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PubMed:17848574 JSONTXT

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LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
3 0-4 GeneOrGeneProduct denotes MDM2 Gene:4193
4 20-23 GeneOrGeneProduct denotes p53 Gene:7157
5 24-29 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
42 46-52 OrganismTaxon denotes murine Tax:10090
43 68-72 GeneOrGeneProduct denotes mdm2 Gene:17246
44 154-157 GeneOrGeneProduct denotes p53 Gene:22060
45 158-163 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
46 225-228 GeneOrGeneProduct denotes p53 Gene:7157
47 254-258 GeneOrGeneProduct denotes MDM2 Gene:4193
48 271-275 GeneOrGeneProduct denotes MDM2 Gene:4193
49 290-293 ChemicalEntity denotes ATP MESH:D000255
50 317-322 GeneOrGeneProduct denotes Hsp90 Gene:3320
51 489-492 GeneOrGeneProduct denotes p53 Gene:7157
52 543-547 GeneOrGeneProduct denotes MDM2 Gene:4193
53 610-614 GeneOrGeneProduct denotes MDM2 Gene:4193
54 638-643 GeneOrGeneProduct denotes Hsp90 Gene:3320
55 688-691 GeneOrGeneProduct denotes p53 Gene:7157
56 699-702 GeneOrGeneProduct denotes p21 Gene:644914
57 770-774 GeneOrGeneProduct denotes MDM2 Gene:4193
58 784-787 GeneOrGeneProduct denotes p53 Gene:7157
59 821-824 ChemicalEntity denotes ATP MESH:D000255
60 828-832 GeneOrGeneProduct denotes MDM2 Gene:4193
61 838-841 ChemicalEntity denotes ATP MESH:D000255
62 857-861 GeneOrGeneProduct denotes MDM2 Gene:4193
63 871-876 SequenceVariant denotes K454A p.K454A
64 934-938 GeneOrGeneProduct denotes Mdm2 Gene:4193
65 991-994 GeneOrGeneProduct denotes p53 Gene:7157
66 1016-1019 GeneOrGeneProduct denotes p53 Gene:7157
67 1088-1091 GeneOrGeneProduct denotes p53 Gene:7157
68 1093-1097 GeneOrGeneProduct denotes MDM2 Gene:4193
69 1118-1120 ChemicalEntity denotes Zn MESH:D015032
70 1159-1164 SequenceVariant denotes C478S p.C478S
71 1168-1173 SequenceVariant denotes C464A rs786202752
72 1218-1221 GeneOrGeneProduct denotes p53 Gene:7157
73 1260-1264 GeneOrGeneProduct denotes MDM2 Gene:4193
74 1338-1341 ChemicalEntity denotes ATP MESH:D000255
75 1362-1366 GeneOrGeneProduct denotes MDM2 Gene:4193
76 1413-1416 GeneOrGeneProduct denotes p53 Gene:7157
77 1417-1422 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 24-29 DiseaseOrPhenotypicFeature denotes tumor D009369
T2 158-163 DiseaseOrPhenotypicFeature denotes tumor D009369
T3 1417-1422 DiseaseOrPhenotypicFeature denotes tumor D009369

LitCoin-PubTator-for-Tuning-SeqVar

Id Subject Object Predicate Lexical cue
T1 871-876 SequenceVariant denotes K454A
T2 1159-1164 SequenceVariant denotes C478S
T3 1168-1173 SequenceVariant denotes C464A

LitCoin-PubTator_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 960-965 CellLine denotes H1299 CVCL_0060

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 24-29 DiseaseOrPhenotypicFeature denotes tumor D009369
T2 158-163 DiseaseOrPhenotypicFeature denotes tumor D009369
T3 1417-1422 DiseaseOrPhenotypicFeature denotes tumor D009369

sentences

Id Subject Object Predicate Lexical cue
T1 0-41 Sentence denotes MDM2 chaperones the p53 tumor suppressor.
T2 42-183 Sentence denotes The murine double minute (mdm2) gene encodes an E3 ubiquitin ligase that plays a key role in the degradation of p53 tumor suppressor protein.
T3 184-259 Sentence denotes Nevertheless recent data highlight other p53-independent functions of MDM2.
T4 260-609 Sentence denotes Given that MDM2 protein binds ATP, can interact with the Hsp90 chaperone, plays a role in the modulation of transcription factors and protection and activation of DNA polymerases, and is involved in ribosome assembly and nascent p53 protein biosynthesis, we have evaluated and found MDM2 protein to possess an intrinsic molecular chaperone activity.
T5 610-729 Sentence denotes MDM2 can substitute for the Hsp90 molecular chaperone in promoting binding of p53 to the p21-derived promoter sequence.
T6 730-833 Sentence denotes This reaction is driven by recycling of MDM2 from the p53 complex, triggered by binding of ATP to MDM2.
T7 834-933 Sentence denotes The ATP binding mutant MDM2 protein (K454A) lacks the chaperone activity both in vivo and in vitro.
T8 934-1092 Sentence denotes Mdm2 cotransfected in the H1299 cell line with wild-type p53 stimulates efficient p53 folding in vivo but at the same time accelerates the degradation of p53.
T9 1093-1222 Sentence denotes MDM2 in which one of the Zn(2+) coordinating residues is mutated (C478S or C464A) blocks degradation but enhances folding of p53.
T10 1223-1434 Sentence denotes This is the first demonstration that MDM2 possesses an intrinsic molecular chaperone activity, indicating that the ATP binding function of MDM2 can mediate its chaperone function toward the p53 tumor suppressor.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 158-163 HP_0002664 denotes tumor
T2 1417-1422 HP_0002664 denotes tumor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 24-29 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 158-163 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 1417-1422 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 24-29 Phenotype denotes tumor HP:0002664
T2 158-163 Phenotype denotes tumor HP:0002664
T3 1417-1422 Phenotype denotes tumor HP:0002664

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 459-467 Body_part denotes ribosome http://purl.obolibrary.org/obo/GO_0005840