PubMed:17623048 / 1236-1438 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"17623048_1","span":{"begin":34,"end":40},"obj":"ProteinMutation"}],"attributes":[{"id":"17623048_1_ProteinMutation","pred":"proteinmutation","subj":"17623048_1","obj":"rs33939927"}],"text":"We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations."}

{"project":"c_corpus","denotations":[{"id":"T138","span":{"begin":25,"end":33},"obj":"SO:0000109"},{"id":"T139","span":{"begin":50,"end":56},"obj":"D020558"},{"id":"T140","span":{"begin":57,"end":63},"obj":"SO:0000417"},{"id":"T141","span":{"begin":79,"end":82},"obj":"D006160"},{"id":"T142","span":{"begin":79,"end":82},"obj":"CHEBI:37565"},{"id":"T143","span":{"begin":79,"end":82},"obj":"D006160"},{"id":"T144","span":{"begin":79,"end":82},"obj":"CHEBI:15996"},{"id":"T145","span":{"begin":79,"end":93},"obj":"GO:0006184"},{"id":"T146","span":{"begin":83,"end":93},"obj":"MOP:0000619"},{"id":"T147","span":{"begin":132,"end":141},"obj":"SO:0001185"},{"id":"T148","span":{"begin":165,"end":170},"obj":"PR:Q5S006"},{"id":"T149","span":{"begin":165,"end":170},"obj":"PR:000003033"},{"id":"T150","span":{"begin":165,"end":170},"obj":"PR:Q5S007"}],"text":"We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations."}

{"project":"PMID_GLOBAL","denotations":[{"id":"T14","span":{"begin":22,"end":24},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":180,"end":182},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A14","pred":"mondo_id","subj":"T14","obj":"0008199"},{"id":"A15","pred":"mondo_id","subj":"T14","obj":"0015873"},{"id":"A16","pred":"mondo_id","subj":"T14","obj":"0005180"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"0008199"},{"id":"A18","pred":"mondo_id","subj":"T17","obj":"0015873"},{"id":"A19","pred":"mondo_id","subj":"T17","obj":"0005180"}],"text":"We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations."}

{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T12","span":{"begin":0,"end":202},"obj":"DRI_Outcome"}],"text":"We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations."}

{"project":"PubMed_ArguminSci","denotations":[{"id":"T10","span":{"begin":0,"end":202},"obj":"DRI_Outcome"}],"text":"We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"17623048-9#79#82#gene92170","span":{"begin":79,"end":82},"obj":"gene92170"},{"id":"17623048-9#22#24#diseaseC0030567","span":{"begin":22,"end":24},"obj":"diseaseC0030567"},{"id":"17623048-9#180#182#diseaseC0030567","span":{"begin":180,"end":182},"obj":"diseaseC0030567"}],"relations":[{"id":"79#82#gene9217022#24#diseaseC0030567","pred":"associated_with","subj":"17623048-9#79#82#gene92170","obj":"17623048-9#22#24#diseaseC0030567"},{"id":"79#82#gene92170180#182#diseaseC0030567","pred":"associated_with","subj":"17623048-9#79#82#gene92170","obj":"17623048-9#180#182#diseaseC0030567"}],"text":"We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations."}