> top > docs > PubMed:17409200 > annotations

PubMed:17409200 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 8-14 SO:0001068 denotes repeat
T2 15-23 SO:0000109 denotes mutation
T5 88-106 D006816 denotes Huntington disease
T6 88-106 D006816 denotes Huntington disease
T9 107-112 UBERON:6110636 denotes brain
T10 107-112 UBERON:0000955 denotes brain
T11 125-132 D004194 denotes disease
T12 125-132 D004194 denotes disease
T13 165-168 CVCL_D569 denotes CAG
T14 169-175 SO:0001068 denotes repeat
T19 197-206 4885 denotes glutamine
T15 197-206 SO:0001448 denotes glutamine
T16 197-206 D005973 denotes glutamine
T17 197-206 CHEBI:28300 denotes glutamine
T18 197-206 CHEBI:18050 denotes glutamine
T20 197-206 D005973 denotes glutamine
T21 207-212 UBERON:0001018 denotes tract
T26 218-225 SO:0000104 denotes protein
T25 218-225 PR:000000001 denotes protein
T22 218-225 GO:0003675 denotes protein
T23 218-225 CHEBI:36080 denotes protein
T24 218-225 CHEBI:11122 denotes protein
T27 233-243 P42858 denotes huntingtin
T28 233-243 P42859 denotes huntingtin
T29 233-243 P51111 denotes huntingtin
T30 233-243 PR:000008840 denotes huntingtin
T31 233-243 P51112 denotes huntingtin
T32 323-331 SO:0000109 denotes mutation
T33 410-422 GO:0009405 denotes pathogenesis
T34 453-459 UBERON:0000479 denotes tissue
T35 511-516 D006801 denotes human
T36 542-546 PR:000005054 denotes mice
T38 542-546 O89094 denotes mice
T37 542-546 D051379 denotes mice
T39 542-546 10095 denotes mice
T40 565-568 CVCL_D569 denotes CAG
T41 569-575 SO:0001068 denotes repeat
T42 650-658 SO:0000109 denotes mutation
T43 683-691 SO:0000109 denotes Mutation
T44 724-731 D004194 denotes disease
T45 724-731 D004194 denotes disease
T46 774-781 D004194 denotes disease
T47 774-781 D004194 denotes disease
T48 851-859 SO:0000109 denotes mutation
T49 906-914 UBERON:0002435 denotes striatum
T50 906-914 UBERON:0005383 denotes striatum
T51 927-933 UBERON:0001851 denotes cortex
T52 947-952 D006801 denotes human
T53 1019-1022 PR:Q8RWZ1 denotes sub
T54 1019-1022 PR:Q9V877 denotes sub
T55 1041-1045 PR:000005054 denotes mice
T57 1041-1045 O89094 denotes mice
T56 1041-1045 D051379 denotes mice
T58 1041-1045 10095 denotes mice
T59 1088-1096 SO:0000109 denotes mutation
T60 1134-1142 SO:0000109 denotes mutation
T64 1165-1177 7442 denotes nitric oxide
T65 1165-1186 O61309 denotes nitric oxide synthase
T66 1165-1186 Q8T8C0 denotes nitric oxide synthase
T67 1165-1186 Q9I9M2 denotes nitric oxide synthase
T68 1165-1186 Q27571 denotes nitric oxide synthase
T70 1165-1186 O61608 denotes nitric oxide synthase
T69 1165-1186 D019001 denotes nitric oxide synthase
T73 1274-1277 PR:Q8UVK2 denotes pan
T74 1373-1379 SO:0001068 denotes repeat
T75 1492-1495 CVCL_D569 denotes CAG
T76 1496-1502 SO:0001068 denotes repeat
T77 1564-1573 UBERON:0004529 denotes processes
T78 1596-1611 GO:0006298 denotes mismatch repair
T81 1624-1627 SO:0000352 denotes DNA
T80 1624-1627 CHEBI:16991 denotes DNA
T82 1624-1627 D004247 denotes DNA
T79 1624-1627 GO:0005574 denotes DNA
T83 1624-1639 GO:0006260 denotes DNA replication
T84 1667-1675 SO:0000109 denotes mutation
T85 1694-1699 UBERON:6110636 denotes brain
T86 1694-1699 UBERON:0000955 denotes brain
T87 1700-1706 UBERON:0000479 denotes tissue

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-113 DRI_Outcome denotes Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.
T2 114-244 DRI_Background denotes Huntington disease is caused by the expansion of a CAG repeat encoding an extended glutamine tract in a protein called huntingtin.
T3 245-423 DRI_Outcome denotes Here, we provide evidence supporting the hypothesis that somatic increases of mutation length play a role in the progressive nature and cell-selective aspects of HD pathogenesis.
T4 424-682 DRI_Outcome denotes Results from micro-dissected tissue and individual laser-dissected cells obtained from human HD cases and knock-in HD mice indicate that the CAG repeat is unstable in all cell types tested although neurons tend to have longer mutation length gains than glia.
T5 683-793 DRI_Challenge denotes Mutation length gains occur early in the disease process and continue to accumulate as the disease progresses.
T6 794-994 DRI_Challenge denotes In keeping with observed patterns of cell loss, neuronal mutation length gains tend to be more prominent in the striatum than in the cortex of low-grade human HD cases, less so in more advanced cases.
T7 995-1307 DRI_Outcome denotes Interestingly, neuronal sub-populations of HD mice appear to have different propensities for mutation length gains; in particular, smaller mutation length gains occur in nitric oxide synthase-positive striatal interneurons (a relatively spared cell type in HD) compared with the pan-striatal neuronal population.
T8 1308-1465 DRI_Outcome denotes More generally, the data demonstrate that neuronal changes in HD repeat length can be at least as great, if not greater, than those observed in the germline.
T9 1466-1707 DRI_Outcome denotes The fact that significant CAG repeat length gains occur in non-replicating cells also argues that processes such as inappropriate mismatch repair rather than DNA replication are involved in generating mutation instability in HD brain tissue.