
PubMed:17384120
Annnotations
Glycan-Motif
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 31-42 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T2 | 170-185 | https://glytoucan.org/Structures/Glycans/G00065MO | denotes | polysialic acid |
T3 | 407-422 | https://glytoucan.org/Structures/Glycans/G00065MO | denotes | polysialic acid |
T4 | 690-693 | https://glytoucan.org/Structures/Glycans/G33570YF | denotes | GT3 |
T5 | 690-693 | https://glytoucan.org/Structures/Glycans/G93899SO | denotes | GT3 |
T6 | 822-833 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T7 | 983-995 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acids |
T8 | 1046-1058 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acids |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 31-42 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
T2 | 170-185 | Glycan_Motif | denotes | polysialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO |
T3 | 407-422 | Glycan_Motif | denotes | polysialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO |
T4 | 690-693 | Glycan_Motif | denotes | GT3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G93899SO|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G33570YF |
T6 | 822-833 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
T7 | 983-995 | Glycan_Motif | denotes | sialic acids | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
T8 | 1046-1058 | Glycan_Motif | denotes | sialic acids | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-128 | Sentence | denotes | Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors. |
TextSentencer_T2 | 129-237 | Sentence | denotes | Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. |
TextSentencer_T3 | 238-339 | Sentence | denotes | This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. |
TextSentencer_T4 | 340-537 | Sentence | denotes | The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. |
TextSentencer_T5 | 538-658 | Sentence | denotes | We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. |
TextSentencer_T6 | 659-723 | Sentence | denotes | The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. |
TextSentencer_T7 | 724-843 | Sentence | denotes | The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. |
TextSentencer_T8 | 844-1009 | Sentence | denotes | This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. |
TextSentencer_T9 | 1010-1195 | Sentence | denotes | The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. |
TextSentencer_T10 | 1196-1383 | Sentence | denotes | The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. |
TextSentencer_T11 | 1384-1431 | Sentence | denotes | Synthesis can be blocked by CMP-9-azido-NeuNAc. |
TextSentencer_T12 | 1432-1555 | Sentence | denotes | These results suggest that the K92 PST forms both alpha2,8 and alpha2,9 linkages in a successive and nonprocessive fashion. |
T1 | 0-128 | Sentence | denotes | Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors. |
T2 | 129-237 | Sentence | denotes | Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. |
T3 | 238-537 | Sentence | denotes | This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. |
T4 | 538-658 | Sentence | denotes | We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. |
T5 | 659-723 | Sentence | denotes | The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. |
T6 | 724-843 | Sentence | denotes | The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. |
T7 | 844-1009 | Sentence | denotes | This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. |
T8 | 1010-1195 | Sentence | denotes | The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. |
T9 | 1196-1383 | Sentence | denotes | The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. |
T10 | 1384-1431 | Sentence | denotes | Synthesis can be blocked by CMP-9-azido-NeuNAc. |
T11 | 1432-1555 | Sentence | denotes | These results suggest that the K92 PST forms both alpha2,8 and alpha2,9 linkages in a successive and nonprocessive fashion. |
T1 | 0-128 | Sentence | denotes | Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors. |
T2 | 129-237 | Sentence | denotes | Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. |
T3 | 238-339 | Sentence | denotes | This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. |
T4 | 340-537 | Sentence | denotes | The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. |
T5 | 538-658 | Sentence | denotes | We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. |
T6 | 659-723 | Sentence | denotes | The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. |
T7 | 724-843 | Sentence | denotes | The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. |
T8 | 844-1009 | Sentence | denotes | This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. |
T9 | 1010-1195 | Sentence | denotes | The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. |
T10 | 1196-1383 | Sentence | denotes | The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. |
T11 | 1384-1431 | Sentence | denotes | Synthesis can be blocked by CMP-9-azido-NeuNAc. |
T12 | 1432-1555 | Sentence | denotes | These results suggest that the K92 PST forms both alpha2,8 and alpha2,9 linkages in a successive and nonprocessive fashion. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 31-42 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T2 | 170-185 | https://glytoucan.org/Structures/Glycans/G00065MO | denotes | polysialic acid |
T3 | 407-422 | https://glytoucan.org/Structures/Glycans/G00065MO | denotes | polysialic acid |
T4 | 690-693 | https://glytoucan.org/Structures/Glycans/G33570YF | denotes | GT3 |
T5 | 690-693 | https://glytoucan.org/Structures/Glycans/G93899SO | denotes | GT3 |
T6 | 822-833 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T7 | 983-995 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acids |
T8 | 1046-1058 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acids |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 690-693 | http://www.glycoepitope.jp/epitopes/EP0070 | denotes | GT3 |
GlycoBiology-PACDB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC002,LEC056,LEC062,LEC069,LEC081,LEC111,LEC133,LEC171,LEC177,LEC187,LEC211,LEC242,LEC252,LEC258,LEC259,LEC260,LEC262,LEC369,LEC377,LEC422,LEC442,LEC448,LEC450,LEC451,LEC454,LEC472,LEC492,LEC620 | denotes | Escherichia coli |
_T2 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC636 | denotes | Escherichia coli |
_T3 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC157,LEC407 | denotes | Escherichia coli |
_T4 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC054,LEC058,LEC073,LEC082,LEC091,LEC103,LEC109,LEC110,LEC123,LEC158,LEC179,LEC198,LEC205,LEC222,LEC223,LEC224,LEC225,LEC232,LEC298,LEC357,LEC378,LEC383,LEC388,LEC389,LEC397,LEC401,LEC410,LEC452 | denotes | Escherichia coli |
_T5 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC295,LEC417 | denotes | Escherichia coli |
_T6 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC244,LEC256,LEC354 | denotes | Escherichia coli |
_T7 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC243,LEC640 | denotes | Escherichia coli |
_T8 | 46-62 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC754 | denotes | Escherichia coli |
_T9 | 46-66 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC487 | denotes | Escherichia coli K92 |
_T10 | 46-66 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC720 | denotes | Escherichia coli K92 |
_T11 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC295,LEC417 | denotes | Escherichia coli |
_T12 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC636 | denotes | Escherichia coli |
_T13 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC243,LEC640 | denotes | Escherichia coli |
_T14 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC002,LEC056,LEC062,LEC069,LEC081,LEC111,LEC133,LEC171,LEC177,LEC187,LEC211,LEC242,LEC252,LEC258,LEC259,LEC260,LEC262,LEC369,LEC377,LEC422,LEC442,LEC448,LEC450,LEC451,LEC454,LEC472,LEC492,LEC620 | denotes | Escherichia coli |
_T15 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC754 | denotes | Escherichia coli |
_T16 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC244,LEC256,LEC354 | denotes | Escherichia coli |
_T17 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC157,LEC407 | denotes | Escherichia coli |
_T18 | 129-145 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC054,LEC058,LEC073,LEC082,LEC091,LEC103,LEC109,LEC110,LEC123,LEC158,LEC179,LEC198,LEC205,LEC222,LEC223,LEC224,LEC225,LEC232,LEC298,LEC357,LEC378,LEC383,LEC388,LEC389,LEC397,LEC401,LEC410,LEC452 | denotes | Escherichia coli |
_T19 | 129-149 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC720 | denotes | Escherichia coli K92 |
_T20 | 129-149 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC487 | denotes | Escherichia coli K92 |
_T21 | 308-330 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC453,LEC742 | denotes | Neisseria meningitidis |
_T22 | 308-338 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC504 | denotes | Neisseria meningitidis Group C |
_T23 | 308-338 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC659 | denotes | Neisseria meningitidis Group C |
_T24 | 308-338 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC561 | denotes | Neisseria meningitidis Group C |
uniprot-human
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 371-374 | http://www.uniprot.org/uniprot/Q92187 | denotes | PST |
T2 | 663-666 | http://www.uniprot.org/uniprot/Q92187 | denotes | PST |
T3 | 1467-1470 | http://www.uniprot.org/uniprot/Q92187 | denotes | PST |
T4 | 480-483 | http://www.uniprot.org/uniprot/P21941 | denotes | CMP |
T5 | 1412-1415 | http://www.uniprot.org/uniprot/P21941 | denotes | CMP |
T6 | 1108-1110 | http://www.uniprot.org/uniprot/P04264 | denotes | K1 |
uniprot-mouse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1108-1110 | http://www.uniprot.org/uniprot/P04104 | denotes | K1 |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 46-57 | http://purl.bioontology.org/ontology/NCBITAXON/561 | denotes | Escherichia |
T2 | 129-140 | http://purl.bioontology.org/ontology/NCBITAXON/561 | denotes | Escherichia |
T3 | 308-317 | http://purl.bioontology.org/ontology/NCBITAXON/482 | denotes | Neisseria |
T4 | 308-317 | http://purl.bioontology.org/ontology/NCBITAXON/206351 | denotes | Neisseria |
T5 | 308-317 | http://purl.bioontology.org/ontology/NCBITAXON/481 | denotes | Neisseria |
T6 | 308-330 | http://purl.bioontology.org/ontology/NCBITAXON/487 | denotes | Neisseria meningitidis |
T7 | 331-336 | http://purl.bioontology.org/ontology/STY/T096 | denotes | Group |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 371-374 | http://purl.obolibrary.org/obo/GO_0004062 | denotes | PST |
T2 | 663-666 | http://purl.obolibrary.org/obo/GO_0004062 | denotes | PST |
T3 | 1467-1470 | http://purl.obolibrary.org/obo/GO_0004062 | denotes | PST |
T4 | 390-399 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T5 | 1384-1393 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | Synthesis |
T6 | 883-892 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
T7 | 1066-1075 | http://purl.obolibrary.org/obo/GO_0046960 | denotes | sensitive |
T8 | 1079-1090 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 648-657 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
GlycoBiology-Epitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-GlycoEpitope-B_T1 | 690-693 | http://www.glycoepitope.jp/epitopes/EP0070 | denotes | GT3 |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 648-657 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 221-227 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
T2 | 468-474 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
T3 | 484-490 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
T4 | 690-693 | Glycan | denotes | GT3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G93899SO |
T5 | 1424-1430 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 690-693 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT3 | http://www.glycoepitope.jp/epitopes/EP0070 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-128 | Sentence | denotes | Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors. |
TextSentencer_T2 | 129-237 | Sentence | denotes | Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. |
TextSentencer_T3 | 238-339 | Sentence | denotes | This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. |
TextSentencer_T4 | 340-537 | Sentence | denotes | The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. |
TextSentencer_T5 | 538-658 | Sentence | denotes | We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. |
TextSentencer_T6 | 659-723 | Sentence | denotes | The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. |
TextSentencer_T7 | 724-843 | Sentence | denotes | The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. |
TextSentencer_T8 | 844-1009 | Sentence | denotes | This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. |
TextSentencer_T9 | 1010-1195 | Sentence | denotes | The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. |
TextSentencer_T10 | 1196-1383 | Sentence | denotes | The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. |
TextSentencer_T11 | 1384-1431 | Sentence | denotes | Synthesis can be blocked by CMP-9-azido-NeuNAc. |
TextSentencer_T12 | 1432-1555 | Sentence | denotes | These results suggest that the K92 PST forms both alpha2,8 and alpha2,9 linkages in a successive and nonprocessive fashion. |
T1 | 0-128 | Sentence | denotes | Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors. |
T2 | 129-237 | Sentence | denotes | Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. |
T3 | 238-537 | Sentence | denotes | This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. |
T4 | 538-658 | Sentence | denotes | We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. |
T5 | 659-723 | Sentence | denotes | The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. |
T6 | 724-843 | Sentence | denotes | The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. |
T7 | 844-1009 | Sentence | denotes | This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. |
T8 | 1010-1195 | Sentence | denotes | The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. |
T9 | 1196-1383 | Sentence | denotes | The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. |
T10 | 1384-1431 | Sentence | denotes | Synthesis can be blocked by CMP-9-azido-NeuNAc. |
T11 | 1432-1555 | Sentence | denotes | These results suggest that the K92 PST forms both alpha2,8 and alpha2,9 linkages in a successive and nonprocessive fashion. |
T1 | 0-128 | Sentence | denotes | Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors. |
T2 | 129-237 | Sentence | denotes | Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. |
T3 | 238-339 | Sentence | denotes | This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. |
T4 | 340-537 | Sentence | denotes | The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. |
T5 | 538-658 | Sentence | denotes | We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. |
T6 | 659-723 | Sentence | denotes | The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. |
T7 | 724-843 | Sentence | denotes | The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. |
T8 | 844-1009 | Sentence | denotes | This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. |
T9 | 1010-1195 | Sentence | denotes | The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. |
T10 | 1196-1383 | Sentence | denotes | The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. |
T11 | 1384-1431 | Sentence | denotes | Synthesis can be blocked by CMP-9-azido-NeuNAc. |
T12 | 1432-1555 | Sentence | denotes | These results suggest that the K92 PST forms both alpha2,8 and alpha2,9 linkages in a successive and nonprocessive fashion. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-128 | Sentence | denotes | Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors. |
T2 | 129-237 | Sentence | denotes | Escherichia coli K92 produces a capsular polysialic acid with alternating alpha2,8 alpha2,9 NeuNAc linkages. |
T3 | 238-537 | Sentence | denotes | This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. |
T4 | 538-658 | Sentence | denotes | We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. |
T5 | 659-723 | Sentence | denotes | The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. |
T6 | 724-843 | Sentence | denotes | The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. |
T7 | 844-1009 | Sentence | denotes | This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. |
T8 | 1010-1195 | Sentence | denotes | The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. |
T9 | 1196-1383 | Sentence | denotes | The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. |
T10 | 1384-1431 | Sentence | denotes | Synthesis can be blocked by CMP-9-azido-NeuNAc. |
T11 | 1432-1555 | Sentence | denotes | These results suggest that the K92 PST forms both alpha2,8 and alpha2,9 linkages in a successive and nonprocessive fashion. |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 690-693 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT3 | http://www.glycoepitope.jp/epitopes/EP0070 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 648-657 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 46-62 | OrganismTaxon | denotes | Escherichia coli | 562 |
T2 | 129-145 | OrganismTaxon | denotes | Escherichia coli | 562 |
T3 | 308-330 | OrganismTaxon | denotes | Neisseria meningitidis | 487 |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 221-227 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
T2 | 468-474 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
T3 | 484-490 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
T4 | 690-693 | Glycan | denotes | GT3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G93899SO |
T5 | 1424-1430 | Glycan | denotes | NeuNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 46-62 | OrganismTaxon | denotes | Escherichia coli | 562 |
T2 | 129-145 | OrganismTaxon | denotes | Escherichia coli | 562 |
T3 | 308-330 | OrganismTaxon | denotes | Neisseria meningitidis | 487 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 648-657 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |