PubMed:17436081
Annnotations
GlyCosmos600-GlycoGenes2
{"project":"GlyCosmos600-GlycoGenes2","denotations":[{"id":"T1","span":{"begin":199,"end":207},"obj":"https://acgg.asia/db/ggdb/info/gg007"},{"id":"T2","span":{"begin":334,"end":342},"obj":"https://acgg.asia/db/ggdb/info/gg007"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
GlyCosmos600-Glycan-Motif-Structure
{"project":"GlyCosmos600-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":1400,"end":1406},"obj":"https://glytoucan.org/Structures/Glycans/G00054MO"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
GlyCosmos600-CLO
{"project":"GlyCosmos600-CLO","denotations":[{"id":"T1","span":{"begin":139,"end":144},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":212,"end":216},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":280,"end":285},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4","span":{"begin":297,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5","span":{"begin":537,"end":542},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":624,"end":629},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7","span":{"begin":656,"end":661},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T8","span":{"begin":811,"end":815},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9","span":{"begin":928,"end":933},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T10","span":{"begin":990,"end":995},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11","span":{"begin":1029,"end":1034},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12","span":{"begin":1156,"end":1161},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T13","span":{"begin":1387,"end":1391},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
GlyCosmos6-Glycan-Motif-Image
{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":1400,"end":1406},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
GlyCosmos6-Glycan-Motif-Structure
{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":1400,"end":1406},"obj":"https://glytoucan.org/Structures/Glycans/G00054MO"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
DisGeNET
{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":874,"end":877},"obj":"gene:5599"},{"id":"T1","span":{"begin":952,"end":958},"obj":"disease:C3825627"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
PubmedHPO
{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":248,"end":272},"obj":"HP_0001402"},{"id":"T1","span":{"begin":248,"end":272},"obj":"HP_0001402"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
GlyCosmos600-FMA
{"project":"GlyCosmos600-FMA","denotations":[{"id":"T1","span":{"begin":139,"end":144},"obj":"Body_part"},{"id":"T2","span":{"begin":212,"end":216},"obj":"Body_part"},{"id":"T3","span":{"begin":280,"end":285},"obj":"Body_part"},{"id":"T4","span":{"begin":297,"end":302},"obj":"Body_part"},{"id":"T5","span":{"begin":441,"end":449},"obj":"Body_part"},{"id":"T6","span":{"begin":537,"end":542},"obj":"Body_part"},{"id":"T7","span":{"begin":624,"end":629},"obj":"Body_part"},{"id":"T8","span":{"begin":656,"end":661},"obj":"Body_part"},{"id":"T9","span":{"begin":811,"end":815},"obj":"Body_part"},{"id":"T10","span":{"begin":928,"end":933},"obj":"Body_part"},{"id":"T11","span":{"begin":990,"end":995},"obj":"Body_part"},{"id":"T12","span":{"begin":1029,"end":1034},"obj":"Body_part"},{"id":"T13","span":{"begin":1156,"end":1161},"obj":"Body_part"},{"id":"T14","span":{"begin":1251,"end":1258},"obj":"Body_part"},{"id":"T15","span":{"begin":1310,"end":1318},"obj":"Body_part"},{"id":"T16","span":{"begin":1378,"end":1382},"obj":"Body_part"},{"id":"T17","span":{"begin":1387,"end":1399},"obj":"Body_part"},{"id":"T18","span":{"begin":1387,"end":1391},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
GlyCosmos600-GlycoProteins
{"project":"GlyCosmos600-GlycoProteins","denotations":[{"id":"PD-GlycoProteins-B_T1","span":{"begin":1378,"end":1382},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005542"},{"id":"PD-GlycoProteins-B_T2","span":{"begin":1378,"end":1382},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005543"},{"id":"PD-GlycoProteins-B_T3","span":{"begin":1378,"end":1382},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005544"},{"id":"PD-GlycoProteins-B_T4","span":{"begin":1378,"end":1382},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005545"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
sentences
{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":145},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":146,"end":286},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":287,"end":630},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":631,"end":996},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":997,"end":1339},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":1340,"end":1633},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":145},"obj":"Sentence"},{"id":"T2","span":{"begin":146,"end":286},"obj":"Sentence"},{"id":"T3","span":{"begin":287,"end":630},"obj":"Sentence"},{"id":"T4","span":{"begin":631,"end":996},"obj":"Sentence"},{"id":"T5","span":{"begin":997,"end":1339},"obj":"Sentence"},{"id":"T6","span":{"begin":1340,"end":1633},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
pubmed-enju-pas
{"project":"pubmed-enju-pas","denotations":[{"id":"EnjuParser_T0","span":{"begin":0,"end":8},"obj":"NN"},{"id":"EnjuParser_T1","span":{"begin":9,"end":31},"obj":"NN"},{"id":"EnjuParser_T2","span":{"begin":32,"end":40},"obj":"VBZ"},{"id":"EnjuParser_T3","span":{"begin":41,"end":44},"obj":"DT"},{"id":"EnjuParser_T4","span":{"begin":45,"end":59},"obj":"NN"},{"id":"EnjuParser_T5","span":{"begin":60,"end":62},"obj":"IN"},{"id":"EnjuParser_T6","span":{"begin":63,"end":72},"obj":"NN"},{"id":"EnjuParser_T7","span":{"begin":73,"end":80},"obj":"VBN"},{"id":"EnjuParser_T8","span":{"begin":81,"end":83},"obj":"IN"},{"id":"EnjuParser_T9","span":{"begin":84,"end":95},"obj":"NN"},{"id":"EnjuParser_T10","span":{"begin":96,"end":99},"obj":"CC"},{"id":"EnjuParser_T11","span":{"begin":100,"end":108},"obj":"JJ"},{"id":"EnjuParser_T12","span":{"begin":109,"end":113},"obj":"NN"},{"id":"EnjuParser_T13","span":{"begin":114,"end":116},"obj":"IN"},{"id":"EnjuParser_T14","span":{"begin":117,"end":122},"obj":"JJ"},{"id":"EnjuParser_T15","span":{"begin":123,"end":138},"obj":"NN"},{"id":"EnjuParser_T16","span":{"begin":139,"end":144},"obj":"NNS"},{"id":"EnjuParser_T17","span":{"begin":146,"end":149},"obj":"DT"},{"id":"EnjuParser_T18","span":{"begin":150,"end":154},"obj":"NN"},{"id":"EnjuParser_T19","span":{"begin":155,"end":157},"obj":"IN"},{"id":"EnjuParser_T20","span":{"begin":158,"end":188},"obj":"NN"},{"id":"EnjuParser_T21","span":{"begin":189,"end":190},"obj":"-LRB-"},{"id":"EnjuParser_T22","span":{"begin":190,"end":198},"obj":"NN"},{"id":"EnjuParser_T23","span":{"begin":199,"end":207},"obj":"NN"},{"id":"EnjuParser_T24","span":{"begin":207,"end":208},"obj":"-RRB-"},{"id":"EnjuParser_T25","span":{"begin":209,"end":211},"obj":"IN"},{"id":"EnjuParser_T26","span":{"begin":212,"end":216},"obj":"NN"},{"id":"EnjuParser_T27","span":{"begin":217,"end":226},"obj":"NN"},{"id":"EnjuParser_T28","span":{"begin":227,"end":230},"obj":"VBD"},{"id":"EnjuParser_T29","span":{"begin":231,"end":238},"obj":"VBN"},{"id":"EnjuParser_T30","span":{"begin":239,"end":241},"obj":"IN"},{"id":"EnjuParser_T31","span":{"begin":242,"end":247},"obj":"JJ"},{"id":"EnjuParser_T32","span":{"begin":248,"end":262},"obj":"JJ"},{"id":"EnjuParser_T33","span":{"begin":263,"end":272},"obj":"NN"},{"id":"EnjuParser_T34","span":{"begin":273,"end":279},"obj":"NN"},{"id":"EnjuParser_T35","span":{"begin":280,"end":285},"obj":"NNS"},{"id":"EnjuParser_T36","span":{"begin":287,"end":292},"obj":"IN"},{"id":"EnjuParser_T37","span":{"begin":293,"end":296},"obj":"DT"},{"id":"EnjuParser_T38","span":{"begin":297,"end":302},"obj":"NNS"},{"id":"EnjuParser_T39","span":{"begin":303,"end":307},"obj":"VBD"},{"id":"EnjuParser_T40","span":{"begin":308,"end":319},"obj":"VBN"},{"id":"EnjuParser_T41","span":{"begin":320,"end":324},"obj":"IN"},{"id":"EnjuParser_T42","span":{"begin":325,"end":333},"obj":"NN"},{"id":"EnjuParser_T43","span":{"begin":334,"end":342},"obj":"NN"},{"id":"EnjuParser_T44","span":{"begin":343,"end":347},"obj":"NN"},{"id":"EnjuParser_T45","span":{"begin":347,"end":348},"obj":"-COMMA-"},{"id":"EnjuParser_T46","span":{"begin":349,"end":352},"obj":"DT"},{"id":"EnjuParser_T47","span":{"begin":353,"end":363},"obj":"NN"},{"id":"EnjuParser_T48","span":{"begin":364,"end":366},"obj":"IN"},{"id":"EnjuParser_T49","span":{"begin":367,"end":376},"obj":"JJ"},{"id":"EnjuParser_T50","span":{"begin":377,"end":385},"obj":"NN"},{"id":"EnjuParser_T51","span":{"begin":385,"end":386},"obj":"-COMMA-"},{"id":"EnjuParser_T52","span":{"begin":387,"end":399},"obj":"NN"},{"id":"EnjuParser_T53","span":{"begin":399,"end":400},"obj":"-COMMA-"},{"id":"EnjuParser_T54","span":{"begin":401,"end":404},"obj":"VBD"},{"id":"EnjuParser_T55","span":{"begin":405,"end":414},"obj":"VBN"},{"id":"EnjuParser_T56","span":{"begin":414,"end":415},"obj":"-COMMA-"},{"id":"EnjuParser_T57","span":{"begin":416,"end":421},"obj":"IN"},{"id":"EnjuParser_T58","span":{"begin":422,"end":425},"obj":"DT"},{"id":"EnjuParser_T59","span":{"begin":426,"end":440},"obj":"JJ"},{"id":"EnjuParser_T60","span":{"begin":441,"end":449},"obj":"NNS"},{"id":"EnjuParser_T61","span":{"begin":449,"end":450},"obj":"-COMMA-"},{"id":"EnjuParser_T62","span":{"begin":451,"end":462},"obj":"NN"},{"id":"EnjuParser_T63","span":{"begin":463,"end":466},"obj":"CC"},{"id":"EnjuParser_T64","span":{"begin":467,"end":478},"obj":"NN"},{"id":"EnjuParser_T65","span":{"begin":479,"end":483},"obj":"VBD"},{"id":"EnjuParser_T66","span":{"begin":484,"end":493},"obj":"VBN"},{"id":"EnjuParser_T67","span":{"begin":494,"end":496},"obj":"IN"},{"id":"EnjuParser_T68","span":{"begin":497,"end":505},"obj":"VBN"},{"id":"EnjuParser_T69","span":{"begin":506,"end":510},"obj":"IN"},{"id":"EnjuParser_T70","span":{"begin":511,"end":515},"obj":"JJ"},{"id":"EnjuParser_T71","span":{"begin":516,"end":517},"obj":"-LRB-"},{"id":"EnjuParser_T72","span":{"begin":517,"end":523},"obj":"NN"},{"id":"EnjuParser_T73","span":{"begin":523,"end":524},"obj":"-RRB-"},{"id":"EnjuParser_T74","span":{"begin":525,"end":536},"obj":"VBN"},{"id":"EnjuParser_T75","span":{"begin":537,"end":542},"obj":"NNS"},{"id":"EnjuParser_T76","span":{"begin":542,"end":543},"obj":"-COMMA-"},{"id":"EnjuParser_T77","span":{"begin":544,"end":554},"obj":"VBG"},{"id":"EnjuParser_T78","span":{"begin":555,"end":559},"obj":"IN"},{"id":"EnjuParser_T79","span":{"begin":560,"end":576},"obj":"NN"},{"id":"EnjuParser_T80","span":{"begin":577,"end":579},"obj":"VBZ"},{"id":"EnjuParser_T81","span":{"begin":580,"end":581},"obj":"DT"},{"id":"EnjuParser_T82","span":{"begin":582,"end":591},"obj":"JJ"},{"id":"EnjuParser_T83","span":{"begin":592,"end":606},"obj":"JJ"},{"id":"EnjuParser_T84","span":{"begin":607,"end":613},"obj":"NN"},{"id":"EnjuParser_T85","span":{"begin":614,"end":616},"obj":"IN"},{"id":"EnjuParser_T86","span":{"begin":617,"end":623},"obj":"NN"},{"id":"EnjuParser_T87","span":{"begin":624,"end":629},"obj":"NNS"},{"id":"EnjuParser_T88","span":{"begin":631,"end":636},"obj":"IN"},{"id":"EnjuParser_T89","span":{"begin":637,"end":638},"obj":"-DQS-"},{"id":"EnjuParser_T90","span":{"begin":638,"end":654},"obj":"NN"},{"id":"EnjuParser_T91","span":{"begin":654,"end":655},"obj":"''"},{"id":"EnjuParser_T92","span":{"begin":656,"end":661},"obj":"NNS"},{"id":"EnjuParser_T93","span":{"begin":662,"end":666},"obj":"VBD"},{"id":"EnjuParser_T94","span":{"begin":667,"end":677},"obj":"VBN"},{"id":"EnjuParser_T95","span":{"begin":678,"end":680},"obj":"IN"},{"id":"EnjuParser_T96","span":{"begin":681,"end":683},"obj":"NN"},{"id":"EnjuParser_T97","span":{"begin":684,"end":686},"obj":"TO"},{"id":"EnjuParser_T98","span":{"begin":687,"end":693},"obj":"VB"},{"id":"EnjuParser_T99","span":{"begin":694,"end":703},"obj":"NN"},{"id":"EnjuParser_T100","span":{"begin":703,"end":704},"obj":"-COMMA-"},{"id":"EnjuParser_T101","span":{"begin":705,"end":708},"obj":"DT"},{"id":"EnjuParser_T102","span":{"begin":709,"end":723},"obj":"JJ"},{"id":"EnjuParser_T103","span":{"begin":724,"end":733},"obj":"NN"},{"id":"EnjuParser_T104","span":{"begin":734,"end":736},"obj":"IN"},{"id":"EnjuParser_T105","span":{"begin":737,"end":753},"obj":"NN"},{"id":"EnjuParser_T106","span":{"begin":754,"end":760},"obj":"VBD"},{"id":"EnjuParser_T107","span":{"begin":761,"end":765},"obj":"RBR"},{"id":"EnjuParser_T108","span":{"begin":766,"end":774},"obj":"JJ"},{"id":"EnjuParser_T109","span":{"begin":774,"end":775},"obj":"-COMMA-"},{"id":"EnjuParser_T110","span":{"begin":776,"end":778},"obj":"IN"},{"id":"EnjuParser_T111","span":{"begin":779,"end":788},"obj":"VBN"},{"id":"EnjuParser_T112","span":{"begin":789,"end":791},"obj":"IN"},{"id":"EnjuParser_T113","span":{"begin":792,"end":795},"obj":"DT"},{"id":"EnjuParser_T114","span":{"begin":796,"end":800},"obj":"RBR"},{"id":"EnjuParser_T115","span":{"begin":801,"end":810},"obj":"JJ"},{"id":"EnjuParser_T116","span":{"begin":811,"end":815},"obj":"NN"},{"id":"EnjuParser_T117","span":{"begin":816,"end":817},"obj":"NN"},{"id":"EnjuParser_T118","span":{"begin":818,"end":821},"obj":"CC"},{"id":"EnjuParser_T119","span":{"begin":822,"end":828},"obj":"JJ"},{"id":"EnjuParser_T120","span":{"begin":829,"end":836},"obj":"JJ"},{"id":"EnjuParser_T121","span":{"begin":837,"end":846},"obj":"NN"},{"id":"EnjuParser_T122","span":{"begin":846,"end":847},"obj":"-COMMA-"},{"id":"EnjuParser_T123","span":{"begin":848,"end":852},"obj":"RBR"},{"id":"EnjuParser_T124","span":{"begin":853,"end":864},"obj":"JJ"},{"id":"EnjuParser_T125","span":{"begin":865,"end":869},"obj":"NN"},{"id":"EnjuParser_T126","span":{"begin":870,"end":873},"obj":"CC"},{"id":"EnjuParser_T127","span":{"begin":874,"end":877},"obj":"NN"},{"id":"EnjuParser_T128","span":{"begin":878,"end":879},"obj":"-LRB-"},{"id":"EnjuParser_T129","span":{"begin":879,"end":882},"obj":"CD"},{"id":"EnjuParser_T130","span":{"begin":883,"end":897},"obj":"JJ"},{"id":"EnjuParser_T131","span":{"begin":898,"end":907},"obj":"VBG"},{"id":"EnjuParser_T132","span":{"begin":908,"end":917},"obj":"NNS"},{"id":"EnjuParser_T133","span":{"begin":918,"end":920},"obj":"IN"},{"id":"EnjuParser_T134","span":{"begin":921,"end":927},"obj":"NN"},{"id":"EnjuParser_T135","span":{"begin":928,"end":933},"obj":"NNS"},{"id":"EnjuParser_T136","span":{"begin":934,"end":945},"obj":"JJ"},{"id":"EnjuParser_T137","span":{"begin":946,"end":948},"obj":"TO"},{"id":"EnjuParser_T138","span":{"begin":949,"end":951},"obj":"NN"},{"id":"EnjuParser_T139","span":{"begin":952,"end":958},"obj":"NN"},{"id":"EnjuParser_T140","span":{"begin":958,"end":959},"obj":"-RRB-"},{"id":"EnjuParser_T141","span":{"begin":960,"end":964},"obj":"WRB"},{"id":"EnjuParser_T142","span":{"begin":965,"end":973},"obj":"VBN"},{"id":"EnjuParser_T143","span":{"begin":974,"end":978},"obj":"IN"},{"id":"EnjuParser_T144","span":{"begin":979,"end":982},"obj":"DT"},{"id":"EnjuParser_T145","span":{"begin":983,"end":984},"obj":"-DQS-"},{"id":"EnjuParser_T146","span":{"begin":984,"end":988},"obj":"NNP"},{"id":"EnjuParser_T147","span":{"begin":988,"end":989},"obj":"''"},{"id":"EnjuParser_T148","span":{"begin":990,"end":995},"obj":"NNS"},{"id":"EnjuParser_T149","span":{"begin":997,"end":999},"obj":"IN"},{"id":"EnjuParser_T150","span":{"begin":1000,"end":1008},"obj":"NN"},{"id":"EnjuParser_T151","span":{"begin":1008,"end":1009},"obj":"-COMMA-"},{"id":"EnjuParser_T152","span":{"begin":1010,"end":1011},"obj":"-DQS-"},{"id":"EnjuParser_T153","span":{"begin":1011,"end":1027},"obj":"NN"},{"id":"EnjuParser_T154","span":{"begin":1027,"end":1028},"obj":"''"},{"id":"EnjuParser_T155","span":{"begin":1029,"end":1034},"obj":"NNS"},{"id":"EnjuParser_T156","span":{"begin":1035,"end":1046},"obj":"VBD"},{"id":"EnjuParser_T157","span":{"begin":1047,"end":1050},"obj":"DT"},{"id":"EnjuParser_T158","span":{"begin":1051,"end":1060},"obj":"NN"},{"id":"EnjuParser_T159","span":{"begin":1061,"end":1068},"obj":"VBN"},{"id":"EnjuParser_T160","span":{"begin":1069,"end":1071},"obj":"IN"},{"id":"EnjuParser_T161","span":{"begin":1072,"end":1081},"obj":"JJ"},{"id":"EnjuParser_T162","span":{"begin":1082,"end":1090},"obj":"JJ"},{"id":"EnjuParser_T163","span":{"begin":1091,"end":1095},"obj":"NN"},{"id":"EnjuParser_T164","span":{"begin":1096,"end":1097},"obj":"-LRB-"},{"id":"EnjuParser_T165","span":{"begin":1097,"end":1101},"obj":"NN"},{"id":"EnjuParser_T166","span":{"begin":1101,"end":1102},"obj":"-RRB-"},{"id":"EnjuParser_T167","span":{"begin":1102,"end":1103},"obj":"-COMMA-"},{"id":"EnjuParser_T168","span":{"begin":1104,"end":1109},"obj":"WDT"},{"id":"EnjuParser_T169","span":{"begin":1110,"end":1113},"obj":"VBD"},{"id":"EnjuParser_T170","span":{"begin":1114,"end":1122},"obj":"VBN"},{"id":"EnjuParser_T171","span":{"begin":1123,"end":1125},"obj":"IN"},{"id":"EnjuParser_T172","span":{"begin":1126,"end":1129},"obj":"DT"},{"id":"EnjuParser_T173","span":{"begin":1130,"end":1137},"obj":"JJR"},{"id":"EnjuParser_T174","span":{"begin":1138,"end":1144},"obj":"NN"},{"id":"EnjuParser_T175","span":{"begin":1145,"end":1146},"obj":"-LRB-"},{"id":"EnjuParser_T176","span":{"begin":1146,"end":1155},"obj":"JJ"},{"id":"EnjuParser_T177","span":{"begin":1156,"end":1161},"obj":"NNS"},{"id":"EnjuParser_T178","span":{"begin":1161,"end":1162},"obj":"-RRB-"},{"id":"EnjuParser_T179","span":{"begin":1163,"end":1167},"obj":"NN"},{"id":"EnjuParser_T180","span":{"begin":1168,"end":1170},"obj":"IN"},{"id":"EnjuParser_T181","span":{"begin":1171,"end":1175},"obj":"NN"},{"id":"EnjuParser_T182","span":{"begin":1176,"end":1185},"obj":"NN"},{"id":"EnjuParser_T183","span":{"begin":1186,"end":1194},"obj":"NN"},{"id":"EnjuParser_T184","span":{"begin":1194,"end":1195},"obj":"-COMMA-"},{"id":"EnjuParser_T185","span":{"begin":1196,"end":1200},"obj":"JJR"},{"id":"EnjuParser_T186","span":{"begin":1201,"end":1212},"obj":"NNS"},{"id":"EnjuParser_T187","span":{"begin":1213,"end":1215},"obj":"IN"},{"id":"EnjuParser_T188","span":{"begin":1216,"end":1222},"obj":"JJ"},{"id":"EnjuParser_T189","span":{"begin":1223,"end":1232},"obj":"NN"},{"id":"EnjuParser_T190","span":{"begin":1233,"end":1236},"obj":"CC"},{"id":"EnjuParser_T191","span":{"begin":1237,"end":1250},"obj":"JJ"},{"id":"EnjuParser_T192","span":{"begin":1251,"end":1258},"obj":"NN"},{"id":"EnjuParser_T193","span":{"begin":1259,"end":1262},"obj":"NN"},{"id":"EnjuParser_T194","span":{"begin":1262,"end":1263},"obj":"-COMMA-"},{"id":"EnjuParser_T195","span":{"begin":1264,"end":1266},"obj":"RB"},{"id":"EnjuParser_T196","span":{"begin":1267,"end":1271},"obj":"RB"},{"id":"EnjuParser_T197","span":{"begin":1272,"end":1274},"obj":"IN"},{"id":"EnjuParser_T198","span":{"begin":1275,"end":1279},"obj":"JJR"},{"id":"EnjuParser_T199","span":{"begin":1280,"end":1291},"obj":"NNS"},{"id":"EnjuParser_T200","span":{"begin":1292,"end":1294},"obj":"IN"},{"id":"EnjuParser_T201","span":{"begin":1295,"end":1309},"obj":"JJ"},{"id":"EnjuParser_T202","span":{"begin":1310,"end":1318},"obj":"NNS"},{"id":"EnjuParser_T203","span":{"begin":1318,"end":1319},"obj":"-COMMA-"},{"id":"EnjuParser_T204","span":{"begin":1320,"end":1325},"obj":"NN"},{"id":"EnjuParser_T205","span":{"begin":1326,"end":1329},"obj":"CC"},{"id":"EnjuParser_T206","span":{"begin":1330,"end":1335},"obj":"NN"},{"id":"EnjuParser_T207","span":{"begin":1335,"end":1336},"obj":"-LRB-"},{"id":"EnjuParser_T208","span":{"begin":1336,"end":1337},"obj":"NN"},{"id":"EnjuParser_T209","span":{"begin":1337,"end":1338},"obj":"-RRB-"},{"id":"EnjuParser_T210","span":{"begin":1340,"end":1343},"obj":"DT"},{"id":"EnjuParser_T211","span":{"begin":1344,"end":1346},"obj":"RP"},{"id":"EnjuParser_T212","span":{"begin":1347,"end":1357},"obj":"NN"},{"id":"EnjuParser_T213","span":{"begin":1358,"end":1360},"obj":"IN"},{"id":"EnjuParser_T214","span":{"begin":1361,"end":1377},"obj":"NN"},{"id":"EnjuParser_T215","span":{"begin":1378,"end":1382},"obj":"NN"},{"id":"EnjuParser_T216","span":{"begin":1383,"end":1386},"obj":"CC"},{"id":"EnjuParser_T217","span":{"begin":1387,"end":1391},"obj":"NN"},{"id":"EnjuParser_T218","span":{"begin":1392,"end":1399},"obj":"NN"},{"id":"EnjuParser_T219","span":{"begin":1400,"end":1403},"obj":"NN"},{"id":"EnjuParser_T220","span":{"begin":1403,"end":1404},"obj":"-LRB-"},{"id":"EnjuParser_T221","span":{"begin":1404,"end":1405},"obj":"NN"},{"id":"EnjuParser_T222","span":{"begin":1405,"end":1406},"obj":"-RRB-"},{"id":"EnjuParser_T223","span":{"begin":1407,"end":1408},"obj":"-LRB-"},{"id":"EnjuParser_T224","span":{"begin":1408,"end":1424},"obj":"NN"},{"id":"EnjuParser_T225","span":{"begin":1425,"end":1432},"obj":"NN"},{"id":"EnjuParser_T226","span":{"begin":1432,"end":1433},"obj":"-RRB-"},{"id":"EnjuParser_T227","span":{"begin":1434,"end":1436},"obj":"IN"},{"id":"EnjuParser_T228","span":{"begin":1437,"end":1439},"obj":"NN"},{"id":"EnjuParser_T229","span":{"begin":1440,"end":1443},"obj":"CC"},{"id":"EnjuParser_T230","span":{"begin":1444,"end":1448},"obj":"JJ"},{"id":"EnjuParser_T231","span":{"begin":1449,"end":1459},"obj":"NN"},{"id":"EnjuParser_T232","span":{"begin":1460,"end":1462},"obj":"IN"},{"id":"EnjuParser_T233","span":{"begin":1463,"end":1467},"obj":"PRP"},{"id":"EnjuParser_T234","span":{"begin":1468,"end":1470},"obj":"IN"},{"id":"EnjuParser_T235","span":{"begin":1471,"end":1475},"obj":"NN"},{"id":"EnjuParser_T236","span":{"begin":1476,"end":1479},"obj":"VBD"},{"id":"EnjuParser_T237","span":{"begin":1480,"end":1490},"obj":"VBN"},{"id":"EnjuParser_T238","span":{"begin":1491,"end":1493},"obj":"TO"},{"id":"EnjuParser_T239","span":{"begin":1494,"end":1496},"obj":"VB"},{"id":"EnjuParser_T240","span":{"begin":1497,"end":1500},"obj":"CD"},{"id":"EnjuParser_T241","span":{"begin":1501,"end":1503},"obj":"IN"},{"id":"EnjuParser_T242","span":{"begin":1504,"end":1507},"obj":"DT"},{"id":"EnjuParser_T243","span":{"begin":1508,"end":1518},"obj":"NNS"},{"id":"EnjuParser_T244","span":{"begin":1519,"end":1523},"obj":"IN"},{"id":"EnjuParser_T245","span":{"begin":1524,"end":1540},"obj":"NN"},{"id":"EnjuParser_T246","span":{"begin":1541,"end":1550},"obj":"VBD"},{"id":"EnjuParser_T247","span":{"begin":1551,"end":1554},"obj":"CC"},{"id":"EnjuParser_T248","span":{"begin":1555,"end":1564},"obj":"VBD"},{"id":"EnjuParser_T249","span":{"begin":1565,"end":1568},"obj":"DT"},{"id":"EnjuParser_T250","span":{"begin":1569,"end":1583},"obj":"NN"},{"id":"EnjuParser_T251","span":{"begin":1584,"end":1586},"obj":"IN"},{"id":"EnjuParser_T252","span":{"begin":1587,"end":1596},"obj":"NN"},{"id":"EnjuParser_T253","span":{"begin":1597,"end":1604},"obj":"VBN"},{"id":"EnjuParser_T254","span":{"begin":1605,"end":1607},"obj":"IN"},{"id":"EnjuParser_T255","span":{"begin":1608,"end":1610},"obj":"NN"},{"id":"EnjuParser_T256","span":{"begin":1611,"end":1614},"obj":"CC"},{"id":"EnjuParser_T257","span":{"begin":1615,"end":1619},"obj":"NN"},{"id":"EnjuParser_T258","span":{"begin":1620,"end":1632},"obj":"RB"}],"relations":[{"id":"EnjuParser_R0","pred":"arg1Of","subj":"EnjuParser_T1","obj":"EnjuParser_T0"},{"id":"EnjuParser_R1","pred":"arg1Of","subj":"EnjuParser_T1","obj":"EnjuParser_T2"},{"id":"EnjuParser_R2","pred":"arg2Of","subj":"EnjuParser_T4","obj":"EnjuParser_T2"},{"id":"EnjuParser_R3","pred":"arg1Of","subj":"EnjuParser_T4","obj":"EnjuParser_T3"},{"id":"EnjuParser_R4","pred":"arg1Of","subj":"EnjuParser_T4","obj":"EnjuParser_T5"},{"id":"EnjuParser_R5","pred":"arg2Of","subj":"EnjuParser_T6","obj":"EnjuParser_T5"},{"id":"EnjuParser_R6","pred":"arg1Of","subj":"EnjuParser_T10","obj":"EnjuParser_T7"},{"id":"EnjuParser_R7","pred":"arg2Of","subj":"EnjuParser_T6","obj":"EnjuParser_T7"},{"id":"EnjuParser_R8","pred":"arg2Of","subj":"EnjuParser_T10","obj":"EnjuParser_T8"},{"id":"EnjuParser_R9","pred":"arg1Of","subj":"EnjuParser_T9","obj":"EnjuParser_T10"},{"id":"EnjuParser_R10","pred":"arg2Of","subj":"EnjuParser_T12","obj":"EnjuParser_T10"},{"id":"EnjuParser_R11","pred":"arg1Of","subj":"EnjuParser_T12","obj":"EnjuParser_T11"},{"id":"EnjuParser_R12","pred":"arg1Of","subj":"EnjuParser_T10","obj":"EnjuParser_T13"},{"id":"EnjuParser_R13","pred":"arg2Of","subj":"EnjuParser_T16","obj":"EnjuParser_T13"},{"id":"EnjuParser_R14","pred":"arg1Of","subj":"EnjuParser_T16","obj":"EnjuParser_T14"},{"id":"EnjuParser_R15","pred":"arg1Of","subj":"EnjuParser_T16","obj":"EnjuParser_T15"},{"id":"EnjuParser_R16","pred":"arg1Of","subj":"EnjuParser_T18","obj":"EnjuParser_T17"},{"id":"EnjuParser_R17","pred":"arg1Of","subj":"EnjuParser_T18","obj":"EnjuParser_T19"},{"id":"EnjuParser_R18","pred":"arg2Of","subj":"EnjuParser_T20","obj":"EnjuParser_T19"},{"id":"EnjuParser_R19","pred":"arg1Of","subj":"EnjuParser_T20","obj":"EnjuParser_T21"},{"id":"EnjuParser_R20","pred":"arg2Of","subj":"EnjuParser_T23","obj":"EnjuParser_T21"},{"id":"EnjuParser_R21","pred":"arg3Of","subj":"EnjuParser_T24","obj":"EnjuParser_T21"},{"id":"EnjuParser_R22","pred":"arg1Of","subj":"EnjuParser_T23","obj":"EnjuParser_T22"},{"id":"EnjuParser_R23","pred":"arg1Of","subj":"EnjuParser_T18","obj":"EnjuParser_T25"},{"id":"EnjuParser_R24","pred":"arg2Of","subj":"EnjuParser_T27","obj":"EnjuParser_T25"},{"id":"EnjuParser_R25","pred":"arg1Of","subj":"EnjuParser_T27","obj":"EnjuParser_T26"},{"id":"EnjuParser_R26","pred":"arg1Of","subj":"EnjuParser_T18","obj":"EnjuParser_T28"},{"id":"EnjuParser_R27","pred":"arg2Of","subj":"EnjuParser_T29","obj":"EnjuParser_T28"},{"id":"EnjuParser_R28","pred":"arg2Of","subj":"EnjuParser_T18","obj":"EnjuParser_T29"},{"id":"EnjuParser_R29","pred":"arg1Of","subj":"EnjuParser_T29","obj":"EnjuParser_T30"},{"id":"EnjuParser_R30","pred":"arg2Of","subj":"EnjuParser_T35","obj":"EnjuParser_T30"},{"id":"EnjuParser_R31","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T31"},{"id":"EnjuParser_R32","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T32"},{"id":"EnjuParser_R33","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T33"},{"id":"EnjuParser_R34","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T34"},{"id":"EnjuParser_R35","pred":"arg1Of","subj":"EnjuParser_T55","obj":"EnjuParser_T36"},{"id":"EnjuParser_R36","pred":"arg2Of","subj":"EnjuParser_T40","obj":"EnjuParser_T36"},{"id":"EnjuParser_R37","pred":"arg1Of","subj":"EnjuParser_T38","obj":"EnjuParser_T37"},{"id":"EnjuParser_R38","pred":"arg1Of","subj":"EnjuParser_T38","obj":"EnjuParser_T39"},{"id":"EnjuParser_R39","pred":"arg2Of","subj":"EnjuParser_T40","obj":"EnjuParser_T39"},{"id":"EnjuParser_R40","pred":"arg2Of","subj":"EnjuParser_T38","obj":"EnjuParser_T40"},{"id":"EnjuParser_R41","pred":"arg1Of","subj":"EnjuParser_T40","obj":"EnjuParser_T41"},{"id":"EnjuParser_R42","pred":"arg2Of","subj":"EnjuParser_T44","obj":"EnjuParser_T41"},{"id":"EnjuParser_R43","pred":"arg1Of","subj":"EnjuParser_T44","obj":"EnjuParser_T42"},{"id":"EnjuParser_R44","pred":"arg1Of","subj":"EnjuParser_T44","obj":"EnjuParser_T43"},{"id":"EnjuParser_R45","pred":"arg1Of","subj":"EnjuParser_T55","obj":"EnjuParser_T45"},{"id":"EnjuParser_R46","pred":"arg1Of","subj":"EnjuParser_T47","obj":"EnjuParser_T46"},{"id":"EnjuParser_R47","pred":"arg1Of","subj":"EnjuParser_T47","obj":"EnjuParser_T48"},{"id":"EnjuParser_R48","pred":"arg2Of","subj":"EnjuParser_T50","obj":"EnjuParser_T48"},{"id":"EnjuParser_R49","pred":"arg1Of","subj":"EnjuParser_T50","obj":"EnjuParser_T49"},{"id":"EnjuParser_R50","pred":"arg1Of","subj":"EnjuParser_T50","obj":"EnjuParser_T51"},{"id":"EnjuParser_R51","pred":"arg2Of","subj":"EnjuParser_T52","obj":"EnjuParser_T51"},{"id":"EnjuParser_R52","pred":"arg1Of","subj":"EnjuParser_T55","obj":"EnjuParser_T53"},{"id":"EnjuParser_R53","pred":"arg1Of","subj":"EnjuParser_T47","obj":"EnjuParser_T54"},{"id":"EnjuParser_R54","pred":"arg2Of","subj":"EnjuParser_T55","obj":"EnjuParser_T54"},{"id":"EnjuParser_R55","pred":"arg2Of","subj":"EnjuParser_T47","obj":"EnjuParser_T55"},{"id":"EnjuParser_R56","pred":"arg3Of","subj":"EnjuParser_T77","obj":"EnjuParser_T55"},{"id":"EnjuParser_R57","pred":"arg1Of","subj":"EnjuParser_T55","obj":"EnjuParser_T56"},{"id":"EnjuParser_R58","pred":"arg1Of","subj":"EnjuParser_T55","obj":"EnjuParser_T57"},{"id":"EnjuParser_R59","pred":"arg2Of","subj":"EnjuParser_T66","obj":"EnjuParser_T57"},{"id":"EnjuParser_R60","pred":"arg1Of","subj":"EnjuParser_T60","obj":"EnjuParser_T58"},{"id":"EnjuParser_R61","pred":"arg1Of","subj":"EnjuParser_T60","obj":"EnjuParser_T59"},{"id":"EnjuParser_R62","pred":"arg1Of","subj":"EnjuParser_T60","obj":"EnjuParser_T61"},{"id":"EnjuParser_R63","pred":"arg2Of","subj":"EnjuParser_T63","obj":"EnjuParser_T61"},{"id":"EnjuParser_R64","pred":"arg1Of","subj":"EnjuParser_T62","obj":"EnjuParser_T63"},{"id":"EnjuParser_R65","pred":"arg2Of","subj":"EnjuParser_T64","obj":"EnjuParser_T63"},{"id":"EnjuParser_R66","pred":"arg1Of","subj":"EnjuParser_T60","obj":"EnjuParser_T65"},{"id":"EnjuParser_R67","pred":"arg2Of","subj":"EnjuParser_T66","obj":"EnjuParser_T65"},{"id":"EnjuParser_R68","pred":"arg2Of","subj":"EnjuParser_T60","obj":"EnjuParser_T66"},{"id":"EnjuParser_R69","pred":"arg1Of","subj":"EnjuParser_T66","obj":"EnjuParser_T67"},{"id":"EnjuParser_R70","pred":"arg2Of","subj":"EnjuParser_T68","obj":"EnjuParser_T67"},{"id":"EnjuParser_R71","pred":"arg1Of","subj":"EnjuParser_T68","obj":"EnjuParser_T69"},{"id":"EnjuParser_R72","pred":"arg2Of","subj":"EnjuParser_T75","obj":"EnjuParser_T69"},{"id":"EnjuParser_R73","pred":"arg1Of","subj":"EnjuParser_T75","obj":"EnjuParser_T70"},{"id":"EnjuParser_R74","pred":"arg1Of","subj":"EnjuParser_T70","obj":"EnjuParser_T71"},{"id":"EnjuParser_R75","pred":"arg2Of","subj":"EnjuParser_T72","obj":"EnjuParser_T71"},{"id":"EnjuParser_R76","pred":"arg3Of","subj":"EnjuParser_T73","obj":"EnjuParser_T71"},{"id":"EnjuParser_R77","pred":"arg2Of","subj":"EnjuParser_T75","obj":"EnjuParser_T74"},{"id":"EnjuParser_R78","pred":"arg1Of","subj":"EnjuParser_T55","obj":"EnjuParser_T76"},{"id":"EnjuParser_R79","pred":"arg2Of","subj":"EnjuParser_T80","obj":"EnjuParser_T77"},{"id":"EnjuParser_R80","pred":"arg1Of","subj":"EnjuParser_T80","obj":"EnjuParser_T78"},{"id":"EnjuParser_R81","pred":"arg1Of","subj":"EnjuParser_T79","obj":"EnjuParser_T80"},{"id":"EnjuParser_R82","pred":"arg2Of","subj":"EnjuParser_T84","obj":"EnjuParser_T80"},{"id":"EnjuParser_R83","pred":"arg1Of","subj":"EnjuParser_T84","obj":"EnjuParser_T81"},{"id":"EnjuParser_R84","pred":"arg1Of","subj":"EnjuParser_T84","obj":"EnjuParser_T82"},{"id":"EnjuParser_R85","pred":"arg1Of","subj":"EnjuParser_T84","obj":"EnjuParser_T83"},{"id":"EnjuParser_R86","pred":"arg1Of","subj":"EnjuParser_T84","obj":"EnjuParser_T85"},{"id":"EnjuParser_R87","pred":"arg2Of","subj":"EnjuParser_T87","obj":"EnjuParser_T85"},{"id":"EnjuParser_R88","pred":"arg1Of","subj":"EnjuParser_T87","obj":"EnjuParser_T86"},{"id":"EnjuParser_R89","pred":"arg1Of","subj":"EnjuParser_T106","obj":"EnjuParser_T88"},{"id":"EnjuParser_R90","pred":"arg2Of","subj":"EnjuParser_T94","obj":"EnjuParser_T88"},{"id":"EnjuParser_R91","pred":"arg1Of","subj":"EnjuParser_T92","obj":"EnjuParser_T89"},{"id":"EnjuParser_R92","pred":"arg1Of","subj":"EnjuParser_T92","obj":"EnjuParser_T90"},{"id":"EnjuParser_R93","pred":"arg1Of","subj":"EnjuParser_T92","obj":"EnjuParser_T91"},{"id":"EnjuParser_R94","pred":"arg1Of","subj":"EnjuParser_T92","obj":"EnjuParser_T93"},{"id":"EnjuParser_R95","pred":"arg2Of","subj":"EnjuParser_T94","obj":"EnjuParser_T93"},{"id":"EnjuParser_R96","pred":"arg2Of","subj":"EnjuParser_T92","obj":"EnjuParser_T94"},{"id":"EnjuParser_R97","pred":"arg3Of","subj":"EnjuParser_T98","obj":"EnjuParser_T94"},{"id":"EnjuParser_R98","pred":"arg1Of","subj":"EnjuParser_T94","obj":"EnjuParser_T95"},{"id":"EnjuParser_R99","pred":"arg2Of","subj":"EnjuParser_T96","obj":"EnjuParser_T95"},{"id":"EnjuParser_R100","pred":"arg1Of","subj":"EnjuParser_T98","obj":"EnjuParser_T97"},{"id":"EnjuParser_R101","pred":"arg1Of","subj":"EnjuParser_T92","obj":"EnjuParser_T98"},{"id":"EnjuParser_R102","pred":"arg2Of","subj":"EnjuParser_T99","obj":"EnjuParser_T98"},{"id":"EnjuParser_R103","pred":"arg1Of","subj":"EnjuParser_T106","obj":"EnjuParser_T100"},{"id":"EnjuParser_R104","pred":"arg1Of","subj":"EnjuParser_T103","obj":"EnjuParser_T101"},{"id":"EnjuParser_R105","pred":"arg1Of","subj":"EnjuParser_T103","obj":"EnjuParser_T102"},{"id":"EnjuParser_R106","pred":"arg1Of","subj":"EnjuParser_T103","obj":"EnjuParser_T104"},{"id":"EnjuParser_R107","pred":"arg2Of","subj":"EnjuParser_T105","obj":"EnjuParser_T104"},{"id":"EnjuParser_R108","pred":"arg1Of","subj":"EnjuParser_T103","obj":"EnjuParser_T106"},{"id":"EnjuParser_R109","pred":"arg2Of","subj":"EnjuParser_T108","obj":"EnjuParser_T106"},{"id":"EnjuParser_R110","pred":"arg1Of","subj":"EnjuParser_T108","obj":"EnjuParser_T107"},{"id":"EnjuParser_R111","pred":"arg1Of","subj":"EnjuParser_T103","obj":"EnjuParser_T108"},{"id":"EnjuParser_R112","pred":"arg1Of","subj":"EnjuParser_T106","obj":"EnjuParser_T109"},{"id":"EnjuParser_R113","pred":"arg1Of","subj":"EnjuParser_T106","obj":"EnjuParser_T110"},{"id":"EnjuParser_R114","pred":"arg2Of","subj":"EnjuParser_T111","obj":"EnjuParser_T110"},{"id":"EnjuParser_R115","pred":"arg1Of","subj":"EnjuParser_T111","obj":"EnjuParser_T112"},{"id":"EnjuParser_R116","pred":"arg2Of","subj":"EnjuParser_T126","obj":"EnjuParser_T112"},{"id":"EnjuParser_R117","pred":"arg1Of","subj":"EnjuParser_T126","obj":"EnjuParser_T113"},{"id":"EnjuParser_R118","pred":"arg1Of","subj":"EnjuParser_T115","obj":"EnjuParser_T114"},{"id":"EnjuParser_R119","pred":"arg1Of","subj":"EnjuParser_T126","obj":"EnjuParser_T115"},{"id":"EnjuParser_R120","pred":"arg1Of","subj":"EnjuParser_T117","obj":"EnjuParser_T116"},{"id":"EnjuParser_R121","pred":"arg1Of","subj":"EnjuParser_T126","obj":"EnjuParser_T117"},{"id":"EnjuParser_R122","pred":"arg1Of","subj":"EnjuParser_T117","obj":"EnjuParser_T118"},{"id":"EnjuParser_R123","pred":"arg2Of","subj":"EnjuParser_T119","obj":"EnjuParser_T118"},{"id":"EnjuParser_R124","pred":"arg1Of","subj":"EnjuParser_T126","obj":"EnjuParser_T119"},{"id":"EnjuParser_R125","pred":"arg1Of","subj":"EnjuParser_T126","obj":"EnjuParser_T120"},{"id":"EnjuParser_R126","pred":"arg1Of","subj":"EnjuParser_T120","obj":"EnjuParser_T121"},{"id":"EnjuParser_R127","pred":"arg1Of","subj":"EnjuParser_T120","obj":"EnjuParser_T122"},{"id":"EnjuParser_R128","pred":"arg2Of","subj":"EnjuParser_T124","obj":"EnjuParser_T122"},{"id":"EnjuParser_R129","pred":"arg1Of","subj":"EnjuParser_T124","obj":"EnjuParser_T123"},{"id":"EnjuParser_R130","pred":"arg1Of","subj":"EnjuParser_T126","obj":"EnjuParser_T124"},{"id":"EnjuParser_R131","pred":"arg1Of","subj":"EnjuParser_T125","obj":"EnjuParser_T126"},{"id":"EnjuParser_R132","pred":"arg2Of","subj":"EnjuParser_T127","obj":"EnjuParser_T126"},{"id":"EnjuParser_R133","pred":"arg1Of","subj":"EnjuParser_T126","obj":"EnjuParser_T128"},{"id":"EnjuParser_R134","pred":"arg2Of","subj":"EnjuParser_T132","obj":"EnjuParser_T128"},{"id":"EnjuParser_R135","pred":"arg3Of","subj":"EnjuParser_T140","obj":"EnjuParser_T128"},{"id":"EnjuParser_R136","pred":"arg1Of","subj":"EnjuParser_T132","obj":"EnjuParser_T129"},{"id":"EnjuParser_R137","pred":"arg1Of","subj":"EnjuParser_T132","obj":"EnjuParser_T130"},{"id":"EnjuParser_R138","pred":"arg1Of","subj":"EnjuParser_T132","obj":"EnjuParser_T131"},{"id":"EnjuParser_R139","pred":"arg1Of","subj":"EnjuParser_T132","obj":"EnjuParser_T133"},{"id":"EnjuParser_R140","pred":"arg2Of","subj":"EnjuParser_T135","obj":"EnjuParser_T133"},{"id":"EnjuParser_R141","pred":"arg1Of","subj":"EnjuParser_T135","obj":"EnjuParser_T134"},{"id":"EnjuParser_R142","pred":"arg1Of","subj":"EnjuParser_T135","obj":"EnjuParser_T136"},{"id":"EnjuParser_R143","pred":"arg1Of","subj":"EnjuParser_T136","obj":"EnjuParser_T137"},{"id":"EnjuParser_R144","pred":"arg2Of","subj":"EnjuParser_T139","obj":"EnjuParser_T137"},{"id":"EnjuParser_R145","pred":"arg1Of","subj":"EnjuParser_T139","obj":"EnjuParser_T138"},{"id":"EnjuParser_R146","pred":"arg1Of","subj":"EnjuParser_T111","obj":"EnjuParser_T141"},{"id":"EnjuParser_R147","pred":"arg2Of","subj":"EnjuParser_T142","obj":"EnjuParser_T141"},{"id":"EnjuParser_R148","pred":"arg1Of","subj":"EnjuParser_T142","obj":"EnjuParser_T143"},{"id":"EnjuParser_R149","pred":"arg2Of","subj":"EnjuParser_T148","obj":"EnjuParser_T143"},{"id":"EnjuParser_R150","pred":"arg1Of","subj":"EnjuParser_T148","obj":"EnjuParser_T144"},{"id":"EnjuParser_R151","pred":"arg1Of","subj":"EnjuParser_T148","obj":"EnjuParser_T145"},{"id":"EnjuParser_R152","pred":"arg1Of","subj":"EnjuParser_T148","obj":"EnjuParser_T146"},{"id":"EnjuParser_R153","pred":"arg1Of","subj":"EnjuParser_T148","obj":"EnjuParser_T147"},{"id":"EnjuParser_R154","pred":"arg1Of","subj":"EnjuParser_T156","obj":"EnjuParser_T149"},{"id":"EnjuParser_R155","pred":"arg2Of","subj":"EnjuParser_T150","obj":"EnjuParser_T149"},{"id":"EnjuParser_R156","pred":"arg1Of","subj":"EnjuParser_T156","obj":"EnjuParser_T151"},{"id":"EnjuParser_R157","pred":"arg1Of","subj":"EnjuParser_T155","obj":"EnjuParser_T152"},{"id":"EnjuParser_R158","pred":"arg1Of","subj":"EnjuParser_T155","obj":"EnjuParser_T153"},{"id":"EnjuParser_R159","pred":"arg1Of","subj":"EnjuParser_T155","obj":"EnjuParser_T154"},{"id":"EnjuParser_R160","pred":"arg1Of","subj":"EnjuParser_T155","obj":"EnjuParser_T156"},{"id":"EnjuParser_R161","pred":"arg2Of","subj":"EnjuParser_T158","obj":"EnjuParser_T156"},{"id":"EnjuParser_R162","pred":"arg1Of","subj":"EnjuParser_T158","obj":"EnjuParser_T157"},{"id":"EnjuParser_R163","pred":"arg1Of","subj":"EnjuParser_T163","obj":"EnjuParser_T159"},{"id":"EnjuParser_R164","pred":"arg2Of","subj":"EnjuParser_T158","obj":"EnjuParser_T159"},{"id":"EnjuParser_R165","pred":"arg2Of","subj":"EnjuParser_T163","obj":"EnjuParser_T160"},{"id":"EnjuParser_R166","pred":"arg1Of","subj":"EnjuParser_T163","obj":"EnjuParser_T161"},{"id":"EnjuParser_R167","pred":"arg1Of","subj":"EnjuParser_T163","obj":"EnjuParser_T162"},{"id":"EnjuParser_R168","pred":"arg1Of","subj":"EnjuParser_T163","obj":"EnjuParser_T164"},{"id":"EnjuParser_R169","pred":"arg2Of","subj":"EnjuParser_T165","obj":"EnjuParser_T164"},{"id":"EnjuParser_R170","pred":"arg3Of","subj":"EnjuParser_T166","obj":"EnjuParser_T164"},{"id":"EnjuParser_R171","pred":"arg1Of","subj":"EnjuParser_T163","obj":"EnjuParser_T167"},{"id":"EnjuParser_R172","pred":"arg1Of","subj":"EnjuParser_T163","obj":"EnjuParser_T168"},{"id":"EnjuParser_R173","pred":"arg1Of","subj":"EnjuParser_T163","obj":"EnjuParser_T169"},{"id":"EnjuParser_R174","pred":"arg2Of","subj":"EnjuParser_T170","obj":"EnjuParser_T169"},{"id":"EnjuParser_R175","pred":"arg1Of","subj":"EnjuParser_T179","obj":"EnjuParser_T170"},{"id":"EnjuParser_R176","pred":"arg2Of","subj":"EnjuParser_T163","obj":"EnjuParser_T170"},{"id":"EnjuParser_R177","pred":"arg2Of","subj":"EnjuParser_T179","obj":"EnjuParser_T171"},{"id":"EnjuParser_R178","pred":"arg1Of","subj":"EnjuParser_T179","obj":"EnjuParser_T172"},{"id":"EnjuParser_R179","pred":"arg1Of","subj":"EnjuParser_T174","obj":"EnjuParser_T173"},{"id":"EnjuParser_R180","pred":"arg1Of","subj":"EnjuParser_T179","obj":"EnjuParser_T174"},{"id":"EnjuParser_R181","pred":"arg1Of","subj":"EnjuParser_T174","obj":"EnjuParser_T175"},{"id":"EnjuParser_R182","pred":"arg2Of","subj":"EnjuParser_T177","obj":"EnjuParser_T175"},{"id":"EnjuParser_R183","pred":"arg3Of","subj":"EnjuParser_T178","obj":"EnjuParser_T175"},{"id":"EnjuParser_R184","pred":"arg1Of","subj":"EnjuParser_T177","obj":"EnjuParser_T176"},{"id":"EnjuParser_R185","pred":"arg1Of","subj":"EnjuParser_T170","obj":"EnjuParser_T180"},{"id":"EnjuParser_R186","pred":"arg2Of","subj":"EnjuParser_T197","obj":"EnjuParser_T180"},{"id":"EnjuParser_R187","pred":"arg1Of","subj":"EnjuParser_T183","obj":"EnjuParser_T181"},{"id":"EnjuParser_R188","pred":"arg1Of","subj":"EnjuParser_T183","obj":"EnjuParser_T182"},{"id":"EnjuParser_R189","pred":"arg1Of","subj":"EnjuParser_T183","obj":"EnjuParser_T184"},{"id":"EnjuParser_R190","pred":"arg2Of","subj":"EnjuParser_T186","obj":"EnjuParser_T184"},{"id":"EnjuParser_R191","pred":"arg1Of","subj":"EnjuParser_T186","obj":"EnjuParser_T185"},{"id":"EnjuParser_R192","pred":"arg1Of","subj":"EnjuParser_T186","obj":"EnjuParser_T187"},{"id":"EnjuParser_R193","pred":"arg2Of","subj":"EnjuParser_T190","obj":"EnjuParser_T187"},{"id":"EnjuParser_R194","pred":"arg1Of","subj":"EnjuParser_T189","obj":"EnjuParser_T188"},{"id":"EnjuParser_R195","pred":"arg1Of","subj":"EnjuParser_T189","obj":"EnjuParser_T190"},{"id":"EnjuParser_R196","pred":"arg2Of","subj":"EnjuParser_T193","obj":"EnjuParser_T190"},{"id":"EnjuParser_R197","pred":"arg1Of","subj":"EnjuParser_T193","obj":"EnjuParser_T191"},{"id":"EnjuParser_R198","pred":"arg1Of","subj":"EnjuParser_T193","obj":"EnjuParser_T192"},{"id":"EnjuParser_R199","pred":"arg1Of","subj":"EnjuParser_T197","obj":"EnjuParser_T194"},{"id":"EnjuParser_R200","pred":"arg1Of","subj":"EnjuParser_T197","obj":"EnjuParser_T195"},{"id":"EnjuParser_R201","pred":"arg1Of","subj":"EnjuParser_T197","obj":"EnjuParser_T196"},{"id":"EnjuParser_R202","pred":"arg1Of","subj":"EnjuParser_T184","obj":"EnjuParser_T197"},{"id":"EnjuParser_R203","pred":"arg2Of","subj":"EnjuParser_T199","obj":"EnjuParser_T197"},{"id":"EnjuParser_R204","pred":"arg1Of","subj":"EnjuParser_T199","obj":"EnjuParser_T198"},{"id":"EnjuParser_R205","pred":"arg1Of","subj":"EnjuParser_T199","obj":"EnjuParser_T200"},{"id":"EnjuParser_R206","pred":"arg2Of","subj":"EnjuParser_T202","obj":"EnjuParser_T200"},{"id":"EnjuParser_R207","pred":"arg1Of","subj":"EnjuParser_T202","obj":"EnjuParser_T201"},{"id":"EnjuParser_R208","pred":"arg1Of","subj":"EnjuParser_T202","obj":"EnjuParser_T203"},{"id":"EnjuParser_R209","pred":"arg2Of","subj":"EnjuParser_T205","obj":"EnjuParser_T203"},{"id":"EnjuParser_R210","pred":"arg1Of","subj":"EnjuParser_T204","obj":"EnjuParser_T205"},{"id":"EnjuParser_R211","pred":"arg2Of","subj":"EnjuParser_T206","obj":"EnjuParser_T205"},{"id":"EnjuParser_R212","pred":"arg1Of","subj":"EnjuParser_T205","obj":"EnjuParser_T207"},{"id":"EnjuParser_R213","pred":"arg2Of","subj":"EnjuParser_T208","obj":"EnjuParser_T207"},{"id":"EnjuParser_R214","pred":"arg3Of","subj":"EnjuParser_T209","obj":"EnjuParser_T207"},{"id":"EnjuParser_R215","pred":"arg1Of","subj":"EnjuParser_T211","obj":"EnjuParser_T210"},{"id":"EnjuParser_R216","pred":"arg1Of","subj":"EnjuParser_T212","obj":"EnjuParser_T213"},{"id":"EnjuParser_R217","pred":"arg2Of","subj":"EnjuParser_T215","obj":"EnjuParser_T213"},{"id":"EnjuParser_R218","pred":"arg1Of","subj":"EnjuParser_T215","obj":"EnjuParser_T214"},{"id":"EnjuParser_R219","pred":"arg1Of","subj":"EnjuParser_T212","obj":"EnjuParser_T216"},{"id":"EnjuParser_R220","pred":"arg2Of","subj":"EnjuParser_T219","obj":"EnjuParser_T216"},{"id":"EnjuParser_R221","pred":"arg1Of","subj":"EnjuParser_T219","obj":"EnjuParser_T217"},{"id":"EnjuParser_R222","pred":"arg1Of","subj":"EnjuParser_T219","obj":"EnjuParser_T218"},{"id":"EnjuParser_R223","pred":"arg1Of","subj":"EnjuParser_T219","obj":"EnjuParser_T220"},{"id":"EnjuParser_R224","pred":"arg2Of","subj":"EnjuParser_T221","obj":"EnjuParser_T220"},{"id":"EnjuParser_R225","pred":"arg3Of","subj":"EnjuParser_T222","obj":"EnjuParser_T220"},{"id":"EnjuParser_R226","pred":"arg1Of","subj":"EnjuParser_T228","obj":"EnjuParser_T223"},{"id":"EnjuParser_R227","pred":"arg2Of","subj":"EnjuParser_T225","obj":"EnjuParser_T223"},{"id":"EnjuParser_R228","pred":"arg3Of","subj":"EnjuParser_T226","obj":"EnjuParser_T223"},{"id":"EnjuParser_R229","pred":"arg1Of","subj":"EnjuParser_T225","obj":"EnjuParser_T224"},{"id":"EnjuParser_R230","pred":"arg1Of","subj":"EnjuParser_T228","obj":"EnjuParser_T227"},{"id":"EnjuParser_R231","pred":"arg1Of","subj":"EnjuParser_T228","obj":"EnjuParser_T229"},{"id":"EnjuParser_R232","pred":"arg2Of","subj":"EnjuParser_T231","obj":"EnjuParser_T229"},{"id":"EnjuParser_R233","pred":"arg1Of","subj":"EnjuParser_T231","obj":"EnjuParser_T230"},{"id":"EnjuParser_R234","pred":"arg1Of","subj":"EnjuParser_T231","obj":"EnjuParser_T232"},{"id":"EnjuParser_R235","pred":"arg2Of","subj":"EnjuParser_T233","obj":"EnjuParser_T232"},{"id":"EnjuParser_R236","pred":"arg1Of","subj":"EnjuParser_T229","obj":"EnjuParser_T234"},{"id":"EnjuParser_R237","pred":"arg2Of","subj":"EnjuParser_T235","obj":"EnjuParser_T234"},{"id":"EnjuParser_R238","pred":"arg1Of","subj":"EnjuParser_T229","obj":"EnjuParser_T236"},{"id":"EnjuParser_R239","pred":"arg2Of","subj":"EnjuParser_T216","obj":"EnjuParser_T236"},{"id":"EnjuParser_R240","pred":"arg1Of","subj":"EnjuParser_T216","obj":"EnjuParser_T237"},{"id":"EnjuParser_R241","pred":"arg1Of","subj":"EnjuParser_T239","obj":"EnjuParser_T238"},{"id":"EnjuParser_R242","pred":"modOf","subj":"EnjuParser_T237","obj":"EnjuParser_T238"},{"id":"EnjuParser_R243","pred":"arg2Of","subj":"EnjuParser_T211","obj":"EnjuParser_T239"},{"id":"EnjuParser_R244","pred":"arg1Of","subj":"EnjuParser_T237","obj":"EnjuParser_T240"},{"id":"EnjuParser_R245","pred":"arg1Of","subj":"EnjuParser_T240","obj":"EnjuParser_T241"},{"id":"EnjuParser_R246","pred":"arg2Of","subj":"EnjuParser_T243","obj":"EnjuParser_T241"},{"id":"EnjuParser_R247","pred":"arg1Of","subj":"EnjuParser_T243","obj":"EnjuParser_T242"},{"id":"EnjuParser_R248","pred":"arg1Of","subj":"EnjuParser_T243","obj":"EnjuParser_T244"},{"id":"EnjuParser_R249","pred":"arg2Of","subj":"EnjuParser_T247","obj":"EnjuParser_T244"},{"id":"EnjuParser_R250","pred":"arg1Of","subj":"EnjuParser_T245","obj":"EnjuParser_T246"},{"id":"EnjuParser_R251","pred":"arg2Of","subj":"EnjuParser_T250","obj":"EnjuParser_T246"},{"id":"EnjuParser_R252","pred":"arg1Of","subj":"EnjuParser_T246","obj":"EnjuParser_T247"},{"id":"EnjuParser_R253","pred":"arg2Of","subj":"EnjuParser_T248","obj":"EnjuParser_T247"},{"id":"EnjuParser_R254","pred":"arg1Of","subj":"EnjuParser_T245","obj":"EnjuParser_T248"},{"id":"EnjuParser_R255","pred":"arg2Of","subj":"EnjuParser_T250","obj":"EnjuParser_T248"},{"id":"EnjuParser_R256","pred":"arg1Of","subj":"EnjuParser_T250","obj":"EnjuParser_T249"},{"id":"EnjuParser_R257","pred":"arg1Of","subj":"EnjuParser_T250","obj":"EnjuParser_T251"},{"id":"EnjuParser_R258","pred":"arg2Of","subj":"EnjuParser_T252","obj":"EnjuParser_T251"},{"id":"EnjuParser_R259","pred":"arg1Of","subj":"EnjuParser_T256","obj":"EnjuParser_T253"},{"id":"EnjuParser_R260","pred":"arg2Of","subj":"EnjuParser_T252","obj":"EnjuParser_T253"},{"id":"EnjuParser_R261","pred":"arg2Of","subj":"EnjuParser_T256","obj":"EnjuParser_T254"},{"id":"EnjuParser_R262","pred":"arg1Of","subj":"EnjuParser_T255","obj":"EnjuParser_T256"},{"id":"EnjuParser_R263","pred":"arg2Of","subj":"EnjuParser_T257","obj":"EnjuParser_T256"},{"id":"EnjuParser_R264","pred":"arg1Of","subj":"EnjuParser_T253","obj":"EnjuParser_T258"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
mondo_disease
{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":248,"end":272},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0007256"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
NCBITAXON
{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":117,"end":122},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":242,"end":247},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}
HP-phenotype
{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":248,"end":272},"obj":"Phenotype"},{"id":"T2","span":{"begin":1400,"end":1403},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0001402"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002725"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.\nThe role of alpha1,3fucosyltransferase-VII (alpha1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7,721 cells. After the cells were transfected with alpha1,3 FucT-VII cDNA, the expression of apoptotic protease, procaspase-3, was decreased, while the anti-apoptotic proteins, phospho-PKB and phospho-Bad were increased as compared with mock (vector) transfected cells, indicating that alpha1,3FucT-VII is a potential anti-apoptotic factor in H7,721 cells. After \"alpha1,3FucT-VII\" cells were irradiated by UV to induce apoptosis, the anti-apoptotic potential of alpha1,3FucT-VII became more apparent, as evidenced by the less apoptotic cell % and active cleaved caspase-3, more phospho-p38 MAPK and JNK (two anti-apoptotic signaling molecules in H7,721 cells responsible to UV stress) when compared with the \"Mock\" cells. In contrast, \"alpha1,3FucT-VII\" cells facilitated the apoptosis induced by all-trans retinoic acid (ATRA), which was verified by the greater sub-G1 (apoptotic cells) peak in flow cytometry analysis, more expressions of active caspase-3 and pro-apoptotic protein Bax, as well as less expressions of anti-apoptotic proteins, Bcl-2 and Bcl-X(L). The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased the susceptibility of apoptosis induced by UV and ATRA respectively."}