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PubMed:17848578 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair.
T2 114-307 Sentence denotes The BRCA1 tumor suppressor exists as a heterodimeric complex with BARD1, and this complex is thought to mediate many of the functions ascribed to BRCA1, including its role in tumor suppression.
T3 308-499 Sentence denotes The two proteins share a common structural organization that features an N-terminal RING domain and two C-terminal BRCT motifs, whereas BARD1 alone also contains three tandem ankyrin repeats.
T4 500-661 Sentence denotes In normal cells, the BRCA1/BARD1 heterodimer is believed to enhance chromosome stability by promoting homology-directed repair (HDR) of double strand DNA breaks.
T5 662-805 Sentence denotes Here we have investigated the structural requirements for BARD1 in this process by complementation of Bard1-null mouse mammary carcinoma cells.
T6 806-929 Sentence denotes Our results demonstrate that the ankyrin and BRCT motifs of BARD1 are each essential for both chromosome stability and HDR.
T7 930-1054 Sentence denotes Tandem BRCT motifs, including those found at the C terminus of BARD1, are known to form a phosphoprotein recognition module.
T8 1055-1328 Sentence denotes Nonetheless, the HDR function of BARD1 was not perturbed by synthetic mutations predicted to ablate the phospho-recognition activity of its BRCT sequences, suggesting that some functions of the BRCT domains are not dependent on their ability to bind phosphorylated ligands.
T9 1329-1515 Sentence denotes Also, cancer-associated missense mutations in the BRCT domains of BARD1 (e.g. C557S, Q564H, V695L, and S761N) have been observed in patients with breast, ovarian, and endometrial tumors.
T10 1516-1708 Sentence denotes However, none of these was found to affect the HDR activity of BARD1, suggesting that any increased cancer risk conferred by these mutations is not because of defects in this repair mechanism.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1579-1584 gene:580 denotes BARD1
T1 1616-1622 disease:C0006826 denotes cancer
T2 1579-1584 gene:580 denotes BARD1
T3 1616-1622 disease:C1306459 denotes cancer
R1 T0 T1 associated_with BARD1,cancer
R2 T2 T3 associated_with BARD1,cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 124-129 HP_0002664 denotes tumor
T2 289-294 HP_0002664 denotes tumor
T3 1335-1341 HP_0002664 denotes cancer
T4 1508-1514 HP_0002664 denotes tumors
T5 1616-1622 HP_0002664 denotes cancer
T1 124-129 HP_0002664 denotes tumor
T2 289-294 HP_0002664 denotes tumor
T3 1335-1341 HP_0002664 denotes cancer
T4 1508-1514 HP_0002664 denotes tumors
T5 1616-1622 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17848578-4#102#107#gene580 764-769 gene580 denotes Bard1
17848578-4#119#136#diseaseC0678222 781-798 diseaseC0678222 denotes mammary carcinoma
102#107#gene580119#136#diseaseC0678222 17848578-4#102#107#gene580 17848578-4#119#136#diseaseC0678222 associated_with Bard1,mammary carcinoma

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 38-43 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 124-129 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 289-294 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 781-798 Disease denotes mammary carcinoma http://purl.obolibrary.org/obo/MONDO_0004989
T5 1335-1341 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T6 1496-1514 Disease denotes endometrial tumors http://purl.obolibrary.org/obo/MONDO_0021251
T7 1616-1622 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 38-43 Phenotype denotes tumor HP:0002664
T2 124-129 Phenotype denotes tumor HP:0002664
T3 289-294 Phenotype denotes tumor HP:0002664
T4 789-798 Phenotype denotes carcinoma HP:0030731
T5 1335-1341 Phenotype denotes cancer HP:0002664
T6 1616-1622 Phenotype denotes cancer HP:0002664

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 775-780 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 568-578 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T2 900-910 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T3 1475-1481 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310