PubMed:17177139 / 1462-1720 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T13","span":{"begin":0,"end":258},"obj":"Sentence"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":234,"end":239},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:9606"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-entities","denotations":[{"id":"3766","span":{"begin":47,"end":52},"obj":"SequenceVariant"},{"id":"3767","span":{"begin":53,"end":59},"obj":"GeneOrGeneProduct"},{"id":"3768","span":{"begin":234,"end":239},"obj":"OrganismTaxon"},{"id":"3769","span":{"begin":240,"end":248},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A33","pred":"db_id","subj":"3766","obj":"p|SUB|E|333|D"},{"id":"A34","pred":"db_id","subj":"3767","obj":"NCBIGene:6955"},{"id":"A35","pred":"db_id","subj":"3768","obj":"NCBITaxon:9606"},{"id":"A36","pred":"db_id","subj":"3769","obj":"NCBIGene:1081"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin_Mondo","denotations":[{"id":"T8","span":{"begin":150,"end":157},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0004126"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-SeqVar","denotations":[{"id":"T6","span":{"begin":47,"end":52},"obj":"SequenceVariant"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T30","span":{"begin":53,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":60,"end":66},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":86,"end":101},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":240,"end":248},"obj":"GeneOrGeneProduct"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T49","span":{"begin":53,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T50","span":{"begin":60,"end":66},"obj":"GeneOrGeneProduct"},{"id":"T51","span":{"begin":86,"end":101},"obj":"GeneOrGeneProduct"},{"id":"T52","span":{"begin":102,"end":112},"obj":"GeneOrGeneProduct"},{"id":"T53","span":{"begin":140,"end":149},"obj":"GeneOrGeneProduct"},{"id":"T54","span":{"begin":185,"end":188},"obj":"GeneOrGeneProduct"},{"id":"T55","span":{"begin":189,"end":193},"obj":"GeneOrGeneProduct"},{"id":"T56","span":{"begin":224,"end":233},"obj":"GeneOrGeneProduct"},{"id":"T57","span":{"begin":240,"end":248},"obj":"GeneOrGeneProduct"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T7","span":{"begin":53,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":86,"end":112},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":240,"end":248},"obj":"GeneOrGeneProduct"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T24","span":{"begin":150,"end":157},"obj":"ChemicalEntity"}],"attributes":[{"id":"A24","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_9584"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":234,"end":239},"obj":"OrganismTaxon"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T24","span":{"begin":150,"end":157},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":240,"end":248},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":86,"end":112},"obj":"GeneOrGeneProduct"},{"id":"T18401","span":{"begin":53,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T96985","span":{"begin":234,"end":239},"obj":"OrganismTaxon"},{"id":"T49295","span":{"begin":47,"end":52},"obj":"SequenceVariant"}],"attributes":[{"id":"A24","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_9584"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}

{"project":"tmVarCorpus","denotations":[{"id":"T6","span":{"begin":47,"end":52},"obj":"ProteinMutation:p|SUB|E|333|D"}],"text":"However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter."}