Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-128 |
Sentence |
denotes |
Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype. |
T2 |
129-139 |
Sentence |
denotes |
OBJECTIVE: |
T3 |
140-296 |
Sentence |
denotes |
To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy. |
T4 |
297-321 |
Sentence |
denotes |
SUMMARY BACKGROUND DATA: |
T5 |
322-430 |
Sentence |
denotes |
Genetic polymorphisms for immunoregulatory cytokines may explain individual variation in response to trauma. |
T6 |
431-624 |
Sentence |
denotes |
Esophagectomy is associated with a high risk of postoperative infection and sepsis, and this study explored a number of SNPs in cytokine genes and their relationship to postoperative infection. |
T7 |
625-635 |
Sentence |
denotes |
METHODS: : |
T8 |
636-761 |
Sentence |
denotes |
In a prospective analysis of 197 patients with esophageal cancer undergoing resection, 55 developed postoperative infections. |
T9 |
762-968 |
Sentence |
denotes |
DNA was extracted and genotyping was performed for polymorphisms in genes encoding TNF-alpha, IL-1beta, IL-1 receptor antagonist, IL-10, and Toll-like receptor 4 (TLR-4) using Taqman chemistry and PCR/RFLP. |
T10 |
969-1132 |
Sentence |
denotes |
In a blinded analysis, the cohort with infections was compared with the no complication cohort (n = 114) and a cohort that had noninfective complications (n = 28). |
T11 |
1133-1141 |
Sentence |
denotes |
RESULTS: |
T12 |
1142-1248 |
Sentence |
denotes |
No differences in polymorphisms for IL-1beta, IL-1 RN, IL-10, and TLR-4 genes were observed across groups. |
T13 |
1249-1370 |
Sentence |
denotes |
The frequency of TNF-alpha -308 GG homozygotes was significantly (P = 0.021) higher in the postoperative infection group. |
T14 |
1371-1539 |
Sentence |
denotes |
The G allele was significantly higher in the postoperative infection group compared with the no complication group (P = 0.017) and other complication group (P = 0.013). |
T15 |
1540-1648 |
Sentence |
denotes |
By multivariate analysis, this polymorphism as well as age and body mass index were predictors of infection. |
T16 |
1649-1660 |
Sentence |
denotes |
CONCLUSION: |
T17 |
1661-1823 |
Sentence |
denotes |
The TNF-alpha -308A allele has been shown to be associated with higher circulating levels of TNF-alpha and the -308 G allele is a comparative low secretor allele. |
T18 |
1824-2076 |
Sentence |
denotes |
We propose that the polymorphism in the promotor region of TNF-alpha gene may lead to altered expression and a possible suboptimal activity of TNF-alpha in persons with GG genotypes, and these data suggest a link with infection following major surgery. |
T1 |
0-128 |
Sentence |
denotes |
Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype. |
T2 |
129-139 |
Sentence |
denotes |
OBJECTIVE: |
T3 |
140-296 |
Sentence |
denotes |
To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy. |
T4 |
297-321 |
Sentence |
denotes |
SUMMARY BACKGROUND DATA: |
T5 |
322-430 |
Sentence |
denotes |
Genetic polymorphisms for immunoregulatory cytokines may explain individual variation in response to trauma. |
T6 |
431-624 |
Sentence |
denotes |
Esophagectomy is associated with a high risk of postoperative infection and sepsis, and this study explored a number of SNPs in cytokine genes and their relationship to postoperative infection. |
T7 |
625-635 |
Sentence |
denotes |
METHODS: : |
T8 |
636-761 |
Sentence |
denotes |
In a prospective analysis of 197 patients with esophageal cancer undergoing resection, 55 developed postoperative infections. |
T9 |
762-968 |
Sentence |
denotes |
DNA was extracted and genotyping was performed for polymorphisms in genes encoding TNF-alpha, IL-1beta, IL-1 receptor antagonist, IL-10, and Toll-like receptor 4 (TLR-4) using Taqman chemistry and PCR/RFLP. |
T10 |
969-1132 |
Sentence |
denotes |
In a blinded analysis, the cohort with infections was compared with the no complication cohort (n = 114) and a cohort that had noninfective complications (n = 28). |
T11 |
1133-1141 |
Sentence |
denotes |
RESULTS: |
T12 |
1142-1248 |
Sentence |
denotes |
No differences in polymorphisms for IL-1beta, IL-1 RN, IL-10, and TLR-4 genes were observed across groups. |
T13 |
1249-1370 |
Sentence |
denotes |
The frequency of TNF-alpha -308 GG homozygotes was significantly (P = 0.021) higher in the postoperative infection group. |
T14 |
1371-1539 |
Sentence |
denotes |
The G allele was significantly higher in the postoperative infection group compared with the no complication group (P = 0.017) and other complication group (P = 0.013). |
T15 |
1540-1648 |
Sentence |
denotes |
By multivariate analysis, this polymorphism as well as age and body mass index were predictors of infection. |
T16 |
1649-1660 |
Sentence |
denotes |
CONCLUSION: |
T17 |
1661-1823 |
Sentence |
denotes |
The TNF-alpha -308A allele has been shown to be associated with higher circulating levels of TNF-alpha and the -308 G allele is a comparative low secretor allele. |
T18 |
1824-2076 |
Sentence |
denotes |
We propose that the polymorphism in the promotor region of TNF-alpha gene may lead to altered expression and a possible suboptimal activity of TNF-alpha in persons with GG genotypes, and these data suggest a link with infection following major surgery. |