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PubMed:17701343 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 35-44 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T4 185-195 Glycan_Motif denotes sulfatides https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T7 595-605 Glycan_Motif denotes sulfatides https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T10 872-881 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T13 942-960 Glycan_Motif denotes galactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T14 1349-1367 Glycan_Motif denotes galactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 35-44 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T2 35-44 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T3 35-44 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T4 185-195 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatides
T5 185-195 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatides
T6 185-195 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatides
T7 595-605 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatides
T8 595-605 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatides
T9 595-605 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatides
T10 872-881 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T11 872-881 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T12 872-881 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T13 942-960 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactosylceramide
T14 1349-1367 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactosylceramide

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-154 Sentence denotes Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies.
TextSentencer_T2 155-326 Sentence denotes 3-O-Sulfogalactosylceramides (sulfatides) accumulate in the genetic disease metachromatic leukodystrophy which is due to a defect in the catabolic enzyme, arylsulfatase A.
TextSentencer_T3 327-428 Sentence denotes Clinical diagnosis is usually confirmed by in vitro enzymatic deficiency of arylsulfatase A activity.
TextSentencer_T4 429-571 Sentence denotes The diagnosis may be complicated because of arylsulfatase A pseudo-deficiencies and another cause of MLD, sphingolipid activator B deficiency.
TextSentencer_T5 572-698 Sentence denotes As large quantities of sulfatides can be found in the urine in this disease, sulfatiduria appears as an extremely useful test.
TextSentencer_T6 699-846 Sentence denotes As recently enzyme replacement is underway, the quantitative determination, using an internal standard, appears particularly useful as a follow-up.
TextSentencer_T7 847-1037 Sentence denotes Thus a non-physiological sulfatide was synthesized for this purpose, i.e. 3-O-sulfo-beta-D-C17 galactosylceramide (3-O-Sulfo-D: -Galactosyl-beta1'-->1-N-Heptadecanoyl-D-erythro-Sphingosine).
TextSentencer_T8 1038-1170 Sentence denotes It has been prepared through condensation of an azidosphingosine derivative with a protected D-galactopyranosyltrichloroacetimidate.
TextSentencer_T9 1171-1241 Sentence denotes Reduction of the azide was followed by acylation of a C-17 fatty acid.
TextSentencer_T10 1242-1453 Sentence denotes The key step was achieved by selective sulfation of the desired hydroxyl group on the sugar residue of the galactosylceramide using the stannylene methodology to give a 3'-sulfated beta-galactosyl C-17 ceramide.
T1 0-154 Sentence denotes Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies.
T2 155-326 Sentence denotes 3-O-Sulfogalactosylceramides (sulfatides) accumulate in the genetic disease metachromatic leukodystrophy which is due to a defect in the catabolic enzyme, arylsulfatase A.
T3 327-428 Sentence denotes Clinical diagnosis is usually confirmed by in vitro enzymatic deficiency of arylsulfatase A activity.
T4 429-571 Sentence denotes The diagnosis may be complicated because of arylsulfatase A pseudo-deficiencies and another cause of MLD, sphingolipid activator B deficiency.
T5 572-698 Sentence denotes As large quantities of sulfatides can be found in the urine in this disease, sulfatiduria appears as an extremely useful test.
T6 699-846 Sentence denotes As recently enzyme replacement is underway, the quantitative determination, using an internal standard, appears particularly useful as a follow-up.
T7 847-1037 Sentence denotes Thus a non-physiological sulfatide was synthesized for this purpose, i.e. 3-O-sulfo-beta-D-C17 galactosylceramide (3-O-Sulfo-D: -Galactosyl-beta1'-->1-N-Heptadecanoyl-D-erythro-Sphingosine).
T8 1038-1170 Sentence denotes It has been prepared through condensation of an azidosphingosine derivative with a protected D-galactopyranosyltrichloroacetimidate.
T9 1171-1241 Sentence denotes Reduction of the azide was followed by acylation of a C-17 fatty acid.
T10 1242-1453 Sentence denotes The key step was achieved by selective sulfation of the desired hydroxyl group on the sugar residue of the galactosylceramide using the stannylene methodology to give a 3'-sulfated beta-galactosyl C-17 ceramide.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 942-960 http://www.glycoepitope.jp/epitopes/EP0074 denotes galactosylceramide
T2 1349-1367 http://www.glycoepitope.jp/epitopes/EP0074 denotes galactosylceramide

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 626-631 http://purl.obolibrary.org/obo/MAT_0000058 denotes urine

DisGeNET

Id Subject Object Predicate Lexical cue
T0 310-325 gene:410 denotes arylsulfatase A
T1 215-230 disease:C0019247 denotes genetic disease
T2 310-325 gene:410 denotes arylsulfatase A
T3 231-259 disease:C0023522 denotes metachromatic leukodystrophy
R1 T0 T1 associated_with arylsulfatase A,genetic disease
R2 T2 T3 associated_with arylsulfatase A,metachromatic leukodystrophy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 245-259 HP_0002415 denotes leukodystrophy
T1 245-259 HP_0002415 denotes leukodystrophy

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17701343-1#155#170#gene410 310-325 gene410 denotes arylsulfatase A
17701343-1#76#104#diseaseC0023522 231-259 diseaseC0023522 denotes metachromatic leukodystrophy
155#170#gene41076#104#diseaseC0023522 17701343-1#155#170#gene410 17701343-1#76#104#diseaseC0023522 associated_with arylsulfatase A,metachromatic leukodystrophy

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 942-960 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T2 1349-1367 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 626-631 Body_part denotes urine http://purl.obolibrary.org/obo/MAT_0000058

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 123-153 Disease denotes metachromatic leukodystrophies http://purl.obolibrary.org/obo/MONDO_0009591|http://purl.obolibrary.org/obo/MONDO_0018868
T3 215-230 Disease denotes genetic disease http://purl.obolibrary.org/obo/MONDO_0003847
T4 231-259 Disease denotes metachromatic leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009591|http://purl.obolibrary.org/obo/MONDO_0018868
T6 530-533 Disease denotes MLD http://purl.obolibrary.org/obo/MONDO_0009591|http://purl.obolibrary.org/obo/MONDO_0018868

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 942-960 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T2 1349-1367 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 137-153 Phenotype denotes leukodystrophies HP:0002415
T2 245-259 Phenotype denotes leukodystrophy HP:0002415

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 123-153 Disease denotes metachromatic leukodystrophies MONDO:0009591|MONDO:0018868
T3 215-230 Disease denotes genetic disease MONDO:0003847
T4 231-259 Disease denotes metachromatic leukodystrophy MONDO:0009591|MONDO:0018868

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 626-631 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-154 Sentence denotes Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies.
T2 155-428 Sentence denotes 3-O-Sulfogalactosylceramides (sulfatides) accumulate in the genetic disease metachromatic leukodystrophy which is due to a defect in the catabolic enzyme, arylsulfatase A. Clinical diagnosis is usually confirmed by in vitro enzymatic deficiency of arylsulfatase A activity.
T3 429-571 Sentence denotes The diagnosis may be complicated because of arylsulfatase A pseudo-deficiencies and another cause of MLD, sphingolipid activator B deficiency.
T4 572-698 Sentence denotes As large quantities of sulfatides can be found in the urine in this disease, sulfatiduria appears as an extremely useful test.
T5 699-846 Sentence denotes As recently enzyme replacement is underway, the quantitative determination, using an internal standard, appears particularly useful as a follow-up.
T6 847-1037 Sentence denotes Thus a non-physiological sulfatide was synthesized for this purpose, i.e. 3-O-sulfo-beta-D-C17 galactosylceramide (3-O-Sulfo-D: -Galactosyl-beta1'-->1-N-Heptadecanoyl-D-erythro-Sphingosine).
T7 1038-1170 Sentence denotes It has been prepared through condensation of an azidosphingosine derivative with a protected D-galactopyranosyltrichloroacetimidate.
T8 1171-1241 Sentence denotes Reduction of the azide was followed by acylation of a C-17 fatty acid.
T9 1242-1453 Sentence denotes The key step was achieved by selective sulfation of the desired hydroxyl group on the sugar residue of the galactosylceramide using the stannylene methodology to give a 3'-sulfated beta-galactosyl C-17 ceramide.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 942-960 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T2 1349-1367 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 626-631 Body_part denotes urine FMA:12274

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 626-631 Body_part denotes urine http://purl.obolibrary.org/obo/MAT_0000058

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 942-960 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T2 1349-1367 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 626-631 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 137-153 Phenotype denotes leukodystrophies HP:0002415
T2 245-259 Phenotype denotes leukodystrophy HP:0002415