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sentences

Id Subject Object Predicate Lexical cue
T1 0-134 Sentence denotes Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
T2 135-380 Sentence denotes In this report, a genome-scale reconstruction of Bacillus subtilis metabolism and its iterative development based on the combination of genomic, biochemical, and physiological information and high-throughput phenotyping experiments is presented.
T3 381-492 Sentence denotes The initial reconstruction was converted into an in silico model and expanded in a four-step iterative fashion.
T4 493-634 Sentence denotes First, network gap analysis was used to identify 48 missing reactions that are needed for growth but were not found in the genome annotation.
T5 635-857 Sentence denotes Second, the computed growth rates under aerobic conditions were compared with high-throughput phenotypic screen data, and the initial in silico model could predict the outcomes qualitatively in 140 of 271 cases considered.
T6 858-1022 Sentence denotes Detailed analysis of the incorrect predictions resulted in the addition of 75 reactions to the initial reconstruction, and 200 of 271 cases were correctly computed.
T7 1023-1188 Sentence denotes Third, in silico computations of the growth phenotypes of knock-out strains were found to be consistent with experimental observations in 720 of 766 cases evaluated.
T8 1189-1459 Sentence denotes Fourth, the integrated analysis of the large-scale substrate utilization and gene essentiality data with the genome-scale metabolic model revealed the requirement of 80 specific enzymes (transport, 53; intracellular reactions, 27) that were not in the genome annotation.
T9 1460-1591 Sentence denotes Subsequent sequence analysis resulted in the identification of genes that could be putatively assigned to 13 intracellular enzymes.
T10 1592-1717 Sentence denotes The final reconstruction accounted for 844 open reading frames and consisted of 1020 metabolic reactions and 988 metabolites.
T11 1718-1848 Sentence denotes Hence, the in silico model can be used to obtain experimentally verifiable hypothesis on the metabolic functions of various genes.
T1 0-134 Sentence denotes Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
T2 135-380 Sentence denotes In this report, a genome-scale reconstruction of Bacillus subtilis metabolism and its iterative development based on the combination of genomic, biochemical, and physiological information and high-throughput phenotyping experiments is presented.
T3 381-492 Sentence denotes The initial reconstruction was converted into an in silico model and expanded in a four-step iterative fashion.
T4 493-634 Sentence denotes First, network gap analysis was used to identify 48 missing reactions that are needed for growth but were not found in the genome annotation.
T5 635-857 Sentence denotes Second, the computed growth rates under aerobic conditions were compared with high-throughput phenotypic screen data, and the initial in silico model could predict the outcomes qualitatively in 140 of 271 cases considered.
T6 858-1022 Sentence denotes Detailed analysis of the incorrect predictions resulted in the addition of 75 reactions to the initial reconstruction, and 200 of 271 cases were correctly computed.
T7 1023-1188 Sentence denotes Third, in silico computations of the growth phenotypes of knock-out strains were found to be consistent with experimental observations in 720 of 766 cases evaluated.
T8 1189-1459 Sentence denotes Fourth, the integrated analysis of the large-scale substrate utilization and gene essentiality data with the genome-scale metabolic model revealed the requirement of 80 specific enzymes (transport, 53; intracellular reactions, 27) that were not in the genome annotation.
T9 1460-1591 Sentence denotes Subsequent sequence analysis resulted in the identification of genes that could be putatively assigned to 13 intracellular enzymes.
T10 1592-1717 Sentence denotes The final reconstruction accounted for 844 open reading frames and consisted of 1020 metabolic reactions and 988 metabolites.
T11 1718-1848 Sentence denotes Hence, the in silico model can be used to obtain experimentally verifiable hypothesis on the metabolic functions of various genes.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 52-69 OrganismTaxon denotes Bacillus subtilis 1423
T2 184-201 OrganismTaxon denotes Bacillus subtilis 1423

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 7-12 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T2 160-165 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T3 1234-1239 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T4 1305-1310 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T5 1391-1404 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 1569-1582 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622