PubMed:17185386
Annnotations
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-133 | Sentence | denotes | Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. |
T2 | 134-333 | Sentence | denotes | We have previously reported a robust association between an allelic haplotype of 'Disrupted in Schizophrenia 1' (DISC1) and schizophrenia in a nationwide collection of Finnish schizophrenia families. |
T3 | 334-444 | Sentence | denotes | This specific DISC1 allele was later identified to associate with visual working memory, selectively in males. |
T4 | 445-571 | Sentence | denotes | DISC1 association to schizophrenia has since been replicated in multiple independent study samples from different populations. |
T5 | 572-790 | Sentence | denotes | In this study, we conditioned our sample of Finnish families for the presence of the Finnish tentative risk allele for DISC1 and re-analyzed our genome-wide scan data of 443 markers on the basis of this stratification. |
T6 | 791-978 | Sentence | denotes | Two additional loci displayed an evidence of linkage (LOD > 3) and included a locus on 16p13, proximal to the gene encoding NDE1, which has been shown to biologically interact with DISC1. |
T7 | 979-1290 | Sentence | denotes | Although none of the observed linkages remained significant after multiple test correction through simulation, further analysis of NDE1 revealed an association between a tag-haplotype and schizophrenia (P = 0.00046) specific to females, which proved to be significant (P = 0.011) after multiple test correction. |
T8 | 1291-1465 | Sentence | denotes | Our finding would support the concept that initial gene findings in multifactorial diseases will assist in the identification of other components of complex genetic etiology. |
T9 | 1466-1614 | Sentence | denotes | Notably, this and other converging lines of evidence underline the importance of DISC1-related functional pathways in the etiology of schizophrenia. |
LitCoin-entities-OrganismTaxon-PD
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 288-298 | OrganismTaxon | denotes | collection | NCBItxid:1768868 |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
3775 | 33-38 | GeneOrGeneProduct | denotes | DISC1 | NCBIGene:27185 |
3776 | 61-74 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3777 | 128-132 | GeneOrGeneProduct | denotes | NDE1 | NCBIGene:54820 |
3778 | 216-244 | GeneOrGeneProduct | denotes | Disrupted in Schizophrenia 1 | NCBIGene:27185 |
3779 | 247-252 | GeneOrGeneProduct | denotes | DISC1 | NCBIGene:27185 |
3780 | 258-271 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3781 | 310-323 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3782 | 348-353 | GeneOrGeneProduct | denotes | DISC1 | NCBIGene:27185 |
3783 | 445-450 | GeneOrGeneProduct | denotes | DISC1 | NCBIGene:27185 |
3784 | 466-479 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3785 | 691-696 | GeneOrGeneProduct | denotes | DISC1 | NCBIGene:27185 |
3786 | 915-919 | GeneOrGeneProduct | denotes | NDE1 | NCBIGene:54820 |
3787 | 972-977 | GeneOrGeneProduct | denotes | DISC1 | NCBIGene:27185 |
3788 | 1110-1114 | GeneOrGeneProduct | denotes | NDE1 | NCBIGene:54820 |
3789 | 1167-1180 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3790 | 1547-1552 | GeneOrGeneProduct | denotes | DISC1 | NCBIGene:27185 |
3791 | 1600-1613 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 61-74 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T2 | 229-244 | DiseaseOrPhenotypicFeature | denotes | Schizophrenia 1 | 0008414 |
T3 | 258-271 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T4 | 310-323 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T5 | 466-479 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T6 | 1167-1180 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T7 | 1600-1613 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 33-38 | GeneOrGeneProduct | denotes | DISC1 |
T2 | 48-52 | GeneOrGeneProduct | denotes | link |
T3 | 128-132 | GeneOrGeneProduct | denotes | NDE1 |
T4 | 216-244 | GeneOrGeneProduct | denotes | Disrupted in Schizophrenia 1 |
T5 | 247-252 | GeneOrGeneProduct | denotes | DISC1 |
T6 | 348-353 | GeneOrGeneProduct | denotes | DISC1 |
T7 | 445-450 | GeneOrGeneProduct | denotes | DISC1 |
T8 | 509-517 | GeneOrGeneProduct | denotes | multiple |
T9 | 691-696 | GeneOrGeneProduct | denotes | DISC1 |
T10 | 915-919 | GeneOrGeneProduct | denotes | NDE1 |
T11 | 972-977 | GeneOrGeneProduct | denotes | DISC1 |
T12 | 988-992 | GeneOrGeneProduct | denotes | none |
T13 | 1045-1053 | GeneOrGeneProduct | denotes | multiple |
T14 | 1110-1114 | GeneOrGeneProduct | denotes | NDE1 |
T15 | 1265-1273 | GeneOrGeneProduct | denotes | multiple |
T16 | 1420-1425 | GeneOrGeneProduct | denotes | other |
T17 | 1484-1489 | GeneOrGeneProduct | denotes | other |
T18 | 1501-1506 | GeneOrGeneProduct | denotes | lines |
T19 | 1547-1552 | GeneOrGeneProduct | denotes | DISC1 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 33-38 | GeneOrGeneProduct | denotes | DISC1 |
T2 | 48-52 | GeneOrGeneProduct | denotes | link |
T3 | 128-132 | GeneOrGeneProduct | denotes | NDE1 |
T4 | 216-244 | GeneOrGeneProduct | denotes | Disrupted in Schizophrenia 1 |
T5 | 247-252 | GeneOrGeneProduct | denotes | DISC1 |
T6 | 272-276 | GeneOrGeneProduct | denotes | in a |
T7 | 348-353 | GeneOrGeneProduct | denotes | DISC1 |
T8 | 365-370 | GeneOrGeneProduct | denotes | later |
T9 | 438-443 | GeneOrGeneProduct | denotes | males |
T10 | 445-450 | GeneOrGeneProduct | denotes | DISC1 |
T11 | 509-517 | GeneOrGeneProduct | denotes | multiple |
T12 | 691-696 | GeneOrGeneProduct | denotes | DISC1 |
T13 | 761-766 | GeneOrGeneProduct | denotes | basis |
T14 | 915-919 | GeneOrGeneProduct | denotes | NDE1 |
T15 | 972-977 | GeneOrGeneProduct | denotes | DISC1 |
T16 | 988-992 | GeneOrGeneProduct | denotes | none |
T17 | 1045-1053 | GeneOrGeneProduct | denotes | multiple |
T18 | 1054-1058 | GeneOrGeneProduct | denotes | test |
T19 | 1110-1114 | GeneOrGeneProduct | denotes | NDE1 |
T20 | 1265-1273 | GeneOrGeneProduct | denotes | multiple |
T21 | 1274-1278 | GeneOrGeneProduct | denotes | test |
T22 | 1295-1302 | GeneOrGeneProduct | denotes | finding |
T23 | 1321-1328 | GeneOrGeneProduct | denotes | concept |
T24 | 1334-1341 | GeneOrGeneProduct | denotes | initial |
T25 | 1347-1355 | GeneOrGeneProduct | denotes | findings |
T26 | 1420-1425 | GeneOrGeneProduct | denotes | other |
T27 | 1484-1489 | GeneOrGeneProduct | denotes | other |
T28 | 1501-1506 | GeneOrGeneProduct | denotes | lines |
T29 | 1547-1552 | GeneOrGeneProduct | denotes | DISC1 |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 61-74 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T2 | 229-242 | DiseaseOrPhenotypicFeature | denotes | Schizophrenia | D012559 |
T3 | 258-271 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T4 | 310-323 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T5 | 466-479 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T6 | 1167-1180 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T7 | 1374-1382 | DiseaseOrPhenotypicFeature | denotes | diseases | D004194 |
T8 | 1600-1613 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 33-38 | GeneOrGeneProduct | denotes | DISC1 |
T2 | 128-132 | GeneOrGeneProduct | denotes | NDE1 |
T3 | 216-244 | GeneOrGeneProduct | denotes | Disrupted in Schizophrenia 1 |
T4 | 247-252 | GeneOrGeneProduct | denotes | DISC1 |
T5 | 348-353 | GeneOrGeneProduct | denotes | DISC1 |
T6 | 445-450 | GeneOrGeneProduct | denotes | DISC1 |
T7 | 691-696 | GeneOrGeneProduct | denotes | DISC1 |
T8 | 915-919 | GeneOrGeneProduct | denotes | NDE1 |
T9 | 972-977 | GeneOrGeneProduct | denotes | DISC1 |
T10 | 1110-1114 | GeneOrGeneProduct | denotes | NDE1 |
T11 | 1547-1552 | GeneOrGeneProduct | denotes | DISC1 |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 61-74 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T2 | 229-244 | DiseaseOrPhenotypicFeature | denotes | Schizophrenia 1 | 0008414 |
T3 | 258-271 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T4 | 310-323 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T5 | 466-479 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T6 | 1167-1180 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T7 | 1600-1613 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 61-74 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T2 | 229-242 | DiseaseOrPhenotypicFeature | denotes | Schizophrenia | D012559 |
T3 | 258-271 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T4 | 310-323 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T5 | 466-479 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T6 | 1167-1180 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T7 | 1374-1382 | DiseaseOrPhenotypicFeature | denotes | diseases | D004194 |
T8 | 1600-1613 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 61-74 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T2 | 229-242 | DiseaseOrPhenotypicFeature | denotes | Schizophrenia | D012559 |
T3 | 258-271 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T4 | 310-323 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T5 | 466-479 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T6 | 1167-1180 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T7 | 1600-1613 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T11 | 1547-1552 | GeneOrGeneProduct | denotes | DISC1 | |
T10 | 1110-1114 | GeneOrGeneProduct | denotes | NDE1 | |
T9 | 972-977 | GeneOrGeneProduct | denotes | DISC1 | |
T8 | 915-919 | GeneOrGeneProduct | denotes | NDE1 | |
T7 | 691-696 | GeneOrGeneProduct | denotes | DISC1 | |
T6 | 445-450 | GeneOrGeneProduct | denotes | DISC1 | |
T5 | 348-353 | GeneOrGeneProduct | denotes | DISC1 | |
T4 | 247-252 | GeneOrGeneProduct | denotes | DISC1 | |
T3 | 216-244 | GeneOrGeneProduct | denotes | Disrupted in Schizophrenia 1 | |
T2 | 128-132 | GeneOrGeneProduct | denotes | NDE1 | |
T1 | 33-38 | GeneOrGeneProduct | denotes | DISC1 | |
T66078 | 1600-1613 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T29215 | 1167-1180 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T10964 | 466-479 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T68829 | 310-323 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T80541 | 258-271 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T13878 | 229-242 | DiseaseOrPhenotypicFeature | denotes | Schizophrenia | D012559 |
T27086 | 61-74 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 33-38 | gene:27185 | denotes | DISC1 |
T1 | 61-74 | disease:C0036341 | denotes | schizophrenia |
T2 | 247-252 | gene:27185 | denotes | DISC1 |
T3 | 258-271 | disease:C0036341 | denotes | schizophrenia |
T4 | 216-244 | gene:27185 | denotes | Disrupted in Schizophrenia 1 |
T5 | 258-271 | disease:C0036341 | denotes | schizophrenia |
T6 | 348-353 | gene:27185 | denotes | DISC1 |
T7 | 466-479 | disease:C0036341 | denotes | schizophrenia |
T8 | 1110-1114 | gene:54820 | denotes | NDE1 |
T9 | 1167-1180 | disease:C0036341 | denotes | schizophrenia |
T10 | 1547-1552 | gene:27185 | denotes | DISC1 |
T11 | 1600-1613 | disease:C0036341 | denotes | schizophrenia |
R1 | T0 | T1 | associated_with | DISC1,schizophrenia |
R2 | T2 | T3 | associated_with | DISC1,schizophrenia |
R3 | T4 | T5 | associated_with | Disrupted in Schizophrenia 1,schizophrenia |
R4 | T6 | T7 | associated_with | DISC1,schizophrenia |
R5 | T8 | T9 | associated_with | NDE1,schizophrenia |
R6 | T10 | T11 | associated_with | DISC1,schizophrenia |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 229-242 | HP_0100753 | denotes | Schizophrenia |
T2 | 258-271 | HP_0100753 | denotes | schizophrenia |
T3 | 310-323 | HP_0100753 | denotes | schizophrenia |
T4 | 466-479 | HP_0100753 | denotes | schizophrenia |
T5 | 1167-1180 | HP_0100753 | denotes | schizophrenia |
T6 | 1600-1613 | HP_0100753 | denotes | schizophrenia |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
17185386-0#33#38#gene27185 | 33-38 | gene27185 | denotes | DISC1 |
17185386-0#61#74#diseaseC0036341 | 61-74 | diseaseC0036341 | denotes | schizophrenia |
17185386-6#131#135#gene54820 | 1110-1114 | gene54820 | denotes | NDE1 |
17185386-6#188#201#diseaseC0036341 | 1167-1180 | diseaseC0036341 | denotes | schizophrenia |
33#38#gene2718561#74#diseaseC0036341 | 17185386-0#33#38#gene27185 | 17185386-0#61#74#diseaseC0036341 | associated_with | DISC1,schizophrenia |
131#135#gene54820188#201#diseaseC0036341 | 17185386-6#131#135#gene54820 | 17185386-6#188#201#diseaseC0036341 | associated_with | NDE1,schizophrenia |