PubMed:17268359 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/17268359","sourcedb":"PubMed","sourceid":"17268359","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/17268359","text":"[Small cell lung cancer (CPC). Second line treatment].\nLes cancers à petites cellules (CPC). Quel traitement de deuxième ligne?\nINTRODUCTION: Despite their initial chemosensitivity 90% of small cell lung cancers (SCLC) need second line treatment on account of failure to respond to initial treatment, progression after a partial response (PR) or relapse after a complete response (CR).\nBACKGROUND: The outlook is universally fatal but, with the exception of patients with very poor performance status, second line treatment is indicated because it gives a 70% response rate in patients relapsing after a CR, using the same treatment if the period before relapse is greater than 3 months. The response rate is 20-30% in cases resistant to first line treatment using different drugs such as topotecan, irinotecan, gemcitabine, and lomustine. Thoracic or cranial irradiation is reserved for palliative indications.\nVIEWPOINT: There is current research aimed at improving quality of life, particularly by using oral treatment. A randomised trial is in progress using a combination of lomustine, cyclophosphamide and etoposide that may lead to comfortable and prolonged survival.\nCONCLUSION: Further collaborative trials are needed to answer this unresolved 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