> top > docs > PubMed:17177139 > annotations

PubMed:17177139 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes A novel mutation (E333D) in the thyroid hormone beta receptor causing resistance to thyroid hormone syndrome.
T2 110-353 Sentence denotes Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by elevated serum thyroid hormones (TH), failure to suppress pituitary thyroid stimulating hormone (TSH) secretion, and variable peripheral tissue responsiveness to TH.
T3 354-450 Sentence denotes The disorder is associated with diverse mutations in the thyroid hormone beta receptor (TRbeta).
T4 451-574 Sentence denotes Here, we report a novel natural RTH mutation (E333D) located in the large carboxy-terminal ligand binding domain of TRbeta.
T5 575-697 Sentence denotes The mutation was identified in a 22-year-old French woman coming to medical attention because of an increasing overweight.
T6 698-751 Sentence denotes Biochemical tests showed elevated free thyroxine (T4:
T7 752-806 Sentence denotes 20.8 pg/ml (normal, 8.5-18)) and triiodothyronine (T3:
T8 807-934 Sentence denotes 5.7 pg/ml (normal, 1.4-4)) in the serum, together with an inappropriately nonsuppressed TSH level of 4.7 mU/ml (normal, 0.4-4).
T9 935-1034 Sentence denotes Her father and her brother's serum tests also showed biochemical abnormalities consistent with RTH.
T10 1035-1205 Sentence denotes Direct sequencing of the TRbeta gene revealed a heterozygous transition 1284A>C in exon 9 resulting in substitution of glutamic acid 333 by aspartic acid residue (E333D).
T11 1206-1276 Sentence denotes Further functional analyses of the novel TRbeta mutant were conducted.
T12 1277-1461 Sentence denotes We found that the E333D mutation neither significantly affected the affinity of the receptor for T3 nor modified heterodimer formation with retinoid X receptor (RXR) when bound to DNA.
T13 1462-1720 Sentence denotes However, in transient transfection assays, the E333D TRbeta mutant exhibited impaired transcriptional regulation on two distinct positively regulated thyroid response elements (F2- and DR4-TREs) as well as on the negatively regulated human TSHalpha promoter.
T14 1721-1890 Sentence denotes Moreover, a dominant inhibition of the wild-type TRbeta counterpart transactivation function was observed on both a positive (F2-TRE) and a negative (TSHalpha) promoter.
T15 1891-2016 Sentence denotes These results strongly suggest that the E333D TRbeta mutation is responsible for the RTH phenotype in the proposita's family.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 1696-1701 OrganismTaxon denotes human NCBItxid:9606

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3734 18-23 SequenceVariant denotes E333D p|SUB|E|333|D
3735 32-61 GeneOrGeneProduct denotes thyroid hormone beta receptor NCBIGene:6955
3736 70-108 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone syndrome MESH:D018382
3737 110-139 DiseaseOrPhenotypicFeature denotes Resistance to thyroid hormone MESH:D018382
3738 141-144 DiseaseOrPhenotypicFeature denotes RTH MESH:D018382
3739 203-219 ChemicalEntity denotes thyroid hormones MESH:D013963
3740 221-223 ChemicalEntity denotes TH MESH:D013963
3741 256-283 GeneOrGeneProduct denotes thyroid stimulating hormone NCBIGene:1081
3742 285-288 GeneOrGeneProduct denotes TSH NCBIGene:1081
3743 350-352 ChemicalEntity denotes TH MESH:D013963
3744 411-440 GeneOrGeneProduct denotes thyroid hormone beta receptor NCBIGene:6955
3745 442-448 GeneOrGeneProduct denotes TRbeta NCBIGene:6955
3746 483-486 DiseaseOrPhenotypicFeature denotes RTH MESH:D018382
3747 497-502 SequenceVariant denotes E333D p|SUB|E|333|D
3748 567-573 GeneOrGeneProduct denotes TRbeta NCBIGene:6955
3749 627-632 OrganismTaxon denotes woman NCBITaxon:9606
3750 686-696 DiseaseOrPhenotypicFeature denotes overweight MESH:D050177
3751 737-746 ChemicalEntity denotes thyroxine MESH:D013974
3752 748-750 ChemicalEntity denotes T4 MESH:D013974
3753 785-801 ChemicalEntity denotes triiodothyronine MESH:D014284
3754 803-805 ChemicalEntity denotes T3 MESH:D014284
3755 895-898 GeneOrGeneProduct denotes TSH NCBIGene:1081
3756 1030-1033 DiseaseOrPhenotypicFeature denotes RTH MESH:D018382
3757 1060-1066 GeneOrGeneProduct denotes TRbeta NCBIGene:6955
3758 1107-1114 SequenceVariant denotes 1284A>C c|SUB|A|1284|C
3759 1154-1188 SequenceVariant denotes glutamic acid 333 by aspartic acid p|SUB|E|333|D
3760 1198-1203 SequenceVariant denotes E333D p|SUB|E|333|D
3761 1247-1253 GeneOrGeneProduct denotes TRbeta NCBIGene:6955
3762 1295-1300 SequenceVariant denotes E333D p|SUB|E|333|D
3763 1374-1376 ChemicalEntity denotes T3 MESH:D014284
3764 1417-1436 GeneOrGeneProduct denotes retinoid X receptor NCBIGene:6256
3765 1438-1441 GeneOrGeneProduct denotes RXR NCBIGene:6256
3766 1509-1514 SequenceVariant denotes E333D p|SUB|E|333|D
3767 1515-1521 GeneOrGeneProduct denotes TRbeta NCBIGene:6955
3768 1696-1701 OrganismTaxon denotes human NCBITaxon:9606
3769 1702-1710 GeneOrGeneProduct denotes TSHalpha NCBIGene:1081
3770 1770-1776 GeneOrGeneProduct denotes TRbeta NCBIGene:6955
3771 1871-1879 GeneOrGeneProduct denotes TSHalpha NCBIGene:1081
3772 1931-1936 SequenceVariant denotes E333D p|SUB|E|333|D
3773 1937-1943 GeneOrGeneProduct denotes TRbeta NCBIGene:6955
3774 1976-1979 DiseaseOrPhenotypicFeature denotes RTH MESH:D018382

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 32-39 DiseaseOrPhenotypicFeature denotes thyroid 0004126
T2 84-91 DiseaseOrPhenotypicFeature denotes thyroid 0004126
T3 124-131 DiseaseOrPhenotypicFeature denotes thyroid 0004126
T4 152-161 DiseaseOrPhenotypicFeature denotes inherited 0021152
T5 203-210 DiseaseOrPhenotypicFeature denotes thyroid 0004126
T6 256-263 DiseaseOrPhenotypicFeature denotes thyroid 0004126
T7 411-418 DiseaseOrPhenotypicFeature denotes thyroid 0004126
T8 1612-1619 DiseaseOrPhenotypicFeature denotes thyroid 0004126

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 18-23 SequenceVariant denotes E333D
T2 497-502 SequenceVariant denotes E333D
T3 1107-1112 SequenceVariant denotes 1284A
T4 1198-1203 SequenceVariant denotes E333D
T5 1295-1300 SequenceVariant denotes E333D
T6 1509-1514 SequenceVariant denotes E333D
T7 1931-1936 SequenceVariant denotes E333D

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 2-7 GeneOrGeneProduct denotes novel
T2 32-47 GeneOrGeneProduct denotes thyroid hormone
T3 48-52 GeneOrGeneProduct denotes beta
T4 53-61 GeneOrGeneProduct denotes receptor
T5 84-99 GeneOrGeneProduct denotes thyroid hormone
T6 100-108 GeneOrGeneProduct denotes syndrome
T7 124-139 GeneOrGeneProduct denotes thyroid hormone
T8 162-170 GeneOrGeneProduct denotes syndrome
T9 203-219 GeneOrGeneProduct denotes thyroid hormones
T10 221-223 GeneOrGeneProduct denotes TH
T11 276-283 GeneOrGeneProduct denotes hormone
T12 350-352 GeneOrGeneProduct denotes TH
T13 411-426 GeneOrGeneProduct denotes thyroid hormone
T14 427-431 GeneOrGeneProduct denotes beta
T15 432-440 GeneOrGeneProduct denotes receptor
T16 442-448 GeneOrGeneProduct denotes TRbeta
T17 469-474 GeneOrGeneProduct denotes novel
T18 519-524 GeneOrGeneProduct denotes large
T19 549-556 GeneOrGeneProduct denotes binding
T20 567-573 GeneOrGeneProduct denotes TRbeta
T21 1060-1066 GeneOrGeneProduct denotes TRbeta
T22 1163-1167 GeneOrGeneProduct denotes acid
T23 1184-1188 GeneOrGeneProduct denotes acid
T24 1241-1246 GeneOrGeneProduct denotes novel
T25 1247-1253 GeneOrGeneProduct denotes TRbeta
T26 1254-1260 GeneOrGeneProduct denotes mutant
T27 1361-1369 GeneOrGeneProduct denotes receptor
T28 1417-1436 GeneOrGeneProduct denotes retinoid X receptor
T29 1438-1441 GeneOrGeneProduct denotes RXR
T30 1515-1521 GeneOrGeneProduct denotes TRbeta
T31 1522-1528 GeneOrGeneProduct denotes mutant
T32 1548-1563 GeneOrGeneProduct denotes transcriptional
T33 1702-1710 GeneOrGeneProduct denotes TSHalpha
T34 1770-1776 GeneOrGeneProduct denotes TRbeta
T35 1871-1879 GeneOrGeneProduct denotes TSHalpha
T36 1937-1943 GeneOrGeneProduct denotes TRbeta

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 2-7 GeneOrGeneProduct denotes novel
T2 8-16 GeneOrGeneProduct denotes mutation
T3 32-47 GeneOrGeneProduct denotes thyroid hormone
T4 48-52 GeneOrGeneProduct denotes beta
T5 53-61 GeneOrGeneProduct denotes receptor
T6 84-99 GeneOrGeneProduct denotes thyroid hormone
T7 100-108 GeneOrGeneProduct denotes syndrome
T8 124-139 GeneOrGeneProduct denotes thyroid hormone
T9 162-170 GeneOrGeneProduct denotes syndrome
T10 203-219 GeneOrGeneProduct denotes thyroid hormones
T11 221-223 GeneOrGeneProduct denotes TH
T12 276-283 GeneOrGeneProduct denotes hormone
T13 290-299 GeneOrGeneProduct denotes secretion
T14 350-352 GeneOrGeneProduct denotes TH
T15 394-403 GeneOrGeneProduct denotes mutations
T16 411-426 GeneOrGeneProduct denotes thyroid hormone
T17 427-431 GeneOrGeneProduct denotes beta
T18 432-440 GeneOrGeneProduct denotes receptor
T19 442-448 GeneOrGeneProduct denotes TRbeta
T20 469-474 GeneOrGeneProduct denotes novel
T21 487-495 GeneOrGeneProduct denotes mutation
T22 519-524 GeneOrGeneProduct denotes large
T23 549-556 GeneOrGeneProduct denotes binding
T24 567-573 GeneOrGeneProduct denotes TRbeta
T25 579-587 GeneOrGeneProduct denotes mutation
T26 603-607 GeneOrGeneProduct denotes in a
T27 611-615 GeneOrGeneProduct denotes year
T28 633-639 GeneOrGeneProduct denotes coming
T29 710-715 GeneOrGeneProduct denotes tests
T30 760-762 GeneOrGeneProduct denotes ml
T31 814-816 GeneOrGeneProduct denotes ml
T32 915-917 GeneOrGeneProduct denotes ml
T33 935-938 GeneOrGeneProduct denotes Her
T34 954-963 GeneOrGeneProduct denotes brother's
T35 970-975 GeneOrGeneProduct denotes tests
T36 1060-1066 GeneOrGeneProduct denotes TRbeta
T37 1154-1162 GeneOrGeneProduct denotes glutamic
T38 1163-1167 GeneOrGeneProduct denotes acid
T39 1175-1183 GeneOrGeneProduct denotes aspartic
T40 1184-1188 GeneOrGeneProduct denotes acid
T41 1241-1246 GeneOrGeneProduct denotes novel
T42 1247-1253 GeneOrGeneProduct denotes TRbeta
T43 1254-1260 GeneOrGeneProduct denotes mutant
T44 1301-1309 GeneOrGeneProduct denotes mutation
T45 1361-1369 GeneOrGeneProduct denotes receptor
T46 1402-1411 GeneOrGeneProduct denotes formation
T47 1417-1436 GeneOrGeneProduct denotes retinoid X receptor
T48 1438-1441 GeneOrGeneProduct denotes RXR
T49 1515-1521 GeneOrGeneProduct denotes TRbeta
T50 1522-1528 GeneOrGeneProduct denotes mutant
T51 1548-1563 GeneOrGeneProduct denotes transcriptional
T52 1564-1574 GeneOrGeneProduct denotes regulation
T53 1602-1611 GeneOrGeneProduct denotes regulated
T54 1647-1650 GeneOrGeneProduct denotes DR4
T55 1651-1655 GeneOrGeneProduct denotes TREs
T56 1686-1695 GeneOrGeneProduct denotes regulated
T57 1702-1710 GeneOrGeneProduct denotes TSHalpha
T58 1770-1776 GeneOrGeneProduct denotes TRbeta
T59 1789-1804 GeneOrGeneProduct denotes transactivation
T60 1871-1879 GeneOrGeneProduct denotes TSHalpha
T61 1937-1943 GeneOrGeneProduct denotes TRbeta
T62 1944-1952 GeneOrGeneProduct denotes mutation

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 70-99 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382
T2 100-108 DiseaseOrPhenotypicFeature denotes syndrome D013577
T3 110-139 DiseaseOrPhenotypicFeature denotes Resistance to thyroid hormone D018382
T4 141-144 DiseaseOrPhenotypicFeature denotes RTH D018382
T5 162-170 DiseaseOrPhenotypicFeature denotes syndrome D013577
T6 483-486 DiseaseOrPhenotypicFeature denotes RTH D018382
T7 686-696 DiseaseOrPhenotypicFeature denotes overweight D050177
T8 1030-1033 DiseaseOrPhenotypicFeature denotes RTH D018382
T9 1976-1979 DiseaseOrPhenotypicFeature denotes RTH D018382

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 442-448 GeneOrGeneProduct denotes TRbeta
T2 567-573 GeneOrGeneProduct denotes TRbeta
T3 1060-1066 GeneOrGeneProduct denotes TRbeta
T4 1247-1253 GeneOrGeneProduct denotes TRbeta
T5 1417-1436 GeneOrGeneProduct denotes retinoid X receptor
T6 1438-1441 GeneOrGeneProduct denotes RXR
T7 1515-1521 GeneOrGeneProduct denotes TRbeta
T8 1548-1574 GeneOrGeneProduct denotes transcriptional regulation
T9 1702-1710 GeneOrGeneProduct denotes TSHalpha
T10 1770-1776 GeneOrGeneProduct denotes TRbeta
T11 1871-1879 GeneOrGeneProduct denotes TSHalpha
T12 1937-1943 GeneOrGeneProduct denotes TRbeta

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 100-108 DiseaseOrPhenotypicFeature denotes syndrome 0002254
T2 141-144 DiseaseOrPhenotypicFeature denotes RTH 0001328
T3 162-170 DiseaseOrPhenotypicFeature denotes syndrome 0002254
T4 246-255 DiseaseOrPhenotypicFeature denotes pituitary 0021156
T5 483-486 DiseaseOrPhenotypicFeature denotes RTH 0001328
T6 1030-1033 DiseaseOrPhenotypicFeature denotes RTH 0001328
T7 1976-1979 DiseaseOrPhenotypicFeature denotes RTH 0001328

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 70-99 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382
T2 100-108 DiseaseOrPhenotypicFeature denotes syndrome D013577
T3 110-139 DiseaseOrPhenotypicFeature denotes Resistance to thyroid hormone D018382
T4 141-144 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382
T6 162-170 DiseaseOrPhenotypicFeature denotes syndrome D013577
T7 483-486 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382
T9 686-696 DiseaseOrPhenotypicFeature denotes overweight D050177
T10 1030-1033 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382
T12 1976-1979 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 70-99 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382
T2 110-139 DiseaseOrPhenotypicFeature denotes Resistance to thyroid hormone D018382
T3 141-144 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382
T5 483-486 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382
T7 686-696 DiseaseOrPhenotypicFeature denotes overweight D050177
T8 1030-1033 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382
T10 1976-1979 DiseaseOrPhenotypicFeature denotes RTH DISEASE|D018382

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 32-47 ChemicalEntity denotes thyroid hormone D013963
T2 84-99 ChemicalEntity denotes thyroid hormone D013963
T3 124-139 ChemicalEntity denotes thyroid hormone D013963
T4 203-219 ChemicalEntity denotes thyroid hormones D013963
T5 221-223 ChemicalEntity denotes TH D013963
T6 256-283 ChemicalEntity denotes thyroid stimulating hormone http://purl.obolibrary.org/obo/CHEBI_81567
T7 285-288 ChemicalEntity denotes TSH http://purl.obolibrary.org/obo/CHEBI_17842|http://purl.obolibrary.org/obo/CHEBI_137741|http://purl.obolibrary.org/obo/CHEBI_81567
T10 350-352 ChemicalEntity denotes TH D013963
T11 411-426 ChemicalEntity denotes thyroid hormone D013963
T12 525-532 ChemicalEntity denotes carboxy http://purl.obolibrary.org/obo/CHEBI_46883
T13 737-746 ChemicalEntity denotes thyroxine http://purl.obolibrary.org/obo/CHEBI_30660|http://purl.obolibrary.org/obo/CHEBI_305790
T15 785-801 ChemicalEntity denotes triiodothyronine http://purl.obolibrary.org/obo/CHEBI_18258
T16 895-898 ChemicalEntity denotes TSH http://purl.obolibrary.org/obo/CHEBI_17842|http://purl.obolibrary.org/obo/CHEBI_137741|http://purl.obolibrary.org/obo/CHEBI_81567
T19 1154-1167 ChemicalEntity denotes glutamic acid http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_16015
T21 1175-1196 ChemicalEntity denotes aspartic acid residue http://purl.obolibrary.org/obo/CHEBI_32470
T22 1417-1425 ChemicalEntity denotes retinoid D012176|http://purl.obolibrary.org/obo/CHEBI_26537
T24 1612-1619 ChemicalEntity denotes thyroid http://purl.obolibrary.org/obo/CHEBI_9584

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 1696-1701 OrganismTaxon denotes human

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T24 1612-1619 ChemicalEntity denotes thyroid http://purl.obolibrary.org/obo/CHEBI_9584
T22 1417-1425 ChemicalEntity denotes retinoid http://purl.obolibrary.org/obo/CHEBI_26537|D012176
T21 1175-1196 ChemicalEntity denotes aspartic acid residue http://purl.obolibrary.org/obo/CHEBI_32470
T19 1154-1167 ChemicalEntity denotes glutamic acid http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237
T16 895-898 ChemicalEntity denotes TSH http://purl.obolibrary.org/obo/CHEBI_81567|http://purl.obolibrary.org/obo/CHEBI_137741|http://purl.obolibrary.org/obo/CHEBI_17842
T15 785-801 ChemicalEntity denotes triiodothyronine http://purl.obolibrary.org/obo/CHEBI_18258
T13 737-746 ChemicalEntity denotes thyroxine http://purl.obolibrary.org/obo/CHEBI_305790|http://purl.obolibrary.org/obo/CHEBI_30660
T12 525-532 ChemicalEntity denotes carboxy http://purl.obolibrary.org/obo/CHEBI_46883
T11 411-426 ChemicalEntity denotes thyroid hormone D013963
T10 350-352 ChemicalEntity denotes TH D013963
T7 285-288 ChemicalEntity denotes TSH http://purl.obolibrary.org/obo/CHEBI_81567|http://purl.obolibrary.org/obo/CHEBI_137741|http://purl.obolibrary.org/obo/CHEBI_17842
T6 256-283 ChemicalEntity denotes thyroid stimulating hormone http://purl.obolibrary.org/obo/CHEBI_81567
T5 221-223 ChemicalEntity denotes TH D013963
T4 203-219 ChemicalEntity denotes thyroid hormones D013963
T3 124-139 ChemicalEntity denotes thyroid hormone D013963
T2 84-99 ChemicalEntity denotes thyroid hormone D013963
T1 32-47 ChemicalEntity denotes thyroid hormone D013963
T11613 1937-1943 GeneOrGeneProduct denotes TRbeta
T34780 1871-1879 GeneOrGeneProduct denotes TSHalpha
T61099 1770-1776 GeneOrGeneProduct denotes TRbeta
T9 1702-1710 GeneOrGeneProduct denotes TSHalpha
T8 1548-1574 GeneOrGeneProduct denotes transcriptional regulation
T18401 1515-1521 GeneOrGeneProduct denotes TRbeta
T90356 1438-1441 GeneOrGeneProduct denotes RXR
T83968 1417-1436 GeneOrGeneProduct denotes retinoid X receptor
T7976 1247-1253 GeneOrGeneProduct denotes TRbeta
T78189 1060-1066 GeneOrGeneProduct denotes TRbeta
T93655 567-573 GeneOrGeneProduct denotes TRbeta
T74813 442-448 GeneOrGeneProduct denotes TRbeta
T96184 1976-1979 DiseaseOrPhenotypicFeature denotes RTH D018382|DISEASE
T94368 1030-1033 DiseaseOrPhenotypicFeature denotes RTH D018382|DISEASE
T33145 686-696 DiseaseOrPhenotypicFeature denotes overweight D050177
T96605 483-486 DiseaseOrPhenotypicFeature denotes RTH D018382|DISEASE
T79764 141-144 DiseaseOrPhenotypicFeature denotes RTH D018382|DISEASE
T53205 110-139 DiseaseOrPhenotypicFeature denotes Resistance to thyroid hormone D018382
T32516 70-99 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382
T96985 1696-1701 OrganismTaxon denotes human
T63645 1931-1936 SequenceVariant denotes E333D
T49295 1509-1514 SequenceVariant denotes E333D
T3328 1295-1300 SequenceVariant denotes E333D
T25928 1198-1203 SequenceVariant denotes E333D
T64082 1107-1112 SequenceVariant denotes 1284A
T5159 497-502 SequenceVariant denotes E333D
T77248 18-23 SequenceVariant denotes E333D

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 110-139 HP_0002930 denotes Resistance to thyroid hormone
T1 110-139 HP_0002930 denotes Resistance to thyroid hormone

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 686-696 HP:0025502 denotes overweight

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 18-23 ProteinMutation:p|SUB|E|333|D denotes E333D
T2 497-502 ProteinMutation:p|SUB|E|333|D denotes E333D
T3 1107-1114 DNAMutation:|SUB|A|1284|C denotes 1284A>C
T4 1198-1203 ProteinMutation:p|SUB|E|333|D denotes E333D
T5 1295-1300 ProteinMutation:p|SUB|E|333|D denotes E333D
T6 1509-1514 ProteinMutation:p|SUB|E|333|D denotes E333D
T7 1931-1936 ProteinMutation:p|SUB|E|333|D denotes E333D