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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
4373 0-8 ChemicalEntity denotes Estrogen MESH:D004967
4374 18-35 ChemicalEntity denotes cholesteryl ester MESH:D002788
4375 79-91 GeneOrGeneProduct denotes HIV protease
4376 102-111 ChemicalEntity denotes ritonavir MESH:D019438
4377 130-133 OrganismTaxon denotes HIV NCBITaxon:11676
4378 224-233 ChemicalEntity denotes ritonavir MESH:D019438
4379 307-332 DiseaseOrPhenotypicFeature denotes premature atherosclerosis MESH:D050197
4380 371-380 ChemicalEntity denotes ritonavir MESH:D019438
4381 401-423 DiseaseOrPhenotypicFeature denotes atherosclerotic lesion MESH:D050197
4382 442-446 OrganismTaxon denotes mice NCBITaxon:10090
4383 482-486 OrganismTaxon denotes mice NCBITaxon:10090
4384 542-551 ChemicalEntity denotes ritonavir MESH:D019438
4385 577-594 ChemicalEntity denotes cholesteryl ester MESH:D002788
4386 712-723 ChemicalEntity denotes cholesterol MESH:D002784
4387 769-781 GeneOrGeneProduct denotes HIV protease
4388 792-801 ChemicalEntity denotes ritonavir MESH:D019438
4389 824-829 OrganismTaxon denotes human NCBITaxon:9606
4390 850-855 CellLine denotes THP-1 NCBITaxon:9606
4391 1026-1042 ChemicalEntity denotes 17beta-estradiol MESH:D004958
4392 1044-1046 ChemicalEntity denotes E2 MESH:D004958
4393 1056-1068 ChemicalEntity denotes progesterone MESH:D011374
4394 1087-1094 ChemicalEntity denotes ethanol MESH:D000431
4395 1135-1144 ChemicalEntity denotes ritonavir MESH:D019438
4396 1234-1239 ChemicalEntity denotes lipid MESH:D008055
4397 1267-1269 ChemicalEntity denotes E2 MESH:D004958
4398 1300-1318 ChemicalEntity denotes cholesteryl esters MESH:D002788
4399 1344-1353 ChemicalEntity denotes ritonavir MESH:D019438
4400 1365-1374 ChemicalEntity denotes Ritonavir MESH:D019438
4401 1427-1431 GeneOrGeneProduct denotes CD36 NCBIGene:948
4402 1487-1496 ChemicalEntity denotes ritonavir MESH:D019438
4403 1552-1561 GeneOrGeneProduct denotes PPARgamma NCBIGene:5468
4404 1625-1629 GeneOrGeneProduct denotes CD36 NCBIGene:948
4405 1662-1664 ChemicalEntity denotes E2 MESH:D004958
4406 1728-1730 ChemicalEntity denotes E2 MESH:D004958
4407 1768-1772 GeneOrGeneProduct denotes CD36 NCBIGene:948
4408 1860-1862 ChemicalEntity denotes E2 MESH:D004958
4409 1890-1894 GeneOrGeneProduct denotes CD36 NCBIGene:948
4410 1983-2000 ChemicalEntity denotes cholesteryl ester MESH:D002788
4411 2024-2033 ChemicalEntity denotes ritonavir MESH:D019438

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Estrogen prevents cholesteryl ester accumulation in macrophages induced by the HIV protease inhibitor ritonavir.
T2 113-234 Sentence denotes Individuals with HIV can now live long lives with drug therapy that often includes protease inhibitors such as ritonavir.
T3 235-333 Sentence denotes Many patients, however, develop negative long-term side effects such as premature atherosclerosis.
T4 334-487 Sentence denotes We have previously demonstrated that ritonavir treatment increases atherosclerotic lesion formation in male mice to a greater extent than in female mice.
T5 488-608 Sentence denotes Furthermore, peripheral blood monocytes isolated from ritonavir-treated females had less cholesteryl ester accumulation.
T6 609-802 Sentence denotes In the present study, we have investigated the molecular mechanisms by which female hormones influence cholesterol metabolism in macrophages in response to the HIV protease inhibitor ritonavir.
T7 803-892 Sentence denotes We have utilized the human monocyte cell line, THP-1 as a model to address this question.
T8 893-1096 Sentence denotes Briefly, cells were differentiated for 72 h with 100 nM PMA to obtain a macrophage-like phenotype in the presence or absence of 1 nM 17beta-estradiol (E2), 100 nM progesterone or vehicle (0.01% ethanol).
T9 1097-1199 Sentence denotes Cells were then treated with 30 ng/ml ritonavir or vehicle in the presence of aggregated LDL for 24 h.
T10 1200-1266 Sentence denotes Cell extracts were harvested, and lipid or total RNA was isolated.
T11 1267-1364 Sentence denotes E2 decreased the accumulation of cholesteryl esters in macrophages following ritonavir treatment.
T12 1365-1472 Sentence denotes Ritonavir increased the expression of the scavenger receptor, CD36 mRNA, responsible for the uptake of LDL.
T13 1473-1646 Sentence denotes Additionally, ritonavir treatment selectively increased the relative levels of PPARgamma mRNA, a transcription factor responsible for the regulation of CD36 mRNA expression.
T14 1647-1727 Sentence denotes Treatment with E2, however, failed to prevent these increases at the mRNA level.
T15 1728-1835 Sentence denotes E2 did, however, significantly suppress CD36 protein levels as measured by fluorescent immunocytochemistry.
T16 1836-2044 Sentence denotes This data suggests that E2 modifies the expression of CD36 at the level of protein expression in monocyte-derived macrophages resulting in reduced cholesteryl ester accumulation following ritonavir treatment.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 79-82 OrganismTaxon denotes HIV NCBItxid:57667|NCBItxid:35274|NCBItxid:12721|NCBItxid:11709|NCBItxid:11676
T6 130-133 OrganismTaxon denotes HIV NCBItxid:57667|NCBItxid:35274|NCBItxid:12721|NCBItxid:11709|NCBItxid:11676
T11 442-446 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T13 482-486 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T15 769-772 OrganismTaxon denotes HIV NCBItxid:57667|NCBItxid:35274|NCBItxid:12721|NCBItxid:11709|NCBItxid:11676
T20 824-829 OrganismTaxon denotes human NCBItxid:9606
T21 1407-1416 OrganismTaxon denotes scavenger NCBItxid:30848

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 317-332 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 64-71 GeneOrGeneProduct denotes induced
T2 83-101 GeneOrGeneProduct denotes protease inhibitor
T3 147-157 GeneOrGeneProduct denotes long lives
T4 196-215 GeneOrGeneProduct denotes protease inhibitors
T5 235-239 GeneOrGeneProduct denotes Many
T6 276-280 GeneOrGeneProduct denotes long
T7 281-285 GeneOrGeneProduct denotes term
T8 286-290 GeneOrGeneProduct denotes side
T9 417-423 GeneOrGeneProduct denotes lesion
T10 424-433 GeneOrGeneProduct denotes formation
T11 437-441 GeneOrGeneProduct denotes male
T12 442-446 GeneOrGeneProduct denotes mice
T13 482-486 GeneOrGeneProduct denotes mice
T14 518-527 GeneOrGeneProduct denotes monocytes
T15 693-701 GeneOrGeneProduct denotes hormones
T16 773-791 GeneOrGeneProduct denotes protease inhibitor
T17 830-838 GeneOrGeneProduct denotes monocyte
T18 839-843 GeneOrGeneProduct denotes cell
T19 844-848 GeneOrGeneProduct denotes line
T20 850-855 GeneOrGeneProduct denotes THP-1
T21 902-907 GeneOrGeneProduct denotes cells
T22 928-934 GeneOrGeneProduct denotes for 72
T23 976-980 GeneOrGeneProduct denotes like
T24 1033-1042 GeneOrGeneProduct denotes estradiol
T25 1097-1102 GeneOrGeneProduct denotes Cells
T26 1132-1134 GeneOrGeneProduct denotes ml
T27 1190-1196 GeneOrGeneProduct denotes for 24
T28 1200-1204 GeneOrGeneProduct denotes Cell
T29 1243-1248 GeneOrGeneProduct denotes total
T30 1407-1425 GeneOrGeneProduct denotes scavenger receptor
T31 1427-1431 GeneOrGeneProduct denotes CD36
T32 1432-1436 GeneOrGeneProduct denotes mRNA
T33 1552-1561 GeneOrGeneProduct denotes PPARgamma
T34 1562-1566 GeneOrGeneProduct denotes mRNA
T35 1570-1590 GeneOrGeneProduct denotes transcription factor
T36 1611-1621 GeneOrGeneProduct denotes regulation
T37 1625-1629 GeneOrGeneProduct denotes CD36
T38 1630-1634 GeneOrGeneProduct denotes mRNA
T39 1716-1720 GeneOrGeneProduct denotes mRNA
T40 1768-1772 GeneOrGeneProduct denotes CD36
T41 1773-1780 GeneOrGeneProduct denotes protein
T42 1890-1894 GeneOrGeneProduct denotes CD36
T43 1911-1918 GeneOrGeneProduct denotes protein
T44 1933-1941 GeneOrGeneProduct denotes monocyte
T45 1975-1982 GeneOrGeneProduct denotes reduced

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 83-101 GeneOrGeneProduct denotes protease inhibitor
T2 196-215 GeneOrGeneProduct denotes protease inhibitors
T3 281-285 GeneOrGeneProduct denotes term
T4 286-290 GeneOrGeneProduct denotes side
T5 518-527 GeneOrGeneProduct denotes monocytes
T6 773-791 GeneOrGeneProduct denotes protease inhibitor
T7 839-843 GeneOrGeneProduct denotes cell
T8 850-855 GeneOrGeneProduct denotes THP-1
T9 976-980 GeneOrGeneProduct denotes like
T10 1033-1042 GeneOrGeneProduct denotes estradiol
T11 1407-1425 GeneOrGeneProduct denotes scavenger receptor
T12 1427-1431 GeneOrGeneProduct denotes CD36
T13 1432-1436 GeneOrGeneProduct denotes mRNA
T14 1552-1561 GeneOrGeneProduct denotes PPARgamma
T15 1562-1566 GeneOrGeneProduct denotes mRNA
T16 1570-1590 GeneOrGeneProduct denotes transcription factor
T17 1625-1629 GeneOrGeneProduct denotes CD36
T18 1630-1634 GeneOrGeneProduct denotes mRNA
T19 1716-1720 GeneOrGeneProduct denotes mRNA
T20 1768-1772 GeneOrGeneProduct denotes CD36
T21 1773-1780 GeneOrGeneProduct denotes protein
T22 1890-1894 GeneOrGeneProduct denotes CD36
T23 1911-1918 GeneOrGeneProduct denotes protein
T24 1975-1982 GeneOrGeneProduct denotes reduced

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 317-332 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 83-101 GeneOrGeneProduct denotes protease inhibitor
T2 196-215 GeneOrGeneProduct denotes protease inhibitors
T3 773-791 GeneOrGeneProduct denotes protease inhibitor
T4 850-855 GeneOrGeneProduct denotes THP-1
T5 1033-1042 GeneOrGeneProduct denotes estradiol
T6 1407-1425 GeneOrGeneProduct denotes scavenger receptor
T7 1427-1431 GeneOrGeneProduct denotes CD36
T8 1552-1561 GeneOrGeneProduct denotes PPARgamma
T9 1570-1590 GeneOrGeneProduct denotes transcription factor
T10 1625-1629 GeneOrGeneProduct denotes CD36
T11 1768-1772 GeneOrGeneProduct denotes CD36
T12 1890-1894 GeneOrGeneProduct denotes CD36
T13 1911-1932 GeneOrGeneProduct denotes protein expression in

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 134-137 DiseaseOrPhenotypicFeature denotes can 0012833
T2 317-332 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311
T3 949-952 DiseaseOrPhenotypicFeature denotes PMA 0018687|0016692

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 79-82 DiseaseOrPhenotypicFeature denotes HIV DISEASE
T2 130-133 DiseaseOrPhenotypicFeature denotes HIV DISEASE
T3 317-332 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T4 401-423 DiseaseOrPhenotypicFeature denotes atherosclerotic lesion DISEASE
T5 769-772 DiseaseOrPhenotypicFeature denotes HIV DISEASE

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 850-855 CellLine denotes THP-1 CVCL_0006

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 317-332 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T2 401-423 DiseaseOrPhenotypicFeature denotes atherosclerotic lesion DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 79-82 OrganismTaxon denotes HIV
T2 130-133 OrganismTaxon denotes HIV
T3 240-248 OrganismTaxon denotes patients
T4 442-446 OrganismTaxon denotes mice
T5 482-486 OrganismTaxon denotes mice
T6 769-772 OrganismTaxon denotes HIV
T7 824-829 OrganismTaxon denotes human
T8 1219-1228 OrganismTaxon denotes harvested
T9 1407-1416 OrganismTaxon denotes scavenger

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-8 ChemicalEntity denotes Estrogen ChemicalEntity
T2 18-35 ChemicalEntity denotes cholesteryl ester D002788|http://purl.obolibrary.org/obo/CHEBI_17002
T4 83-91 ChemicalEntity denotes protease D010447
T5 102-111 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T7 196-204 ChemicalEntity denotes protease D010447
T8 224-233 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T10 371-380 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T12 542-551 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T14 577-594 ChemicalEntity denotes cholesteryl ester D002788|http://purl.obolibrary.org/obo/CHEBI_17002
T16 712-723 ChemicalEntity denotes cholesterol D002784|http://purl.obolibrary.org/obo/CHEBI_16113
T18 773-781 ChemicalEntity denotes protease D010447
T19 792-801 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T21 850-853 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941
T22 949-952 ChemicalEntity denotes PMA http://purl.obolibrary.org/obo/CHEBI_60755|http://purl.obolibrary.org/obo/CHEBI_53780|http://purl.obolibrary.org/obo/CHEBI_37537
T25 1026-1042 ChemicalEntity denotes 17beta-estradiol http://purl.obolibrary.org/obo/CHEBI_16469
T26 1056-1068 ChemicalEntity denotes progesterone D011374|http://purl.obolibrary.org/obo/CHEBI_17026
T28 1087-1094 ChemicalEntity denotes ethanol D000431|http://purl.obolibrary.org/obo/CHEBI_16236
T30 1135-1144 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T32 1186-1189 ChemicalEntity denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T33 1200-1213 ChemicalEntity denotes Cell extracts D002457
T34 1300-1318 ChemicalEntity denotes cholesteryl esters D002788|http://purl.obolibrary.org/obo/CHEBI_17002
T36 1344-1353 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T38 1365-1374 ChemicalEntity denotes Ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T40 1468-1471 ChemicalEntity denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T41 1487-1496 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409
T43 1983-2000 ChemicalEntity denotes cholesteryl ester D002788|http://purl.obolibrary.org/obo/CHEBI_17002
T45 2024-2033 ChemicalEntity denotes ritonavir D019438|http://purl.obolibrary.org/obo/CHEBI_45409

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T1 850-855 CellLine denotes THP-1 CVCL_0006
T45 2024-2033 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T43 1983-2000 ChemicalEntity denotes cholesteryl ester http://purl.obolibrary.org/obo/CHEBI_17002|D002788
T41 1487-1496 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T40 1468-1471 ChemicalEntity denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T38 1365-1374 ChemicalEntity denotes Ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T36 1344-1353 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T34 1300-1318 ChemicalEntity denotes cholesteryl esters http://purl.obolibrary.org/obo/CHEBI_17002|D002788
T33 1200-1213 ChemicalEntity denotes Cell extracts D002457
T32 1186-1189 ChemicalEntity denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T30 1135-1144 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T28 1087-1094 ChemicalEntity denotes ethanol http://purl.obolibrary.org/obo/CHEBI_16236|D000431
T26 1056-1068 ChemicalEntity denotes progesterone http://purl.obolibrary.org/obo/CHEBI_17026|D011374
T25 1026-1042 ChemicalEntity denotes 17beta-estradiol http://purl.obolibrary.org/obo/CHEBI_16469
T22 949-952 ChemicalEntity denotes PMA http://purl.obolibrary.org/obo/CHEBI_37537|http://purl.obolibrary.org/obo/CHEBI_53780|http://purl.obolibrary.org/obo/CHEBI_60755
T21 850-853 ChemicalEntity denotes THP http://purl.obolibrary.org/obo/CHEBI_46941
T19 792-801 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T18 773-781 ChemicalEntity denotes protease D010447
T16 712-723 ChemicalEntity denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113|D002784
T14 577-594 ChemicalEntity denotes cholesteryl ester http://purl.obolibrary.org/obo/CHEBI_17002|D002788
T12 542-551 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T10 371-380 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T8 224-233 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T7 196-204 ChemicalEntity denotes protease D010447
T5 102-111 ChemicalEntity denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409|D019438
T4 83-91 ChemicalEntity denotes protease D010447
T2 18-35 ChemicalEntity denotes cholesteryl ester http://purl.obolibrary.org/obo/CHEBI_17002|D002788
T66304 0-8 ChemicalEntity denotes Estrogen ChemicalEntity
T13 1911-1932 GeneOrGeneProduct denotes protein expression in
T10817 1890-1894 GeneOrGeneProduct denotes CD36
T11 1768-1772 GeneOrGeneProduct denotes CD36
T70711 1625-1629 GeneOrGeneProduct denotes CD36
T9 1570-1590 GeneOrGeneProduct denotes transcription factor
T46334 1552-1561 GeneOrGeneProduct denotes PPARgamma
T46296 1427-1431 GeneOrGeneProduct denotes CD36
T6 1407-1425 GeneOrGeneProduct denotes scavenger receptor
T49566 1033-1042 GeneOrGeneProduct denotes estradiol
T39642 850-855 GeneOrGeneProduct denotes THP-1
T3 773-791 GeneOrGeneProduct denotes protease inhibitor
T99987 196-215 GeneOrGeneProduct denotes protease inhibitors
T86185 83-101 GeneOrGeneProduct denotes protease inhibitor
T33534 401-423 DiseaseOrPhenotypicFeature denotes atherosclerotic lesion DISEASE
T9508 317-332 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T80990 1407-1416 OrganismTaxon denotes scavenger
T46896 1219-1228 OrganismTaxon denotes harvested
T60162 824-829 OrganismTaxon denotes human
T31928 769-772 OrganismTaxon denotes HIV
T75545 482-486 OrganismTaxon denotes mice
T53459 442-446 OrganismTaxon denotes mice
T37227 240-248 OrganismTaxon denotes patients
T54145 130-133 OrganismTaxon denotes HIV
T21628 79-82 OrganismTaxon denotes HIV

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 307-332 HP_0004416 denotes premature atherosclerosis
T2 317-332 HP_0002621 denotes atherosclerosis