> top > docs > PubMed:1731815 > annotations

PubMed:1731815 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 137-255 OBJECTIVE denotes To assess the activity of systemic lupus erythematosus (SLE) during pregnancy and to distinguish it from preeclampsia.
T2 265-493 METHODS denotes We prospectively measured the complement activation products Ba, Bb, SC5b-9, and C4d, as well as the conventional complement determinants C3, C4, and CH50, during pregnancy in 14 patients with SLE and 10 women with preeclampsia.
T3 503-1473 RESULTS denotes Four of the 14 SLE patients were considered to have disease flares, 3 occurring in the second trimester and 1 postpartum. In these patients, significant abnormalities of Ba, Bb, SC5b-9, and CH50 were noted. In contrast, measures of C4d did not distinguish between pregnant patients who had flares and those whose SLE remained stable. Although decreased values of C3 were rarely seen in the patients with stable disease, normal values of C3 during lupus pregnancy were not reliably associated with stable disease. Three of 10 non-SLE patients with preeclampsia had elevated levels of Ba; however, in each case, the CH50 level was close to or within the normal range. This was in sharp contrast to the findings observed in the 4 patients with active SLE, in whom high levels of plasma Ba were always associated with low CH50 values. Moreover, the ratio of CH50 to Ba was significantly lower in the patients with lupus flares than in the non-SLE patients with preeclampsia.
T4 1486-1746 CONCLUSIONS denotes While a decline in the CH50 level alone could otherwise be attributed to decreased synthesis of complement components, these data demonstrate that ongoing activation of the alternative complement pathway can accompany disease flares in pregnant women with SLE.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes Activation of the alternative complement pathway accompanies disease flares in systemic lupus erythematosus during pregnancy.
TextSentencer_T2 126-136 Sentence denotes OBJECTIVE:
TextSentencer_T3 137-255 Sentence denotes To assess the activity of systemic lupus erythematosus (SLE) during pregnancy and to distinguish it from preeclampsia.
TextSentencer_T4 256-264 Sentence denotes METHODS:
TextSentencer_T5 265-493 Sentence denotes We prospectively measured the complement activation products Ba, Bb, SC5b-9, and C4d, as well as the conventional complement determinants C3, C4, and CH50, during pregnancy in 14 patients with SLE and 10 women with preeclampsia.
TextSentencer_T6 494-502 Sentence denotes RESULTS:
TextSentencer_T7 503-624 Sentence denotes Four of the 14 SLE patients were considered to have disease flares, 3 occurring in the second trimester and 1 postpartum.
TextSentencer_T8 625-709 Sentence denotes In these patients, significant abnormalities of Ba, Bb, SC5b-9, and CH50 were noted.
TextSentencer_T9 710-836 Sentence denotes In contrast, measures of C4d did not distinguish between pregnant patients who had flares and those whose SLE remained stable.
TextSentencer_T10 837-1015 Sentence denotes Although decreased values of C3 were rarely seen in the patients with stable disease, normal values of C3 during lupus pregnancy were not reliably associated with stable disease.
TextSentencer_T11 1016-1168 Sentence denotes Three of 10 non-SLE patients with preeclampsia had elevated levels of Ba; however, in each case, the CH50 level was close to or within the normal range.
TextSentencer_T12 1169-1333 Sentence denotes This was in sharp contrast to the findings observed in the 4 patients with active SLE, in whom high levels of plasma Ba were always associated with low CH50 values.
TextSentencer_T13 1334-1473 Sentence denotes Moreover, the ratio of CH50 to Ba was significantly lower in the patients with lupus flares than in the non-SLE patients with preeclampsia.
TextSentencer_T14 1474-1485 Sentence denotes CONCLUSION:
TextSentencer_T15 1486-1746 Sentence denotes While a decline in the CH50 level alone could otherwise be attributed to decreased synthesis of complement components, these data demonstrate that ongoing activation of the alternative complement pathway can accompany disease flares in pregnant women with SLE.
T1 0-125 Sentence denotes Activation of the alternative complement pathway accompanies disease flares in systemic lupus erythematosus during pregnancy.
T2 126-136 Sentence denotes OBJECTIVE:
T3 137-255 Sentence denotes To assess the activity of systemic lupus erythematosus (SLE) during pregnancy and to distinguish it from preeclampsia.
T4 256-264 Sentence denotes METHODS:
T5 265-493 Sentence denotes We prospectively measured the complement activation products Ba, Bb, SC5b-9, and C4d, as well as the conventional complement determinants C3, C4, and CH50, during pregnancy in 14 patients with SLE and 10 women with preeclampsia.
T6 494-502 Sentence denotes RESULTS:
T7 503-624 Sentence denotes Four of the 14 SLE patients were considered to have disease flares, 3 occurring in the second trimester and 1 postpartum.
T8 625-709 Sentence denotes In these patients, significant abnormalities of Ba, Bb, SC5b-9, and CH50 were noted.
T9 710-836 Sentence denotes In contrast, measures of C4d did not distinguish between pregnant patients who had flares and those whose SLE remained stable.
T10 837-1015 Sentence denotes Although decreased values of C3 were rarely seen in the patients with stable disease, normal values of C3 during lupus pregnancy were not reliably associated with stable disease.
T11 1016-1168 Sentence denotes Three of 10 non-SLE patients with preeclampsia had elevated levels of Ba; however, in each case, the CH50 level was close to or within the normal range.
T12 1169-1333 Sentence denotes This was in sharp contrast to the findings observed in the 4 patients with active SLE, in whom high levels of plasma Ba were always associated with low CH50 values.
T13 1334-1473 Sentence denotes Moreover, the ratio of CH50 to Ba was significantly lower in the patients with lupus flares than in the non-SLE patients with preeclampsia.
T14 1474-1485 Sentence denotes CONCLUSION:
T15 1486-1746 Sentence denotes While a decline in the CH50 level alone could otherwise be attributed to decreased synthesis of complement components, these data demonstrate that ongoing activation of the alternative complement pathway can accompany disease flares in pregnant women with SLE.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 163-191 HP_0002725 denotes systemic lupus erythematosus
T2 242-254 HP_0100602 denotes preeclampsia

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 242-254 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 480-492 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 1050-1062 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1460-1472 ORPHA:275555 denotes preeclampsia

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 242-254 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 480-492 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 1050-1062 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1460-1472 ORPHA:275555 denotes preeclampsia