PubMed:17403684
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-119 | Sentence | denotes | Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils. |
| T2 | 120-243 | Sentence | denotes | High mobility group box 1 (HMGB1) protein plays multiple roles in transcription, replication, and cellular differentiation. |
| T3 | 244-384 | Sentence | denotes | HMGB1 is also secreted by activated monocytes and macrophages and passively released by necrotic or damaged cells, stimulating inflammation. |
| T4 | 385-621 | Sentence | denotes | HMGB1 is a novel antigen of anti-neutrophil cytoplasmic antibodies (ANCA) observed in the sera of patients with ulcerative colitis and autoimmune hepatitis, suggesting that HMGB1 is secreted from neutrophils to the extracellular milieu. |
| T5 | 622-746 | Sentence | denotes | However, the actual distribution of HMGB1 in the cytoplasm of neutrophils and the mechanisms responsible for it are obscure. |
| T6 | 747-835 | Sentence | denotes | Here we show that HMGB1 in neutrophils is post-translationally mono-methylated at Lys42. |
| T7 | 836-1021 | Sentence | denotes | The methylation alters the conformation of HMGB1 and weakens its DNA binding activity, causing it to become largely distributed in the cytoplasm by passive diffusion out of the nucleus. |
| T8 | 1022-1119 | Sentence | denotes | Thus, post-translational methylation of HMGB1 causes its cytoplasmic localization in neutrophils. |
| T9 | 1120-1292 | Sentence | denotes | This novel pathway explains the distribution of nuclear HMGB1 to the cytoplasm and is important for understanding how neutrophils release HMGB1 to the extracellular milieu. |
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-119 | Sentence | denotes | Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils. |
| T2 | 120-243 | Sentence | denotes | High mobility group box 1 (HMGB1) protein plays multiple roles in transcription, replication, and cellular differentiation. |
| T3 | 244-384 | Sentence | denotes | HMGB1 is also secreted by activated monocytes and macrophages and passively released by necrotic or damaged cells, stimulating inflammation. |
| T4 | 385-621 | Sentence | denotes | HMGB1 is a novel antigen of anti-neutrophil cytoplasmic antibodies (ANCA) observed in the sera of patients with ulcerative colitis and autoimmune hepatitis, suggesting that HMGB1 is secreted from neutrophils to the extracellular milieu. |
| T5 | 622-746 | Sentence | denotes | However, the actual distribution of HMGB1 in the cytoplasm of neutrophils and the mechanisms responsible for it are obscure. |
| T6 | 747-835 | Sentence | denotes | Here we show that HMGB1 in neutrophils is post-translationally mono-methylated at Lys42. |
| T7 | 836-1021 | Sentence | denotes | The methylation alters the conformation of HMGB1 and weakens its DNA binding activity, causing it to become largely distributed in the cytoplasm by passive diffusion out of the nucleus. |
| T8 | 1022-1119 | Sentence | denotes | Thus, post-translational methylation of HMGB1 causes its cytoplasmic localization in neutrophils. |
| T9 | 1120-1292 | Sentence | denotes | This novel pathway explains the distribution of nuclear HMGB1 to the cytoplasm and is important for understanding how neutrophils release HMGB1 to the extracellular milieu. |
| T1 | 0-119 | Sentence | denotes | Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils. |
| T2 | 120-243 | Sentence | denotes | High mobility group box 1 (HMGB1) protein plays multiple roles in transcription, replication, and cellular differentiation. |
| T3 | 244-384 | Sentence | denotes | HMGB1 is also secreted by activated monocytes and macrophages and passively released by necrotic or damaged cells, stimulating inflammation. |
| T4 | 385-621 | Sentence | denotes | HMGB1 is a novel antigen of anti-neutrophil cytoplasmic antibodies (ANCA) observed in the sera of patients with ulcerative colitis and autoimmune hepatitis, suggesting that HMGB1 is secreted from neutrophils to the extracellular milieu. |
| T5 | 622-746 | Sentence | denotes | However, the actual distribution of HMGB1 in the cytoplasm of neutrophils and the mechanisms responsible for it are obscure. |
| T6 | 747-835 | Sentence | denotes | Here we show that HMGB1 in neutrophils is post-translationally mono-methylated at Lys42. |
| T7 | 836-1021 | Sentence | denotes | The methylation alters the conformation of HMGB1 and weakens its DNA binding activity, causing it to become largely distributed in the cytoplasm by passive diffusion out of the nucleus. |
| T8 | 1022-1119 | Sentence | denotes | Thus, post-translational methylation of HMGB1 causes its cytoplasmic localization in neutrophils. |
| T9 | 1120-1292 | Sentence | denotes | This novel pathway explains the distribution of nuclear HMGB1 to the cytoplasm and is important for understanding how neutrophils release HMGB1 to the extracellular milieu. |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 520-530 | HP_0002960 | denotes | autoimmune |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 497-515 | Phenotype | denotes | ulcerative colitis | HP:0100279 |
| T2 | 531-540 | Phenotype | denotes | hepatitis | HP:0012115 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 371-383 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T2 | 497-515 | Disease | denotes | ulcerative colitis | http://purl.obolibrary.org/obo/MONDO_0005101|http://purl.obolibrary.org/obo/MONDO_0009960 |
| T4 | 520-540 | Disease | denotes | autoimmune hepatitis | http://purl.obolibrary.org/obo/MONDO_0016264 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 79-90 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T2 | 107-118 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T3 | 280-289 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T5 | 294-305 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T6 | 418-440 | Body_part | denotes | neutrophil cytoplasmic | http://purl.obolibrary.org/obo/CL_0017500 |
| T7 | 581-592 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T8 | 600-613 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T9 | 671-680 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T10 | 684-695 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T11 | 774-785 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T12 | 971-980 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T13 | 1013-1020 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
| T15 | 1079-1090 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T16 | 1107-1118 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T17 | 1189-1198 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T18 | 1238-1249 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T19 | 1271-1284 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 107-118 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T2 | 280-289 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T4 | 294-305 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T6 | 418-428 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T7 | 581-592 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T8 | 684-695 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T9 | 774-785 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T10 | 1107-1118 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T11 | 1238-1249 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |