PubMed:1759227
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1759227","sourcedb":"PubMed","sourceid":"1759227","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1759227","text":"[The dynamics of the concentrations of immunoglobulins and circulating immune complexes during low-density lipoprotein apheresis in patients with hereditary hypercholesterolemia].\nSessions of-low density lipoproteins (LDL) apheresis using sorbents with mono- and polyclonal antibodies possessing the most selective and specific effect with respect to LDL provoked a less marked decrease of the concentrations of immunoglobulins and circulating immune complexes. This attests to their high selectivity and specificity. Sorbents with dextran sulfate and heparin sepharose exerted a more evident influence on the concentrations of these serum components. However, that was not accompanied by any clinical manifestations of immune deficiency. The use of plasmapheresis brought about a more pronounced lowering of the concentrations of the serum components under study.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":720,"end":737},"obj":"HP_0002721"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"2","span":{"begin":132,"end":140},"obj":"OrganismTaxon"},{"id":"3","span":{"begin":146,"end":177},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8","span":{"begin":532,"end":547},"obj":"ChemicalEntity"},{"id":"9","span":{"begin":552,"end":559},"obj":"ChemicalEntity"},{"id":"10","span":{"begin":560,"end":569},"obj":"ChemicalEntity"},{"id":"11","span":{"begin":720,"end":737},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"Tax:9606"},{"id":"A8","pred":"tao:has_database_id","subj":"8","obj":"MESH:D016264"},{"id":"A9","pred":"tao:has_database_id","subj":"9","obj":"MESH:D006493"},{"id":"A10","pred":"tao:has_database_id","subj":"10","obj":"MESH:D012685"},{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:D007153"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:D006937"},{"subj":"2","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"3","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"8","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"9","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"10","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"11","pred":"source","obj":"LitCoin-PubTator-for-Tuning"}]},{"project":"LitCoin-Disease-Tuning-1","denotations":[{"id":"T1","span":{"begin":157,"end":177},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D006937"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-Tuning-1"}]},{"project":"LitEisuke","denotations":[{"id":"T1","span":{"begin":157,"end":177},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D006937"},{"subj":"T1","pred":"source","obj":"LitEisuke"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#ecac93","default":true},{"id":"LitCoin-PubTator-for-Tuning","color":"#9393ec"},{"id":"LitCoin-Disease-Tuning-1","color":"#adec93"},{"id":"LitEisuke","color":"#ec93c7"}]}]}}