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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen.
T2 115-126 Sentence denotes BACKGROUND:
T3 127-200 Sentence denotes Methadone is prescribed to heroin addicts to decrease illicit opioid use.
T4 201-323 Sentence denotes Prolongation of the QT interval in the ECG of patients with torsade de pointes (TdP) has been reported in methadone users.
T5 324-640 Sentence denotes As heroin addicts sometimes faint while using illicit drugs, doctors might attribute too many episodes of syncope to illicit drug use and thereby underestimate the incidence of TdP in this special population, and the high mortality in this population may, in part, be caused by the proarrhythmic effect of methadone.
T6 641-649 Sentence denotes METHODS:
T7 650-826 Sentence denotes In this cross-sectional study interview, ECGs and blood samples were collected in a population of adult heroin addicts treated with methadone or buprenorphine on a daily basis.
T8 827-943 Sentence denotes Of the patients at the Drug Addiction Service in the municipal of Copenhagen, 450 (approximately 52%) were included.
T9 944-992 Sentence denotes The QT interval was estimated from 12 lead ECGs.
T10 993-1059 Sentence denotes All participants were interviewed about any experience of syncope.
T11 1060-1236 Sentence denotes The association between opioid dose and QT, and methadone dose and reporting of syncope was assessed using multivariate linear regression and logistic regression, respectively.
T12 1237-1245 Sentence denotes RESULTS:
T13 1246-1327 Sentence denotes Methadone dose was associated with longer QT interval of 0.140 ms/mg (p = 0.002).
T14 1328-1383 Sentence denotes No association between buprenorphine and QTc was found.
T15 1384-1476 Sentence denotes Among the subjects treated with methadone, 28% men and 32% women had prolonged QTc interval.
T16 1477-1558 Sentence denotes None of the subjects treated with buprenorphine had QTc interval >0.440 s((1/2)).
T17 1559-1665 Sentence denotes A 50 mg higher methadone dose was associated with a 1.2 (95% CI 1.1 to 1.4) times higher odds for syncope.
T18 1666-1678 Sentence denotes CONCLUSIONS:
T19 1679-1790 Sentence denotes Methadone is associated with QT prolongation and higher reporting of syncope in a population of heroin addicts.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 0-7 OrganismTaxon denotes Syncope NCBItxid:1271638
T2 430-437 OrganismTaxon denotes syncope NCBItxid:1271638
T3 1051-1058 OrganismTaxon denotes syncope NCBItxid:1271638
T4 1140-1147 OrganismTaxon denotes syncope NCBItxid:1271638
T5 1657-1664 OrganismTaxon denotes syncope NCBItxid:1271638
T6 1748-1755 OrganismTaxon denotes syncope NCBItxid:1271638

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
4011 0-7 DiseaseOrPhenotypicFeature denotes Syncope MESH:D013575
4012 12-27 DiseaseOrPhenotypicFeature denotes QT prolongation MESH:D008133
4013 34-42 OrganismTaxon denotes patients NCBITaxon:9606
4014 56-65 ChemicalEntity denotes methadone MESH:D008691
4015 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence MESH:D006556
4016 127-136 ChemicalEntity denotes Methadone MESH:D008691
4017 154-168 DiseaseOrPhenotypicFeature denotes heroin addicts MESH:D006556
4018 189-195 ChemicalEntity denotes opioid MESH:D000701
4019 201-232 DiseaseOrPhenotypicFeature denotes Prolongation of the QT interval MESH:D008133
4020 247-255 OrganismTaxon denotes patients NCBITaxon:9606
4021 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes MESH:D016171
4022 281-284 DiseaseOrPhenotypicFeature denotes TdP MESH:D016171
4023 307-316 ChemicalEntity denotes methadone MESH:D008691
4024 327-341 DiseaseOrPhenotypicFeature denotes heroin addicts MESH:D006556
4025 430-437 DiseaseOrPhenotypicFeature denotes syncope MESH:D013575
4026 501-504 DiseaseOrPhenotypicFeature denotes TdP MESH:D016171
4027 630-639 ChemicalEntity denotes methadone MESH:D008691
4028 754-768 DiseaseOrPhenotypicFeature denotes heroin addicts MESH:D006556
4029 782-791 ChemicalEntity denotes methadone MESH:D008691
4030 795-808 ChemicalEntity denotes buprenorphine MESH:D002047
4031 834-842 OrganismTaxon denotes patients NCBITaxon:9606
4032 1051-1058 DiseaseOrPhenotypicFeature denotes syncope MESH:D013575
4033 1084-1090 ChemicalEntity denotes opioid MESH:D000701
4034 1108-1117 ChemicalEntity denotes methadone MESH:D008691
4035 1140-1147 DiseaseOrPhenotypicFeature denotes syncope MESH:D013575
4036 1246-1255 ChemicalEntity denotes Methadone MESH:D008691
4037 1281-1299 DiseaseOrPhenotypicFeature denotes longer QT interval MESH:D008133
4038 1351-1364 ChemicalEntity denotes buprenorphine MESH:D002047
4039 1416-1425 ChemicalEntity denotes methadone MESH:D008691
4040 1431-1434 OrganismTaxon denotes men NCBITaxon:9606
4041 1443-1448 OrganismTaxon denotes women NCBITaxon:9606
4042 1453-1475 DiseaseOrPhenotypicFeature denotes prolonged QTc interval MESH:D008133
4043 1511-1524 ChemicalEntity denotes buprenorphine MESH:D002047
4044 1574-1583 ChemicalEntity denotes methadone MESH:D008691
4045 1657-1664 DiseaseOrPhenotypicFeature denotes syncope MESH:D013575
4046 1679-1688 ChemicalEntity denotes Methadone MESH:D008691
4047 1708-1723 DiseaseOrPhenotypicFeature denotes QT prolongation MESH:D008133
4048 1748-1755 DiseaseOrPhenotypicFeature denotes syncope MESH:D013575
4049 1775-1789 DiseaseOrPhenotypicFeature denotes heroin addicts MESH:D006556

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence 0005367
T2 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes 0005478
T3 281-284 DiseaseOrPhenotypicFeature denotes TdP 0005478
T4 501-504 DiseaseOrPhenotypicFeature denotes TdP 0005478
T5 1431-1434 DiseaseOrPhenotypicFeature denotes men 0017169

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence 0005367
T2 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes 0005478

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 352-357 GeneOrGeneProduct denotes faint
T2 541-545 GeneOrGeneProduct denotes high

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 272-279 GeneOrGeneProduct denotes pointes
T2 352-357 GeneOrGeneProduct denotes faint
T3 413-417 GeneOrGeneProduct denotes many
T4 541-545 GeneOrGeneProduct denotes high
T5 583-587 GeneOrGeneProduct denotes part
T6 641-648 GeneOrGeneProduct denotes METHODS
T7 729-733 GeneOrGeneProduct denotes in a
T8 820-825 GeneOrGeneProduct denotes basis
T9 910-923 GeneOrGeneProduct denotes approximately
T10 993-996 GeneOrGeneProduct denotes All
T11 1309-1314 GeneOrGeneProduct denotes ms/mg
T12 1477-1481 GeneOrGeneProduct denotes None
T13 1564-1566 GeneOrGeneProduct denotes mg
T14 1635-1640 GeneOrGeneProduct denotes times
T15 1756-1760 GeneOrGeneProduct denotes in a

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 0-7 DiseaseOrPhenotypicFeature denotes Syncope D013575
T2 12-27 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T3 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T4 154-168 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T5 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes D016171
T6 281-284 DiseaseOrPhenotypicFeature denotes TdP D016171
T7 327-341 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T8 430-437 DiseaseOrPhenotypicFeature denotes syncope D013575
T9 501-504 DiseaseOrPhenotypicFeature denotes TdP D016171
T10 754-768 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T11 850-864 DiseaseOrPhenotypicFeature denotes Drug Addiction D019966
T12 1051-1058 DiseaseOrPhenotypicFeature denotes syncope D013575
T13 1140-1147 DiseaseOrPhenotypicFeature denotes syncope D013575
T14 1657-1664 DiseaseOrPhenotypicFeature denotes syncope D013575
T15 1708-1723 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T16 1748-1755 DiseaseOrPhenotypicFeature denotes syncope D013575
T17 1775-1789 DiseaseOrPhenotypicFeature denotes heroin addicts D006556

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 352-357 GeneOrGeneProduct denotes faint

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence 0005367
T2 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes 0005478
T3 281-284 DiseaseOrPhenotypicFeature denotes TdP 0005478
T4 501-504 DiseaseOrPhenotypicFeature denotes TdP 0005478
T5 1431-1434 DiseaseOrPhenotypicFeature denotes men 0017169

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 0-7 DiseaseOrPhenotypicFeature denotes Syncope D013575
T2 12-27 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T3 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T4 154-168 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T5 201-232 DiseaseOrPhenotypicFeature denotes Prolongation of the QT interval DISEASE
T6 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes D016171
T7 281-284 DiseaseOrPhenotypicFeature denotes TdP D016171
T8 327-341 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T9 430-437 DiseaseOrPhenotypicFeature denotes syncope D013575
T10 501-504 DiseaseOrPhenotypicFeature denotes TdP D016171
T11 754-768 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T12 850-864 DiseaseOrPhenotypicFeature denotes Drug Addiction D019966
T13 1051-1058 DiseaseOrPhenotypicFeature denotes syncope D013575
T14 1140-1147 DiseaseOrPhenotypicFeature denotes syncope D013575
T15 1281-1299 DiseaseOrPhenotypicFeature denotes longer QT interval DISEASE
T16 1453-1475 DiseaseOrPhenotypicFeature denotes prolonged QTc interval DISEASE
T17 1657-1664 DiseaseOrPhenotypicFeature denotes syncope D013575
T18 1708-1723 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T19 1748-1755 DiseaseOrPhenotypicFeature denotes syncope D013575
T20 1775-1789 DiseaseOrPhenotypicFeature denotes heroin addicts D006556

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 0-7 DiseaseOrPhenotypicFeature denotes Syncope D013575
T2 12-27 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T3 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T4 154-168 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T5 201-232 DiseaseOrPhenotypicFeature denotes Prolongation of the QT interval DISEASE
T6 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes D016171
T7 281-284 DiseaseOrPhenotypicFeature denotes TdP D016171
T8 327-341 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T9 430-437 DiseaseOrPhenotypicFeature denotes syncope D013575
T10 501-504 DiseaseOrPhenotypicFeature denotes TdP D016171
T11 754-768 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T12 850-864 DiseaseOrPhenotypicFeature denotes Drug Addiction D019966
T13 1051-1058 DiseaseOrPhenotypicFeature denotes syncope D013575
T14 1140-1147 DiseaseOrPhenotypicFeature denotes syncope D013575
T15 1281-1299 DiseaseOrPhenotypicFeature denotes longer QT interval DISEASE
T16 1453-1475 DiseaseOrPhenotypicFeature denotes prolonged QTc interval DISEASE
T17 1657-1664 DiseaseOrPhenotypicFeature denotes syncope D013575
T18 1708-1723 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T19 1748-1755 DiseaseOrPhenotypicFeature denotes syncope D013575
T20 1775-1789 DiseaseOrPhenotypicFeature denotes heroin addicts D006556

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 56-65 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T3 70-76 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T5 127-136 ChemicalEntity denotes Methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T7 154-160 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T9 189-195 ChemicalEntity denotes opioid ChemicalEntity
T10 240-243 ChemicalEntity denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T11 307-316 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T13 327-333 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T15 370-383 ChemicalEntity denotes illicit drugs D013287
T16 441-453 ChemicalEntity denotes illicit drug D013287
T17 630-639 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T19 754-760 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T21 782-791 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T23 795-808 ChemicalEntity denotes buprenorphine D002047|http://purl.obolibrary.org/obo/CHEBI_3216
T25 982-986 ChemicalEntity denotes lead D007854
T26 1084-1090 ChemicalEntity denotes opioid ChemicalEntity
T27 1108-1117 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T29 1246-1255 ChemicalEntity denotes Methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T31 1351-1364 ChemicalEntity denotes buprenorphine D002047|http://purl.obolibrary.org/obo/CHEBI_3216
T33 1416-1425 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T35 1511-1524 ChemicalEntity denotes buprenorphine D002047|http://purl.obolibrary.org/obo/CHEBI_3216
T37 1574-1583 ChemicalEntity denotes methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T39 1679-1688 ChemicalEntity denotes Methadone D008691|http://purl.obolibrary.org/obo/CHEBI_6807
T41 1775-1781 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 34-42 OrganismTaxon denotes patients
T2 247-255 OrganismTaxon denotes patients
T3 834-845 OrganismTaxon denotes patients at
T4 1431-1434 OrganismTaxon denotes men
T5 1443-1448 OrganismTaxon denotes women

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T41 1775-1781 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T39 1679-1688 ChemicalEntity denotes Methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T37 1574-1583 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T35 1511-1524 ChemicalEntity denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216|D002047
T33 1416-1425 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T31 1351-1364 ChemicalEntity denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216|D002047
T29 1246-1255 ChemicalEntity denotes Methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T27 1108-1117 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T26 1084-1090 ChemicalEntity denotes opioid ChemicalEntity
T25 982-986 ChemicalEntity denotes lead D007854
T23 795-808 ChemicalEntity denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216|D002047
T21 782-791 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T19 754-760 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T17 630-639 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T16 441-453 ChemicalEntity denotes illicit drug D013287
T15 370-383 ChemicalEntity denotes illicit drugs D013287
T13 327-333 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T11 307-316 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T10 240-243 ChemicalEntity denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T9 189-195 ChemicalEntity denotes opioid ChemicalEntity
T7 154-160 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T5 127-136 ChemicalEntity denotes Methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T3 70-76 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T1 56-65 ChemicalEntity denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807|D008691
T90983 352-357 GeneOrGeneProduct denotes faint
T20 1775-1789 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T75684 1748-1755 DiseaseOrPhenotypicFeature denotes syncope D013575
T18 1708-1723 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T66876 1657-1664 DiseaseOrPhenotypicFeature denotes syncope D013575
T6025 1453-1475 DiseaseOrPhenotypicFeature denotes prolonged QTc interval DISEASE
T13332 1281-1299 DiseaseOrPhenotypicFeature denotes longer QT interval DISEASE
T14 1140-1147 DiseaseOrPhenotypicFeature denotes syncope D013575
T15189 1051-1058 DiseaseOrPhenotypicFeature denotes syncope D013575
T12 850-864 DiseaseOrPhenotypicFeature denotes Drug Addiction D019966
T83456 754-768 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T67730 501-504 DiseaseOrPhenotypicFeature denotes TdP D016171
T82889 430-437 DiseaseOrPhenotypicFeature denotes syncope D013575
T8 327-341 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T51651 281-284 DiseaseOrPhenotypicFeature denotes TdP D016171
T6 261-279 DiseaseOrPhenotypicFeature denotes torsade de pointes D016171
T38256 201-232 DiseaseOrPhenotypicFeature denotes Prolongation of the QT interval DISEASE
T4 154-168 DiseaseOrPhenotypicFeature denotes heroin addicts D006556
T99360 70-87 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T2 12-27 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T8172 0-7 DiseaseOrPhenotypicFeature denotes Syncope D013575
T76666 1443-1448 OrganismTaxon denotes women
T29933 1431-1434 OrganismTaxon denotes men
T62106 834-845 OrganismTaxon denotes patients at
T36344 247-255 OrganismTaxon denotes patients
T6771 34-42 OrganismTaxon denotes patients

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 201-232 HP_0001657 denotes Prolongation of the QT interval
T2 430-437 HP_0001279 denotes syncope