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PubMed:1733953 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.
T2 142-299 Sentence denotes Calreticulin (CR) is a calcium binding protein that resides in the endoplasmic and sarcoplasmic reticulum and is reactive with human Ro/SS-A autoimmune sera.
T3 300-535 Sentence denotes We have used human CR cDNA to isolate a human 6-kilobase genomic clone that contains 529 base pairs upstream of the presumed transcription start site, 9 exons, 8 introns, and several hundred base pairs 3' of a polyadenylation sequence.
T4 536-856 Sentence denotes Analysis of the human CR promoter region reveals a number of potential regulatory sites also found in the human GRP78, GRP94, and protein disulfide isomerase promoters, including multiple Sp1 and CCAAT consensus sequences, an AP-2 recognition sequence (absent in protein disulfide isomerase), and multiple GC-rich areas.
T5 857-1016 Sentence denotes DNA footprint and gel shift analysis on the CR 5'-flanking region demonstrates an area that is bound by protein found in human but not murine nuclear extracts.
T6 1017-1132 Sentence denotes This sequence is homologous with previously determined regulatory sequences of the human GRP78 and GRP94 promoters.
T7 1133-1368 Sentence denotes These data indicate that CR, GRP78, GRP94, and protein disulfide isomerase may in part have similar transcriptional regulation and suggest that their gene products while structurally distinct may have similar functions or co-functions.
T8 1369-1508 Sentence denotes These observations are of additional interest as all four of these genes encode acidic proteins that localize to the endoplasmic reticulum.
T1 0-141 Sentence denotes The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.
T2 142-299 Sentence denotes Calreticulin (CR) is a calcium binding protein that resides in the endoplasmic and sarcoplasmic reticulum and is reactive with human Ro/SS-A autoimmune sera.
T3 300-535 Sentence denotes We have used human CR cDNA to isolate a human 6-kilobase genomic clone that contains 529 base pairs upstream of the presumed transcription start site, 9 exons, 8 introns, and several hundred base pairs 3' of a polyadenylation sequence.
T4 536-856 Sentence denotes Analysis of the human CR promoter region reveals a number of potential regulatory sites also found in the human GRP78, GRP94, and protein disulfide isomerase promoters, including multiple Sp1 and CCAAT consensus sequences, an AP-2 recognition sequence (absent in protein disulfide isomerase), and multiple GC-rich areas.
T5 857-1016 Sentence denotes DNA footprint and gel shift analysis on the CR 5'-flanking region demonstrates an area that is bound by protein found in human but not murine nuclear extracts.
T6 1017-1132 Sentence denotes This sequence is homologous with previously determined regulatory sequences of the human GRP78 and GRP94 promoters.
T7 1133-1368 Sentence denotes These data indicate that CR, GRP78, GRP94, and protein disulfide isomerase may in part have similar transcriptional regulation and suggest that their gene products while structurally distinct may have similar functions or co-functions.
T8 1369-1508 Sentence denotes These observations are of additional interest as all four of these genes encode acidic proteins that localize to the endoplasmic reticulum.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 283-293 HP_0002960 denotes autoimmune

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 30-35 OrganismTaxon denotes human 9606
T2 79-84 OrganismTaxon denotes human 9606
T3 269-274 OrganismTaxon denotes human 9606
T4 313-318 OrganismTaxon denotes human 9606
T5 340-345 OrganismTaxon denotes human 9606
T6 552-557 OrganismTaxon denotes human 9606
T7 642-647 OrganismTaxon denotes human 9606
T8 978-983 OrganismTaxon denotes human 9606
T9 1100-1105 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 225-237 Body_part denotes sarcoplasmic http://purl.obolibrary.org/obo/GO_0016528
T2 238-247 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T3 1498-1507 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361