> top > docs > PubMed:17444670 > annotations

PubMed:17444670 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
T2 93-189 Sentence denotes Spontaneous equine recurrent uveitis (ERU) is an incurable autoimmune disease affecting the eye.
T3 190-409 Sentence denotes Although retinal-autoantigen specific T-helper 1 cells have been demonstrated to trigger disease progression and relapses, the molecular processes leading to retinal degeneration and consequent blindness remain unknown.
T4 410-540 Sentence denotes To elucidate such processes, we studied changes in the total retinal proteome of ERU-diseased horses compared to healthy controls.
T5 541-698 Sentence denotes Severe changes in the retinal proteome were found for several markers for blood-retinal barrier breakdown and whose emergence depended upon disease severity.
T6 699-1022 Sentence denotes Additionally, uveitic changes in the retina were accompanied by upregulation of aldose 1-epimerase, selenium-binding protein 1, alpha crystallin A chain, phosphatase 2A inhibitor (SET), and glial fibrillary acidic protein (GFAP), the latter indicating an involvement of retinal Mueller glial cells (RMG) in disease process.
T7 1023-1221 Sentence denotes To confirm this, we screened for additional RMG-specific markers and could demonstrate that, in uveitic retinas, RMG concomitantly upregulate vimentin and GFAP and downregulate glutamine synthetase.
T8 1222-1469 Sentence denotes These expression patterns suggest for an activated state of RMG, which further downregulate the expression of pigment epithelium-derived factor (PEDF) and begin expressing interferon-gamma, a pro-inflammatory cytokine typical for T-helper 1 cells.
T9 1470-1651 Sentence denotes We thus propose that RMG may play a fatal role in uveitic disease progression by directly triggering inflammatory processes through the expression and secretion of interferon-gamma.
T1 0-92 Sentence denotes Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
T2 93-189 Sentence denotes Spontaneous equine recurrent uveitis (ERU) is an incurable autoimmune disease affecting the eye.
T3 190-409 Sentence denotes Although retinal-autoantigen specific T-helper 1 cells have been demonstrated to trigger disease progression and relapses, the molecular processes leading to retinal degeneration and consequent blindness remain unknown.
T4 410-540 Sentence denotes To elucidate such processes, we studied changes in the total retinal proteome of ERU-diseased horses compared to healthy controls.
T5 541-698 Sentence denotes Severe changes in the retinal proteome were found for several markers for blood-retinal barrier breakdown and whose emergence depended upon disease severity.
T6 699-1022 Sentence denotes Additionally, uveitic changes in the retina were accompanied by upregulation of aldose 1-epimerase, selenium-binding protein 1, alpha crystallin A chain, phosphatase 2A inhibitor (SET), and glial fibrillary acidic protein (GFAP), the latter indicating an involvement of retinal Mueller glial cells (RMG) in disease process.
T7 1023-1221 Sentence denotes To confirm this, we screened for additional RMG-specific markers and could demonstrate that, in uveitic retinas, RMG concomitantly upregulate vimentin and GFAP and downregulate glutamine synthetase.
T8 1222-1469 Sentence denotes These expression patterns suggest for an activated state of RMG, which further downregulate the expression of pigment epithelium-derived factor (PEDF) and begin expressing interferon-gamma, a pro-inflammatory cytokine typical for T-helper 1 cells.
T9 1470-1651 Sentence denotes We thus propose that RMG may play a fatal role in uveitic disease progression by directly triggering inflammatory processes through the expression and secretion of interferon-gamma.

LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
1 73-91 DiseaseOrPhenotypicFeature denotes autoimmune uveitis MESH:D014605
22 105-111 OrganismTaxon denotes equine Tax:9796
23 122-129 DiseaseOrPhenotypicFeature denotes uveitis MESH:D014605
24 152-170 DiseaseOrPhenotypicFeature denotes autoimmune disease MESH:D001327
25 348-368 DiseaseOrPhenotypicFeature denotes retinal degeneration MESH:D012162
26 384-393 DiseaseOrPhenotypicFeature denotes blindness MESH:D001766
27 504-510 OrganismTaxon denotes horses Tax:9796
28 713-720 DiseaseOrPhenotypicFeature denotes uveitic
29 799-825 GeneOrGeneProduct denotes selenium-binding protein 1 Gene:100034054
30 889-920 GeneOrGeneProduct denotes glial fibrillary acidic protein Gene:100033970
31 922-926 GeneOrGeneProduct denotes GFAP Gene:100033970
32 969-990 DiseaseOrPhenotypicFeature denotes retinal Mueller glial MESH:D012164
33 1119-1134 DiseaseOrPhenotypicFeature denotes uveitic retinas MESH:D019572
34 1165-1173 GeneOrGeneProduct denotes vimentin Gene:100056088
35 1178-1182 GeneOrGeneProduct denotes GFAP Gene:100033970
36 1200-1220 GeneOrGeneProduct denotes glutamine synthetase Gene:100054716
37 1332-1365 GeneOrGeneProduct denotes pigment epithelium-derived factor Gene:100072415
38 1367-1371 GeneOrGeneProduct denotes PEDF Gene:100072415
39 1394-1410 GeneOrGeneProduct denotes interferon-gamma Gene:100034181
40 1520-1535 DiseaseOrPhenotypicFeature denotes uveitic disease MESH:D004194
41 1634-1650 GeneOrGeneProduct denotes interferon-gamma Gene:100034181

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 49-61 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T2 84-91 DiseaseOrPhenotypicFeature denotes uveitis D014605
T3 122-129 DiseaseOrPhenotypicFeature denotes uveitis D014605
T4 152-170 DiseaseOrPhenotypicFeature denotes autoimmune disease D001327
T5 279-298 DiseaseOrPhenotypicFeature denotes disease progression D018450
T6 303-311 DiseaseOrPhenotypicFeature denotes relapses D012008
T7 348-368 DiseaseOrPhenotypicFeature denotes retinal degeneration D012162
T8 384-393 DiseaseOrPhenotypicFeature denotes blindness D001766
T9 495-510 DiseaseOrPhenotypicFeature denotes diseased horses D006734
T10 681-688 DiseaseOrPhenotypicFeature denotes disease D004194
T11 1006-1013 DiseaseOrPhenotypicFeature denotes disease D004194
T12 1418-1430 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T13 1528-1547 DiseaseOrPhenotypicFeature denotes disease progression D018450
T14 1571-1583 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE

LitCoin-PubTator_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 879-882 CellLine denotes SET CVCL_WY71

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 84-91 DiseaseOrPhenotypicFeature denotes uveitis D014605
T2 122-129 DiseaseOrPhenotypicFeature denotes uveitis D014605
T3 152-170 DiseaseOrPhenotypicFeature denotes autoimmune disease D001327
T4 348-368 DiseaseOrPhenotypicFeature denotes retinal degeneration D012162
T5 384-393 DiseaseOrPhenotypicFeature denotes blindness D001766
T6 495-510 DiseaseOrPhenotypicFeature denotes diseased horses D006734
T7 1414-1430 DiseaseOrPhenotypicFeature denotes pro-inflammatory DISEASE

sentences

Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
T2 93-189 Sentence denotes Spontaneous equine recurrent uveitis (ERU) is an incurable autoimmune disease affecting the eye.
T3 190-409 Sentence denotes Although retinal-autoantigen specific T-helper 1 cells have been demonstrated to trigger disease progression and relapses, the molecular processes leading to retinal degeneration and consequent blindness remain unknown.
T4 410-540 Sentence denotes To elucidate such processes, we studied changes in the total retinal proteome of ERU-diseased horses compared to healthy controls.
T5 541-698 Sentence denotes Severe changes in the retinal proteome were found for several markers for blood-retinal barrier breakdown and whose emergence depended upon disease severity.
T6 699-1022 Sentence denotes Additionally, uveitic changes in the retina were accompanied by upregulation of aldose 1-epimerase, selenium-binding protein 1, alpha crystallin A chain, phosphatase 2A inhibitor (SET), and glial fibrillary acidic protein (GFAP), the latter indicating an involvement of retinal Mueller glial cells (RMG) in disease process.
T7 1023-1221 Sentence denotes To confirm this, we screened for additional RMG-specific markers and could demonstrate that, in uveitic retinas, RMG concomitantly upregulate vimentin and GFAP and downregulate glutamine synthetase.
T8 1222-1469 Sentence denotes These expression patterns suggest for an activated state of RMG, which further downregulate the expression of pigment epithelium-derived factor (PEDF) and begin expressing interferon-gamma, a pro-inflammatory cytokine typical for T-helper 1 cells.
T9 1470-1651 Sentence denotes We thus propose that RMG may play a fatal role in uveitic disease progression by directly triggering inflammatory processes through the expression and secretion of interferon-gamma.
T1 0-92 Sentence denotes Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
T2 93-189 Sentence denotes Spontaneous equine recurrent uveitis (ERU) is an incurable autoimmune disease affecting the eye.
T3 190-409 Sentence denotes Although retinal-autoantigen specific T-helper 1 cells have been demonstrated to trigger disease progression and relapses, the molecular processes leading to retinal degeneration and consequent blindness remain unknown.
T4 410-540 Sentence denotes To elucidate such processes, we studied changes in the total retinal proteome of ERU-diseased horses compared to healthy controls.
T5 541-698 Sentence denotes Severe changes in the retinal proteome were found for several markers for blood-retinal barrier breakdown and whose emergence depended upon disease severity.
T6 699-1022 Sentence denotes Additionally, uveitic changes in the retina were accompanied by upregulation of aldose 1-epimerase, selenium-binding protein 1, alpha crystallin A chain, phosphatase 2A inhibitor (SET), and glial fibrillary acidic protein (GFAP), the latter indicating an involvement of retinal Mueller glial cells (RMG) in disease process.
T7 1023-1221 Sentence denotes To confirm this, we screened for additional RMG-specific markers and could demonstrate that, in uveitic retinas, RMG concomitantly upregulate vimentin and GFAP and downregulate glutamine synthetase.
T8 1222-1469 Sentence denotes These expression patterns suggest for an activated state of RMG, which further downregulate the expression of pigment epithelium-derived factor (PEDF) and begin expressing interferon-gamma, a pro-inflammatory cytokine typical for T-helper 1 cells.
T9 1470-1651 Sentence denotes We thus propose that RMG may play a fatal role in uveitic disease progression by directly triggering inflammatory processes through the expression and secretion of interferon-gamma.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 185-188 http://purl.obolibrary.org/obo/MAT_0000140 denotes eye
T2 615-620 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 615-620 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 736-742 http://purl.obolibrary.org/obo/MAT_0000142 denotes retina
T5 1127-1134 http://purl.obolibrary.org/obo/MAT_0000142 denotes retinas
T6 1332-1339 http://purl.obolibrary.org/obo/MAT_0000159 denotes pigment

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 152-170 HP_0002960 denotes autoimmune disease
T2 152-162 HP_0002960 denotes autoimmune
T3 348-368 HP_0000546 denotes retinal degeneration
T4 384-393 HP_0000618 denotes blindness
T5 954-976 HP_0000479 denotes involvement of retinal
T6 954-976 HP_0007901 denotes involvement of retinal

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 73-91 Disease denotes autoimmune uveitis http://purl.obolibrary.org/obo/MONDO_0031012
T2 122-129 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T3 152-170 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T4 348-368 Disease denotes retinal degeneration http://purl.obolibrary.org/obo/MONDO_0004580
T5 384-393 Disease denotes blindness http://purl.obolibrary.org/obo/MONDO_0001941
T6 495-510 Disease denotes diseased horses http://purl.obolibrary.org/obo/MONDO_0024950

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 185-188 Body_part denotes eye http://purl.obolibrary.org/obo/MAT_0000140
T2 615-620 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T4 736-742 Body_part denotes retina http://purl.obolibrary.org/obo/MAT_0000142
T5 1127-1134 Body_part denotes retinas http://purl.obolibrary.org/obo/MAT_0000142
T6 1332-1339 Body_part denotes pigment http://purl.obolibrary.org/obo/MAT_0000159

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 105-111 OrganismTaxon denotes equine 9796

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 16-27 Body_part denotes glial cells http://purl.obolibrary.org/obo/CL_0000125
T2 185-188 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000019|http://purl.obolibrary.org/obo/UBERON_0000970|http://purl.obolibrary.org/obo/UBERON_0010230
T5 615-620 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 736-742 Body_part denotes retina http://purl.obolibrary.org/obo/UBERON_0000966
T7 985-996 Body_part denotes glial cells http://purl.obolibrary.org/obo/CL_0000125
T8 1127-1134 Body_part denotes retinas http://purl.obolibrary.org/obo/UBERON_0000966
T9 1332-1350 Body_part denotes pigment epithelium http://purl.obolibrary.org/obo/UBERON_0001782

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 84-91 Phenotype denotes uveitis HP:0000554
T2 122-129 Phenotype denotes uveitis HP:0000554
T3 152-170 Phenotype denotes autoimmune disease HP:0002960
T4 348-368 Phenotype denotes retinal degeneration HP:0000546
T5 384-393 Phenotype denotes blindness HP:0000618

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 16-27 Cell denotes glial cells http://purl.obolibrary.org/obo/CL:0000125
T2 228-244 Cell denotes T-helper 1 cells http://purl.obolibrary.org/obo/CL:0000545
T3 985-996 Cell denotes glial cells http://purl.obolibrary.org/obo/CL:0000125
T4 1452-1468 Cell denotes T-helper 1 cells http://purl.obolibrary.org/obo/CL:0000545