 +/- 1.7, 2.6 +/- 2.8, and 0.5 +/- 4.3 (mean +/- SD) ng/ml, respectively.
T12 1506-1663 Sentence denotes The concentrations of sIL-6R in tears in the VKC and GPC groups were significantly higher than those in the control group (P < 0.001 and 0.05, respectively).
T13 1664-1784 Sentence denotes The AKC group showed no significant change in the concentration of sIL-6R in tears in comparison with the control group.
T14 1785-1901 Sentence denotes The gp130/GAPDH mRNA ratio was significantly higher in the patients with ACD than in control individuals (P < 0.05).
T15 1902-2077 Sentence denotes The concentration of sIL-6R in tears and the clinical score of allergic inflammation of the ocular surface were significantly correlated in the VKC group (r = 0.53, P < 0.01).
T16 2078-2090 Sentence denotes CONCLUSIONS:
T17 2091-2287 Sentence denotes We concluded that IL-6/sIL-6R complex trans-signaling via gp130 is an exacerbating factor of ACD, and that the concentration of sIL-6R in tears is a useful clinical biomarker in patients with ACD.

LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
3 25-38 GeneOrGeneProduct denotes interleukin-6 Gene:3569
4 61-90 DiseaseOrPhenotypicFeature denotes allergic conjunctival disease MESH:D004342
5 91-99 OrganismTaxon denotes patients Tax:9606
38 150-172 GeneOrGeneProduct denotes interleukin-6 receptor Gene:3570
39 242-250 OrganismTaxon denotes patients Tax:9606
40 256-287 DiseaseOrPhenotypicFeature denotes allergic conjunctivitis disease MESH:D004342
41 289-292 DiseaseOrPhenotypicFeature denotes ACD MESH:C535474
42 334-342 OrganismTaxon denotes patients Tax:9606
43 358-385 DiseaseOrPhenotypicFeature denotes vernal keratoconjunctivitis MESH:D003233
44 402-410 OrganismTaxon denotes patients Tax:9606
45 426-453 DiseaseOrPhenotypicFeature denotes atopic keratoconjunctivitis MESH:D007637
46 470-478 OrganismTaxon denotes patients Tax:9606
47 494-524 DiseaseOrPhenotypicFeature denotes giant papillary conjunctivitis MESH:D003233
48 932-948 GeneOrGeneProduct denotes glycoprotein 130 Gene:3572
49 950-955 GeneOrGeneProduct denotes gp130 Gene:3572
50 961-1001 GeneOrGeneProduct denotes glyceraldehyde-3-phosphate dehydrogenase Gene:2597
51 1003-1008 GeneOrGeneProduct denotes GAPDH Gene:2597
52 1188-1209 DiseaseOrPhenotypicFeature denotes allergic inflammation MESH:D004342
53 1282-1288 ChemicalEntity denotes sIL-6R
54 1355-1361 ChemicalEntity denotes sIL-6R
55 1528-1534 ChemicalEntity denotes sIL-6R
56 1668-1671 ChemicalEntity denotes AKC
57 1731-1737 ChemicalEntity denotes sIL-6R
58 1789-1794 GeneOrGeneProduct denotes gp130 Gene:3572
59 1795-1800 GeneOrGeneProduct denotes GAPDH Gene:2597
60 1844-1852 OrganismTaxon denotes patients Tax:9606
61 1858-1861 DiseaseOrPhenotypicFeature denotes ACD MESH:C535474
62 1923-1929 ChemicalEntity denotes sIL-6R
63 1965-1986 DiseaseOrPhenotypicFeature denotes allergic inflammation MESH:D004342
64 2109-2113 GeneOrGeneProduct denotes IL-6 Gene:3569
65 2149-2154 GeneOrGeneProduct denotes gp130 Gene:3572
66 2184-2187 DiseaseOrPhenotypicFeature denotes ACD MESH:C535474
67 2219-2225 ChemicalEntity denotes sIL-6R
68 2269-2277 OrganismTaxon denotes patients Tax:9606
69 2283-2286 DiseaseOrPhenotypicFeature denotes ACD MESH:C535474

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 70-90 DiseaseOrPhenotypicFeature denotes conjunctival disease D003229
T2 218-238 DiseaseOrPhenotypicFeature denotes disease exacerbation D018450
T3 256-279 DiseaseOrPhenotypicFeature denotes allergic conjunctivitis D003233
T4 280-287 DiseaseOrPhenotypicFeature denotes disease D004194
T5 358-385 DiseaseOrPhenotypicFeature denotes vernal keratoconjunctivitis D003233
T6 433-453 DiseaseOrPhenotypicFeature denotes keratoconjunctivitis D007637
T7 494-524 DiseaseOrPhenotypicFeature denotes giant papillary conjunctivitis D003233
T8 1197-1209 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T10 1974-1986 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 70-90 DiseaseOrPhenotypicFeature denotes conjunctival disease D003229
T2 218-238 DiseaseOrPhenotypicFeature denotes disease exacerbation D018450
T3 256-279 DiseaseOrPhenotypicFeature denotes allergic conjunctivitis D003233
T4 358-385 DiseaseOrPhenotypicFeature denotes vernal keratoconjunctivitis D003233
T5 433-453 DiseaseOrPhenotypicFeature denotes keratoconjunctivitis D007637
T6 494-524 DiseaseOrPhenotypicFeature denotes giant papillary conjunctivitis D003233
T7 1197-1209 DiseaseOrPhenotypicFeature denotes inflammation D007249
T8 1974-1986 DiseaseOrPhenotypicFeature denotes inflammation D007249

DisGeNET

Id Subject Object Predicate Lexical cue
T0 526-529 gene:2995 denotes GPC
T1 358-385 disease:C0022577 denotes vernal keratoconjunctivitis
T2 526-529 gene:2995 denotes GPC
T3 426-453 disease:C1274788 denotes atopic keratoconjunctivitis
T4 526-529 gene:2995 denotes GPC
T5 494-524 disease:C0009769 denotes giant papillary conjunctivitis
R1 T0 T1 associated_with GPC,vernal keratoconjunctivitis
R2 T2 T3 associated_with GPC,atopic keratoconjunctivitis
R3 T4 T5 associated_with GPC,giant papillary conjunctivitis