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PubMed:17339318 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.
T2 85-333 Sentence denotes The von Hippel-Lindau tumor suppressor (pVHL) targets hydroxylated alpha-subunits of hypoxia-inducible factor (HIF) for ubiquitin-mediated proteasomal destruction through direct interaction with the hydroxyproline binding pocket in its beta-domain.
T3 334-599 Sentence denotes Although disruption of this process may contribute to VHL-associated tumor predisposition by up-regulation of HIF target genes, genetic and biochemical analyses support the existence of additional functions, including a role in the assembly of extracellular matrix.
T4 600-687 Sentence denotes In an attempt to delineate these pathways, we searched for novel pVHL-binding proteins.
T5 688-782 Sentence denotes Here we report a direct, hydroxylation-dependent interaction with alpha-chains of collagen IV.
T6 783-896 Sentence denotes Interaction with pVHL was also observed with fibrillar collagen chains, but not the folded collagen triple helix.
T7 897-1098 Sentence denotes The interaction was suppressed by a wide range of tumor-associated mutations, including those that do not disturb the regulation of HIF, supporting a role in HIF-independent tumor suppressor functions.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 107-112 HP_0002664 denotes tumor
T2 403-408 HP_0002664 denotes tumor
T3 947-952 HP_0002664 denotes tumor
T4 1071-1076 HP_0002664 denotes tumor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 67-72 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 107-112 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 388-391 Disease denotes VHL http://purl.obolibrary.org/obo/MONDO_0008667
T4 403-408 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 947-952 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1071-1076 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 578-598 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T2 890-895 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 67-72 Phenotype denotes tumor HP:0002664
T2 107-112 Phenotype denotes tumor HP:0002664
T3 170-177 Phenotype denotes hypoxia HP:0012418
T4 403-408 Phenotype denotes tumor HP:0002664
T5 947-952 Phenotype denotes tumor HP:0002664
T6 1071-1076 Phenotype denotes tumor HP:0002664