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PubMed:17380205 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 98-125 DiseaseOrPhenotypicFeature denotes Duchenne muscular dystrophy 0010679
T2 127-154 DiseaseOrPhenotypicFeature denotes Duchenne muscular dystrophy 0010679
T3 156-159 DiseaseOrPhenotypicFeature denotes DMD 0010679
T4 310-313 DiseaseOrPhenotypicFeature denotes DMD 0010679
T5 591-594 DiseaseOrPhenotypicFeature denotes DMD 0010679
T6 1058-1091 DiseaseOrPhenotypicFeature denotes progression of muscular dystrophy 0016106
T7 1178-1181 DiseaseOrPhenotypicFeature denotes DMD 0010679

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
T2 127-306 Sentence denotes Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder associated with dystrophin deficiency that results in chronic inflammation and severe skeletal muscle degeneration.
T3 307-477 Sentence denotes In DMD mouse models and patients, we find that IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling is persistently elevated in immune cells and regenerative muscle fibers.
T4 478-595 Sentence denotes Ablation of 1 allele of the p65 subunit of NF-kappaB was sufficient to improve pathology in mdx mice, a model of DMD.
T5 596-860 Sentence denotes In addition, conditional deletion of IKKbeta in mdx mice elucidated that NF-kappaB functions in activated macrophages to promote inflammation and muscle necrosis and in skeletal muscle fibers to limit regeneration through the inhibition of muscle progenitor cells.
T6 861-980 Sentence denotes Furthermore, specific pharmacological inhibition of IKK resulted in improved pathology and muscle function in mdx mice.
T7 981-1182 Sentence denotes Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD.
T1 0-126 Sentence denotes Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
T2 127-306 Sentence denotes Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder associated with dystrophin deficiency that results in chronic inflammation and severe skeletal muscle degeneration.
T3 307-477 Sentence denotes In DMD mouse models and patients, we find that IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling is persistently elevated in immune cells and regenerative muscle fibers.
T4 478-595 Sentence denotes Ablation of 1 allele of the p65 subunit of NF-kappaB was sufficient to improve pathology in mdx mice, a model of DMD.
T5 596-860 Sentence denotes In addition, conditional deletion of IKKbeta in mdx mice elucidated that NF-kappaB functions in activated macrophages to promote inflammation and muscle necrosis and in skeletal muscle fibers to limit regeneration through the inhibition of muscle progenitor cells.
T6 861-980 Sentence denotes Furthermore, specific pharmacological inhibition of IKK resulted in improved pathology and muscle function in mdx mice.
T7 981-1182 Sentence denotes Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 207-217 gene:1756 denotes dystrophin
T1 286-305 disease:C0234958 denotes muscle degeneration
T2 207-217 gene:1756 denotes dystrophin
T3 127-159 disease:C0013264 denotes Duchenne muscular dystrophy (DMD
T4 506-509 gene:65125 denotes p65
T5 591-594 disease:C0026850 denotes DMD
T6 506-509 gene:5970 denotes p65
T7 591-594 disease:C0026850 denotes DMD
T8 506-509 gene:6857 denotes p65
T9 591-594 disease:C0026850 denotes DMD
T10 506-509 gene:64689 denotes p65
T11 591-594 disease:C0026850 denotes DMD
R1 T0 T1 associated_with dystrophin,muscle degeneration
R2 T2 T3 associated_with dystrophin,Duchenne muscular dystrophy (DMD
R3 T4 T5 associated_with p65,DMD
R4 T6 T7 associated_with p65,DMD
R5 T8 T9 associated_with p65,DMD
R6 T10 T11 associated_with p65,DMD

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 136-154 HP_0003560 denotes muscular dystrophy
T2 173-181 HP_0001417 denotes X-linked
T3 1073-1091 HP_0003560 denotes muscular dystrophy

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17380205-1#80#90#gene1756 207-217 gene1756 denotes dystrophin
17380205-1#0#27#diseaseC0013264 127-154 diseaseC0013264 denotes Duchenne muscular dystrophy
17380205-1#29#32#diseaseC0013264 156-159 diseaseC0013264 denotes DMD
17380205-1#159#178#diseaseC0234958 286-305 diseaseC0234958 denotes muscle degeneration
17380205-3#28#31#gene64689 506-509 gene64689 denotes p65
17380205-3#28#31#gene5970 506-509 gene5970 denotes p65
17380205-3#28#31#gene6857 506-509 gene6857 denotes p65
17380205-3#28#31#gene65125 506-509 gene65125 denotes p65
17380205-3#113#116#diseaseC0013264 591-594 diseaseC0013264 denotes DMD
80#90#gene17560#27#diseaseC0013264 17380205-1#80#90#gene1756 17380205-1#0#27#diseaseC0013264 associated_with dystrophin,Duchenne muscular dystrophy
80#90#gene175629#32#diseaseC0013264 17380205-1#80#90#gene1756 17380205-1#29#32#diseaseC0013264 associated_with dystrophin,DMD
80#90#gene1756159#178#diseaseC0234958 17380205-1#80#90#gene1756 17380205-1#159#178#diseaseC0234958 associated_with dystrophin,muscle degeneration
28#31#gene64689113#116#diseaseC0013264 17380205-3#28#31#gene64689 17380205-3#113#116#diseaseC0013264 associated_with p65,DMD
28#31#gene5970113#116#diseaseC0013264 17380205-3#28#31#gene5970 17380205-3#113#116#diseaseC0013264 associated_with p65,DMD
28#31#gene6857113#116#diseaseC0013264 17380205-3#28#31#gene6857 17380205-3#113#116#diseaseC0013264 associated_with p65,DMD
28#31#gene65125113#116#diseaseC0013264 17380205-3#28#31#gene65125 17380205-3#113#116#diseaseC0013264 associated_with p65,DMD

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1537 506-509 gene:64689 denotes p65
T1538 591-594 disease:C0013264 denotes DMD
R1 T1537 T1538 associated_with p65,DMD
R2 T1537 T1538 associated_with p65,DMD
R3 T1537 T1538 associated_with p65,DMD
R4 T1537 T1538 associated_with p65,DMD

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-126 Sentence denotes Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
TextSentencer_T2 127-306 Sentence denotes Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder associated with dystrophin deficiency that results in chronic inflammation and severe skeletal muscle degeneration.
TextSentencer_T3 307-477 Sentence denotes In DMD mouse models and patients, we find that IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling is persistently elevated in immune cells and regenerative muscle fibers.
TextSentencer_T4 478-595 Sentence denotes Ablation of 1 allele of the p65 subunit of NF-kappaB was sufficient to improve pathology in mdx mice, a model of DMD.
TextSentencer_T5 596-860 Sentence denotes In addition, conditional deletion of IKKbeta in mdx mice elucidated that NF-kappaB functions in activated macrophages to promote inflammation and muscle necrosis and in skeletal muscle fibers to limit regeneration through the inhibition of muscle progenitor cells.
TextSentencer_T6 861-980 Sentence denotes Furthermore, specific pharmacological inhibition of IKK resulted in improved pathology and muscle function in mdx mice.
TextSentencer_T7 981-1182 Sentence denotes Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD.
T1 0-126 Sentence denotes Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
T2 127-306 Sentence denotes Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder associated with dystrophin deficiency that results in chronic inflammation and severe skeletal muscle degeneration.
T3 307-477 Sentence denotes In DMD mouse models and patients, we find that IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling is persistently elevated in immune cells and regenerative muscle fibers.
T4 478-595 Sentence denotes Ablation of 1 allele of the p65 subunit of NF-kappaB was sufficient to improve pathology in mdx mice, a model of DMD.
T5 596-860 Sentence denotes In addition, conditional deletion of IKKbeta in mdx mice elucidated that NF-kappaB functions in activated macrophages to promote inflammation and muscle necrosis and in skeletal muscle fibers to limit regeneration through the inhibition of muscle progenitor cells.
T6 861-980 Sentence denotes Furthermore, specific pharmacological inhibition of IKK resulted in improved pathology and muscle function in mdx mice.
T7 981-1182 Sentence denotes Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD.