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PubMed:17221831 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients.
T2 124-328 Sentence denotes Alzheimer's disease (AD) is a polygenic and multifactorial complex disease, whose etiopathology is still unclear, however several genetic factors have shown to increase the risk of developing the disease.
T3 329-400 Sentence denotes Purine nucleotides and nucleosides play an important role in the brain.
T4 401-545 Sentence denotes Besides their role in neurotransmission and neuromodulation, they are involved in trophic factor release, apoptosis, and inflammatory responses.
T5 546-656 Sentence denotes These mediators may also have a pivotal role in the control of neurodegenerative processes associated with AD.
T6 657-968 Sentence denotes In this report the distribution of the exonic G/A single nucleotide polymorphism (SNP) in purine nucleoside phosphorylase (PNP) gene, resulting in the amino acid substitution serine to glycine at position 51 (G51S), was investigated in a large population of AD patients (n=321) and non-demented control (n=208).
T7 969-1051 Sentence denotes The PNP polymorphism distribution was not different between patients and controls.
T8 1052-1216 Sentence denotes The polymorphism distribution was also analyzed in AD patients stratified according to differential progressive rate of cognitive decline during a 2-year follow-up.
T9 1217-1397 Sentence denotes An increased representation of the PNP AA genotype was observed in AD patients with fast cognitive deterioration in comparison with that from patients with slow deterioration rate.
T10 1398-1627 Sentence denotes Our findings suggest that the G51S PNP polymorphism is associated with a faster rate of cognitive decline in AD patients, highlighting the important role of purine metabolism in the progression of this neurodegenerative disorder.
T1 0-123 Sentence denotes The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients.
T2 124-328 Sentence denotes Alzheimer's disease (AD) is a polygenic and multifactorial complex disease, whose etiopathology is still unclear, however several genetic factors have shown to increase the risk of developing the disease.
T3 329-400 Sentence denotes Purine nucleotides and nucleosides play an important role in the brain.
T4 401-545 Sentence denotes Besides their role in neurotransmission and neuromodulation, they are involved in trophic factor release, apoptosis, and inflammatory responses.
T5 546-656 Sentence denotes These mediators may also have a pivotal role in the control of neurodegenerative processes associated with AD.
T6 657-968 Sentence denotes In this report the distribution of the exonic G/A single nucleotide polymorphism (SNP) in purine nucleoside phosphorylase (PNP) gene, resulting in the amino acid substitution serine to glycine at position 51 (G51S), was investigated in a large population of AD patients (n=321) and non-demented control (n=208).
T7 969-1051 Sentence denotes The PNP polymorphism distribution was not different between patients and controls.
T8 1052-1216 Sentence denotes The polymorphism distribution was also analyzed in AD patients stratified according to differential progressive rate of cognitive decline during a 2-year follow-up.
T9 1217-1397 Sentence denotes An increased representation of the PNP AA genotype was observed in AD patients with fast cognitive deterioration in comparison with that from patients with slow deterioration rate.
T10 1398-1627 Sentence denotes Our findings suggest that the G51S PNP polymorphism is associated with a faster rate of cognitive decline in AD patients, highlighting the important role of purine metabolism in the progression of this neurodegenerative disorder.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3849 4-8 SequenceVariant denotes G51S DBSNP:rs1049564
3850 9-40 GeneOrGeneProduct denotes purine nucleoside phosphorylase NCBIGene:4860
3851 73-90 DiseaseOrPhenotypicFeature denotes cognitive decline MESH:D003072
3852 94-113 DiseaseOrPhenotypicFeature denotes Alzheimer's disease MESH:D000544
3853 114-122 OrganismTaxon denotes patients NCBITaxon:9606
3854 124-143 DiseaseOrPhenotypicFeature denotes Alzheimer's disease MESH:D000544
3855 145-147 DiseaseOrPhenotypicFeature denotes AD MESH:D000544
3856 522-534 DiseaseOrPhenotypicFeature denotes inflammatory MESH:D007249
3857 653-655 DiseaseOrPhenotypicFeature denotes AD MESH:D000544
3858 703-706 SequenceVariant denotes G/A DBSNP:rs1049564
3859 747-778 GeneOrGeneProduct denotes purine nucleoside phosphorylase NCBIGene:4860
3860 780-783 GeneOrGeneProduct denotes PNP NCBIGene:4860
3861 832-864 SequenceVariant denotes serine to glycine at position 51 DBSNP:rs1049564
3862 866-870 SequenceVariant denotes G51S DBSNP:rs1049564
3863 915-917 DiseaseOrPhenotypicFeature denotes AD MESH:D000544
3864 918-926 OrganismTaxon denotes patients NCBITaxon:9606
3865 973-976 GeneOrGeneProduct denotes PNP NCBIGene:4860
3866 1029-1037 OrganismTaxon denotes patients NCBITaxon:9606
3867 1103-1105 DiseaseOrPhenotypicFeature denotes AD MESH:D000544
3868 1106-1114 OrganismTaxon denotes patients NCBITaxon:9606
3869 1172-1189 DiseaseOrPhenotypicFeature denotes cognitive decline MESH:D003072
3870 1252-1255 GeneOrGeneProduct denotes PNP NCBIGene:4860
3871 1284-1286 DiseaseOrPhenotypicFeature denotes AD MESH:D000544
3872 1287-1295 OrganismTaxon denotes patients NCBITaxon:9606
3873 1306-1329 DiseaseOrPhenotypicFeature denotes cognitive deterioration MESH:D003072
3874 1359-1367 OrganismTaxon denotes patients NCBITaxon:9606
3875 1428-1432 SequenceVariant denotes G51S DBSNP:rs1049564
3876 1433-1436 GeneOrGeneProduct denotes PNP NCBIGene:4860
3877 1486-1503 DiseaseOrPhenotypicFeature denotes cognitive decline MESH:D003072
3878 1507-1509 DiseaseOrPhenotypicFeature denotes AD MESH:D000544
3879 1510-1518 OrganismTaxon denotes patients NCBITaxon:9606
3880 1600-1626 DiseaseOrPhenotypicFeature denotes neurodegenerative disorder MESH:D019636

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients.
T2 124-328 Sentence denotes Alzheimer's disease (AD) is a polygenic and multifactorial complex disease, whose etiopathology is still unclear, however several genetic factors have shown to increase the risk of developing the disease.
T3 329-400 Sentence denotes Purine nucleotides and nucleosides play an important role in the brain.
T4 401-545 Sentence denotes Besides their role in neurotransmission and neuromodulation, they are involved in trophic factor release, apoptosis, and inflammatory responses.
T5 546-656 Sentence denotes These mediators may also have a pivotal role in the control of neurodegenerative processes associated with AD.
T6 657-968 Sentence denotes In this report the distribution of the exonic G/A single nucleotide polymorphism (SNP) in purine nucleoside phosphorylase (PNP) gene, resulting in the amino acid substitution serine to glycine at position 51 (G51S), was investigated in a large population of AD patients (n=321) and non-demented control (n=208).
T7 969-1051 Sentence denotes The PNP polymorphism distribution was not different between patients and controls.
T8 1052-1216 Sentence denotes The polymorphism distribution was also analyzed in AD patients stratified according to differential progressive rate of cognitive decline during a 2-year follow-up.
T9 1217-1397 Sentence denotes An increased representation of the PNP AA genotype was observed in AD patients with fast cognitive deterioration in comparison with that from patients with slow deterioration rate.
T10 1398-1627 Sentence denotes Our findings suggest that the G51S PNP polymorphism is associated with a faster rate of cognitive decline in AD patients, highlighting the important role of purine metabolism in the progression of this neurodegenerative disorder.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 94-113 DiseaseOrPhenotypicFeature denotes Alzheimer's disease 0004975
T2 124-143 DiseaseOrPhenotypicFeature denotes Alzheimer's disease 0004975

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 4-8 SequenceVariant denotes G51S
T2 866-870 SequenceVariant denotes G51S
T3 1428-1432 SequenceVariant denotes G51S

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 9-40 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T2 229-236 GeneOrGeneProduct denotes unclear
T3 262-269 GeneOrGeneProduct denotes factors
T4 352-363 GeneOrGeneProduct denotes nucleosides
T5 394-399 GeneOrGeneProduct denotes brain
T6 491-497 GeneOrGeneProduct denotes factor
T7 507-516 GeneOrGeneProduct denotes apoptosis
T8 552-561 GeneOrGeneProduct denotes mediators
T9 578-585 GeneOrGeneProduct denotes pivotal
T10 627-636 GeneOrGeneProduct denotes processes
T11 747-778 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T12 808-818 GeneOrGeneProduct denotes amino acid
T13 890-894 GeneOrGeneProduct denotes in a
T14 895-900 GeneOrGeneProduct denotes large
T15 1197-1200 GeneOrGeneProduct denotes a 2
T16 1201-1205 GeneOrGeneProduct denotes year
T17 1301-1305 GeneOrGeneProduct denotes fast
T18 1373-1377 GeneOrGeneProduct denotes slow
T19 1402-1410 GeneOrGeneProduct denotes findings

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 9-40 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T2 229-236 GeneOrGeneProduct denotes unclear
T3 352-363 GeneOrGeneProduct denotes nucleosides
T4 394-399 GeneOrGeneProduct denotes brain
T5 491-497 GeneOrGeneProduct denotes factor
T6 507-516 GeneOrGeneProduct denotes apoptosis
T7 747-778 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T8 808-818 GeneOrGeneProduct denotes amino acid
T9 895-900 GeneOrGeneProduct denotes large
T10 1301-1305 GeneOrGeneProduct denotes fast
T11 1373-1377 GeneOrGeneProduct denotes slow

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 73-90 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T2 94-113 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T3 124-143 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T4 145-147 DiseaseOrPhenotypicFeature denotes AD D000544
T5 191-198 DiseaseOrPhenotypicFeature denotes disease D004194
T6 320-327 DiseaseOrPhenotypicFeature denotes disease D004194
T7 522-534 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T8 653-655 DiseaseOrPhenotypicFeature denotes AD D000544
T9 915-917 DiseaseOrPhenotypicFeature denotes AD D000544
T10 1103-1105 DiseaseOrPhenotypicFeature denotes AD D000544
T11 1172-1189 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T12 1284-1286 DiseaseOrPhenotypicFeature denotes AD D000544
T13 1486-1503 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T14 1507-1509 DiseaseOrPhenotypicFeature denotes AD D000544
T15 1600-1626 DiseaseOrPhenotypicFeature denotes neurodegenerative disorder D019636

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 9-40 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T2 352-363 GeneOrGeneProduct denotes nucleosides
T3 747-778 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T4 1373-1377 GeneOrGeneProduct denotes slow

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 94-113 DiseaseOrPhenotypicFeature denotes Alzheimer's disease 0004975
T2 124-143 DiseaseOrPhenotypicFeature denotes Alzheimer's disease 0004975
T3 145-147 DiseaseOrPhenotypicFeature denotes AD 0011913|0007088|0004975
T6 653-655 DiseaseOrPhenotypicFeature denotes AD 0011913|0007088|0004975
T9 915-917 DiseaseOrPhenotypicFeature denotes AD 0011913|0007088|0004975
T12 1103-1105 DiseaseOrPhenotypicFeature denotes AD 0011913|0007088|0004975
T15 1284-1286 DiseaseOrPhenotypicFeature denotes AD 0011913|0007088|0004975
T18 1507-1509 DiseaseOrPhenotypicFeature denotes AD 0011913|0007088|0004975

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 73-90 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T2 94-113 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T3 124-143 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T4 145-147 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T6 191-198 DiseaseOrPhenotypicFeature denotes disease D004194
T7 320-327 DiseaseOrPhenotypicFeature denotes disease D004194
T8 522-534 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T9 653-655 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T11 915-917 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T13 1103-1105 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T15 1172-1189 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T16 1284-1286 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T18 1306-1329 DiseaseOrPhenotypicFeature denotes cognitive deterioration DISEASE
T19 1486-1503 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T20 1507-1509 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T22 1600-1626 DiseaseOrPhenotypicFeature denotes neurodegenerative disorder D019636

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 73-90 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T2 94-113 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T3 124-143 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T4 145-147 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T6 653-655 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T8 915-917 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T10 1103-1105 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T12 1172-1189 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T13 1284-1286 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T15 1306-1329 DiseaseOrPhenotypicFeature denotes cognitive deterioration DISEASE
T16 1486-1503 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T17 1507-1509 DiseaseOrPhenotypicFeature denotes AD DISEASE|D000544
T19 1600-1626 DiseaseOrPhenotypicFeature denotes neurodegenerative disorder D019636

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 9-40 ChemicalEntity denotes purine nucleoside phosphorylase D011683
T2 329-335 ChemicalEntity denotes Purine http://purl.obolibrary.org/obo/CHEBI_17258
T3 352-363 ChemicalEntity denotes nucleosides http://purl.obolibrary.org/obo/CHEBI_33838
T4 747-778 ChemicalEntity denotes purine nucleoside phosphorylase D011683
T5 780-783 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T6 832-838 ChemicalEntity denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T7 842-849 ChemicalEntity denotes glycine http://purl.obolibrary.org/obo/CHEBI_57305|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_15428
T10 973-976 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T11 1252-1255 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T12 1433-1436 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T13 1555-1561 ChemicalEntity denotes purine C030985|http://purl.obolibrary.org/obo/CHEBI_35584

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 114-122 OrganismTaxon denotes patients
T2 918-926 OrganismTaxon denotes patients
T3 1029-1037 OrganismTaxon denotes patients
T4 1106-1114 OrganismTaxon denotes patients
T5 1287-1295 OrganismTaxon denotes patients
T6 1359-1367 OrganismTaxon denotes patients
T7 1510-1518 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T13 1555-1561 ChemicalEntity denotes purine http://purl.obolibrary.org/obo/CHEBI_35584|C030985
T12 1433-1436 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T11 1252-1255 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T10 973-976 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T7 842-849 ChemicalEntity denotes glycine http://purl.obolibrary.org/obo/CHEBI_15428|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_57305
T6 832-838 ChemicalEntity denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T5 780-783 ChemicalEntity denotes PNP http://purl.obolibrary.org/obo/CHEBI_16836
T4 747-778 ChemicalEntity denotes purine nucleoside phosphorylase D011683
T3 352-363 ChemicalEntity denotes nucleosides http://purl.obolibrary.org/obo/CHEBI_33838
T2 329-335 ChemicalEntity denotes Purine http://purl.obolibrary.org/obo/CHEBI_17258
T1 9-40 ChemicalEntity denotes purine nucleoside phosphorylase D011683
T35685 1373-1377 GeneOrGeneProduct denotes slow
T84050 747-778 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T5991 352-363 GeneOrGeneProduct denotes nucleosides
T30473 9-40 GeneOrGeneProduct denotes purine nucleoside phosphorylase
T19 1600-1626 DiseaseOrPhenotypicFeature denotes neurodegenerative disorder D019636
T17 1507-1509 DiseaseOrPhenotypicFeature denotes AD D000544|DISEASE
T16 1486-1503 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T15 1306-1329 DiseaseOrPhenotypicFeature denotes cognitive deterioration DISEASE
T89557 1284-1286 DiseaseOrPhenotypicFeature denotes AD D000544|DISEASE
T68515 1172-1189 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T66237 1103-1105 DiseaseOrPhenotypicFeature denotes AD D000544|DISEASE
T8 915-917 DiseaseOrPhenotypicFeature denotes AD D000544|DISEASE
T20833 653-655 DiseaseOrPhenotypicFeature denotes AD D000544|DISEASE
T12320 145-147 DiseaseOrPhenotypicFeature denotes AD D000544|DISEASE
T68831 124-143 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T37709 94-113 DiseaseOrPhenotypicFeature denotes Alzheimer's disease D000544
T58916 73-90 DiseaseOrPhenotypicFeature denotes cognitive decline D060825
T49955 1510-1518 OrganismTaxon denotes patients
T30695 1359-1367 OrganismTaxon denotes patients
T56412 1287-1295 OrganismTaxon denotes patients
T92765 1106-1114 OrganismTaxon denotes patients
T10239 1029-1037 OrganismTaxon denotes patients
T77991 918-926 OrganismTaxon denotes patients
T47356 114-122 OrganismTaxon denotes patients
T4721 1428-1432 SequenceVariant denotes G51S
T56403 866-870 SequenceVariant denotes G51S
T61763 4-8 SequenceVariant denotes G51S

DisGeNET

Id Subject Object Predicate Lexical cue
T0 9-40 gene:4860 denotes purine nucleoside phosphorylase
T1 73-90 disease:C0338656 denotes cognitive decline
T2 780-783 gene:4860 denotes PNP
T3 915-917 disease:C0002395 denotes AD
T4 1252-1255 gene:4860 denotes PNP
T5 1306-1329 disease:C0854193 denotes cognitive deterioration
T6 1433-1436 gene:4860 denotes PNP
T7 1507-1509 disease:C0002395 denotes AD
T8 1433-1436 gene:4860 denotes PNP
T9 1486-1503 disease:C0338656 denotes cognitive decline
T10 1433-1436 gene:4860 denotes PNP
T11 1600-1626 disease:C0524851 denotes neurodegenerative disorder
R1 T0 T1 associated_with purine nucleoside phosphorylase,cognitive decline
R2 T2 T3 associated_with PNP,AD
R3 T4 T5 associated_with PNP,cognitive deterioration
R4 T6 T7 associated_with PNP,AD
R5 T8 T9 associated_with PNP,cognitive decline
R6 T10 T11 associated_with PNP,neurodegenerative disorder

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 124-143 HP_0002511 denotes Alzheimer's disease
T2 1172-1189 HP_0001268 denotes cognitive decline
T3 1486-1503 HP_0001268 denotes cognitive decline

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 4-8 ProteinMutation:p|SUB|G|51|S denotes G51S
T2 703-706 DNAMutation:|SUB|G||A denotes G/A
T3 866-870 ProteinMutation:p|SUB|G|51|S denotes G51S
T4 1428-1432 ProteinMutation:p|SUB|G|51|S denotes G51S