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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Glycoengineering of alphaGal xenoantigen on recombinant peptide bearing the J28 pancreatic oncofetal glycotope.
TextSentencer_T2 112-310 Sentence denotes In human pancreatic adenocarcinoma, alterations of glycosylation processes leads to the expression of tumor-associated carbohydrate antigens, representing potential targets for cancer immunotherapy.
TextSentencer_T3 311-611 Sentence denotes Among these pancreatic tumor-associated carbohydrate antigens, the J28 glycotope located within the O-glycosylated mucin-like C-terminal domain of the fetoacinar pancreatic protein (FAPP) and expressed at the surface of human tumoral tissues, can be a good target for anticancer therapeutic vaccines.
TextSentencer_T4 612-824 Sentence denotes However, the oncodevelopmental self character of the J28 glycotope associated with the low immunogenicity of tumor-associated carbohydrate antigens may be a major obstacle to effective anti-tumor vaccine therapy.
TextSentencer_T5 825-1098 Sentence denotes In this study, we have investigated a method to increase the immunogenicity of the recombinant pancreatic oncofetal J28 glycotope by glycoengineering Galalpha1,3Galss1,4GlcNAc-R (alphaGal epitope) which may be recognized by natural anti-alphaGal antibody present in humans.
TextSentencer_T6 1099-1277 Sentence denotes For this purpose, we have developed a stable Chinese hamster ovary cell clone expressing the alphaGal epitope by transfecting the cDNA encoding the alpha1,3galactosyltransferase.
TextSentencer_T7 1278-1415 Sentence denotes These cells have been previously equipped to produce the recombinant O-glycosylated C-terminal domain of FAPP carrying the J28 glycotope.
TextSentencer_T8 1416-1581 Sentence denotes As a consequence, the C-terminal domain of FAPP produced by these cells carries the alphaGal epitope on oligosaccharide structures associated with the J28 glycotope.
TextSentencer_T9 1582-1850 Sentence denotes Furthermore, we show that this recombinant "alpha1,3galactosyl and J28 glycotope" may not only be targeted by human natural anti-alphaGal antibodies but also by the mAbJ28, suggesting that the J28 glycotope remains accessible to the immune system as vaccinating agent.
TextSentencer_T10 1851-2062 Sentence denotes This approach may be used for many identified tumor-associated carbohydrate antigens which can be glycoengineered to carry a alphaGal epitope to increase their immunogenicity and to develop therapeutic vaccines.
T1 0-111 Sentence denotes Glycoengineering of alphaGal xenoantigen on recombinant peptide bearing the J28 pancreatic oncofetal glycotope.
T2 112-310 Sentence denotes In human pancreatic adenocarcinoma, alterations of glycosylation processes leads to the expression of tumor-associated carbohydrate antigens, representing potential targets for cancer immunotherapy.
T3 311-611 Sentence denotes Among these pancreatic tumor-associated carbohydrate antigens, the J28 glycotope located within the O-glycosylated mucin-like C-terminal domain of the fetoacinar pancreatic protein (FAPP) and expressed at the surface of human tumoral tissues, can be a good target for anticancer therapeutic vaccines.
T4 612-824 Sentence denotes However, the oncodevelopmental self character of the J28 glycotope associated with the low immunogenicity of tumor-associated carbohydrate antigens may be a major obstacle to effective anti-tumor vaccine therapy.
T5 825-1098 Sentence denotes In this study, we have investigated a method to increase the immunogenicity of the recombinant pancreatic oncofetal J28 glycotope by glycoengineering Galalpha1,3Galss1,4GlcNAc-R (alphaGal epitope) which may be recognized by natural anti-alphaGal antibody present in humans.
T6 1099-1277 Sentence denotes For this purpose, we have developed a stable Chinese hamster ovary cell clone expressing the alphaGal epitope by transfecting the cDNA encoding the alpha1,3galactosyltransferase.
T7 1278-1415 Sentence denotes These cells have been previously equipped to produce the recombinant O-glycosylated C-terminal domain of FAPP carrying the J28 glycotope.
T8 1416-1581 Sentence denotes As a consequence, the C-terminal domain of FAPP produced by these cells carries the alphaGal epitope on oligosaccharide structures associated with the J28 glycotope.
T9 1582-1850 Sentence denotes Furthermore, we show that this recombinant "alpha1,3galactosyl and J28 glycotope" may not only be targeted by human natural anti-alphaGal antibodies but also by the mAbJ28, suggesting that the J28 glycotope remains accessible to the immune system as vaccinating agent.
T10 1851-2062 Sentence denotes This approach may be used for many identified tumor-associated carbohydrate antigens which can be glycoengineered to carry a alphaGal epitope to increase their immunogenicity and to develop therapeutic vaccines.
T1 0-111 Sentence denotes Glycoengineering of alphaGal xenoantigen on recombinant peptide bearing the J28 pancreatic oncofetal glycotope.
T2 112-310 Sentence denotes In human pancreatic adenocarcinoma, alterations of glycosylation processes leads to the expression of tumor-associated carbohydrate antigens, representing potential targets for cancer immunotherapy.
T3 311-611 Sentence denotes Among these pancreatic tumor-associated carbohydrate antigens, the J28 glycotope located within the O-glycosylated mucin-like C-terminal domain of the fetoacinar pancreatic protein (FAPP) and expressed at the surface of human tumoral tissues, can be a good target for anticancer therapeutic vaccines.
T4 612-824 Sentence denotes However, the oncodevelopmental self character of the J28 glycotope associated with the low immunogenicity of tumor-associated carbohydrate antigens may be a major obstacle to effective anti-tumor vaccine therapy.
T5 825-1098 Sentence denotes In this study, we have investigated a method to increase the immunogenicity of the recombinant pancreatic oncofetal J28 glycotope by glycoengineering Galalpha1,3Galss1,4GlcNAc-R (alphaGal epitope) which may be recognized by natural anti-alphaGal antibody present in humans.
T6 1099-1277 Sentence denotes For this purpose, we have developed a stable Chinese hamster ovary cell clone expressing the alphaGal epitope by transfecting the cDNA encoding the alpha1,3galactosyltransferase.
T7 1278-1415 Sentence denotes These cells have been previously equipped to produce the recombinant O-glycosylated C-terminal domain of FAPP carrying the J28 glycotope.
T8 1416-1581 Sentence denotes As a consequence, the C-terminal domain of FAPP produced by these cells carries the alphaGal epitope on oligosaccharide structures associated with the J28 glycotope.
T9 1582-1850 Sentence denotes Furthermore, we show that this recombinant "alpha1,3galactosyl and J28 glycotope" may not only be targeted by human natural anti-alphaGal antibodies but also by the mAbJ28, suggesting that the J28 glycotope remains accessible to the immune system as vaccinating agent.
T10 1851-2062 Sentence denotes This approach may be used for many identified tumor-associated carbohydrate antigens which can be glycoengineered to carry a alphaGal epitope to increase their immunogenicity and to develop therapeutic vaccines.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 462-491 gene:1056 denotes fetoacinar pancreatic protein
T1 323-339 disease:C0030297 denotes pancreatic tumor
T2 493-497 gene:1056 denotes FAPP
T3 323-339 disease:C0030297 denotes pancreatic tumor
R1 T0 T1 associated_with fetoacinar pancreatic protein,pancreatic tumor
R2 T2 T3 associated_with FAPP,pancreatic tumor

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 121-146 HP_0006725 denotes pancreatic adenocarcinoma
T2 214-219 HP_0002664 denotes tumor
T3 289-295 HP_0002664 denotes cancer
T4 323-339 HP_0002894 denotes pancreatic tumor
T5 334-339 HP_0002664 denotes tumor
T6 537-544 HP_0002664 denotes tumoral
T7 721-726 HP_0002664 denotes tumor
T8 802-807 HP_0002664 denotes tumor
T9 1897-1902 HP_0002664 denotes tumor
T1 121-146 HP_0006725 denotes pancreatic adenocarcinoma
T2 214-219 HP_0002664 denotes tumor
T3 289-295 HP_0002664 denotes cancer
T4 323-339 HP_0002894 denotes pancreatic tumor
T5 334-339 HP_0002664 denotes tumor
T6 537-544 HP_0002664 denotes tumoral
T7 721-726 HP_0002664 denotes tumor
T8 802-807 HP_0002664 denotes tumor
T9 1897-1902 HP_0002664 denotes tumor

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 289-295 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 545-552 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T3 1284-1289 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 1482-1487 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 1881-1885 http://purl.bioontology.org/ontology/NCBITAXON/9973 denotes many

GO-BP

Id Subject Object Predicate Lexical cue
T1 163-176 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T2 413-425 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T3 1349-1361 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T4 1125-1134 http://purl.obolibrary.org/obo/GO_0032502 denotes developed
T5 2033-2040 http://purl.obolibrary.org/obo/GO_0032502 denotes develop

GO-MF

Id Subject Object Predicate Lexical cue
T1 1071-1079 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2 1720-1730 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies

GO-CC

Id Subject Object Predicate Lexical cue
T1 1166-1170 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 1284-1289 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 1482-1487 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 545-552 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T2 1815-1828 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 545-552 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 1815-1828 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 121-146 Phenotype denotes pancreatic adenocarcinoma HP:0006725
T2 214-219 Phenotype denotes tumor HP:0002664
T3 289-295 Phenotype denotes cancer HP:0002664
T4 323-339 Phenotype denotes pancreatic tumor HP:0002894
T5 721-726 Phenotype denotes tumor HP:0002664
T6 802-807 Phenotype denotes tumor HP:0002664
T7 1897-1902 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 121-146 Disease denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0006047
T2 214-219 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 289-295 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 323-339 Disease denotes pancreatic tumor http://purl.obolibrary.org/obo/MONDO_0009831|http://purl.obolibrary.org/obo/MONDO_0021040
T6 721-726 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 802-807 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T8 1897-1902 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 115-120 OrganismTaxon denotes human 9606
T2 531-536 OrganismTaxon denotes human 9606
T3 1144-1159 OrganismTaxon denotes Chinese hamster 10029
T4 1692-1697 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1160-1165 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 1815-1828 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405