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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide.
T2 120-262 Sentence denotes Organic peroxides, widely used in the chemical and pharmaceutical industries, can act as skin tumor promoters and cause epidermal hyperplasia.
T3 263-318 Sentence denotes They are also known to trigger free radical generation.
T4 319-540 Sentence denotes The present study evaluated the effect of cumene hydroperoxide (Cum-OOH) on the induction of activator protein-1 (AP-1), which is linked to the expression of genes regulating cell proliferation, growth and transformation.
T5 541-693 Sentence denotes Previously, we reported that topical exposure to Cum-OOH caused formation of free radicals and oxidative stress in the skin of vitamin E-deficient mice.
T6 694-954 Sentence denotes The present study used JB6 P+ mouse epidermal cells and AP-1-luciferase reporter transgenic mice to identify whether exposure to Cum-OOH caused activation of AP-1, oxidative stress, depletion of antioxidants and tumor formation during two-stage carcinogenesis.
T7 955-1109 Sentence denotes In vitro studies found that exposure to Cum-OOH reduced the level of glutathione (GSH) in mouse epidermal cells (JB6 P+) and caused the induction of AP-1.
T8 1110-1315 Sentence denotes Mice primed with dimethyl-benz[a]anthracene (DMBA) were topically exposed to Cum-OOH (82.6 micromol) or the positive control, 12-O-tetradecanoylphorbol-13-acetate (TPA, 17 nmol), twice weekly for 29 weeks.
T9 1316-1410 Sentence denotes Activation of AP-1 in skin was detected as early as 2 weeks following Cum-OOH or TPA exposure.
T10 1411-1466 Sentence denotes No AP-1 expression was found 19 weeks after initiation.
T11 1467-1629 Sentence denotes Papilloma formation was observed in both the DMBA-TPA- and DMBA-Cum-OOH-exposed animals, whereas skin carcinomas were found only in the DMBA-Cum-OOH-treated mice.
T12 1630-1853 Sentence denotes A greater accumulation of peroxidative products (thiobarbituric acid-reactive substances), inflammation and decreased levels of GSH and total antioxidant reserves were also observed in the skin of DMBA-Cum-OOH-exposed mice.
T13 1854-1990 Sentence denotes These results suggest that Cum-OOH-induced carcinogenesis is accompanied by increased AP-1 activation and changes in antioxidant status.
T1 0-119 Sentence denotes Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide.
T2 120-262 Sentence denotes Organic peroxides, widely used in the chemical and pharmaceutical industries, can act as skin tumor promoters and cause epidermal hyperplasia.
T3 263-318 Sentence denotes They are also known to trigger free radical generation.
T4 319-540 Sentence denotes The present study evaluated the effect of cumene hydroperoxide (Cum-OOH) on the induction of activator protein-1 (AP-1), which is linked to the expression of genes regulating cell proliferation, growth and transformation.
T5 541-693 Sentence denotes Previously, we reported that topical exposure to Cum-OOH caused formation of free radicals and oxidative stress in the skin of vitamin E-deficient mice.
T6 694-954 Sentence denotes The present study used JB6 P+ mouse epidermal cells and AP-1-luciferase reporter transgenic mice to identify whether exposure to Cum-OOH caused activation of AP-1, oxidative stress, depletion of antioxidants and tumor formation during two-stage carcinogenesis.
T7 955-1109 Sentence denotes In vitro studies found that exposure to Cum-OOH reduced the level of glutathione (GSH) in mouse epidermal cells (JB6 P+) and caused the induction of AP-1.
T8 1110-1315 Sentence denotes Mice primed with dimethyl-benz[a]anthracene (DMBA) were topically exposed to Cum-OOH (82.6 micromol) or the positive control, 12-O-tetradecanoylphorbol-13-acetate (TPA, 17 nmol), twice weekly for 29 weeks.
T9 1316-1410 Sentence denotes Activation of AP-1 in skin was detected as early as 2 weeks following Cum-OOH or TPA exposure.
T10 1411-1466 Sentence denotes No AP-1 expression was found 19 weeks after initiation.
T11 1467-1629 Sentence denotes Papilloma formation was observed in both the DMBA-TPA- and DMBA-Cum-OOH-exposed animals, whereas skin carcinomas were found only in the DMBA-Cum-OOH-treated mice.
T12 1630-1853 Sentence denotes A greater accumulation of peroxidative products (thiobarbituric acid-reactive substances), inflammation and decreased levels of GSH and total antioxidant reserves were also observed in the skin of DMBA-Cum-OOH-exposed mice.
T13 1854-1990 Sentence denotes These results suggest that Cum-OOH-induced carcinogenesis is accompanied by increased AP-1 activation and changes in antioxidant status.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 209-219 HP_0008069 denotes skin tumor
T2 214-219 HP_0002664 denotes tumor
T3 668-687 HP_0100513 denotes vitamin E-deficient
T4 906-911 HP_0002664 denotes tumor
T5 1467-1476 HP_0012740 denotes Papilloma
T6 1564-1579 HP_0030447 denotes skin carcinomas

bionlp-st-cg-2013-training

Id Subject Object Predicate Lexical cue
T1 27-31 Gene_or_gene_product denotes AP-1
T2 56-62 Organism denotes murine
T3 63-67 Organ denotes skin
T4 98-118 Simple_chemical denotes cumene hydroperoxide
T5 120-137 Simple_chemical denotes Organic peroxides
T6 209-219 Cancer denotes skin tumor
T7 240-261 Pathological_formation denotes epidermal hyperplasia
T8 294-306 Simple_chemical denotes free radical
T9 361-381 Simple_chemical denotes cumene hydroperoxide
T10 383-390 Simple_chemical denotes Cum-OOH
T11 412-431 Gene_or_gene_product denotes activator protein-1
T12 433-437 Gene_or_gene_product denotes AP-1
T13 494-498 Cell denotes cell
T14 590-597 Simple_chemical denotes Cum-OOH
T15 618-631 Simple_chemical denotes free radicals
T16 660-664 Organ denotes skin
T17 668-677 Simple_chemical denotes vitamin E
T18 688-692 Organism denotes mice
T19 717-745 Cell denotes JB6 P+ mouse epidermal cells
T20 724-729 Organism denotes mouse
T21 750-754 Gene_or_gene_product denotes AP-1
T22 755-765 Gene_or_gene_product denotes luciferase
T23 786-790 Organism denotes mice
T24 823-830 Simple_chemical denotes Cum-OOH
T25 852-856 Gene_or_gene_product denotes AP-1
T26 906-911 Cancer denotes tumor
T27 995-1002 Simple_chemical denotes Cum-OOH
T28 1024-1035 Simple_chemical denotes glutathione
T29 1037-1040 Simple_chemical denotes GSH
T30 1045-1050 Organism denotes mouse
T31 1051-1066 Cell denotes epidermal cells
T32 1068-1074 Cell denotes JB6 P+
T33 1104-1108 Gene_or_gene_product denotes AP-1
T34 1110-1114 Organism denotes Mice
T35 1127-1153 Simple_chemical denotes dimethyl-benz[a]anthracene
T36 1155-1159 Simple_chemical denotes DMBA
T37 1187-1194 Simple_chemical denotes Cum-OOH
T38 1236-1272 Simple_chemical denotes 12-O-tetradecanoylphorbol-13-acetate
T39 1274-1277 Simple_chemical denotes TPA
T40 1330-1334 Gene_or_gene_product denotes AP-1
T41 1338-1342 Organ denotes skin
T42 1386-1393 Simple_chemical denotes Cum-OOH
T43 1397-1400 Simple_chemical denotes TPA
T44 1414-1418 Gene_or_gene_product denotes AP-1
T45 1467-1476 Pathological_formation denotes Papilloma
T46 1512-1516 Simple_chemical denotes DMBA
T47 1517-1520 Simple_chemical denotes TPA
T48 1526-1530 Simple_chemical denotes DMBA
T49 1531-1538 Simple_chemical denotes Cum-OOH
T50 1547-1554 Organism denotes animals
T51 1564-1579 Cancer denotes skin carcinomas
T52 1603-1607 Simple_chemical denotes DMBA
T53 1608-1615 Simple_chemical denotes Cum-OOH
T54 1624-1628 Organism denotes mice
T55 1679-1698 Simple_chemical denotes thiobarbituric acid
T56 1758-1761 Simple_chemical denotes GSH
T57 1819-1823 Organ denotes skin
T58 1827-1831 Simple_chemical denotes DMBA
T59 1832-1839 Simple_chemical denotes Cum-OOH
T60 1848-1852 Organism denotes mice
T61 1881-1888 Simple_chemical denotes Cum-OOH
T62 1940-1944 Gene_or_gene_product denotes AP-1