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PubMed:1782151 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-35 DNA denotes interferon beta gene
T2 71-81 protein denotes NF-kappa B
T3 94-104 protein denotes TH protein
T4 110-161 DNA denotes human interferon beta (IFN-beta) regulatory element
T5 183-199 DNA denotes enhanson domains
T6 222-243 protein denotes transcription factors
T7 284-292 DNA denotes promoter
T8 357-365 protein denotes IFN-beta
T9 377-429 protein denotes positive regulatory domain (PRD) II binding proteins
T10 471-485 cell_line denotes Jurkat T-cells
T11 495-574 cell_line denotes IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells
T12 581-591 cell_line denotes HeLa cells
T13 615-641 protein denotes 52 and 45 kilodaltons (kD)
T14 693-700 cell_type denotes T-cells
T15 719-732 protein denotes major protein
T16 736-741 protein denotes 52 kD
T17 752-766 protein denotes minor proteins
T18 770-772 protein denotes 82
T19 774-776 protein denotes 67
T20 782-790 protein denotes 43-47 kD
T21 826-854 protein denotes specific DNA binding protein
T22 873-883 cell_line denotes HeLa cells
T23 919-940 DNA denotes tetrahexamer sequence
T24 949-960 DNA denotes PRDI domain
T25 1008-1019 protein denotes IRF-1/ISGF2
T26 1131-1158 DNA denotes IFN beta promoter deletions
T27 1186-1199 DNA denotes PRDII element
T28 1302-1310 DNA denotes promoter
T29 1335-1352 DNA denotes IFN-beta promoter
T30 1430-1434 DNA denotes PRDI
T31 1439-1453 DNA denotes PRDII elements
T32 1515-1554 protein denotes PRDII and tetrahexamer binding proteins
T33 1805-1813 protein denotes IFN-beta

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-105 Sentence denotes Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein.
S2 106-293 Sentence denotes The human interferon beta (IFN-beta) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the promoter.
S3 294-575 Sentence denotes To further characterize the protein-DNA interactions mediating IFN-beta induction, positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells.
S4 576-806 Sentence denotes From HeLa cells, two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity, whereas from T-cells, four proteins--a major protein of 52 kD and three minor proteins of 82, 67, and 43-47 kD--were purified.
S5 807-961 Sentence denotes Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the (AAGTGA)4 tetrahexamer sequence and the PRDI domain.
S6 962-1020 Sentence denotes This protein is immunologically distinct from IRF-1/ISGF2.
S7 1021-1159 Sentence denotes Uninduced or Sendai virus induced HeLa extracts were used to examine transcription in vitro using a series of IFN beta promoter deletions.
S8 1160-1311 Sentence denotes Deletions upstream of the PRDII element increased transcription in the uninduced extract, indicating predominantly negative regulation of the promoter.
S9 1312-1500 Sentence denotes A 2-4-fold increase in IFN-beta promoter transcription was observed in Sendai virus induced extracts, and deletion of PRDI and PRDII elements decreased this induced level of transcription.
S10 1501-1638 Sentence denotes When purified PRDII and tetrahexamer binding proteins were added to the induced extract, a 4-fold increase in transcription was observed.
S11 1639-1828 Sentence denotes These experiments demonstrate that it is possible to modulate IFN-beta transcription in vitro but indicate that additional proteins may be required to fully activate IFN-beta transcription.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 15-35 NP denotes interferon beta gene
C1 15-49 NP denotes interferon beta gene transcription
C3 106-161 NP denotes The human interferon beta (IFN-beta) regulatory element
C4 174-199 NP denotes multiple enhanson domains
C5 200-205 NP denotes which
C6 377-429 NP denotes positive regulatory domain (PRD) II binding proteins
C7 471-485 NP denotes Jurkat T-cells
C8 495-574 NP denotes IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells
C9 581-591 NP denotes HeLa cells
C10 693-700 NP denotes T-cells
C11 702-715 NP denotes four proteins
C12 717-790 NP denotes a major protein of 52 kD and three minor proteins of 82, 67, and 43-47 kD
C13 813-854 NP denotes an induction specific DNA binding protein
C14 873-883 NP denotes HeLa cells
C15 884-888 NP denotes that
C16 945-960 NP denotes the PRDI domain
C17 962-974 NP denotes This protein
C18 1034-1068 NP denotes Sendai virus induced HeLa extracts
C19 1090-1103 NP denotes transcription
C20 1182-1199 NP denotes the PRDII element
C21 1210-1223 NP denotes transcription
C23 1335-1343 NP denotes IFN-beta
C22 1335-1366 NP denotes IFN-beta promoter transcription
C24 1383-1412 NP denotes Sendai virus induced extracts
C25 1430-1434 NP denotes PRDI
C26 1439-1453 NP denotes PRDII elements
C27 1486-1499 NP denotes transcription
C28 1506-1520 NP denotes purified PRDII
C29 1569-1588 NP denotes the induced extract
C30 1611-1624 NP denotes transcription
C32 1701-1709 NP denotes IFN-beta
C31 1701-1723 NP denotes IFN-beta transcription
C34 1805-1813 NP denotes IFN-beta
C33 1805-1827 NP denotes IFN-beta transcription
R1 C3 C2 coref-ident The human interferon beta (IFN-beta) regulatory element,interferon beta gene
R2 C5 C4 coref-relat which,multiple enhanson domains
R3 C9 C8 coref-ident HeLa cells,"IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells"
R4 C10 C7 coref-ident T-cells,Jurkat T-cells
R5 C12 C11 coref-appos "a major protein of 52 kD and three minor proteins of 82, 67, and 43-47 kD",four proteins
R6 C14 C9 coref-ident HeLa cells,HeLa cells
R7 C15 C12 coref-relat that,"a major protein of 52 kD and three minor proteins of 82, 67, and 43-47 kD"
R8 C17 C13 coref-ident This protein,an induction specific DNA binding protein
R9 C19 C1 coref-ident transcription,interferon beta gene transcription
R10 C20 C6 coref-other the PRDII element,positive regulatory domain (PRD) II binding proteins
R11 C21 C19 coref-ident transcription,transcription
R12 C23 C3 coref-ident IFN-beta,The human interferon beta (IFN-beta) regulatory element
R13 C22 C21 coref-other IFN-beta promoter transcription,transcription
R14 C24 C18 coref-ident Sendai virus induced extracts,Sendai virus induced HeLa extracts
R15 C25 C16 coref-other PRDI,the PRDI domain
R16 C26 C20 coref-ident PRDII elements,the PRDII element
R17 C27 C22 coref-ident transcription,IFN-beta promoter transcription
R18 C28 C26 coref-other purified PRDII,PRDII elements
R19 C29 C24 coref-ident the induced extract,Sendai virus induced extracts
R20 C30 C27 coref-ident transcription,transcription
R21 C32 C23 coref-ident IFN-beta,IFN-beta
R22 C31 C30 coref-ident IFN-beta transcription,transcription
R23 C34 C32 coref-ident IFN-beta,IFN-beta
R24 C33 C31 coref-ident IFN-beta transcription,IFN-beta transcription

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-35 DNA_domain_or_region denotes interferon beta gene
T2 71-81 protein_molecule denotes NF-kappa B
T3 94-104 protein_molecule denotes TH protein
T4 110-131 protein_molecule denotes human interferon beta
T5 133-141 protein_molecule denotes IFN-beta
T6 183-199 DNA_domain_or_region denotes enhanson domains
T7 222-243 protein_family_or_group denotes transcription factors
T8 284-292 DNA_domain_or_region denotes promoter
T9 322-346 other_name denotes protein-DNA interactions
T10 357-365 protein_molecule denotes IFN-beta
T11 377-412 DNA_domain_or_region denotes positive regulatory domain (PRD) II
T12 449-462 other_organic_compound denotes phorbol ester
T13 471-485 cell_line denotes Jurkat T-cells
T14 495-498 protein_molecule denotes IFN
T15 507-552 other_organic_compound denotes cycloheximide/polyinosinic-polycytidylic acid
T16 581-591 cell_line denotes HeLa cells
T17 658-678 other_name denotes DNA binding activity
T18 693-700 cell_type denotes T-cells
T19 719-732 protein_family_or_group denotes major protein
T20 736-741 protein_molecule denotes 52 kD
T21 752-766 protein_family_or_group denotes minor proteins
T22 770-772 protein_molecule denotes 82
T23 774-776 protein_molecule denotes 67
T24 782-790 protein_molecule denotes 43-47 kD
T25 826-854 protein_family_or_group denotes specific DNA binding protein
T26 873-883 cell_line denotes HeLa cells
T27 910-916 polynucleotide denotes AAGTGA
T28 919-940 DNA_domain_or_region denotes tetrahexamer sequence
T29 949-960 DNA_domain_or_region denotes PRDI domain
T30 1008-1019 protein_molecule denotes IRF-1/ISGF2
T31 1021-1030 cell_component denotes Uninduced
T32 1034-1046 virus denotes Sendai virus
T33 1055-1068 cell_component denotes HeLa extracts
T34 1090-1103 other_name denotes transcription
T35 1131-1158 DNA_domain_or_region denotes IFN beta promoter deletions
T36 1186-1199 DNA_domain_or_region denotes PRDII element
T37 1210-1223 other_name denotes transcription
T38 1275-1294 other_name denotes negative regulation
T39 1302-1310 DNA_domain_or_region denotes promoter
T40 1335-1352 DNA_domain_or_region denotes IFN-beta promoter
T41 1353-1366 other_name denotes transcription
T42 1383-1395 virus denotes Sendai virus
T43 1430-1434 DNA_domain_or_region denotes PRDI
T44 1439-1444 DNA_domain_or_region denotes PRDII
T45 1486-1499 other_name denotes transcription
T46 1611-1624 other_name denotes transcription
T47 1710-1723 other_name denotes transcription
T48 1805-1813 protein_molecule denotes IFN-beta
T49 1814-1827 other_name denotes transcription