PubMed:17156757 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/17156757","sourcedb":"PubMed","sourceid":"17156757","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/17156757","text":"Peripheral thermal injury causes blood-brain barrier dysfunction and matrix metalloproteinase (MMP) expression in rat.\nMortality after serious systemic thermal injury may be linked to significant increases in cerebral vascular permeability and edema due to blood-brain barrier (BBB) breakdown. This BBB disruption is thought to be mediated by a family of proteolytic enzymes known as matrix metalloproteinases (MMPs). The gelatinases, MMP-2 and MMP-9, digest the endothelial basal lamina of the BBB, which is essential for maintaining BBB integrity. The current study investigated whether disruption of microvascular integrity in a rat thermal injury model is associated with gelatinase expression and activity. Seventy-two adult Sprague-Dawley rats were anesthetized and submerged horizontally, in the supine position, in 100 degrees C (37 degrees C for controls) water for 6 s producing a third-degree burn affecting 60-70% of the total body surface area. Brain edema was detected by calculating water content. Real time PCR, Western blot, and zymography were used to quantify MMP mRNA, protein, and enzyme activity levels. Each group was quantified at 3, 7, 24, and 72 h post thermal injury. Brain water content was significantly increased 7 through 72 h after burn. Expression of brain MMP-9 mRNA was significantly increased as early as 3 h after thermal injury compared to controls, remained at 7 h (p\u003c0.01), and returned to control levels by 24 h. MMP-9 protein levels and enzyme activity began to increase at 7 h and reached significant levels between 7 and 24 h after thermal injury. While MMP-9 protein levels continued to increase significantly through 72 h, enzyme activity returned to control level. The increase in MMP-9 expression and activity, associated with increased BBB permeability following thermal injury, indicates that MMP-9 may contribute to observed cerebral edema in peripheral thermal injury.","tracks":[{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":119,"end":293},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":294,"end":417},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":418,"end":549},"obj":"DRI_Background"},{"id":"T4","span":{"begin":550,"end":711},"obj":"DRI_Challenge"},{"id":"T5","span":{"begin":712,"end":957},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":958,"end":1012},"obj":"DRI_Background"},{"id":"T7","span":{"begin":1013,"end":1125},"obj":"DRI_Background"},{"id":"T8","span":{"begin":1126,"end":1194},"obj":"DRI_Approach"},{"id":"T9","span":{"begin":1195,"end":1269},"obj":"DRI_Background"},{"id":"T10","span":{"begin":1270,"end":1591},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1592,"end":1711},"obj":"DRI_Background"},{"id":"T12","span":{"begin":1712,"end":1920},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T11","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T12","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":33,"end":52},"obj":"UBERON:0000120"},{"id":"T4","span":{"begin":69,"end":75},"obj":"UBERON:0027368"},{"id":"T7","span":{"begin":95,"end":98},"obj":"PR:O04529"},{"id":"T5","span":{"begin":95,"end":98},"obj":"CHEBI:340824"},{"id":"T8","span":{"begin":95,"end":98},"obj":"CHEBI:59761"},{"id":"T6","span":{"begin":95,"end":98},"obj":"GO:0004235"},{"id":"T10","span":{"begin":114,"end":117},"obj":"PR:P63003-1"},{"id":"T11","span":{"begin":114,"end":117},"obj":"PR:Q2G0B1"},{"id":"T12","span":{"begin":114,"end":117},"obj":"PR:Q8VHJ4"},{"id":"T9","span":{"begin":114,"end":117},"obj":"10116"},{"id":"T13","span":{"begin":114,"end":117},"obj":"D051381"},{"id":"T14","span":{"begin":244,"end":249},"obj":"D004487"},{"id":"T15","span":{"begin":244,"end":249},"obj":"D004487"},{"id":"T16","span":{"begin":257,"end":276},"obj":"UBERON:0000120"},{"id":"T19","span":{"begin":278,"end":281},"obj":"UBERON:0000120"},{"id":"T20","span":{"begin":283,"end":292},"obj":"GO:0009056"},{"id":"T21","span":{"begin":299,"end":302},"obj":"UBERON:0000120"},{"id":"T22","span":{"begin":355,"end":374},"obj":"D010447"},{"id":"T23","span":{"begin":384,"end":390},"obj":"UBERON:0027368"},{"id":"T24","span":{"begin":384,"end":409},"obj":"D020782"},{"id":"T26","span":{"begin":411,"end":415},"obj":"D020782"},{"id":"T27","span":{"begin":422,"end":433},"obj":"D018093"},{"id":"T28","span":{"begin":435,"end":438},"obj":"CHEBI:340824"},{"id":"T31","span":{"begin":435,"end":438},"obj":"CHEBI:59761"},{"id":"T32","span":{"begin":435,"end":440},"obj":"PR:P08253"},{"id":"T33","span":{"begin":435,"end":440},"obj":"Q9GLE5"},{"id":"T34","span":{"begin":435,"end":440},"obj":"P08253"},{"id":"T35","span":{"begin":435,"end":440},"obj":"Q90611"},{"id":"T37","span":{"begin":435,"end":440},"obj":"PR:Q8MPP3"},{"id":"T38","span":{"begin":435,"end":440},"obj":"P33436"},{"id":"T39","span":{"begin":435,"end":440},"obj":"PR:Q90611"},{"id":"T40","span":{"begin":435,"end":440},"obj":"PR:P33436"},{"id":"T41","span":{"begin":435,"end":440},"obj":"PR:000010479"},{"id":"T42","span":{"begin":435,"end":440},"obj":"PR:P33434"},{"id":"T43","span":{"begin":435,"end":440},"obj":"P33434"},{"id":"T44","span":{"begin":435,"end":440},"obj":"P50757"},{"id":"T36","span":{"begin":435,"end":440},"obj":"GO:0004228"},{"id":"T45","span":{"begin":445,"end":448},"obj":"CHEBI:340824"},{"id":"T48","span":{"begin":445,"end":448},"obj":"CHEBI:59761"},{"id":"T49","span":{"begin":445,"end":450},"obj":"PR:P50282"},{"id":"T50","span":{"begin":445,"end":450},"obj":"PR:P14780"},{"id":"T51","span":{"begin":445,"end":450},"obj":"P14780"},{"id":"T52","span":{"begin":445,"end":450},"obj":"PR:P41245"},{"id":"T53","span":{"begin":445,"end":450},"obj":"P41246"},{"id":"T54","span":{"begin":445,"end":450},"obj":"P41245"},{"id":"T55","span":{"begin":445,"end":450},"obj":"PR:P52176"},{"id":"T56","span":{"begin":445,"end":450},"obj":"P50282"},{"id":"T58","span":{"begin":445,"end":450},"obj":"PR:000010491"},{"id":"T59","span":{"begin":445,"end":450},"obj":"P52176"},{"id":"T60","span":{"begin":445,"end":450},"obj":"O18733"},{"id":"T57","span":{"begin":445,"end":450},"obj":"GO:0004229"},{"id":"T61","span":{"begin":475,"end":487},"obj":"GO:0005604"},{"id":"T62","span":{"begin":475,"end":487},"obj":"UBERON:0000482"},{"id":"T66","span":{"begin":495,"end":498},"obj":"UBERON:0000120"},{"id":"T67","span":{"begin":535,"end":538},"obj":"UBERON:0000120"},{"id":"T69","span":{"begin":632,"end":635},"obj":"PR:P63003-1"},{"id":"T70","span":{"begin":632,"end":635},"obj":"PR:Q2G0B1"},{"id":"T71","span":{"begin":632,"end":635},"obj":"PR:Q8VHJ4"},{"id":"T68","span":{"begin":632,"end":635},"obj":"10116"},{"id":"T72","span":{"begin":632,"end":635},"obj":"D051381"},{"id":"T74","span":{"begin":676,"end":686},"obj":"Q833V7"},{"id":"T73","span":{"begin":676,"end":686},"obj":"D018093"},{"id":"T75","span":{"begin":724,"end":729},"obj":"UBERON:0007023"},{"id":"T76","span":{"begin":730,"end":749},"obj":"D017207"},{"id":"T81","span":{"begin":835,"end":840},"obj":"P07703"},{"id":"T80","span":{"begin":835,"end":840},"obj":"CVCL_9106"},{"id":"T82","span":{"begin":939,"end":951},"obj":"UBERON:0002416"},{"id":"T83","span":{"begin":958,"end":969},"obj":"D001929"},{"id":"T84","span":{"begin":958,"end":969},"obj":"D001929"},{"id":"T87","span":{"begin":1023,"end":1026},"obj":"Q41249"},{"id":"T88","span":{"begin":1023,"end":1026},"obj":"O66148"},{"id":"T89","span":{"begin":1023,"end":1026},"obj":"Q59987"},{"id":"T90","span":{"begin":1023,"end":1026},"obj":"Q01289"},{"id":"T91","span":{"begin":1023,"end":1026},"obj":"O80333"},{"id":"T92","span":{"begin":1023,"end":1026},"obj":"P15904"},{"id":"T93","span":{"begin":1023,"end":1026},"obj":"Q9SDT1"},{"id":"T94","span":{"begin":1023,"end":1026},"obj":"Q39617"},{"id":"T97","span":{"begin":1079,"end":1082},"obj":"PR:O04529"},{"id":"T95","span":{"begin":1079,"end":1082},"obj":"CHEBI:340824"},{"id":"T98","span":{"begin":1079,"end":1082},"obj":"CHEBI:59761"},{"id":"T96","span":{"begin":1079,"end":1082},"obj":"GO:0004235"},{"id":"T101","span":{"begin":1083,"end":1087},"obj":"SO:0000234"},{"id":"T99","span":{"begin":1083,"end":1087},"obj":"D012333"},{"id":"T100","span":{"begin":1083,"end":1087},"obj":"CHEBI:33699"},{"id":"T105","span":{"begin":1089,"end":1096},"obj":"PR:000000001"},{"id":"T106","span":{"begin":1089,"end":1096},"obj":"SO:0000104"},{"id":"T102","span":{"begin":1089,"end":1096},"obj":"GO:0003675"},{"id":"T103","span":{"begin":1089,"end":1096},"obj":"CHEBI:36080"},{"id":"T104","span":{"begin":1089,"end":1096},"obj":"CHEBI:11122"},{"id":"T107","span":{"begin":1102,"end":1117},"obj":"GO:0003824"},{"id":"T121","span":{"begin":1284,"end":1289},"obj":"UBERON:6110636"},{"id":"T122","span":{"begin":1284,"end":1289},"obj":"UBERON:0000955"},{"id":"T123","span":{"begin":1290,"end":1293},"obj":"CHEBI:340824"},{"id":"T126","span":{"begin":1290,"end":1293},"obj":"CHEBI:59761"},{"id":"T127","span":{"begin":1290,"end":1295},"obj":"PR:P50282"},{"id":"T128","span":{"begin":1290,"end":1295},"obj":"PR:P14780"},{"id":"T129","span":{"begin":1290,"end":1295},"obj":"P14780"},{"id":"T130","span":{"begin":1290,"end":1295},"obj":"PR:P41245"},{"id":"T131","span":{"begin":1290,"end":1295},"obj":"P41246"},{"id":"T132","span":{"begin":1290,"end":1295},"obj":"P41245"},{"id":"T133","span":{"begin":1290,"end":1295},"obj":"PR:P52176"},{"id":"T134","span":{"begin":1290,"end":1295},"obj":"P50282"},{"id":"T136","span":{"begin":1290,"end":1295},"obj":"PR:000010491"},{"id":"T137","span":{"begin":1290,"end":1295},"obj":"P52176"},{"id":"T138","span":{"begin":1290,"end":1295},"obj":"O18733"},{"id":"T135","span":{"begin":1290,"end":1295},"obj":"GO:0004229"},{"id":"T141","span":{"begin":1296,"end":1300},"obj":"SO:0000234"},{"id":"T139","span":{"begin":1296,"end":1300},"obj":"D012333"},{"id":"T140","span":{"begin":1296,"end":1300},"obj":"CHEBI:33699"},{"id":"T151","span":{"begin":1448,"end":1452},"obj":"CVCL_8262"},{"id":"T152","span":{"begin":1454,"end":1457},"obj":"CHEBI:340824"},{"id":"T155","span":{"begin":1454,"end":1457},"obj":"CHEBI:59761"},{"id":"T156","span":{"begin":1454,"end":1459},"obj":"PR:P50282"},{"id":"T157","span":{"begin":1454,"end":1459},"obj":"PR:P14780"},{"id":"T158","span":{"begin":1454,"end":1459},"obj":"P14780"},{"id":"T159","span":{"begin":1454,"end":1459},"obj":"PR:P41245"},{"id":"T160","span":{"begin":1454,"end":1459},"obj":"P41246"},{"id":"T161","span":{"begin":1454,"end":1459},"obj":"P41245"},{"id":"T162","span":{"begin":1454,"end":1459},"obj":"PR:P52176"},{"id":"T163","span":{"begin":1454,"end":1459},"obj":"P50282"},{"id":"T165","span":{"begin":1454,"end":1459},"obj":"PR:000010491"},{"id":"T166","span":{"begin":1454,"end":1459},"obj":"P52176"},{"id":"T167","span":{"begin":1454,"end":1459},"obj":"O18733"},{"id":"T164","span":{"begin":1454,"end":1459},"obj":"GO:0004229"},{"id":"T172","span":{"begin":1460,"end":1467},"obj":"SO:0000104"},{"id":"T171","span":{"begin":1460,"end":1467},"obj":"PR:000000001"},{"id":"T169","span":{"begin":1460,"end":1467},"obj":"CHEBI:36080"},{"id":"T170","span":{"begin":1460,"end":1467},"obj":"CHEBI:11122"},{"id":"T168","span":{"begin":1460,"end":1467},"obj":"GO:0003675"},{"id":"T173","span":{"begin":1479,"end":1494},"obj":"GO:0003824"},{"id":"T176","span":{"begin":1565,"end":1569},"obj":"CVCL_8262"},{"id":"T177","span":{"begin":1598,"end":1601},"obj":"CHEBI:340824"},{"id":"T180","span":{"begin":1598,"end":1601},"obj":"CHEBI:59761"},{"id":"T181","span":{"begin":1598,"end":1603},"obj":"PR:P50282"},{"id":"T182","span":{"begin":1598,"end":1603},"obj":"PR:P14780"},{"id":"T183","span":{"begin":1598,"end":1603},"obj":"P14780"},{"id":"T184","span":{"begin":1598,"end":1603},"obj":"PR:P41245"},{"id":"T185","span":{"begin":1598,"end":1603},"obj":"P41246"},{"id":"T186","span":{"begin":1598,"end":1603},"obj":"P41245"},{"id":"T187","span":{"begin":1598,"end":1603},"obj":"PR:P52176"},{"id":"T188","span":{"begin":1598,"end":1603},"obj":"P50282"},{"id":"T190","span":{"begin":1598,"end":1603},"obj":"PR:000010491"},{"id":"T191","span":{"begin":1598,"end":1603},"obj":"P52176"},{"id":"T192","span":{"begin":1598,"end":1603},"obj":"O18733"},{"id":"T189","span":{"begin":1598,"end":1603},"obj":"GO:0004229"},{"id":"T196","span":{"begin":1604,"end":1611},"obj":"PR:000000001"},{"id":"T193","span":{"begin":1604,"end":1611},"obj":"GO:0003675"},{"id":"T197","span":{"begin":1604,"end":1611},"obj":"SO:0000104"},{"id":"T194","span":{"begin":1604,"end":1611},"obj":"CHEBI:36080"},{"id":"T195","span":{"begin":1604,"end":1611},"obj":"CHEBI:11122"},{"id":"T198","span":{"begin":1669,"end":1684},"obj":"GO:0003824"},{"id":"T199","span":{"begin":1728,"end":1731},"obj":"CHEBI:340824"},{"id":"T202","span":{"begin":1728,"end":1731},"obj":"CHEBI:59761"},{"id":"T203","span":{"begin":1728,"end":1733},"obj":"PR:P50282"},{"id":"T204","span":{"begin":1728,"end":1733},"obj":"PR:P14780"},{"id":"T205","span":{"begin":1728,"end":1733},"obj":"P14780"},{"id":"T206","span":{"begin":1728,"end":1733},"obj":"PR:P41245"},{"id":"T207","span":{"begin":1728,"end":1733},"obj":"P41246"},{"id":"T208","span":{"begin":1728,"end":1733},"obj":"P41245"},{"id":"T209","span":{"begin":1728,"end":1733},"obj":"PR:P52176"},{"id":"T210","span":{"begin":1728,"end":1733},"obj":"P50282"},{"id":"T212","span":{"begin":1728,"end":1733},"obj":"PR:000010491"},{"id":"T213","span":{"begin":1728,"end":1733},"obj":"P52176"},{"id":"T214","span":{"begin":1728,"end":1733},"obj":"O18733"},{"id":"T211","span":{"begin":1728,"end":1733},"obj":"GO:0004229"},{"id":"T215","span":{"begin":1785,"end":1788},"obj":"UBERON:0000120"},{"id":"T216","span":{"begin":1843,"end":1846},"obj":"CHEBI:340824"},{"id":"T219","span":{"begin":1843,"end":1846},"obj":"CHEBI:59761"},{"id":"T220","span":{"begin":1843,"end":1848},"obj":"PR:P50282"},{"id":"T221","span":{"begin":1843,"end":1848},"obj":"PR:P14780"},{"id":"T222","span":{"begin":1843,"end":1848},"obj":"P14780"},{"id":"T223","span":{"begin":1843,"end":1848},"obj":"PR:P41245"},{"id":"T224","span":{"begin":1843,"end":1848},"obj":"P41246"},{"id":"T225","span":{"begin":1843,"end":1848},"obj":"P41245"},{"id":"T226","span":{"begin":1843,"end":1848},"obj":"PR:P52176"},{"id":"T227","span":{"begin":1843,"end":1848},"obj":"P50282"},{"id":"T229","span":{"begin":1843,"end":1848},"obj":"PR:000010491"},{"id":"T230","span":{"begin":1843,"end":1848},"obj":"P52176"},{"id":"T231","span":{"begin":1843,"end":1848},"obj":"O18733"},{"id":"T228","span":{"begin":1843,"end":1848},"obj":"GO:0004229"},{"id":"T232","span":{"begin":1876,"end":1890},"obj":"D001929"},{"id":"T233","span":{"begin":1876,"end":1890},"obj":"D001929"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T196","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T202","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T205","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T207","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T209","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T212","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T211","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T227","pred":"source","obj":"c_corpus"},{"subj":"T229","pred":"source","obj":"c_corpus"},{"subj":"T230","pred":"source","obj":"c_corpus"},{"subj":"T231","pred":"source","obj":"c_corpus"},{"subj":"T228","pred":"source","obj":"c_corpus"},{"subj":"T232","pred":"source","obj":"c_corpus"},{"subj":"T233","pred":"source","obj":"c_corpus"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":244,"end":249},"obj":"HP_0000969"},{"id":"T2","span":{"begin":958,"end":969},"obj":"HP_0002181"},{"id":"T3","span":{"begin":964,"end":969},"obj":"HP_0000969"},{"id":"T4","span":{"begin":1876,"end":1890},"obj":"HP_0002181"},{"id":"T5","span":{"begin":1885,"end":1890},"obj":"HP_0000969"},{"id":"T6","span":{"begin":1885,"end":1904},"obj":"HP_0012398"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":118},"obj":"DRI_Background"},{"id":"T2","span":{"begin":119,"end":293},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":294,"end":417},"obj":"DRI_Challenge"},{"id":"T4","span":{"begin":418,"end":549},"obj":"DRI_Background"},{"id":"T5","span":{"begin":550,"end":711},"obj":"DRI_Challenge"},{"id":"T6","span":{"begin":712,"end":957},"obj":"DRI_Approach"},{"id":"T7","span":{"begin":958,"end":1012},"obj":"DRI_Background"},{"id":"T8","span":{"begin":1013,"end":1125},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1126,"end":1194},"obj":"DRI_Approach"},{"id":"T10","span":{"begin":1195,"end":1269},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1270,"end":1591},"obj":"DRI_Unspecified"},{"id":"T12","span":{"begin":1592,"end":1711},"obj":"DRI_Background"},{"id":"T13","span":{"begin":1712,"end":1920},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T13","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubMed_ArguminSci","color":"#9593ec","default":true},{"id":"c_corpus","color":"#aaec93"},{"id":"PubmedHPO","color":"#ec93c4"},{"id":"UseCases_ArguminSci_Discourse","color":"#93dfec"}]}]}}