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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 111-199 DRI_Background denotes Diphenyleneiodonium (DPI) is an inhibitor of the free radical producing NAD(P)H-oxidase.
T2 200-374 DRI_Approach denotes We tested whether DPI shows neuroprotective properties after focal cerebral ischemia and we used dimethylsulfoxide (DMSO), a nonspecific free radical scavenger, as a solvent.
T3 375-515 DRI_Background denotes In male Wistar rats middle cerebral artery occlusion (1.5 h) and subsequent reperfusion (48 h) (MCAO/R) was induced with the filament model.
T4 516-672 DRI_Background denotes Immediately after reperfusion the animals received either 0.25 ml normal saline, DMSO, or a combination of DMSO and DPI; each group consisted of 10 animals.
T5 673-728 DRI_Outcome denotes MRI was performed at different times after reperfusion.
T6 729-799 DRI_Background denotes Gelatine zymography of brain tissue for MMP-2 and MMP-9 was performed.
T7 800-952 DRI_Outcome denotes The infarct sizes and BBB damage showed a significant difference between controls and the DPI/DMSO group for almost all points in time in all sequences.
T8 953-1045 DRI_Background denotes The activity of MMP-2 and MMP-9 was significantly reduced by DPI/DMSO but not by DMSO alone.
T9 1046-1225 DRI_Background denotes DMSO treatment alone resulted in a protective effect with reduced lesion sizes measured by MRI at selected points of time, consistent with its known free radical scavenger effect.
T10 1226-1359 DRI_Challenge denotes The combination of DMSO with DPI partly augmented this effect, presumably due to the additional inhibition of MMP-2 and MMP-9 by DPI.
T11 1360-1543 DRI_Outcome denotes Moreover, the neurological outcome in both therapeutic groups was improved compared to controls with a significant difference between the therapeutic groups in favour of DPI and DMSO.
T12 1544-1706 DRI_Outcome denotes The combination of DPI and DMSO reduced the activity of MMP-2 and MMP-9, attenuated the postischemic blood-brain barrier damage and improved neurological outcome.
T13 1707-1760 DRI_Background denotes This was most likely due to reduced oxidative stress.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-19 C007517 denotes Diphenyleneiodonium
T2 0-19 CHEBI:77986 denotes Diphenyleneiodonium
T3 0-19 C007517 denotes Diphenyleneiodonium
T4 24-41 D004121 denotes dimethylsulfoxide
T5 24-41 D004121 denotes dimethylsulfoxide
T6 59-77 D015427 denotes reperfusion injury
T7 59-77 D015427 denotes reperfusion injury
T8 81-98 D002545 denotes cerebral ischemia
T9 81-98 D002545 denotes cerebral ischemia
T13 106-109 PR:P63003-1 denotes rat
T14 106-109 PR:Q2G0B1 denotes rat
T15 106-109 PR:Q8VHJ4 denotes rat
T12 106-109 10116 denotes rat
T16 106-109 D051381 denotes rat
T17 143-152 CHEBI:35222 denotes inhibitor
T18 160-172 CHEBI:26519 denotes free radical
T28 183-198 D019255 denotes NAD(P)H-oxidase
T30 267-284 D002545 denotes cerebral ischemia
T31 267-284 D002545 denotes cerebral ischemia
T34 297-314 D004121 denotes dimethylsulfoxide
T35 297-314 D004121 denotes dimethylsulfoxide
T36 316-320 D004121 denotes DMSO
T37 316-320 CHEBI:28262 denotes DMSO
T38 316-320 D004121 denotes DMSO
T40 337-359 CHEBI:48578 denotes free radical scavenger
T43 366-373 CHEBI:46787 denotes solvent
T44 378-382 UBERON:0003101 denotes male
T45 378-382 CHEBI:30780 denotes male
T46 383-394 10116 denotes Wistar rats
T47 383-394 D017208 denotes Wistar rats
T51 395-417 UBERON:0001627 denotes middle cerebral artery
T52 395-427 D020244 denotes middle cerebral artery occlusion
T53 395-427 D020244 denotes middle cerebral artery occlusion
T58 582-595 D000077330 denotes normal saline
T59 597-601 D004121 denotes DMSO
T60 597-601 CHEBI:28262 denotes DMSO
T61 597-601 D004121 denotes DMSO
T62 623-627 D004121 denotes DMSO
T63 623-627 CHEBI:28262 denotes DMSO
T64 623-627 D004121 denotes DMSO
T65 673-676 PR:000010565 denotes MRI
T66 673-676 PR:Q6AYH4 denotes MRI
T67 673-676 PR:Q8BHZ5 denotes MRI
T68 673-676 PR:Q9BWK5 denotes MRI
T69 729-737 CHEBI:5291 denotes Gelatine
T70 752-757 UBERON:6110636 denotes brain
T71 752-757 UBERON:0000955 denotes brain
T72 758-764 UBERON:0000479 denotes tissue
T73 769-772 CHEBI:340824 denotes MMP
T76 769-772 CHEBI:59761 denotes MMP
T77 769-774 PR:P08253 denotes MMP-2
T78 769-774 Q9GLE5 denotes MMP-2
T79 769-774 P08253 denotes MMP-2
T80 769-774 Q90611 denotes MMP-2
T82 769-774 PR:Q8MPP3 denotes MMP-2
T83 769-774 P33436 denotes MMP-2
T84 769-774 PR:Q90611 denotes MMP-2
T85 769-774 PR:P33436 denotes MMP-2
T86 769-774 PR:000010479 denotes MMP-2
T87 769-774 PR:P33434 denotes MMP-2
T88 769-774 P33434 denotes MMP-2
T89 769-774 P50757 denotes MMP-2
T81 769-774 GO:0004228 denotes MMP-2
T90 779-782 CHEBI:340824 denotes MMP
T93 779-782 CHEBI:59761 denotes MMP
T94 779-784 PR:P50282 denotes MMP-9
T95 779-784 PR:P14780 denotes MMP-9
T96 779-784 P14780 denotes MMP-9
T97 779-784 PR:P41245 denotes MMP-9
T98 779-784 P41246 denotes MMP-9
T99 779-784 P41245 denotes MMP-9
T100 779-784 PR:P52176 denotes MMP-9
T101 779-784 P50282 denotes MMP-9
T103 779-784 PR:000010491 denotes MMP-9
T104 779-784 P52176 denotes MMP-9
T105 779-784 O18733 denotes MMP-9
T102 779-784 GO:0004229 denotes MMP-9
T106 804-811 D007238 denotes infarct
T107 804-811 D007238 denotes infarct
T108 822-825 UBERON:0000120 denotes BBB
T109 894-898 D004121 denotes DMSO
T110 894-898 CHEBI:28262 denotes DMSO
T111 894-898 D004121 denotes DMSO
T112 969-972 CHEBI:340824 denotes MMP
T115 969-972 CHEBI:59761 denotes MMP
T116 969-974 PR:P08253 denotes MMP-2
T117 969-974 Q9GLE5 denotes MMP-2
T118 969-974 P08253 denotes MMP-2
T119 969-974 Q90611 denotes MMP-2
T121 969-974 PR:Q8MPP3 denotes MMP-2
T122 969-974 P33436 denotes MMP-2
T123 969-974 PR:Q90611 denotes MMP-2
T124 969-974 PR:P33436 denotes MMP-2
T125 969-974 PR:000010479 denotes MMP-2
T126 969-974 PR:P33434 denotes MMP-2
T127 969-974 P33434 denotes MMP-2
T128 969-974 P50757 denotes MMP-2
T120 969-974 GO:0004228 denotes MMP-2
T129 979-982 CHEBI:340824 denotes MMP
T132 979-982 CHEBI:59761 denotes MMP
T133 979-984 PR:P50282 denotes MMP-9
T134 979-984 PR:P14780 denotes MMP-9
T135 979-984 P14780 denotes MMP-9
T136 979-984 PR:P41245 denotes MMP-9
T137 979-984 P41246 denotes MMP-9
T138 979-984 P41245 denotes MMP-9
T139 979-984 PR:P52176 denotes MMP-9
T140 979-984 P50282 denotes MMP-9
T142 979-984 PR:000010491 denotes MMP-9
T143 979-984 P52176 denotes MMP-9
T144 979-984 O18733 denotes MMP-9
T141 979-984 GO:0004229 denotes MMP-9
T145 1018-1022 D004121 denotes DMSO
T146 1018-1022 CHEBI:28262 denotes DMSO
T147 1018-1022 D004121 denotes DMSO
T148 1034-1038 D004121 denotes DMSO
T149 1034-1038 CHEBI:28262 denotes DMSO
T150 1034-1038 D004121 denotes DMSO
T151 1046-1050 D004121 denotes DMSO
T152 1046-1050 CHEBI:28262 denotes DMSO
T153 1046-1050 D004121 denotes DMSO
T154 1137-1140 PR:000010565 denotes MRI
T155 1137-1140 PR:Q6AYH4 denotes MRI
T156 1137-1140 PR:Q8BHZ5 denotes MRI
T157 1137-1140 PR:Q9BWK5 denotes MRI
T159 1195-1217 CHEBI:48578 denotes free radical scavenger
T162 1245-1249 D004121 denotes DMSO
T163 1245-1249 CHEBI:28262 denotes DMSO
T164 1245-1249 D004121 denotes DMSO
T165 1336-1339 CHEBI:340824 denotes MMP
T168 1336-1339 CHEBI:59761 denotes MMP
T169 1336-1341 PR:P08253 denotes MMP-2
T170 1336-1341 Q9GLE5 denotes MMP-2
T171 1336-1341 P08253 denotes MMP-2
T172 1336-1341 Q90611 denotes MMP-2
T174 1336-1341 PR:Q8MPP3 denotes MMP-2
T175 1336-1341 P33436 denotes MMP-2
T176 1336-1341 PR:Q90611 denotes MMP-2
T177 1336-1341 PR:P33436 denotes MMP-2
T178 1336-1341 PR:000010479 denotes MMP-2
T179 1336-1341 PR:P33434 denotes MMP-2
T180 1336-1341 P33434 denotes MMP-2
T181 1336-1341 P50757 denotes MMP-2
T173 1336-1341 GO:0004228 denotes MMP-2
T182 1346-1349 CHEBI:340824 denotes MMP
T185 1346-1349 CHEBI:59761 denotes MMP
T186 1346-1351 PR:P50282 denotes MMP-9
T187 1346-1351 PR:P14780 denotes MMP-9
T188 1346-1351 P14780 denotes MMP-9
T189 1346-1351 PR:P41245 denotes MMP-9
T190 1346-1351 P41246 denotes MMP-9
T191 1346-1351 P41245 denotes MMP-9
T192 1346-1351 PR:P52176 denotes MMP-9
T193 1346-1351 P50282 denotes MMP-9
T195 1346-1351 PR:000010491 denotes MMP-9
T196 1346-1351 P52176 denotes MMP-9
T197 1346-1351 O18733 denotes MMP-9
T194 1346-1351 GO:0004229 denotes MMP-9
T198 1538-1542 D004121 denotes DMSO
T199 1538-1542 CHEBI:28262 denotes DMSO
T200 1538-1542 D004121 denotes DMSO
T201 1571-1575 D004121 denotes DMSO
T202 1571-1575 CHEBI:28262 denotes DMSO
T203 1571-1575 D004121 denotes DMSO
T204 1600-1603 CHEBI:340824 denotes MMP
T207 1600-1603 CHEBI:59761 denotes MMP
T208 1600-1605 PR:P08253 denotes MMP-2
T209 1600-1605 Q9GLE5 denotes MMP-2
T210 1600-1605 P08253 denotes MMP-2
T211 1600-1605 Q90611 denotes MMP-2
T213 1600-1605 PR:Q8MPP3 denotes MMP-2
T214 1600-1605 P33436 denotes MMP-2
T215 1600-1605 PR:Q90611 denotes MMP-2
T216 1600-1605 PR:P33436 denotes MMP-2
T217 1600-1605 PR:000010479 denotes MMP-2
T218 1600-1605 PR:P33434 denotes MMP-2
T219 1600-1605 P33434 denotes MMP-2
T220 1600-1605 P50757 denotes MMP-2
T212 1600-1605 GO:0004228 denotes MMP-2
T221 1610-1613 CHEBI:340824 denotes MMP
T224 1610-1613 CHEBI:59761 denotes MMP
T225 1610-1615 PR:P50282 denotes MMP-9
T226 1610-1615 PR:P14780 denotes MMP-9
T227 1610-1615 P14780 denotes MMP-9
T228 1610-1615 PR:P41245 denotes MMP-9
T229 1610-1615 P41246 denotes MMP-9
T230 1610-1615 P41245 denotes MMP-9
T231 1610-1615 PR:P52176 denotes MMP-9
T232 1610-1615 P50282 denotes MMP-9
T234 1610-1615 PR:000010491 denotes MMP-9
T235 1610-1615 P52176 denotes MMP-9
T236 1610-1615 O18733 denotes MMP-9
T233 1610-1615 GO:0004229 denotes MMP-9
T237 1645-1664 UBERON:0000120 denotes blood-brain barrier

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 267-284 HP_0002637 denotes cerebral ischemia

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-110 DRI_Background denotes Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat.
T2 111-199 DRI_Background denotes Diphenyleneiodonium (DPI) is an inhibitor of the free radical producing NAD(P)H-oxidase.
T3 200-374 DRI_Approach denotes We tested whether DPI shows neuroprotective properties after focal cerebral ischemia and we used dimethylsulfoxide (DMSO), a nonspecific free radical scavenger, as a solvent.
T4 375-515 DRI_Background denotes In male Wistar rats middle cerebral artery occlusion (1.5 h) and subsequent reperfusion (48 h) (MCAO/R) was induced with the filament model.
T5 516-672 DRI_Background denotes Immediately after reperfusion the animals received either 0.25 ml normal saline, DMSO, or a combination of DMSO and DPI; each group consisted of 10 animals.
T6 673-728 DRI_Outcome denotes MRI was performed at different times after reperfusion.
T7 729-799 DRI_Background denotes Gelatine zymography of brain tissue for MMP-2 and MMP-9 was performed.
T8 800-952 DRI_Outcome denotes The infarct sizes and BBB damage showed a significant difference between controls and the DPI/DMSO group for almost all points in time in all sequences.
T9 953-1045 DRI_Background denotes The activity of MMP-2 and MMP-9 was significantly reduced by DPI/DMSO but not by DMSO alone.
T10 1046-1225 DRI_Background denotes DMSO treatment alone resulted in a protective effect with reduced lesion sizes measured by MRI at selected points of time, consistent with its known free radical scavenger effect.
T11 1226-1359 DRI_Challenge denotes The combination of DMSO with DPI partly augmented this effect, presumably due to the additional inhibition of MMP-2 and MMP-9 by DPI.
T12 1360-1543 DRI_Outcome denotes Moreover, the neurological outcome in both therapeutic groups was improved compared to controls with a significant difference between the therapeutic groups in favour of DPI and DMSO.
T13 1544-1706 DRI_Outcome denotes The combination of DPI and DMSO reduced the activity of MMP-2 and MMP-9, attenuated the postischemic blood-brain barrier damage and improved neurological outcome.
T14 1707-1760 DRI_Background denotes This was most likely due to reduced oxidative stress.