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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells.
T2 129-256 Sentence denotes Lysophosphatidic acid (LPA) is a bioactive lipid with functional properties that overlap those of growth factors and cytokines.
T3 257-394 Sentence denotes LPA production in vivo is linked to platelet degranulation and the biological activities of this lipid are associated with wound healing.
T4 395-572 Sentence denotes Osteoblasts and their progenitor cells are exposed to high levels of this lipid factor in regions adjacent to bone fractures and we postulate a role for LPA in skeletal healing.
T5 573-742 Sentence denotes The regeneration of bone injuries requires a complex array of changes in gene expression, but the effects of LPA on mRNA levels in bone cells have not been investigated.
T6 743-870 Sentence denotes We performed a genome-wide expression analysis in LPA-treated MC3T3-E1 pre-osteoblastic cells using Affymetrix GeneChip arrays.
T7 871-1020 Sentence denotes Cells exposed to LPA for 6 h exhibited 513 regulated genes, whereas changes in the levels of 54 transcripts were detected after a 24-h LPA treatment.
T8 1021-1256 Sentence denotes Gene ontology analysis linked LPA-regulated gene products to biological processes that are known to govern bone healing, including cell proliferation, response to stress, organ development, chemotaxis/motility, and response to stimuli.
T9 1257-1416 Sentence denotes Among the gene products most highly up-regulated by LPA were transcripts encoding the anti-inflammatory proteins sST2, ST2L, and heat-shock protein 25 (HSP25).
T10 1417-1546 Sentence denotes RT-PCR analysis confirmed that these mRNAs were increased significantly in MC3T3-E1 cells and primary osteoblasts exposed to LPA.
T11 1547-1768 Sentence denotes The response of cells to LPA is mediated by G-protein-coupled receptors, and the stimulation of anti-inflammatory gene expression in MC3T3-E1 cells was blocked by Ki16425, an inhibitor of LPA(1) and LPA(3) receptor forms.
T12 1769-1834 Sentence denotes Pertussis toxin impaired only the LPA-induced expression of sST2.
T13 1835-1979 Sentence denotes LPA-stimulated levels of sST2, ST2L and HSP25 mRNAs persisted if the cytosolic Ca(2+) elevations elicited by this lipid were blocked with BAPTA.
T14 1980-2135 Sentence denotes In contrast to the stimulatory effect of LPA, exposure of MC3T3-E1 cells to fluid shear reduced the transcript levels of all three anti-inflammatory genes.
T15 2136-2309 Sentence denotes The induction of sST2, ST2L and HSP25 expression by LPA suggests a role for this lipid factor in the regulation of osteoblastic cell function during periods of inflammation.
T1 0-128 Sentence denotes DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells.
T2 129-256 Sentence denotes Lysophosphatidic acid (LPA) is a bioactive lipid with functional properties that overlap those of growth factors and cytokines.
T3 257-394 Sentence denotes LPA production in vivo is linked to platelet degranulation and the biological activities of this lipid are associated with wound healing.
T4 395-572 Sentence denotes Osteoblasts and their progenitor cells are exposed to high levels of this lipid factor in regions adjacent to bone fractures and we postulate a role for LPA in skeletal healing.
T5 573-742 Sentence denotes The regeneration of bone injuries requires a complex array of changes in gene expression, but the effects of LPA on mRNA levels in bone cells have not been investigated.
T6 743-870 Sentence denotes We performed a genome-wide expression analysis in LPA-treated MC3T3-E1 pre-osteoblastic cells using Affymetrix GeneChip arrays.
T7 871-1020 Sentence denotes Cells exposed to LPA for 6 h exhibited 513 regulated genes, whereas changes in the levels of 54 transcripts were detected after a 24-h LPA treatment.
T8 1021-1256 Sentence denotes Gene ontology analysis linked LPA-regulated gene products to biological processes that are known to govern bone healing, including cell proliferation, response to stress, organ development, chemotaxis/motility, and response to stimuli.
T9 1257-1416 Sentence denotes Among the gene products most highly up-regulated by LPA were transcripts encoding the anti-inflammatory proteins sST2, ST2L, and heat-shock protein 25 (HSP25).
T10 1417-1546 Sentence denotes RT-PCR analysis confirmed that these mRNAs were increased significantly in MC3T3-E1 cells and primary osteoblasts exposed to LPA.
T11 1547-1768 Sentence denotes The response of cells to LPA is mediated by G-protein-coupled receptors, and the stimulation of anti-inflammatory gene expression in MC3T3-E1 cells was blocked by Ki16425, an inhibitor of LPA(1) and LPA(3) receptor forms.
T12 1769-1834 Sentence denotes Pertussis toxin impaired only the LPA-induced expression of sST2.
T13 1835-1979 Sentence denotes LPA-stimulated levels of sST2, ST2L and HSP25 mRNAs persisted if the cytosolic Ca(2+) elevations elicited by this lipid were blocked with BAPTA.
T14 1980-2135 Sentence denotes In contrast to the stimulatory effect of LPA, exposure of MC3T3-E1 cells to fluid shear reduced the transcript levels of all three anti-inflammatory genes.
T15 2136-2309 Sentence denotes The induction of sST2, ST2L and HSP25 expression by LPA suggests a role for this lipid factor in the regulation of osteoblastic cell function during periods of inflammation.

LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
1 43-64 ChemicalEntity denotes lysophosphatidic acid MESH:C032881
36 129-150 ChemicalEntity denotes Lysophosphatidic acid MESH:C032881
37 152-155 ChemicalEntity denotes LPA MESH:C032881
38 172-177 ChemicalEntity denotes lipid MESH:D008055
39 257-260 ChemicalEntity denotes LPA MESH:C032881
40 293-315 DiseaseOrPhenotypicFeature denotes platelet degranulation MESH:D001791
41 354-359 ChemicalEntity denotes lipid MESH:D008055
42 469-474 ChemicalEntity denotes lipid MESH:D008055
43 505-519 DiseaseOrPhenotypicFeature denotes bone fractures MESH:D050723
44 548-551 ChemicalEntity denotes LPA MESH:C032881
45 593-606 DiseaseOrPhenotypicFeature denotes bone injuries MESH:D001848
46 793-796 ChemicalEntity denotes LPA MESH:C032881
47 888-891 ChemicalEntity denotes LPA MESH:C032881
48 1006-1009 ChemicalEntity denotes LPA MESH:C032881
49 1370-1374 GeneOrGeneProduct denotes sST2 Gene:20606
50 1376-1380 GeneOrGeneProduct denotes ST2L Gene:17082
51 1386-1407 GeneOrGeneProduct denotes heat-shock protein 25 Gene:15507
52 1409-1414 GeneOrGeneProduct denotes HSP25 Gene:15507
53 1542-1545 ChemicalEntity denotes LPA MESH:C032881
54 1572-1575 ChemicalEntity denotes LPA MESH:C032881
55 1710-1717 ChemicalEntity denotes Ki16425 MESH:C477898
56 1803-1806 ChemicalEntity denotes LPA MESH:C032881
57 1829-1833 GeneOrGeneProduct denotes sST2 Gene:20606
58 1835-1838 ChemicalEntity denotes LPA MESH:C032881
59 1860-1864 GeneOrGeneProduct denotes sST2 Gene:20606
60 1866-1870 GeneOrGeneProduct denotes ST2L Gene:17082
61 1875-1880 GeneOrGeneProduct denotes HSP25 Gene:15507
62 1914-1920 ChemicalEntity denotes Ca(2+) MESH:D000069285
63 1949-1954 ChemicalEntity denotes lipid MESH:D008055
64 1973-1978 ChemicalEntity denotes BAPTA MESH:C025603
65 2021-2024 ChemicalEntity denotes LPA MESH:C032881
66 2153-2157 GeneOrGeneProduct denotes sST2 Gene:20606
67 2159-2163 GeneOrGeneProduct denotes ST2L Gene:17082
68 2168-2173 GeneOrGeneProduct denotes HSP25 Gene:15507
69 2296-2308 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 91-103 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T2 380-385 DiseaseOrPhenotypicFeature denotes wound D014947
T3 505-519 DiseaseOrPhenotypicFeature denotes bone fractures D050723
T4 598-606 DiseaseOrPhenotypicFeature denotes injuries D014947
T5 1348-1360 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T6 1391-1396 DiseaseOrPhenotypicFeature denotes shock D012769
T7 1648-1660 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T8 1769-1778 DiseaseOrPhenotypicFeature denotes Pertussis D014917
T9 2116-2128 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T10 2296-2308 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249

LitCoin-PubTator_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 113-121 CellLine denotes MC3T3-E1 CVCL_0409
T2 805-813 CellLine denotes MC3T3-E1 CVCL_0409
T3 1492-1500 CellLine denotes MC3T3-E1 CVCL_0409
T4 1680-1688 CellLine denotes MC3T3-E1 CVCL_0409
T5 2038-2046 CellLine denotes MC3T3-E1 CVCL_0409

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 505-519 DiseaseOrPhenotypicFeature denotes bone fractures D050723
T2 598-606 DiseaseOrPhenotypicFeature denotes injuries D014947
T3 1391-1396 DiseaseOrPhenotypicFeature denotes shock D012769
T4 1769-1778 DiseaseOrPhenotypicFeature denotes Pertussis D014917
T5 2296-2308 DiseaseOrPhenotypicFeature denotes inflammation D007249

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 395-406 HP_0011846 denotes Osteoblasts
T2 818-830 HP_0011846 denotes osteoblastic
T3 1519-1530 HP_0011846 denotes osteoblasts
T4 2251-2263 HP_0011846 denotes osteoblastic