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PubMed:17592300 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.
T2 129-139 Sentence denotes OBJECTIVE:
T3 140-296 Sentence denotes To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy.
T4 297-321 Sentence denotes SUMMARY BACKGROUND DATA:
T5 322-430 Sentence denotes Genetic polymorphisms for immunoregulatory cytokines may explain individual variation in response to trauma.
T6 431-624 Sentence denotes Esophagectomy is associated with a high risk of postoperative infection and sepsis, and this study explored a number of SNPs in cytokine genes and their relationship to postoperative infection.
T7 625-635 Sentence denotes METHODS: :
T8 636-761 Sentence denotes In a prospective analysis of 197 patients with esophageal cancer undergoing resection, 55 developed postoperative infections.
T9 762-968 Sentence denotes DNA was extracted and genotyping was performed for polymorphisms in genes encoding TNF-alpha, IL-1beta, IL-1 receptor antagonist, IL-10, and Toll-like receptor 4 (TLR-4) using Taqman chemistry and PCR/RFLP.
T10 969-1132 Sentence denotes In a blinded analysis, the cohort with infections was compared with the no complication cohort (n = 114) and a cohort that had noninfective complications (n = 28).
T11 1133-1141 Sentence denotes RESULTS:
T12 1142-1248 Sentence denotes No differences in polymorphisms for IL-1beta, IL-1 RN, IL-10, and TLR-4 genes were observed across groups.
T13 1249-1370 Sentence denotes The frequency of TNF-alpha -308 GG homozygotes was significantly (P = 0.021) higher in the postoperative infection group.
T14 1371-1539 Sentence denotes The G allele was significantly higher in the postoperative infection group compared with the no complication group (P = 0.017) and other complication group (P = 0.013).
T15 1540-1648 Sentence denotes By multivariate analysis, this polymorphism as well as age and body mass index were predictors of infection.
T16 1649-1660 Sentence denotes CONCLUSION:
T17 1661-1823 Sentence denotes The TNF-alpha -308A allele has been shown to be associated with higher circulating levels of TNF-alpha and the -308 G allele is a comparative low secretor allele.
T18 1824-2076 Sentence denotes We propose that the polymorphism in the promotor region of TNF-alpha gene may lead to altered expression and a possible suboptimal activity of TNF-alpha in persons with GG genotypes, and these data suggest a link with infection following major surgery.
T1 0-128 Sentence denotes Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.
T2 129-139 Sentence denotes OBJECTIVE:
T3 140-296 Sentence denotes To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy.
T4 297-321 Sentence denotes SUMMARY BACKGROUND DATA:
T5 322-430 Sentence denotes Genetic polymorphisms for immunoregulatory cytokines may explain individual variation in response to trauma.
T6 431-624 Sentence denotes Esophagectomy is associated with a high risk of postoperative infection and sepsis, and this study explored a number of SNPs in cytokine genes and their relationship to postoperative infection.
T7 625-635 Sentence denotes METHODS: :
T8 636-761 Sentence denotes In a prospective analysis of 197 patients with esophageal cancer undergoing resection, 55 developed postoperative infections.
T9 762-968 Sentence denotes DNA was extracted and genotyping was performed for polymorphisms in genes encoding TNF-alpha, IL-1beta, IL-1 receptor antagonist, IL-10, and Toll-like receptor 4 (TLR-4) using Taqman chemistry and PCR/RFLP.
T10 969-1132 Sentence denotes In a blinded analysis, the cohort with infections was compared with the no complication cohort (n = 114) and a cohort that had noninfective complications (n = 28).
T11 1133-1141 Sentence denotes RESULTS:
T12 1142-1248 Sentence denotes No differences in polymorphisms for IL-1beta, IL-1 RN, IL-10, and TLR-4 genes were observed across groups.
T13 1249-1370 Sentence denotes The frequency of TNF-alpha -308 GG homozygotes was significantly (P = 0.021) higher in the postoperative infection group.
T14 1371-1539 Sentence denotes The G allele was significantly higher in the postoperative infection group compared with the no complication group (P = 0.017) and other complication group (P = 0.013).
T15 1540-1648 Sentence denotes By multivariate analysis, this polymorphism as well as age and body mass index were predictors of infection.
T16 1649-1660 Sentence denotes CONCLUSION:
T17 1661-1823 Sentence denotes The TNF-alpha -308A allele has been shown to be associated with higher circulating levels of TNF-alpha and the -308 G allele is a comparative low secretor allele.
T18 1824-2076 Sentence denotes We propose that the polymorphism in the promotor region of TNF-alpha gene may lead to altered expression and a possible suboptimal activity of TNF-alpha in persons with GG genotypes, and these data suggest a link with infection following major surgery.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 38-47 DiseaseOrPhenotypicFeature denotes infection 0005550
T2 423-429 DiseaseOrPhenotypicFeature denotes trauma 0021178
T3 493-502 DiseaseOrPhenotypicFeature denotes infection 0005550
T4 614-623 DiseaseOrPhenotypicFeature denotes infection 0005550
T5 683-700 DiseaseOrPhenotypicFeature denotes esophageal cancer 0007576
T6 1354-1363 DiseaseOrPhenotypicFeature denotes infection 0005550
T7 1430-1439 DiseaseOrPhenotypicFeature denotes infection 0005550
T8 1638-1647 DiseaseOrPhenotypicFeature denotes infection 0005550
T9 2042-2051 DiseaseOrPhenotypicFeature denotes infection 0005550

Wangshuguang

Id Subject Object Predicate Lexical cue
T1 246-257 B-Variation denotes development
T2 411-419 B-Variation denotes response
T3 541-547 B-Negative_Function denotes number
T4 1571-1583 B-Variation denotes polymorphism
T5 1603-1607 B-Molecular_Activity denotes body
T6 1608-1612 I-Molecular_Activity denotes mass
T7 1613-1618 I-Molecular_Activity denotes index
T8 1786-1788 B-Negtive_Regulation denotes is
T9 1955-1963 B-Variation denotes activity
T10 2032-2036 B-Negative_Function denotes link
T11 2037-2041 I-Negative_Function denotes with
T12 2042-2051 I-Negative_Function denotes infection

123123123

Id Subject Object Predicate Lexical cue
T1 246-257 B-Variation denotes development
T2 411-419 B-Variation denotes response
T3 541-547 B-Negative_Function denotes number
T4 1571-1583 B-Variation denotes polymorphism
T5 1603-1607 B-Molecular_Activity denotes body
T6 1608-1612 I-Molecular_Activity denotes mass
T7 1613-1618 I-Molecular_Activity denotes index
T8 1786-1788 B-Negtive_Regulation denotes is
T9 1955-1963 B-Variation denotes activity
T10 2032-2036 B-Negative_Function denotes link
T11 2037-2041 I-Negative_Function denotes with
T12 2042-2051 I-Negative_Function denotes infection