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sentences

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity.
T2 118-357 Sentence denotes In budding yeast, acetylation of histone H3 lysine 56 (H3-K56) is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex, with Rtt109 being the catalytic subunit, and histone chaperone Asf1 is required for this modification.
T3 358-431 Sentence denotes Cells lacking Rtt109 are susceptible to perturbations in DNA replication.
T4 432-553 Sentence denotes However, how Asf1 regulates acetylation of H3-K56 and how loss of H3-K56 acetylation affects DNA replication are unclear.
T5 554-802 Sentence denotes We show that at low concentrations the Rtt109-Vps75 HAT complex acetylates H3-K56 in vitro when H3/H4 is complexed with Asf1, but not H3/H4 tetramers, recapitulating the in vivo requirement of Asf1 for H3-K56 acetylation using recombinant proteins.
T6 803-877 Sentence denotes Moreover, the Rtt109-Vps75 complex interacts with Asf1-H3/H4 but not Asf1.
T7 878-970 Sentence denotes In vivo, the Rtt109-Asf1 interaction is also dependent on the ability of Asf1 to bind H3/H4.
T8 971-1105 Sentence denotes Furthermore, the Rtt109 homolog in Schizosaccharomyces pombe (SpRtt109) also displayed an Asf1-dependent H3-K56 HAT activity in vitro.
T9 1106-1280 Sentence denotes These results indicate that Asf1 regulates H3-K56 acetylation by presenting histones H3 and H4 to Rtt109-Vps575 for acetylation, and this mechanism is likely to be conserved.
T10 1281-1602 Sentence denotes Finally, we have shown that cells lacking Rtt109 or expressing H3-K56 mutants exhibited significant reduction in the association of three proteins with stalled DNA replication forks and hyper-recombination of replication forks stalled at replication fork barriers of the ribosomal DNA locus compared with wild-type cells.
T11 1603-1774 Sentence denotes Taken together, these studies provide novel insight into the role of Asf1 in the regulation of H3-K56 acetylation and the function of this modification in DNA replication.

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 15-24 Simple_chemical denotes lysine 56
T2 28-38 Gene_or_gene_product denotes histone H3
T3 52-58 Gene_or_gene_product denotes RTT109
T4 76-80 Gene_or_gene_product denotes ASF1
T5 151-161 Gene_or_gene_product denotes histone H3
T6 162-171 Simple_chemical denotes lysine 56
T7 173-175 Gene_or_gene_product denotes H3
T8 176-179 Simple_chemical denotes K56
T9 201-213 Complex denotes Rtt109-Vps75
T10 214-239 Gene_or_gene_product denotes histone acetyltransferase
T11 241-244 Gene_or_gene_product denotes HAT
T12 260-266 Gene_or_gene_product denotes Rtt109
T13 300-307 Gene_or_gene_product denotes histone
T14 318-322 Gene_or_gene_product denotes Asf1
T15 372-378 Gene_or_gene_product denotes Rtt109
T16 445-449 Gene_or_gene_product denotes Asf1
T17 475-477 Gene_or_gene_product denotes H3
T18 478-481 Simple_chemical denotes K56
T19 498-500 Gene_or_gene_product denotes H3
T20 501-504 Simple_chemical denotes K56
T21 593-605 Complex denotes Rtt109-Vps75
T22 606-609 Gene_or_gene_product denotes HAT
T23 629-631 Gene_or_gene_product denotes H3
T24 632-635 Simple_chemical denotes K56
T25 650-652 Gene_or_gene_product denotes H3
T26 653-655 Gene_or_gene_product denotes H4
T27 674-678 Gene_or_gene_product denotes Asf1
T28 688-693 Complex denotes H3/H4
T29 747-751 Gene_or_gene_product denotes Asf1
T30 756-758 Gene_or_gene_product denotes H3
T31 759-762 Simple_chemical denotes K56
T32 817-829 Complex denotes Rtt109-Vps75
T33 853-860 Complex denotes Asf1-H3
T34 861-863 Complex denotes H4
T35 872-876 Gene_or_gene_product denotes Asf1
T36 891-902 Complex denotes Rtt109-Asf1
T37 951-955 Gene_or_gene_product denotes Asf1
T38 964-969 Gene_or_gene_product denotes H3/H4
T39 988-994 Gene_or_gene_product denotes Rtt109
T40 1033-1041 Gene_or_gene_product denotes SpRtt109
T41 1061-1065 Gene_or_gene_product denotes Asf1
T42 1076-1078 Gene_or_gene_product denotes H3
T43 1079-1082 Simple_chemical denotes K56
T44 1083-1086 Gene_or_gene_product denotes HAT
T45 1134-1138 Gene_or_gene_product denotes Asf1
T46 1149-1151 Gene_or_gene_product denotes H3
T47 1152-1155 Simple_chemical denotes K56
T48 1182-1193 Gene_or_gene_product denotes histones H3
T49 1198-1200 Gene_or_gene_product denotes H4
T50 1204-1217 Complex denotes Rtt109-Vps575
T51 1323-1329 Gene_or_gene_product denotes Rtt109
T52 1344-1346 Gene_or_gene_product denotes H3
T53 1347-1350 Simple_chemical denotes K56
T54 1552-1561 Cellular_component denotes ribosomal
T55 1672-1676 Gene_or_gene_product denotes Asf1
T56 1698-1700 Gene_or_gene_product denotes H3
T57 1701-1704 Simple_chemical denotes K56

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 241-244 Disease denotes HAT http://purl.obolibrary.org/obo/MONDO_0018048
T2 606-609 Disease denotes HAT http://purl.obolibrary.org/obo/MONDO_0018048
T3 1083-1086 Disease denotes HAT http://purl.obolibrary.org/obo/MONDO_0018048

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1006-1031 OrganismTaxon denotes Schizosaccharomyces pombe 4896