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PubMed:17185386 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1.
T2 134-333 Sentence denotes We have previously reported a robust association between an allelic haplotype of 'Disrupted in Schizophrenia 1' (DISC1) and schizophrenia in a nationwide collection of Finnish schizophrenia families.
T3 334-444 Sentence denotes This specific DISC1 allele was later identified to associate with visual working memory, selectively in males.
T4 445-571 Sentence denotes DISC1 association to schizophrenia has since been replicated in multiple independent study samples from different populations.
T5 572-790 Sentence denotes In this study, we conditioned our sample of Finnish families for the presence of the Finnish tentative risk allele for DISC1 and re-analyzed our genome-wide scan data of 443 markers on the basis of this stratification.
T6 791-978 Sentence denotes Two additional loci displayed an evidence of linkage (LOD > 3) and included a locus on 16p13, proximal to the gene encoding NDE1, which has been shown to biologically interact with DISC1.
T7 979-1290 Sentence denotes Although none of the observed linkages remained significant after multiple test correction through simulation, further analysis of NDE1 revealed an association between a tag-haplotype and schizophrenia (P = 0.00046) specific to females, which proved to be significant (P = 0.011) after multiple test correction.
T8 1291-1465 Sentence denotes Our finding would support the concept that initial gene findings in multifactorial diseases will assist in the identification of other components of complex genetic etiology.
T9 1466-1614 Sentence denotes Notably, this and other converging lines of evidence underline the importance of DISC1-related functional pathways in the etiology of schizophrenia.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 288-298 OrganismTaxon denotes collection NCBItxid:1768868

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3775 33-38 GeneOrGeneProduct denotes DISC1 NCBIGene:27185
3776 61-74 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3777 128-132 GeneOrGeneProduct denotes NDE1 NCBIGene:54820
3778 216-244 GeneOrGeneProduct denotes Disrupted in Schizophrenia 1 NCBIGene:27185
3779 247-252 GeneOrGeneProduct denotes DISC1 NCBIGene:27185
3780 258-271 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3781 310-323 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3782 348-353 GeneOrGeneProduct denotes DISC1 NCBIGene:27185
3783 445-450 GeneOrGeneProduct denotes DISC1 NCBIGene:27185
3784 466-479 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3785 691-696 GeneOrGeneProduct denotes DISC1 NCBIGene:27185
3786 915-919 GeneOrGeneProduct denotes NDE1 NCBIGene:54820
3787 972-977 GeneOrGeneProduct denotes DISC1 NCBIGene:27185
3788 1110-1114 GeneOrGeneProduct denotes NDE1 NCBIGene:54820
3789 1167-1180 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
3790 1547-1552 GeneOrGeneProduct denotes DISC1 NCBIGene:27185
3791 1600-1613 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 61-74 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T2 229-244 DiseaseOrPhenotypicFeature denotes Schizophrenia 1 0008414
T3 258-271 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T4 310-323 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T5 466-479 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T6 1167-1180 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T7 1600-1613 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 33-38 GeneOrGeneProduct denotes DISC1
T2 48-52 GeneOrGeneProduct denotes link
T3 128-132 GeneOrGeneProduct denotes NDE1
T4 216-244 GeneOrGeneProduct denotes Disrupted in Schizophrenia 1
T5 247-252 GeneOrGeneProduct denotes DISC1
T6 348-353 GeneOrGeneProduct denotes DISC1
T7 445-450 GeneOrGeneProduct denotes DISC1
T8 509-517 GeneOrGeneProduct denotes multiple
T9 691-696 GeneOrGeneProduct denotes DISC1
T10 915-919 GeneOrGeneProduct denotes NDE1
T11 972-977 GeneOrGeneProduct denotes DISC1
T12 988-992 GeneOrGeneProduct denotes none
T13 1045-1053 GeneOrGeneProduct denotes multiple
T14 1110-1114 GeneOrGeneProduct denotes NDE1
T15 1265-1273 GeneOrGeneProduct denotes multiple
T16 1420-1425 GeneOrGeneProduct denotes other
T17 1484-1489 GeneOrGeneProduct denotes other
T18 1501-1506 GeneOrGeneProduct denotes lines
T19 1547-1552 GeneOrGeneProduct denotes DISC1

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 33-38 GeneOrGeneProduct denotes DISC1
T2 48-52 GeneOrGeneProduct denotes link
T3 128-132 GeneOrGeneProduct denotes NDE1
T4 216-244 GeneOrGeneProduct denotes Disrupted in Schizophrenia 1
T5 247-252 GeneOrGeneProduct denotes DISC1
T6 272-276 GeneOrGeneProduct denotes in a
T7 348-353 GeneOrGeneProduct denotes DISC1
T8 365-370 GeneOrGeneProduct denotes later
T9 438-443 GeneOrGeneProduct denotes males
T10 445-450 GeneOrGeneProduct denotes DISC1
T11 509-517 GeneOrGeneProduct denotes multiple
T12 691-696 GeneOrGeneProduct denotes DISC1
T13 761-766 GeneOrGeneProduct denotes basis
T14 915-919 GeneOrGeneProduct denotes NDE1
T15 972-977 GeneOrGeneProduct denotes DISC1
T16 988-992 GeneOrGeneProduct denotes none
T17 1045-1053 GeneOrGeneProduct denotes multiple
T18 1054-1058 GeneOrGeneProduct denotes test
T19 1110-1114 GeneOrGeneProduct denotes NDE1
T20 1265-1273 GeneOrGeneProduct denotes multiple
T21 1274-1278 GeneOrGeneProduct denotes test
T22 1295-1302 GeneOrGeneProduct denotes finding
T23 1321-1328 GeneOrGeneProduct denotes concept
T24 1334-1341 GeneOrGeneProduct denotes initial
T25 1347-1355 GeneOrGeneProduct denotes findings
T26 1420-1425 GeneOrGeneProduct denotes other
T27 1484-1489 GeneOrGeneProduct denotes other
T28 1501-1506 GeneOrGeneProduct denotes lines
T29 1547-1552 GeneOrGeneProduct denotes DISC1

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 61-74 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 229-242 DiseaseOrPhenotypicFeature denotes Schizophrenia D012559
T3 258-271 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T4 310-323 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T5 466-479 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T6 1167-1180 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T7 1374-1382 DiseaseOrPhenotypicFeature denotes diseases D004194
T8 1600-1613 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 33-38 GeneOrGeneProduct denotes DISC1
T2 128-132 GeneOrGeneProduct denotes NDE1
T3 216-244 GeneOrGeneProduct denotes Disrupted in Schizophrenia 1
T4 247-252 GeneOrGeneProduct denotes DISC1
T5 348-353 GeneOrGeneProduct denotes DISC1
T6 445-450 GeneOrGeneProduct denotes DISC1
T7 691-696 GeneOrGeneProduct denotes DISC1
T8 915-919 GeneOrGeneProduct denotes NDE1
T9 972-977 GeneOrGeneProduct denotes DISC1
T10 1110-1114 GeneOrGeneProduct denotes NDE1
T11 1547-1552 GeneOrGeneProduct denotes DISC1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 61-74 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T2 229-244 DiseaseOrPhenotypicFeature denotes Schizophrenia 1 0008414
T3 258-271 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T4 310-323 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T5 466-479 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T6 1167-1180 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T7 1600-1613 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 61-74 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 229-242 DiseaseOrPhenotypicFeature denotes Schizophrenia D012559
T3 258-271 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T4 310-323 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T5 466-479 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T6 1167-1180 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T7 1374-1382 DiseaseOrPhenotypicFeature denotes diseases D004194
T8 1600-1613 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 61-74 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 229-242 DiseaseOrPhenotypicFeature denotes Schizophrenia D012559
T3 258-271 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T4 310-323 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T5 466-479 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T6 1167-1180 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T7 1600-1613 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label
T11 1547-1552 GeneOrGeneProduct denotes DISC1
T10 1110-1114 GeneOrGeneProduct denotes NDE1
T9 972-977 GeneOrGeneProduct denotes DISC1
T8 915-919 GeneOrGeneProduct denotes NDE1
T7 691-696 GeneOrGeneProduct denotes DISC1
T6 445-450 GeneOrGeneProduct denotes DISC1
T5 348-353 GeneOrGeneProduct denotes DISC1
T4 247-252 GeneOrGeneProduct denotes DISC1
T3 216-244 GeneOrGeneProduct denotes Disrupted in Schizophrenia 1
T2 128-132 GeneOrGeneProduct denotes NDE1
T1 33-38 GeneOrGeneProduct denotes DISC1
T66078 1600-1613 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T29215 1167-1180 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T10964 466-479 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T68829 310-323 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T80541 258-271 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T13878 229-242 DiseaseOrPhenotypicFeature denotes Schizophrenia D012559
T27086 61-74 DiseaseOrPhenotypicFeature denotes schizophrenia D012559

DisGeNET

Id Subject Object Predicate Lexical cue
T0 33-38 gene:27185 denotes DISC1
T1 61-74 disease:C0036341 denotes schizophrenia
T2 247-252 gene:27185 denotes DISC1
T3 258-271 disease:C0036341 denotes schizophrenia
T4 216-244 gene:27185 denotes Disrupted in Schizophrenia 1
T5 258-271 disease:C0036341 denotes schizophrenia
T6 348-353 gene:27185 denotes DISC1
T7 466-479 disease:C0036341 denotes schizophrenia
T8 1110-1114 gene:54820 denotes NDE1
T9 1167-1180 disease:C0036341 denotes schizophrenia
T10 1547-1552 gene:27185 denotes DISC1
T11 1600-1613 disease:C0036341 denotes schizophrenia
R1 T0 T1 associated_with DISC1,schizophrenia
R2 T2 T3 associated_with DISC1,schizophrenia
R3 T4 T5 associated_with Disrupted in Schizophrenia 1,schizophrenia
R4 T6 T7 associated_with DISC1,schizophrenia
R5 T8 T9 associated_with NDE1,schizophrenia
R6 T10 T11 associated_with DISC1,schizophrenia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 229-242 HP_0100753 denotes Schizophrenia
T2 258-271 HP_0100753 denotes schizophrenia
T3 310-323 HP_0100753 denotes schizophrenia
T4 466-479 HP_0100753 denotes schizophrenia
T5 1167-1180 HP_0100753 denotes schizophrenia
T6 1600-1613 HP_0100753 denotes schizophrenia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17185386-0#33#38#gene27185 33-38 gene27185 denotes DISC1
17185386-0#61#74#diseaseC0036341 61-74 diseaseC0036341 denotes schizophrenia
17185386-6#131#135#gene54820 1110-1114 gene54820 denotes NDE1
17185386-6#188#201#diseaseC0036341 1167-1180 diseaseC0036341 denotes schizophrenia
33#38#gene2718561#74#diseaseC0036341 17185386-0#33#38#gene27185 17185386-0#61#74#diseaseC0036341 associated_with DISC1,schizophrenia
131#135#gene54820188#201#diseaseC0036341 17185386-6#131#135#gene54820 17185386-6#188#201#diseaseC0036341 associated_with NDE1,schizophrenia