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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.
T2 110-121 Sentence denotes BACKGROUND:
T3 122-274 Sentence denotes Epidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, but the mechanisms remain unknown.
T4 275-286 Sentence denotes OBJECTIVES:
T5 287-412 Sentence denotes We tested the hypothesis that the ultrafine fraction of ambient pollutant particles would cause endothelial cell dysfunction.
T6 413-421 Sentence denotes METHODS:
T7 422-661 Sentence denotes We profiled gene expression of human pulmonary artery endothelial cells (HPAEC) exposed to ultrafine particles (UFPs; 100 microg/mL) from Chapel Hill, North Carolina, or vehicle for 4 hr with Affymetrix HG U133 Plus 2.0 chips (n = 4 each).
T8 662-670 Sentence denotes RESULTS:
T9 671-768 Sentence denotes We found 320 up-regulated genes and 106 down-regulated genes (p < 0.01, 5% false discovery rate).
T10 769-979 Sentence denotes We noted up-regulation of genes related to coagulation [tissue factor (F3) and coagulation factor II receptor-like 2 (F2RL2)] and differential regulation of genes related to F3 signaling (FOS, JUN, and NFKBIA).
T11 980-1109 Sentence denotes Results of quantitative polymerase chain reaction show a significant up-regulation of F3 after 10 and 100 microg/mLUFP exposures.
T12 1110-1244 Sentence denotes Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1).
T13 1245-1337 Sentence denotes Treatment of HPAEC with UFPs for 16 hr increased the release of interleukin (IL)-6 and IL-8.
T14 1338-1457 Sentence denotes Pretreatment of HPAEC with a blocking antibody against F3 attenuated IL-6 and IL-8 release by 30 and 70%, respectively.
T15 1458-1470 Sentence denotes CONCLUSIONS:
T16 1471-1592 Sentence denotes Using gene profiling, we discovered that UFPs may induce vascular endothelial cells to express genes related to clotting.
T17 1593-1721 Sentence denotes These results indicate that PM may cause adverse cardiovascular health effects by activating coagulation-inflammation circuitry.
T1 0-109 Sentence denotes Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.
T2 110-121 Sentence denotes BACKGROUND:
T3 122-274 Sentence denotes Epidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, but the mechanisms remain unknown.
T4 275-286 Sentence denotes OBJECTIVES:
T5 287-412 Sentence denotes We tested the hypothesis that the ultrafine fraction of ambient pollutant particles would cause endothelial cell dysfunction.
T6 413-421 Sentence denotes METHODS:
T7 422-661 Sentence denotes We profiled gene expression of human pulmonary artery endothelial cells (HPAEC) exposed to ultrafine particles (UFPs; 100 microg/mL) from Chapel Hill, North Carolina, or vehicle for 4 hr with Affymetrix HG U133 Plus 2.0 chips (n = 4 each).
T8 662-670 Sentence denotes RESULTS:
T9 671-768 Sentence denotes We found 320 up-regulated genes and 106 down-regulated genes (p < 0.01, 5% false discovery rate).
T10 769-979 Sentence denotes We noted up-regulation of genes related to coagulation [tissue factor (F3) and coagulation factor II receptor-like 2 (F2RL2)] and differential regulation of genes related to F3 signaling (FOS, JUN, and NFKBIA).
T11 980-1109 Sentence denotes Results of quantitative polymerase chain reaction show a significant up-regulation of F3 after 10 and 100 microg/mLUFP exposures.
T12 1110-1244 Sentence denotes Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1).
T13 1245-1337 Sentence denotes Treatment of HPAEC with UFPs for 16 hr increased the release of interleukin (IL)-6 and IL-8.
T14 1338-1457 Sentence denotes Pretreatment of HPAEC with a blocking antibody against F3 attenuated IL-6 and IL-8 release by 30 and 70%, respectively.
T15 1458-1470 Sentence denotes CONCLUSIONS:
T16 1471-1592 Sentence denotes Using gene profiling, we discovered that UFPs may induce vascular endothelial cells to express genes related to clotting.
T17 1593-1721 Sentence denotes These results indicate that PM may cause adverse cardiovascular health effects by activating coagulation-inflammation circuitry.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 1621-1623 DiseaseOrPhenotypicFeature denotes PM 0019127|0019168