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PubMed:17726031 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 625-639 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010
T2 1263-1269 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138

sentences

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha.
T2 126-325 Sentence denotes Prolyl 4-hydroxylases (P4Hs) act on collagens (C-P4Hs) and the oxygen-dependent degradation domains (ODDDs) of hypoxia-inducible factor alpha subunits (HIF-P4Hs) leading to degradation of the latter.
T3 326-399 Sentence denotes We report data on a human P4H possessing a transmembrane domain (P4H-TM).
T4 400-467 Sentence denotes Its gene is also found in zebrafish but not in flies and nematodes.
T5 468-607 Sentence denotes Its sequence more closely resembles those of the C-P4Hs than the HIF-P4Hs, but it lacks the peptide substrate-binding domain of the C-P4Hs.
T6 608-835 Sentence denotes P4H-TM levels in cultured cells are increased by hypoxia, and P4H-TM is N-glycosylated and is located in endoplasmic reticulum membranes with its catalytic site inside the lumen, a location differing from those of the HIF-P4Hs.
T7 836-1057 Sentence denotes Despite this, P4H-TM overexpression in cultured neuroblastoma cells reduced HIF-alpha ODDD reporter construct levels, and its small interfering RNA increased HIF-1alpha protein level, in the same way as those of HIF-P4Hs.
T8 1058-1289 Sentence denotes Furthermore, recombinant P4H-TM hydroxylated the two critical prolines in HIF-1alpha ODDD in vitro, with a preference for the C-terminal proline, whereas it did not hydroxylate any prolines in recombinant type I procollagen chains.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 884-897 HP_0003006 denotes neuroblastoma
T1 884-897 HP_0003006 denotes neuroblastoma

LocText

Id Subject Object Predicate Lexical cue
T1 3-24 go:GO:0005783 denotes endoplasmic reticulum
T2 25-59 uniprot:Q9NXG6 denotes transmembrane prolyl 4-hydroxylase
T3 346-351 taxonomy:9606 denotes human
T4 369-382 go:GO:0016021 denotes transmembrane
T5 391-397 uniprot:Q9NXG6 denotes P4H-TM
T6 426-435 taxonomy:7955 denotes zebrafish
T7 447-452 taxonomy:7227 denotes flies
T8 457-466 taxonomy:6239 denotes nematodes
T9 608-614 uniprot:Q9NXG6 denotes P4H-TM
T10 670-676 uniprot:Q9NXG6 denotes P4H-TM
T11 713-744 go:GO:0005789 denotes endoplasmic reticulum membranes
T12 780-785 go:GO:0005788 denotes lumen
T13 850-856 uniprot:Q9NXG6 denotes P4H-TM
T14 994-1004 uniprot:Q16665 denotes HIF-1alpha
T15 1083-1089 uniprot:Q9NXG6 denotes P4H-TM
T16 1132-1142 uniprot:Q16665 denotes HIF-1alpha
R1 T2 T1 localizeTo transmembrane prolyl 4-hydroxylase,endoplasmic reticulum
R2 T5 T4 localizeTo P4H-TM,transmembrane
R3 T10 T11 localizeTo P4H-TM,endoplasmic reticulum membranes

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 74-81 Phenotype denotes hypoxia HP:0012418
T2 94-101 Phenotype denotes hypoxia HP:0012418
T3 237-244 Phenotype denotes hypoxia HP:0012418
T4 657-664 Phenotype denotes hypoxia HP:0012418
T5 884-897 Phenotype denotes neuroblastoma HP:0003006

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 884-897 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T2 922-926 Disease denotes ODDD http://purl.obolibrary.org/obo/MONDO_0008111
T3 1143-1147 Disease denotes ODDD http://purl.obolibrary.org/obo/MONDO_0008111

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 346-351 OrganismTaxon denotes human 9606
T2 426-435 OrganismTaxon denotes zebrafish 7955
T3 457-466 OrganismTaxon denotes nematodes 6231

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 15-24 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 25-38 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T3 369-382 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T4 725-734 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T5 735-744 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T8 780-785 Body_part denotes lumen http://purl.obolibrary.org/obo/UBERON_0000464