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PubMed:17553349 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 293-302 HP_0001369 denotes arthritis

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes [Paharmacological mechanisms of cellular immunity of overall alkali of tongbiling for the treatment of joint destruction].
T2 123-127 Sentence denotes AIM:
T3 128-371 Sentence denotes To investigate the effect of the overall alkali of Traditional Chinese Medicine tongbiling(TBL) which comprises brucine and strychnine alkaloids on collagen induced-arthritis(CIA) and study its paharmacological mechanisms of cellular immunity.
T4 372-380 Sentence denotes METHODS:
T5 381-439 Sentence denotes Bovine CII was emulsified in Freund's incomplete adjuvant.
T6 440-526 Sentence denotes Wistar rats were injected with Type II collagen intradermally at the base of the tail.
T7 527-629 Sentence denotes After swelling, CIA groups were, randomly divided into physiological saline group and treatment group.
T8 630-685 Sentence denotes Then the swelling of the rats' hindlimbs was evaluated.
T9 686-773 Sentence denotes The whole body of the rats treated on 35 th days was photographed by mammography X-Ray.
T10 774-962 Sentence denotes 96 joints in erosion scoring system and 100 joints in joint spacing narrow(JSN) scoring system were used to observe the joint destruction of CIA from X-Ray comprehensively and objectively.
T11 963-1179 Sentence denotes After the rats were killed, the third proximal claw pad of the right hindlimb and left forelimb were stained by HE dying, Neutrophil, lymphocyte, plasmacyte infiltration and hyperplasia of synoviocytes were assessed.
T12 1180-1359 Sentence denotes Then MTT and Western blot were used to determine the effect of the overall alkali of TBL on proliferation of Jurkat cells and ERK1/2 phosphorylation of Jurkat cells, respectively.
T13 1360-1368 Sentence denotes RESULTS:
T14 1369-1419 Sentence denotes Inflammation of CIA joints was aggravated quickly.
T15 1420-1520 Sentence denotes The swelling of CIA rats treated by MTX and overall alkali of TBL for 35 days was relieved (P<0.05).
T16 1521-1593 Sentence denotes MTX and overall alkali of TBL inhibited the hyperplasia of synoviocytes.
T17 1594-1674 Sentence denotes Overall alkali of TBL inhibited the infiltration of lymphocyteS and plasmacytes.
T18 1675-1768 Sentence denotes Overall alkali of TBL inhibited the proliferation and ERK1/2 phosphorylation of Jurkat cells.
T19 1769-1780 Sentence denotes CONCLUSION:
T20 1781-1964 Sentence denotes Overall alkali of TBL could relieve joint inflammation and destruction of CIA rats by blocking the MAPK cell signalling pathway to inhibit the activation and proliferation of T cells.
T21 1965-2076 Sentence denotes Our study might provide an experimental basis for treatment of rheumatoid arthritis with overall alkali of TBL.
T1 0-122 Sentence denotes [Paharmacological mechanisms of cellular immunity of overall alkali of tongbiling for the treatment of joint destruction].
T2 123-127 Sentence denotes AIM:
T3 128-371 Sentence denotes To investigate the effect of the overall alkali of Traditional Chinese Medicine tongbiling(TBL) which comprises brucine and strychnine alkaloids on collagen induced-arthritis(CIA) and study its paharmacological mechanisms of cellular immunity.
T4 372-380 Sentence denotes METHODS:
T5 381-439 Sentence denotes Bovine CII was emulsified in Freund's incomplete adjuvant.
T6 440-526 Sentence denotes Wistar rats were injected with Type II collagen intradermally at the base of the tail.
T7 527-629 Sentence denotes After swelling, CIA groups were, randomly divided into physiological saline group and treatment group.
T8 630-685 Sentence denotes Then the swelling of the rats' hindlimbs was evaluated.
T9 686-773 Sentence denotes The whole body of the rats treated on 35 th days was photographed by mammography X-Ray.
T10 774-962 Sentence denotes 96 joints in erosion scoring system and 100 joints in joint spacing narrow(JSN) scoring system were used to observe the joint destruction of CIA from X-Ray comprehensively and objectively.
T11 963-1179 Sentence denotes After the rats were killed, the third proximal claw pad of the right hindlimb and left forelimb were stained by HE dying, Neutrophil, lymphocyte, plasmacyte infiltration and hyperplasia of synoviocytes were assessed.
T12 1180-1359 Sentence denotes Then MTT and Western blot were used to determine the effect of the overall alkali of TBL on proliferation of Jurkat cells and ERK1/2 phosphorylation of Jurkat cells, respectively.
T13 1360-1368 Sentence denotes RESULTS:
T14 1369-1419 Sentence denotes Inflammation of CIA joints was aggravated quickly.
T15 1420-1520 Sentence denotes The swelling of CIA rats treated by MTX and overall alkali of TBL for 35 days was relieved (P<0.05).
T16 1521-1593 Sentence denotes MTX and overall alkali of TBL inhibited the hyperplasia of synoviocytes.
T17 1594-1674 Sentence denotes Overall alkali of TBL inhibited the infiltration of lymphocyteS and plasmacytes.
T18 1675-1768 Sentence denotes Overall alkali of TBL inhibited the proliferation and ERK1/2 phosphorylation of Jurkat cells.
T19 1769-1780 Sentence denotes CONCLUSION:
T20 1781-1964 Sentence denotes Overall alkali of TBL could relieve joint inflammation and destruction of CIA rats by blocking the MAPK cell signalling pathway to inhibit the activation and proliferation of T cells.
T21 1965-2076 Sentence denotes Our study might provide an experimental basis for treatment of rheumatoid arthritis with overall alkali of TBL.