PubMed:17495183 JSON TXT

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TEST-DiseaseOrPhenotypicFeature

TEST-ChemicalEntity

{"project":"TEST-ChemicalEntity","denotations":[{"id":"T1","span":{"begin":242,"end":249},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":483,"end":490},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":953,"end":960},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":1221,"end":1228},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":1459,"end":1466},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D005947"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D005947"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A6","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D005947"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A9","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D005947"},{"id":"A11","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A12","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D005947"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A15","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

TEST-OrganismTaxon

{"project":"TEST-OrganismTaxon","denotations":[{"id":"T1","span":{"begin":817,"end":822},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":850,"end":853},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":971,"end":974},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":1097,"end":1100},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1512,"end":1515},"obj":"OrganismTaxon"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

Test-SequenceVariant

{"project":"Test-SequenceVariant","denotations":[{"id":"T1","span":{"begin":536,"end":539},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":824,"end":833},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":835,"end":844},"obj":"SequenceVariant"},{"id":"T4","span":{"begin":855,"end":865},"obj":"SequenceVariant"},{"id":"T5","span":{"begin":876,"end":885},"obj":"SequenceVariant"},{"id":"T6","span":{"begin":890,"end":899},"obj":"SequenceVariant"},{"id":"T7","span":{"begin":1039,"end":1048},"obj":"SequenceVariant"},{"id":"T8","span":{"begin":1090,"end":1093},"obj":"SequenceVariant"},{"id":"T9","span":{"begin":1125,"end":1128},"obj":"SequenceVariant"},{"id":"T10","span":{"begin":1282,"end":1291},"obj":"SequenceVariant"},{"id":"T11","span":{"begin":1317,"end":1326},"obj":"SequenceVariant"},{"id":"T12","span":{"begin":1356,"end":1365},"obj":"SequenceVariant"},{"id":"T13","span":{"begin":1505,"end":1508},"obj":"SequenceVariant"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

Test-GeneOrGeneProduct

{"project":"Test-GeneOrGeneProduct","denotations":[{"id":"T1","span":{"begin":0,"end":11},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":299,"end":312},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":313,"end":324},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":326,"end":330},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":953,"end":967},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":1221,"end":1235},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1396,"end":1400},"obj":"GeneOrGeneProduct"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

Test-merged-2

DisGeNET

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":1396,"end":1400},"obj":"gene:64102"},{"id":"T1","span":{"begin":1498,"end":1501},"obj":"disease:C0271650"},{"id":"T2","span":{"begin":1396,"end":1400},"obj":"gene:64102"},{"id":"T3","span":{"begin":1505,"end":1508},"obj":"disease:C0011860"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":233,"end":259},"obj":"HP_0000833"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

DisGeNET5_variant_disease

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"17495183-8#35#44#geners2073162","span":{"begin":1039,"end":1048},"obj":"geners2073162"},{"id":"17495183-8#79#82#diseaseC0271650","span":{"begin":1083,"end":1086},"obj":"diseaseC0271650"},{"id":"17495183-9#254#263#geners1155974","span":{"begin":1356,"end":1365},"obj":"geners1155974"},{"id":"17495183-9#180#189#geners2073162","span":{"begin":1282,"end":1291},"obj":"geners2073162"},{"id":"17495183-9#215#224#geners2073163","span":{"begin":1317,"end":1326},"obj":"geners2073163"},{"id":"17495183-9#23#26#diseaseC0011860","span":{"begin":1125,"end":1128},"obj":"diseaseC0011860"}],"relations":[{"id":"35#44#geners207316279#82#diseaseC0271650","pred":"associated_with","subj":"17495183-8#35#44#geners2073162","obj":"17495183-8#79#82#diseaseC0271650"},{"id":"254#263#geners115597423#26#diseaseC0011860","pred":"associated_with","subj":"17495183-9#254#263#geners1155974","obj":"17495183-9#23#26#diseaseC0011860"},{"id":"180#189#geners207316223#26#diseaseC0011860","pred":"associated_with","subj":"17495183-9#180#189#geners2073162","obj":"17495183-9#23#26#diseaseC0011860"},{"id":"215#224#geners207316323#26#diseaseC0011860","pred":"associated_with","subj":"17495183-9#215#224#geners2073163","obj":"17495183-9#23#26#diseaseC0011860"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

DisGeNET5_gene_disease

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"17495183-0#0#11#gene64102","span":{"begin":0,"end":11},"obj":"gene64102"},{"id":"17495183-0#43#51#diseaseC0011847","span":{"begin":43,"end":51},"obj":"diseaseC0011847"},{"id":"17495183-0#43#51#diseaseC0011849","span":{"begin":43,"end":51},"obj":"diseaseC0011849"},{"id":"17495183-0#70#78#diseaseC0011847","span":{"begin":70,"end":78},"obj":"diseaseC0011847"},{"id":"17495183-0#70#78#diseaseC0011849","span":{"begin":70,"end":78},"obj":"diseaseC0011849"},{"id":"17495183-0#31#38#diseaseC0028754","span":{"begin":31,"end":38},"obj":"diseaseC0028754"},{"id":"17495183-10#27#31#gene64102","span":{"begin":1396,"end":1400},"obj":"gene64102"},{"id":"17495183-10#129#132#diseaseC0271650","span":{"begin":1498,"end":1501},"obj":"diseaseC0271650"},{"id":"17495183-10#136#139#diseaseC0011860","span":{"begin":1505,"end":1508},"obj":"diseaseC0011860"}],"relations":[{"id":"0#11#gene6410243#51#diseaseC0011847","pred":"associated_with","subj":"17495183-0#0#11#gene64102","obj":"17495183-0#43#51#diseaseC0011847"},{"id":"0#11#gene6410243#51#diseaseC0011849","pred":"associated_with","subj":"17495183-0#0#11#gene64102","obj":"17495183-0#43#51#diseaseC0011849"},{"id":"0#11#gene6410270#78#diseaseC0011847","pred":"associated_with","subj":"17495183-0#0#11#gene64102","obj":"17495183-0#70#78#diseaseC0011847"},{"id":"0#11#gene6410270#78#diseaseC0011849","pred":"associated_with","subj":"17495183-0#0#11#gene64102","obj":"17495183-0#70#78#diseaseC0011849"},{"id":"0#11#gene6410231#38#diseaseC0028754","pred":"associated_with","subj":"17495183-0#0#11#gene64102","obj":"17495183-0#31#38#diseaseC0028754"},{"id":"27#31#gene64102129#132#diseaseC0271650","pred":"associated_with","subj":"17495183-10#27#31#gene64102","obj":"17495183-10#129#132#diseaseC0271650"},{"id":"27#31#gene64102136#139#diseaseC0011860","pred":"associated_with","subj":"17495183-10#27#31#gene64102","obj":"17495183-10#136#139#diseaseC0011860"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

tmVarCorpus

{"project":"tmVarCorpus","denotations":[{"id":"T1","span":{"begin":824,"end":833},"obj":"SNP:rs5966709"},{"id":"T2","span":{"begin":835,"end":844},"obj":"SNP:rs4828037"},{"id":"T3","span":{"begin":855,"end":865},"obj":"SNP:rs11798018"},{"id":"T4","span":{"begin":876,"end":885},"obj":"SNP:rs2073163"},{"id":"T5","span":{"begin":890,"end":899},"obj":"SNP:rs1155794"},{"id":"T6","span":{"begin":1039,"end":1048},"obj":"SNP:rs2073162"},{"id":"T7","span":{"begin":1282,"end":1291},"obj":"SNP:rs2073162"},{"id":"T8","span":{"begin":1317,"end":1326},"obj":"SNP:rs2073163"},{"id":"T9","span":{"begin":1356,"end":1365},"obj":"SNP:rs1155974"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

PubTator4TogoVar

{"project":"PubTator4TogoVar","denotations":[{"id":"55","span":{"begin":824,"end":833},"obj":"SNP"},{"id":"56","span":{"begin":835,"end":844},"obj":"SNP"},{"id":"58","span":{"begin":855,"end":865},"obj":"SNP"},{"id":"59","span":{"begin":876,"end":885},"obj":"SNP"},{"id":"60","span":{"begin":890,"end":899},"obj":"SNP"},{"id":"63","span":{"begin":1039,"end":1048},"obj":"SNP"},{"id":"69","span":{"begin":1282,"end":1291},"obj":"SNP"},{"id":"70","span":{"begin":1317,"end":1326},"obj":"SNP"},{"id":"71","span":{"begin":1356,"end":1365},"obj":"SNP"}],"attributes":[{"id":"A55","pred":"resolved_to","subj":"55","obj":"tmVar:rs5966709;VariantGroup:0;CorrespondingGene:64102;RS#:5966709;CorrespondingSpecies:9606"},{"id":"A56","pred":"resolved_to","subj":"56","obj":"tmVar:rs4828037;VariantGroup:3;CorrespondingGene:64102;RS#:4828037;CorrespondingSpecies:9606"},{"id":"A58","pred":"resolved_to","subj":"58","obj":"tmVar:rs11798018;VariantGroup:2;CorrespondingGene:64102;RS#:11798018;CorrespondingSpecies:9606"},{"id":"A59","pred":"resolved_to","subj":"59","obj":"tmVar:rs2073163;VariantGroup:5;CorrespondingGene:64102;RS#:2073163;CorrespondingSpecies:9606"},{"id":"A60","pred":"resolved_to","subj":"60","obj":"tmVar:rs1155794;VariantGroup:1;CorrespondingGene:10085;RS#:1155794;CorrespondingSpecies:9606"},{"id":"A63","pred":"resolved_to","subj":"63","obj":"tmVar:rs2073162;VariantGroup:6;CorrespondingGene:64102;RS#:2073162;CorrespondingSpecies:9606"},{"id":"A69","pred":"resolved_to","subj":"69","obj":"tmVar:rs2073162;VariantGroup:6;CorrespondingGene:64102;RS#:2073162;CorrespondingSpecies:9606"},{"id":"A70","pred":"resolved_to","subj":"70","obj":"tmVar:rs2073163;VariantGroup:5;CorrespondingGene:64102;RS#:2073163;CorrespondingSpecies:9606"},{"id":"A71","pred":"resolved_to","subj":"71","obj":"tmVar:rs1155974;VariantGroup:4;CorrespondingGene:64102;RS#:1155974;CorrespondingSpecies:9606"}],"text":"Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.\nWe recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men."}

PubTatorOnTogoVar